The histaminergic network in the brain: basic organization and role in disease

Presenilin1 Regulates Histamine Neuron Development and Behavior in Zebrafish, Danio rerio

(2013) M. Sundvik et al.   JOURNAL OF NEUROSCIENCE

Randomized Clinical Study of a Histamine H3 Receptor Antagonist for the Treatment of Adults with Attention-Deficit Hyperactivity Disorder

(2012) Richard H. Weisler et al.   CNS DRUGS

Combinatorial roles for histamine H1-H2 and H3-H4 receptors in autoimmune inflammatory disease of the central nervous system

(2012) Naresha Saligrama et al.   EUROPEAN JOURNAL OF IMMUNOLOGY

Organization of the histaminergic system in adult zebrafish (Danio rerio) brain: Neuron number, location, and cotransmitters

(2012) Maria Sundvik et al.   JOURNAL OF COMPARATIVE NEUROLOGY

Histamine Release in the Basal Forebrain Mediates Cortical Activation through Cholinergic Neurons

(2012) J. C. Zant et al.   JOURNAL OF NEUROSCIENCE

GABAergic Inhibition of Histaminergic Neurons Regulates Active Waking But Not the Sleep-Wake Switch or Propofol-Induced Loss of Consciousness

(2012) A. Y. Zecharia et al.   JOURNAL OF NEUROSCIENCE

Rare Copy Number Variants in Tourette Syndrome Disrupt Genes in Histaminergic Pathways and Overlap with Autism

(2011) Thomas V. Fernandez et al.   BIOLOGICAL PSYCHIATRY

Deprivation of anticipated food under scheduled feeding induces c-Fos expression in the caudal part of the arcuate nucleus of hypothalamus through histamine H1 receptors in rats: Potential involvement of E3 subgroup of histaminergic neurons in tuberomammillary nucleus

(2011) Hayato Umehara et al.   BRAIN RESEARCH

The histamine H3 receptor: from discovery to clinical trials with pitolisant

(2011) Jean-Charles Schwartz   BRITISH JOURNAL OF PHARMACOLOGY

Histamine Receptor Expression, Hippocampal Plasticity and Ammonia in Histidine Decarboxylase Knockout Mice

(2011) Aisa Chepkova et al.   CELLULAR AND MOLECULAR NEUROBIOLOGY

Several down, a few to go: histamine H3 receptor ligands making the final push towards the market?

(2011) Sebastiaan Kuhne et al.   EXPERT OPINION ON INVESTIGATIONAL DRUGS

The histaminergic system regulates wakefulness and orexin/hypocretin neuron development via histamine receptor H1 in zebrafish

(2011) Maria Sundvik et al.   FASEB JOURNAL

Histamine H4 Receptor Optimizes T Regulatory Cell Frequency and Facilitates Anti-Inflammatory Responses within the Central Nervous System

(2011) R. del Rio et al.   JOURNAL OF IMMUNOLOGY

Crystal Structure-Based Virtual Screening for Fragment-like Ligands of the Human Histamine H1Receptor

(2011) Chris de Graaf et al.   JOURNAL OF MEDICINAL CHEMISTRY

Differential Modulation of Excitatory and Inhibitory Striatal Synaptic Transmission by Histamine

(2011) T. J. Ellender et al.   JOURNAL OF NEUROSCIENCE

l-Dopa activates histaminergic neurons

(2011) Yevgenij Yanovsky et al.   JOURNAL OF PHYSIOLOGY-LONDON

Structure of the human histamine H1 receptor complex with doxepin

(2011) Tatsuro Shimamura et al.   NATURE

Evidence for the Role of Histamine H3 Receptor in Alcohol Consumption and Alcohol Reward in Mice

(2011) Saara Nuutinen et al.   NEUROPSYCHOPHARMACOLOGY

Additive effects of a cholinesterase inhibitor and a histamine inverse agonist on scopolamine deficits in humans

(2011) William Cho et al.   PSYCHOPHARMACOLOGY

Involvement of histamine receptors in the atypical antipsychotic profile of clozapine: a reassessment in vitro and in vivo

(2011) Marie Humbert-Claude et al.   PSYCHOPHARMACOLOGY

Histamine receptors in the CNS as targets for therapeutic intervention

(2011) Maria Beatrice Passani et al.   TRENDS IN PHARMACOLOGICAL SCIENCES

Connectomics of orexin-producing neurons: interface of systems of emotion, energy homeostasis and arousal

(2011) Takeshi Sakurai et al.   TRENDS IN PHARMACOLOGICAL SCIENCES

Sleep-waking discharge of ventral tuberomammillary neurons in wild-type and histidine decarboxylase knock-out mice

(2011) Kazuya Sakai   Frontiers in Behavioral Neuroscience

Cognitive domains affected by histamine H1-antagonism in humans: A literature review

(2010) P. Van Ruitenbeek et al.   BRAIN RESEARCH REVIEWS

Dopamine D1-histamine H3Receptor Heteromers Provide a Selective Link to MAPK Signaling in GABAergic Neurons of the Direct Striatal Pathway

(2010) Estefanía Moreno et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Discovery of Histamine H3 Antagonists for the Treatment of Cognitive Disorders and Alzheimer's Disease

(2010) J. D. Brioni et al.   JOURNAL OF PHARMACOLOGY AND EXPERIMENTAL THERAPEUTICS

The Histamine H3 Receptor and Eating Behavior

(2010) M. B. Passani et al.   JOURNAL OF PHARMACOLOGY AND EXPERIMENTAL THERAPEUTICS

Effect of histamine H2receptor antagonism on levodopa-induced dyskinesia in the MPTP-macaque model of Parkinson's disease

(2010) Tom H. Johnston et al.   MOVEMENT DISORDERS

Environmental factors and their timing in adult-onset multiple sclerosis

(2010) Adam E. Handel et al.   Nature Reviews Neurology

The comparative neuroanatomy and neurochemistry of zebrafish CNS systems of relevance to human neuropsychiatric diseases

(2010) P. Panula et al.   NEUROBIOLOGY OF DISEASE

Ciproxifan, an H3 receptor antagonist, alleviates hyperactivity and cognitive deficits in the APPTg2576 mouse model of Alzheimer’s disease

(2010) Mark E. Bardgett et al.   NEUROBIOLOGY OF LEARNING AND MEMORY

Effects of histamine H3 receptor ligands on the rewarding, stimulant and motor-impairing effects of ethanol in DBA/2J mice

(2010) Saara Nuutinen et al.   NEUROPHARMACOLOGY

Modanifil activates the histaminergic system through the orexinergic neurons

(2010) Tomoko Ishizuka et al.   NEUROSCIENCE LETTERS

L-Histidine Decarboxylase and Tourette's Syndrome

(2010) A. Gulhan Ercan-Sencicek et al.   NEW ENGLAND JOURNAL OF MEDICINE

JNJ-39220675, a novel selective histamine H3 receptor antagonist, reduces the abuse-related effects of alcohol in rats

(2010) Ruggero Galici et al.   PSYCHOPHARMACOLOGY

The histamine H4 receptor is functionally expressed on neurons in the mammalian CNS

(2009) WM Connelly et al.   BRITISH JOURNAL OF PHARMACOLOGY

Marked changes in signal transduction upon heteromerization of dopamine D1 and histamine H3 receptors

(2009) Carla Ferrada et al.   BRITISH JOURNAL OF PHARMACOLOGY

Altered histamine H3 receptor radioligand binding in post-mortem brain samples from subjects with psychiatric diseases

(2009) CY Jin et al.   BRITISH JOURNAL OF PHARMACOLOGY

Heterogeneity of histaminergic neurons in the tuberomammillary nucleus of the rat

(2009) Patrizia Giannoni et al.   EUROPEAN JOURNAL OF NEUROSCIENCE

Feeding signals and brain circuitry

(2009) Marcelo O. Dietrich et al.   EUROPEAN JOURNAL OF NEUROSCIENCE

Decreased number of parvalbumin and cholinergic interneurons in the striatum of individuals with Tourette syndrome

(2009) Yuko Kataoka et al.   JOURNAL OF COMPARATIVE NEUROLOGY

Orexin/Hypocretin and Histamine: Distinct Roles in the Control of Wakefulness Demonstrated Using Knock-Out Mouse Models

(2009) C. Anaclet et al.   JOURNAL OF NEUROSCIENCE

JNJ-10181457, a selective non-imidazole histamine H3 receptor antagonist, normalizes acetylcholine neurotransmission and has efficacy in translational rat models of cognition

(2009) Ruggero Galici et al.   NEUROPHARMACOLOGY

Morphine induces conditioned place preference behavior in histidine decarboxylase knockout mice

(2009) Ying-xia Gong et al.   NEUROSCIENCE LETTERS

Histamine H3 receptor ligands modulate L-dopa-evoked behavioral responses and L-dopa-derived extracellular dopamine in dopamine-denervated rat striatum

(2009) Przemyslaw Nowak et al.   NEUROTOXICITY RESEARCH

Histaminergic Activity in a Rodent Model of Parkinson’s Disease

(2009) Przemysław Nowak et al.   NEUROTOXICITY RESEARCH

The effects of thioperamide on extracellular levels of glutamate and GABA in the rat prefrontal cortex

(2009) Natalie Welty et al.   PSYCHOPHARMACOLOGY

Histamine and H3 receptor-dependent mechanisms regulate ethanol stimulation and conditioned place preference in mice

(2009) Saara Nuutinen et al.   PSYCHOPHARMACOLOGY

The role of histamine on cognition

(2008) Edgardo O. Alvarez   BEHAVIOURAL BRAIN RESEARCH

Histamine H3 Receptor Antagonists Go to Clinics

(2008) Kerstin Sander et al.   BIOLOGICAL & PHARMACEUTICAL BULLETIN

The histamine H3receptor: an attractive target for the treatment of cognitive disorders

(2008) T A Esbenshade et al.   BRITISH JOURNAL OF PHARMACOLOGY

N-acylphosphatidylethanolamine, a Gut- Derived Circulating Factor Induced by Fat Ingestion, Inhibits Food Intake

(2008) Matthew P. Gillum et al.   CELL

Histamine induces neural stem cell proliferation and neuronal differentiation by activation of distinct histamine receptors

(2008) Anayansi Molina-Hernndez et al.   JOURNAL OF NEUROCHEMISTRY

The role of histamine H1 and H4 receptors in allergic inflammation: the search for new antihistamines

(2008) Robin L. Thurmond et al.   NATURE REVIEWS DRUG DISCOVERY

Interactions between histamine H3 and dopamine D2 receptors and the implications for striatal function

(2008) Carla Ferrada et al.   NEUROPHARMACOLOGY

Histamine in the Nervous System

(2008) Helmut L. Haas et al.   PHYSIOLOGICAL REVIEWS

Effects of the H3 receptor inverse agonist thioperamide on cocaine-induced locomotion in mice: role of the histaminergic system and potential pharmacokinetic interactions

(2008) Christian Brabant et al.   PSYCHOPHARMACOLOGY

H3 receptor antagonists reverse delay-dependent deficits in novel object discrimination by enhancing retrieval

(2008) Vincent Pascoli et al.   PSYCHOPHARMACOLOGY

An inverse agonist of the histamine H3 receptor improves wakefulness in narcolepsy: Studies in orexin−/− mice and patients

(2007) Jian-Sheng Lin et al.   NEUROBIOLOGY OF DISEASE