The 3-iodothyronamine (T1AM) and the 3-iodothyroacetic acid (TA1) indicate a novel connection with the histamine system for neuroprotection

Determination of 3-iodothyronamine (3-T1AM) in mouse liver using liquid chromatography-tandem mass spectrometry

(2021) Zhong-Min Li et al.   JOURNAL OF CHROMATOGRAPHY B-ANALYTICAL TECHNOLOGIES IN THE BIOMEDICAL AND LIFE SCIENCES

Commentary: Euthyroid Sick Syndrome in Patients With COVID-19

(2021) Annunziatina Laurino et al.   Frontiers in Endocrinology

Delivery of Thyronamines (TAMs) to the Brain: A Preliminary Study

(2021) Nicoletta di Leo et al.   MOLECULES

T1AM-TAAR1 signalling protects against OGD-induced synaptic dysfunction in the entorhinal cortex

(2021) Francesca Tozzi et al.   NEUROBIOLOGY OF DISEASE

Physiological Role and Use of Thyroid Hormone Metabolites - Potential Utility in COVID-19 Patients

(2021) Eleonore Fröhlich et al.   Frontiers in Endocrinology

Role of Monoamine Oxidase Activity in Alzheimer’s Disease: An Insight into the Therapeutic Potential of Inhibitors

(2021) Tapan Behl et al.   MOLECULES

Endogenous 3-Iodothyronamine (T1AM) and Synthetic Thyronamine-Like Analog SG-2 Act as Novel Pleiotropic Neuroprotective Agents through the Modulation of SIRT6

(2020) Lorenza Bellusci et al.   MOLECULES

Trace Amine-Associated Receptor 5 Provides Olfactory Input Into Limbic Brain Areas and Modulates Emotional Behaviors and Serotonin Transmission

(2020) Stefano Espinoza et al.   Frontiers in Molecular Neuroscience

Mixture and concentration effects on odorant receptor response patterns in vivo

(2020) Timothy S McClintock et al.   CHEMICAL SENSES

Integrin αvβ3 in the Mediating Effects of Dihydrotestosterone and Resveratrol on Breast Cancer Cell Proliferation

(2020) Yih Ho et al.   INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

Antagonism of Histamine H3 receptors Alleviates Pentylenetetrazole-Induced Kindling and Associated Memory Deficits by Mitigating Oxidative Stress, Central Neurotransmitters, and c-Fos Protein Expression in Rats

(2020) Alaa Alachkar et al.   MOLECULES

Histaminergic Neurons in the Tuberomammillary Nucleus as a Control Centre for Wakefulness

(2020) Takeo Yoshikawa et al.   BRITISH JOURNAL OF PHARMACOLOGY

3-Iodothyronamine Affects Thermogenic Substrates’ Mobilization in Brown Adipocytes

(2020) Manuela Gencarelli et al.   Biology-Basel

Peroxisome Proliferator-Activated Receptor γ Coactivator 1α Activates Vascular Endothelial Growth Factor That Protects Against Neuronal Cell Death Following Status Epilepticus through PI3K/AKT and MEK/ERK Signaling

(2020) Jyun-Bin Huang et al.   INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

Chronic brain histamine depletion in adult mice induced depression-like behaviours and impaired sleep-wake cycle

(2020) Yo Yamada et al.   NEUROPHARMACOLOGY

Mechanism of Action of Atypical Antipsychotic Drugs in Mood Disorders

(2020) Daniil Grinchii et al.   INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

Histamine, histamine H 3 receptor, and alcohol use disorder

(2019) Pertti Panula   BRITISH JOURNAL OF PHARMACOLOGY

Procognitive impact of ciproxifan (a histaminergic H 3 receptor antagonist) on contextual memory retrieval after acute stress

(2019) Frédéric Chauveau et al.   CNS Neuroscience & Therapeutics

Brain Histamine Modulates the Antidepressant-Like Effect of the 3-Iodothyroacetic Acid (TA1)

(2019) Annunziatina Laurino et al.   Frontiers in Cellular Neuroscience

Histamine beyond its effects on allergy: Potential therapeutic benefits for the treatment of Amyotrophic Lateral Sclerosis (ALS)

(2019) Cinzia Volonté et al.   PHARMACOLOGY & THERAPEUTICS

Long-Term Use of Pitolisant to Treat Patients with Narcolepsy: Harmony III Study

(2019) Yves Dauvilliers et al.   SLEEP

N-(3-Ethoxy-phenyl)-4-pyrrolidin-1-yl-3-trifluoromethyl-benzamide (EPPTB) prevents 3-iodothyronamine (T1AM)-induced neuroprotection against kainic acid toxicity

(2019) Elisa Landucci et al.   NEUROCHEMISTRY INTERNATIONAL

3-Iodothyronamine reduces insulin secretion in vitro via a mitochondrial mechanism

(2018) Ina Lehmphul et al.   MOLECULAR AND CELLULAR ENDOCRINOLOGY

3-Iodothyroacetic acid (TA 1 ), a by-product of thyroid hormone metabolism, reduces the hypnotic effect of ethanol without interacting at GABA-A receptors

(2018) Annunziatina Laurino et al.   NEUROCHEMISTRY INTERNATIONAL

Trace Amines and Their Receptors

(2018) Raul R. Gainetdinov et al.   PHARMACOLOGICAL REVIEWS

Brain histamine modulates recognition memory: possible implications in major cognitive disorders

(2018) Gustavo Provensi et al.   BRITISH JOURNAL OF PHARMACOLOGY

Anticonvulsant and Neuroprotective Effects of the Thyroid Hormone Metabolite 3-Iodothyroacetic Acid

(2018) Annunziatina Laurino et al.   THYROID

3-Iodothyronamine Induces Tail Vasodilation Through Central Action in Male Mice

(2017) Sogol Gachkar et al.   ENDOCRINOLOGY

The impact of scopolamine pretreatment on 3-iodothyronamine (T1AM) effects on memory and pain in mice

(2017) Annunziatina Laurino et al.   HORMONES AND BEHAVIOR

Avoiding the pitfalls when quantifying thyroid hormones and their metabolites using mass spectrometric methods: The role of quality assurance

(2017) Keith Richards et al.   MOLECULAR AND CELLULAR ENDOCRINOLOGY

Histamine regulates memory consolidation

(2017) Maria Beatrice Passani et al.   NEUROBIOLOGY OF LEARNING AND MEMORY

New Insights into the Potential Roles of 3-Iodothyronamine (T1AM) and Newly Developed Thyronamine-Like TAAR1 Agonists in Neuroprotection

(2017) Lorenza Bellusci et al.   Frontiers in Pharmacology

Thyroid hormones derivatives reduce proliferation and induce cell death and DNA damage in ovarian cancer

(2017) Elena Shinderman-Maman et al.   Scientific Reports

3-iodothyronamine (T1AM), a novel antagonist of muscarinic receptors

(2016) Annunziatina Laurino et al.   EUROPEAN JOURNAL OF PHARMACOLOGY

Suppression of Brain Mast Cells Degranulation Inhibits Microglial Activation and Central Nervous System Inflammation

(2016) Hongquan Dong et al.   MOLECULAR NEUROBIOLOGY

Isoform-Specific Biased Agonism of Histamine H 3 Receptor Agonists

(2016) Darren M. Riddy et al.   MOLECULAR PHARMACOLOGY

Donepezil, an acetylcholine esterase inhibitor, and ABT-239, a histamine H 3 receptor antagonist/inverse agonist, require the integrity of brain histamine system to exert biochemical and procognitive effects in the mouse

(2016) Gustavo Provensi et al.   NEUROPHARMACOLOGY

The Histaminergic Tuberomamillary Nucleus Is Involved in Appetite for Sex, Water and Amphetamine

(2016) Marco Contreras et al.   PLoS One

Trace Amines and the Trace Amine-Associated Receptor 1: Pharmacology, Neurochemistry, and Clinical Implications

(2016) Yue Pei et al.   Frontiers in Neuroscience

3-iodothyroacetic acid, a metabolite of thyroid hormone, induces itch and reduces threshold to noxious and to painful heat stimuli in mice

(2015) Annunziatina Laurino et al.   BRITISH JOURNAL OF PHARMACOLOGY

Thyronamine induces TRPM8 channel activation in human conjunctival epithelial cells

(2015) Noushafarin Khajavi et al.   CELLULAR SIGNALLING

In-vivo pharmacology of Trace-Amine Associated Receptor 1

(2015) Vincent M. Lam et al.   EUROPEAN JOURNAL OF PHARMACOLOGY

Trace amine-associated receptor 1: A promising target for the treatment of psychostimulant addiction

(2015) Li Jing et al.   EUROPEAN JOURNAL OF PHARMACOLOGY

In the brain of mice, 3-iodothyronamine (T1AM) is converted into 3-iodothyroacetic acid (TA1) and it is included within the signaling network connecting thyroid hormone metabolites with histamine

(2015) Annunziatina Laurino et al.   EUROPEAN JOURNAL OF PHARMACOLOGY

Trace amine-associated receptor 1 activation silences GSK3β signaling of TAAR1 and D2R heteromers

(2015) Anja Harmeier et al.   EUROPEAN NEUROPSYCHOPHARMACOLOGY

3-iodothyronamine differentially modulates  -2A-adrenergic receptor-mediated signaling

(2015) J. Dinter et al.   JOURNAL OF MOLECULAR ENDOCRINOLOGY

Inverse Agonistic Action of 3-Iodothyronamine at the Human Trace Amine-Associated Receptor 5

(2015) Juliane Dinter et al.   PLoS One

Histamine mediates behavioural and metabolic effects of 3-iodothyroacetic acid, an endogenous end product of thyroid hormone metabolism

(2014) Claudia Musilli et al.   BRITISH JOURNAL OF PHARMACOLOGY

Psychiatric and cognitive manifestations of hypothyroidism

(2014) Mary H. Samuels   Current Opinion in Endocrinology Diabetes and Obesity

Effects of acute microinjections of the thyroid hormone derivative 3-iodothyronamine to the preoptic region of adult male rats on sleep, thermoregulation and motor activity

(2013) Thomas D. James et al.   HORMONES AND BEHAVIOR

Biogenic amines activate blood leukocytes via trace amine-associated receptors TAAR1 and TAAR2

(2013) A. Babusyte et al.   JOURNAL OF LEUKOCYTE BIOLOGY

The histaminergic network in the brain: basic organization and role in disease

(2013) Pertti Panula et al.   NATURE REVIEWS NEUROSCIENCE

Trace Amine-Associated Receptor 1 Partial Agonism Reveals Novel Paradigm for Neuropsychiatric Therapeutics

(2012) Florent G. Revel et al.   BIOLOGICAL PSYCHIATRY

Histamine H3receptor antagonists in relation to epilepsy and neurodegeneration: a systemic consideration of recent progress and perspectives

(2012) M Bhowmik et al.   BRITISH JOURNAL OF PHARMACOLOGY

3-Iodothyronamine: a modulator of the hypothalamus-pancreas-thyroid axes in mice

(2012) Maria Elena Manni et al.   BRITISH JOURNAL OF PHARMACOLOGY

Pharmacological effects of 3-iodothyronamine (T1AM) in mice include facilitation of memory acquisition and retention and reduction of pain threshold

(2012) Maria Elena Manni et al.   BRITISH JOURNAL OF PHARMACOLOGY

Systematic analysis of histamine and N-methylhistamine concentrations in organs from two common laboratory mouse strains: C57Bl/6 and Balb/c

(2011) Anna Sophie Zimmermann et al.   INFLAMMATION RESEARCH

MAO-inhibitors in Parkinson's Disease

(2011) Peter Riederer et al.   Experimental Neurobiology

Exploration of Structure-Activity Relationships for Dual Serotonin Transporter Reuptake Inhibitors-Histamine H3 Receptor Antagonists

(2010) Emily M. Stocking et al.   CURRENT TOPICS IN MEDICINAL CHEMISTRY

The Histamine H3 Receptor and Eating Behavior

(2010) M. B. Passani et al.   JOURNAL OF PHARMACOLOGY AND EXPERIMENTAL THERAPEUTICS

Histamine in the regulation of wakefulness

(2010) Mahesh M. Thakkar   SLEEP MEDICINE REVIEWS

The Prevalence of Thyrotoxicosis-Related Seizures

(2010) Tae-Jin Song et al.   THYROID

Effect of L-Thyroxine and Carbimazole on Blood Levels of Biogenic Amines in Rat

(2009) L. Upadhyaya et al.   EXPERIMENTAL AND CLINICAL ENDOCRINOLOGY & DIABETES

Activation of the histaminergic H3receptor induces phosphorylation of the Akt/GSK-3β pathway in cultured cortical neurons and protects against neurotoxic insults

(2009) Chiara Mariottini et al.   JOURNAL OF NEUROCHEMISTRY

The Thyroid-Brain Interaction in Thyroid Disorders and Mood Disorders

(2008) M. Bauer et al.   JOURNAL OF NEUROENDOCRINOLOGY

Hypothalamic neuronal histamine regulates body weight through the modulation of diurnal feeding rhythm

(2008) Hironobu Yoshimatsu   NUTRITION