Mechanisms of RPE senescence and potential role of αB crystallin peptide as a senolytic agent in experimental AMD
Published 2022 View Full Article
- Home
- Publications
- Publication Search
- Publication Details
Title
Mechanisms of RPE senescence and potential role of αB crystallin peptide as a senolytic agent in experimental AMD
Authors
Keywords
αB crystallin peptide, Mitochondrial dysfunction, Oxidative stress, Retinal pigment epithelium, SASP, Senescence, Senolytic drugs, Subretinal fibrosis
Journal
EXPERIMENTAL EYE RESEARCH
Volume 215, Issue -, Pages 108918
Publisher
Elsevier BV
Online
2022-01-02
DOI
10.1016/j.exer.2021.108918
References
Ask authors/readers for more resources
Related references
Note: Only part of the references are listed.- Cellular senescence in the aging retina and developments of senotherapies for age-related macular degeneration
- (2021) Keng Siang Lee et al. Journal of Neuroinflammation
- Pathological angiogenesis in retinopathy engages cellular senescence and is amenable to therapeutic elimination via BCL-xL inhibition
- (2021) Sergio Crespo-Garcia et al. Cell Metabolism
- National Institute on Aging Workshop: Repurposing Drugs or Dietary Supplements for Their Senolytic or Senomorphic Effects: Considerations for Clinical Trials
- (2021) Sergei Romashkan et al. JOURNALS OF GERONTOLOGY SERIES A-BIOLOGICAL SCIENCES AND MEDICAL SCIENCES
- Senolytics and Senomorphics: natural and synthetic therapeutics in the treatment of aging and chronic diseases
- (2021) Sofia M. Lagoumtzi et al. FREE RADICAL BIOLOGY AND MEDICINE
- Radiation-Induced Senescence Reprograms Secretory and Metabolic Pathways in Colon Cancer HCT-116 Cells
- (2021) Chandrasekharam N. Nagineni et al. INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
- Cellular senescence in pathologic retinal angiogenesis
- (2021) Zhongjie Fu et al. TRENDS IN ENDOCRINOLOGY AND METABOLISM
- Sodium Iodate-Induced Degeneration Results in Local Complement Changes and Inflammatory Processes in Murine Retina
- (2021) Anne Enzbrenner et al. INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
- Sulodexide reduces glucose induced senescence in human retinal endothelial cells
- (2021) A. Gericke et al. Scientific Reports
- Grape Seed Proanthocyanidin Extract Moderated Retinal Pigment Epithelium Cellular Senescence Through NAMPT/SIRT1/NLRP3 Pathway
- (2021) Wencui Wan et al. Journal of Inflammation Research
- Targeting senescent retinal pigment epithelial cells facilitates retinal regeneration in mouse models of age-related macular degeneration
- (2021) Jae-Byoung Chae et al. GeroScience
- Tissue specificity of senescent cell accumulation during physiologic and accelerated aging of mice
- (2020) Matthew J. Yousefzadeh et al. AGING CELL
- Senescence in the pathogenesis of age-related macular degeneration
- (2020) Janusz Blasiak CELLULAR AND MOLECULAR LIFE SCIENCES
- A proteomic atlas of senescence-associated secretomes for aging biomarker development
- (2020) Nathan Basisty et al. PLOS BIOLOGY
- Survey of senescent cell markers with age in human tissues
- (2020) M. Laura Idda et al. Aging-US
- Mitochondrial Determinants of Doxorubicin-Induced Cardiomyopathy
- (2020) Kendall B. Wallace et al. CIRCULATION RESEARCH
- The Emerging Role of Senescence in Ocular Disease
- (2020) Parameswaran G. Sreekumar et al. Oxidative Medicine and Cellular Longevity
- Mitochondrial phosphatase PGAM5 modulates cellular senescence by regulating mitochondrial dynamics
- (2020) Bo Yu et al. Nature Communications
- Transporter-Mediated Mitochondrial GSH Depletion Leading to Mitochondrial Dysfunction and Rescue with αB Crystallin Peptide in RPE Cells
- (2020) Parameswaran G Sreekumar et al. Antioxidants
- Interleukin-1β Drives Cellular Senescence of Rat Astrocytes Induced by Oligomerized Amyloid β Peptide and Oxidative Stress
- (2020) Dongsheng Shang et al. Frontiers in Neurology
- Crosstalk between Long-Term Sublethal Oxidative Stress and Detrimental Inflammation as Potential Drivers for Age-Related Retinal Degeneration
- (2020) Lara Macchioni et al. Antioxidants
- Loss of MPC1 reprograms retinal metabolism to impair visual function
- (2019) Allison Grenell et al. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
- Activation of mTORC1/PGC1 axis promotes mitochondrial biogenesis and induces cellular senescence in the lung epithelium
- (2019) Ross Summer et al. AMERICAN JOURNAL OF PHYSIOLOGY-LUNG CELLULAR AND MOLECULAR PHYSIOLOGY
- Regulation of Mitochondrial Biogenesis as a Way for Active Longevity: Interaction Between the Nrf2 and PGC-1α Signaling Pathways
- (2019) Artem P. Gureev et al. Frontiers in Genetics
- From discoveries in ageing research to therapeutics for healthy ageing
- (2019) Judith Campisi et al. NATURE
- Mitochondrial Homeostasis and Cellular Senescence
- (2019) Panagiotis V.S. Vasileiou et al. Cells
- Mitofusins modulate the increase in mitochondrial length, bioenergetics and secretory phenotype in therapy-induced senescent melanoma cells
- (2019) Jennyfer Martínez et al. BIOCHEMICAL JOURNAL
- A Novel HDL-Mimetic Peptide HM-10/10 Protects RPE and Photoreceptors in Murine Models of Retinal Degeneration
- (2019) Feng Su et al. INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
- Early removal of senescent cells protects retinal ganglion cells loss in experimental ocular hypertension
- (2019) Lorena Raquel Rocha et al. AGING CELL
- Loss of NAMPT in aging retinal pigment epithelium reduces NAD+ availability and promotes cellular senescence
- (2018) Ravirajsinh N. Jadeja et al. Aging-US
- Mitochondrial peptides modulate mitochondrial function during cellular senescence
- (2018) Su-Jeong Kim et al. Aging-US
- Intra-vitreal αB crystallin fused to elastin-like polypeptide provides neuroprotection in a mouse model of age-related macular degeneration
- (2018) Parameswaran G. Sreekumar et al. JOURNAL OF CONTROLLED RELEASE
- Epigenetic control of gene regulation during development and disease: A view from the retina
- (2018) Ximena Corso-Díaz et al. PROGRESS IN RETINAL AND EYE RESEARCH
- Hallmarks of Cellular Senescence
- (2018) Alejandra Hernandez-Segura et al. TRENDS IN CELL BIOLOGY
- Lung cellular senescence is independent of aging in a mouse model of COPD/emphysema
- (2018) Kahkashan Rashid et al. Scientific Reports
- Rapamycin increases oxidative metabolism and enhances metabolic flexibility in human cardiac fibroblasts
- (2018) Timothy Nacarelli et al. GeroScience
- Immune regulation in the aging retina
- (2018) Mei Chen et al. PROGRESS IN RETINAL AND EYE RESEARCH
- Drp1-Dependent Mitochondrial Fission Plays Critical Roles in Physiological and Pathological Progresses in Mammals
- (2017) Chenxia Hu et al. INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
- Roles of IL-6 in Ocular Inflammation: A Review
- (2017) Hassan Ghasemi OCULAR IMMUNOLOGY AND INFLAMMATION
- Cellular Senescence in Age-Related Macular Degeneration: Can Autophagy and DNA Damage Response Play a Role?
- (2017) Janusz Blasiak et al. Oxidative Medicine and Cellular Longevity
- The impact of oxidative stress and inflammation on RPE degeneration in non-neovascular AMD
- (2017) Sayantan Datta et al. PROGRESS IN RETINAL AND EYE RESEARCH
- Biochemical adaptations of the retina and retinal pigment epithelium support a metabolic ecosystem in the vertebrate eye
- (2017) Mark A Kanow et al. eLife
- Altered bioenergetics and enhanced resistance to oxidative stress in human retinal pigment epithelial cells from donors with age-related macular degeneration
- (2017) Deborah A. Ferrington et al. Redox Biology
- αB-Crystallin Regulates Subretinal Fibrosis by Modulation of Epithelial-Mesenchymal Transition
- (2016) Keijiro Ishikawa et al. AMERICAN JOURNAL OF PATHOLOGY
- Alpha crystallins in the retinal pigment epithelium and implications for the pathogenesis and treatment of age-related macular degeneration
- (2016) Ram Kannan et al. BIOCHIMICA ET BIOPHYSICA ACTA-GENERAL SUBJECTS
- From Ancient Pathways to Aging Cells—Connecting Metabolism and Cellular Senescence
- (2016) Christopher D. Wiley et al. Cell Metabolism
- Mitochondrial stress induces cellular senescence in an mTORC1-dependent manner
- (2016) Timothy Nacarelli et al. FREE RADICAL BIOLOGY AND MEDICINE
- Senescence-associated secretory phenotype contributes to pathological angiogenesis in retinopathy
- (2016) M. Oubaha et al. Science Translational Medicine
- Cellular Senescence Promotes Adverse Effects of Chemotherapy and Cancer Relapse
- (2016) Marco Demaria et al. Cancer Discovery
- Oxidative stress-induced premature senescence dysregulates VEGF and CFH expression in retinal pigment epithelial cells: Implications for Age-related Macular Degeneration
- (2016) Mariela C. Marazita et al. Redox Biology
- Attainment of polarity promotes growth factor secretion by retinal pigment epithelial cells: Relevance to age-related macular degeneration
- (2016) Shozo Sonoda et al. Aging-US
- Retinoblastoma protein promotes oxidative phosphorylation through upregulation of glycolytic genes in oncogene-induced senescent cells
- (2015) Shin-ichiro Takebayashi et al. AGING CELL
- Mitochondria: Are they causal players in cellular senescence?
- (2015) Clara Correia-Melo et al. BIOCHIMICA ET BIOPHYSICA ACTA-BIOENERGETICS
- Loss of MT1-MMP causes cell senescence and nuclear defects which can be reversed by retinoic acid
- (2015) A. Gutierrez-Fernandez et al. EMBO JOURNAL
- Genomic regulation of senescence and innate immunity signaling in the retinal pigment epithelium
- (2015) Edward Chaum et al. MAMMALIAN GENOME
- P16INK4a Upregulation Mediated by SIX6 Defines Retinal Ganglion Cell Pathogenesis in Glaucoma
- (2015) Dorota Skowronska-Krawczyk et al. MOLECULAR CELL
- Cellular senescence in aging and age-related disease: from mechanisms to therapy
- (2015) Bennett G Childs et al. NATURE MEDICINE
- Sodium iodate induced retinal degeneration: new insights from an old model
- (2015) DavidR Hinton et al. Neural Regeneration Research
- Protein polymer nanoparticles engineered as chaperones protect against apoptosis in human retinal pigment epithelial cells
- (2014) Wan Wang et al. JOURNAL OF CONTROLLED RELEASE
- Mitochondrial fragmentation in cigarette smoke-induced bronchial epithelial cell senescence
- (2013) Hiromichi Hara et al. AMERICAN JOURNAL OF PHYSIOLOGY-LUNG CELLULAR AND MOLECULAR PHYSIOLOGY
- A comparison of replicative senescence and doxorubicin-induced premature senescence of vascular smooth muscle cells isolated from human aorta
- (2013) Anna Bielak-Zmijewska et al. BIOGERONTOLOGY
- Cellular senescence and the senescent secretory phenotype: therapeutic opportunities
- (2013) Tamara Tchkonia et al. JOURNAL OF CLINICAL INVESTIGATION
- Endothelial Sirtuin 1 Deficiency Perpetrates Nephrosclerosis through Downregulation of Matrix Metalloproteinase-14: Relevance to Fibrosis of Vascular Senescence
- (2013) R. Vasko et al. JOURNAL OF THE AMERICAN SOCIETY OF NEPHROLOGY
- The Molecular Balancing Act of p16 INK4a in Cancer and Aging
- (2013) Kyle M. LaPak et al. MOLECULAR CANCER RESEARCH
- A key role for mitochondrial gatekeeper pyruvate dehydrogenase in oncogene-induced senescence
- (2013) Joanna Kaplon et al. NATURE
- Synthetic lethal metabolic targeting of cellular senescence in cancer therapy
- (2013) Jan R. Dörr et al. NATURE
- mtDNA makes a U-turn for the mitochondrial nucleoid
- (2013) Christian Kukat et al. TRENDS IN CELL BIOLOGY
- Aging, Cellular Senescence, and Cancer
- (2012) Judith Campisi Annual Review of Physiology
- Recent advances into the understanding of mitochondrial fission
- (2012) Kirstin Elgass et al. BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR CELL RESEARCH
- Oncogene-induced senescence results in marked metabolic and bioenergetic alterations
- (2012) Celia Quijano et al. CELL CYCLE
- Deficiency of αB crystallin augments ER stress-induced apoptosis by enhancing mitochondrial dysfunction
- (2012) Guorui Dou et al. FREE RADICAL BIOLOGY AND MEDICINE
- Chaperone Activity of Small Heat Shock Proteins Underlies Therapeutic Efficacy in Experimental Autoimmune Encephalomyelitis
- (2012) Michael P. Kurnellas et al. JOURNAL OF BIOLOGICAL CHEMISTRY
- RPE cell senescence: A key contributor to age-related macular degeneration
- (2012) Michael R. Kozlowski MEDICAL HYPOTHESES
- Understanding age-related macular degeneration (AMD): Relationships between the photoreceptor/retinal pigment epithelium/Bruch’s membrane/choriocapillaris complex
- (2012) Imran Bhutto et al. MOLECULAR ASPECTS OF MEDICINE
- Mechanisms of Age-Related Macular Degeneration
- (2012) Jayakrishna Ambati et al. NEURON
- Mechanism of RPE Cell Death in α-Crystallin Deficient Mice: A Novel and Critical Role for MRP1-Mediated GSH Efflux
- (2012) Parameswaran G. Sreekumar et al. PLoS One
- ERK1/2 activation is a therapeutic target in age-related macular degeneration
- (2012) S. Dridi et al. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
- Novel roles for α-crystallins in retinal function and disease
- (2012) Ram Kannan et al. PROGRESS IN RETINAL AND EYE RESEARCH
- Retinal pigment epithelial expression of complement regulator CD46 is altered early in the course of geographic atrophy
- (2011) Susan D. Vogt et al. EXPERIMENTAL EYE RESEARCH
- Molecular mechanisms and physiologic functions of mitochondrial dynamics
- (2011) H. Otera et al. JOURNAL OF BIOCHEMISTRY
- Regulation of VEGF expression in human retinal cells by cytokines: Implications for the role of inflammation in age-related macular degeneration
- (2011) Chandrasekharam N. Nagineni et al. JOURNAL OF CELLULAR PHYSIOLOGY
- Clearance of p16Ink4a-positive senescent cells delays ageing-associated disorders
- (2011) Darren J. Baker et al. NATURE
- Roles of IL-8 in Ocular Inflammations: A Review
- (2011) Hassan Ghasemi et al. OCULAR IMMUNOLOGY AND INFLAMMATION
- The Senescence-Associated Secretory Phenotype: The Dark Side of Tumor Suppression
- (2010) Jean-Philippe Coppé et al. Annual Review of Pathology-Mechanisms of Disease
- mTOR-mediated dedifferentiation of the retinal pigment epithelium initiates photoreceptor degeneration in mice
- (2010) Chen Zhao et al. JOURNAL OF CLINICAL INVESTIGATION
- Feedback between p21 and reactive oxygen production is necessary for cell senescence
- (2010) João F Passos et al. Molecular Systems Biology
- αB Crystallin Is Apically Secreted within Exosomes by Polarized Human Retinal Pigment Epithelium and Provides Neuroprotection to Adjacent Cells
- (2010) Parameswaran G. Sreekumar et al. PLoS One
- Loss of human Greatwall results in G2 arrest and multiple mitotic defects due to deregulation of the cyclin B-Cdc2/PP2A balance
- (2010) Andrew Burgess et al. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
- B-crystallin regulation of angiogenesis by modulation of VEGF
- (2009) S. Kase et al. BLOOD
- BMP4 Mediates Oxidative Stress-induced Retinal Pigment Epithelial Cell Senescence and Is Overexpressed in Age-related Macular Degeneration
- (2009) DanHong Zhu et al. JOURNAL OF BIOLOGICAL CHEMISTRY
- A protocol for the culture and differentiation of highly polarized human retinal pigment epithelial cells
- (2009) Shozo Sonoda et al. Nature Protocols
- Expression and regulation of enzymes in the ceramide metabolic pathway in human retinal pigment epithelial cells and their relevance to retinal degeneration
- (2009) DanHong Zhu et al. VISION RESEARCH
- Induction of premature senescence in cardiomyocytes by doxorubicin as a novel mechanism of myocardial damage
- (2008) Yasuhiro Maejima et al. AGING CELL
Find Funding. Review Successful Grants.
Explore over 25,000 new funding opportunities and over 6,000,000 successful grants.
ExploreCreate your own webinar
Interested in hosting your own webinar? Check the schedule and propose your idea to the Peeref Content Team.
Create Now