Peroxisome Proliferator-Activated Receptor γ Coactivator 1α Activates Vascular Endothelial Growth Factor That Protects Against Neuronal Cell Death Following Status Epilepticus through PI3K/AKT and MEK/ERK Signaling

Vascular Abnormalities and the Role of Vascular Endothelial Growth Factor in the Epileptic Brain

(2020) Ari Ogaki et al.   Frontiers in Pharmacology

Anlotinib suppresses tumor progression via blocking the VEGFR2/PI3K/AKT cascade in intrahepatic cholangiocarcinoma

(2020) Fei Song et al.   Cell Death & Disease

Epilepsy in adults

(2019) Roland D Thijs et al.   LANCET

Resveratrol Promotes Mitochondrial Biogenesis and Protects against Seizure-Induced Neuronal Cell Damage in the Hippocampus Following Status Epilepticus by Activation of the PGC-1α Signaling Pathway

(2019) Yao-Chung Chuang et al.   INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

Sirtuin 1 Regulates Mitochondrial Biogenesis and Provides an Endogenous Neuroprotective Mechanism Against Seizure-Induced Neuronal Cell Death in the Hippocampus Following Status Epilepticus

(2019) Yao-Chung Chuang et al.   INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

VEGF-C Induces Alternative Activation of Microglia to Promote Recovery from Traumatic Brain Injury

(2019) Shiming Ju et al.   JOURNAL OF ALZHEIMERS DISEASE

Role of PGC-1α in Mitochondrial Quality Control in Neurodegenerative Diseases

(2019) Qi Zhang et al.   NEUROCHEMICAL RESEARCH

Post-stroke Constraint-induced Movement Therapy Increases Functional Recovery, Angiogenesis, and Neurogenesis with Enhanced Expression of HIF-1α and VEGF

(2018) Ce Li et al.   CURRENT NEUROVASCULAR RESEARCH

The Janus Face of VEGF in Stroke

(2018) Samuel Geiseler et al.   INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

VEGF Signaling in Neurological Disorders

(2018) Joon Shim et al.   INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

Effect of Resveratrol on Oxidative Stress and Mitochondrial Dysfunction in Immature Brain during Epileptogenesis

(2018) Jaroslava Folbergrová et al.   MOLECULAR NEUROBIOLOGY

Inhibition of VEGF-Flk-1 binding induced profound biochemical alteration in the hippocampus of a rat model of BBB breakdown by spider venom. A preliminary assessment using FT-IR spectroscopy

(2018) Maria Helena Rodrigues Mesquita-Britto et al.   NEUROCHEMISTRY INTERNATIONAL

Mechanistic insight into activation of MAPK signaling by pro-angiogenic factors

(2018) Min Song et al.   BMC Systems Biology

PI3K Signaling in Neurons: A Central Node for the Control of Multiple Functions

(2018) Karina Sánchez-Alegría et al.   INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

Evidence that activation of P2X7R does not exacerbate neuronal death after optic nerve transection and focal cerebral ischemia in mice

(2017) Berrak Caglayan et al.   EXPERIMENTAL NEUROLOGY

The extracellular signal-regulated kinase 1/2 pathway in neurological diseases: A potential therapeutic target (Review)

(2017) Jing Sun et al.   INTERNATIONAL JOURNAL OF MOLECULAR MEDICINE

The Emerging Role of GLP-1 Receptors in DNA Repair: Implications in Neurological Disorders

(2017) Jenq-Lin Yang et al.   INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

VEGFR1 and VEGFR2 in Alzheimer’s Disease

(2017) Rachel Harris et al.   JOURNAL OF ALZHEIMERS DISEASE

Mitochondrial biogenesis in neurodegeneration

(2017) P. Andy Li et al.   JOURNAL OF NEUROSCIENCE RESEARCH

Mitochondrial function in hypoxic ischemic injury and influence of aging

(2017) P. Benson Ham et al.   PROGRESS IN NEUROBIOLOGY

Cystatin C as a potential therapeutic mediator against Parkinson’s disease via VEGF-induced angiogenesis and enhanced neuronal autophagy in neurovascular units

(2017) Jing Zou et al.   Cell Death & Disease

Valproic Acid Protects Primary Dopamine Neurons from MPP+-Induced Neurotoxicity: Involvement of GSK3β Phosphorylation by Akt and ERK through the Mitochondrial Intrinsic Apoptotic Pathway

(2017) Chi Zhang et al.   Biomed Research International

Desensitizing Mitochondrial Permeability Transition by ERK-Cyclophilin D Axis Contributes to the Neuroprotective Effect of Gallic Acid against Cerebral Ischemia/Reperfusion Injury

(2017) Jing Sun et al.   Frontiers in Pharmacology

Dynamin-Related Protein 1 Promotes Mitochondrial Fission and Contributes to The Hippocampal Neuronal Cell Death Following Experimental Status Epilepticus

(2016) Shang-Der Chen et al.   CNS Neuroscience & Therapeutics

Recent advances in status epilepticus

(2016) Eugen Trinka et al.   CURRENT OPINION IN NEUROLOGY

Regulation of endothelial dynamics by PGC-1α relies on ROS control of VEGF-A signaling

(2016) Nieves García-Quintans et al.   FREE RADICAL BIOLOGY AND MEDICINE

Effective PI3K modulators for improved therapy against malignant tumors and for neuroprotection of brain damage after tumor therapy (Review)

(2016) Satoru Matsuda et al.   INTERNATIONAL JOURNAL OF ONCOLOGY

Mechanisms and regulation of endothelial VEGF receptor signalling

(2016) Michael Simons et al.   NATURE REVIEWS MOLECULAR CELL BIOLOGY

The Neuroprotection of Liraglutide Against Ischaemia-induced Apoptosis through the Activation of the PI3K/AKT and MAPK Pathways

(2016) Huili Zhu et al.   Scientific Reports

Aberrant astrocytes impair vascular reactivity in Huntington disease

(2015) Han-Yun Hsiao et al.   ANNALS OF NEUROLOGY

Status epilepticus in adults

(2015) John P Betjemann et al.   LANCET NEUROLOGY

Editorial (Thematic Issue: Mitochondrial Biogenesis: Pharmacological Approaches)

(2014) Teresa Valero   CURRENT PHARMACEUTICAL DESIGN

Hypoxic Induction of Vascular Endothelial Growth Factor (VEGF) and Angiogenesis in Muscle by Truncated Peroxisome Proliferator-activated Receptor γ Coactivator (PGC)-1α

(2014) Robyn Thom et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Crosstalk between mitogen-activated protein kinases and mitochondria in cardiac diseases: Therapeutic perspectives

(2014) Sabzali Javadov et al.   PHARMACOLOGY & THERAPEUTICS

Signaling through the vascular endothelial growth factor receptor VEGFR-2 protects hippocampal neurons from mitochondrial dysfunction and oxidative stress

(2013) Tianfeng Hao et al.   FREE RADICAL BIOLOGY AND MEDICINE

Heat shock protein 70 protects against seizure-induced neuronal cell death in the hippocampus following experimental status epilepticus via inhibition of nuclear factor-κB activation-induced nitric oxide synthase II expression

(2013) Chiung-Chih Chang et al.   NEUROBIOLOGY OF DISEASE

BDNF and Exercise Enhance Neuronal DNA Repair by Stimulating CREB-Mediated Production of Apurinic/Apyrimidinic Endonuclease 1

(2013) Jenq-Lin Yang et al.   NEUROMOLECULAR MEDICINE

Autophagy proteins regulate ERK phosphorylation

(2013) Nuria Martinez-Lopez et al.   Nature Communications

Clinical significance of serological biomarkers and neuropsychological performances in patients with temporal lobe epilepsy

(2012) Chiung-Chih Chang et al.   BMC Neurology

VEGF signaling inside vascular endothelial cells and beyond

(2012) Anne Eichmann et al.   CURRENT OPINION IN CELL BIOLOGY

PGC1  and mitochondrial metabolism - emerging concepts and relevance in ageing and neurodegenerative disorders

(2012) S. Austin et al.   JOURNAL OF CELL SCIENCE

Peroxisome proliferator-activated receptors γ/mitochondrial uncoupling protein 2 signaling protects against seizure-induced neuronal cell death in the hippocampus following experimental status epilepticus

(2012) Yao-Chung Chuang et al.   Journal of Neuroinflammation

Vascular endothelial growth factor regulates adult hippocampal cell proliferation through MEK/ERK- and PI3K/Akt-dependent signaling

(2012) Neil M. Fournier et al.   NEUROPHARMACOLOGY

VEGF Receptor-2 (Flk-1) Overexpression in Mice Counteracts Focal Epileptic Seizures

(2012) Litsa Nikitidou et al.   PLoS One

Roles of Oxidative Stress, Apoptosis, PGC-1α and Mitochondrial Biogenesis in Cerebral Ischemia

(2011) Shang-Der Chen et al.   INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

Vascular endothelial growth factor in cerebral ischemia

(2011) Yihui Ma et al.   JOURNAL OF NEUROSCIENCE RESEARCH

Vascular Endothelial Growth Factor Attenuates Neurodegenerative Changes in the NSC-34 Motor Neuron Cell Line Induced by Cerebrospinal Fluid of Sporadic Amyotrophic Lateral Sclerosis Patients

(2011) Dinkar Kulshreshtha et al.   Neurodegenerative Diseases

PGC-1α at the intersection of bioenergetics regulation and neuron function: From Huntington's disease to Parkinson's disease and beyond

(2011) Taiji Tsunemi et al.   PROGRESS IN NEUROBIOLOGY

VEGF in the nervous system

(2011) Jeffrey M. Rosenstein et al.   Organogenesis

The MAPK cascades: Signaling components, nuclear roles and mechanisms of nuclear translocation

(2010) Alexander Plotnikov et al.   BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR CELL RESEARCH

Baicalin increases VEGF expression and angiogenesis by activating the ERR /PGC-1  pathway

(2010) K. Zhang et al.   CARDIOVASCULAR RESEARCH

Vascular endothelial growth factor attenuates status epilepticus-induced behavioral impairments in rats

(2010) Jamee N. Nicoletti et al.   EPILEPSY & BEHAVIOR

The potential role of mitochondrial dysfunction in seizure-associated cell death in the hippocampus and epileptogenesis

(2010) Shang-Der Chen et al.   JOURNAL OF BIOENERGETICS AND BIOMEMBRANES

Direct survival role of vascular endothelial growth factor (VEGF) on rat ovarian follicular cells

(2010) Griselda Irusta et al.   MOLECULAR AND CELLULAR ENDOCRINOLOGY

Vascular Endothelial Growth Factor Receptor-2 Inhibition Promotes Cell Death and Limits Endothelial Cell Proliferation in a Neonatal Rodent Model of Stroke

(2010) Janet Shimotake et al.   STROKE

Contribution of nitric oxide, superoxide anion, and peroxynitrite to activation of mitochondrial apoptotic signaling in hippocampal CA3 subfield following experimental temporal lobe status epilepticus

(2009) Yao-Chung Chuang et al.   EPILEPSIA

Protective effects of peroxisome proliferator-activated receptors γ coactivator-1α against neuronal cell death in the hippocampal CA1 subfield after transient global ischemia

(2009) Shang-Der Chen et al.   JOURNAL OF NEUROSCIENCE RESEARCH

Targeting protein kinases in central nervous system disorders

(2009) Laura K. Chico et al.   NATURE REVIEWS DRUG DISCOVERY

Protective Effect of Resveratrol against Kainate-induced Temporal Lobe Epilepsy in Rats

(2009) Zheng Wu et al.   NEUROCHEMICAL RESEARCH

Role and Therapeutic Potential of VEGF in the Nervous System

(2009) Carmen Ruiz de Almodovar et al.   PHYSIOLOGICAL REVIEWS

Vascular endothelial growth factor is up-regulated after status epilepticus and protects against seizure-induced neuronal loss in hippocampus

(2007) J.N. Nicoletti et al.   NEUROSCIENCE