Neuroinflammation PET imaging of the translocator protein (TSPO) in Alzheimer's disease: An update
Published 2022 View Full Article
- Home
- Publications
- Publication Search
- Publication Details
Title
Neuroinflammation PET imaging of the translocator protein (TSPO) in Alzheimer's disease: An update
Authors
Keywords
-
Journal
EUROPEAN JOURNAL OF NEUROSCIENCE
Volume -, Issue -, Pages -
Publisher
Wiley
Online
2022-01-27
DOI
10.1111/ejn.15613
References
Ask authors/readers for more resources
Related references
Note: Only part of the references are listed.- Cellular sources of TSPO expression in healthy and diseased brain
- (2021) Erik Nutma et al. EUROPEAN JOURNAL OF NUCLEAR MEDICINE AND MOLECULAR IMAGING
- Kinetic modeling and parameter estimation of TSPO PET imaging in the human brain
- (2021) Catriona Wimberley et al. EUROPEAN JOURNAL OF NUCLEAR MEDICINE AND MOLECULAR IMAGING
- Olfactory Impairment is Related to Tau Pathology and Neuroinflammation in Alzheimer’s Disease
- (2021) Julia Klein et al. JOURNAL OF ALZHEIMERS DISEASE
- Reactive astrocyte nomenclature, definitions, and future directions
- (2021) Carole Escartin et al. NATURE NEUROSCIENCE
- Knowledge gaps in Alzheimer's disease immune biomarker research
- (2021) David G. Morgan et al. Alzheimers & Dementia
- Neuroinflammation is highest in areas of disease progression in semantic dementia
- (2021) Belen Pascual et al. BRAIN
- Supervised clustering for TSPO PET imaging
- (2021) Julia Schubert et al. EUROPEAN JOURNAL OF NUCLEAR MEDICINE AND MOLECULAR IMAGING
- Microglial activation and tau propagate jointly across Braak stages
- (2021) Tharick A. Pascoal et al. NATURE MEDICINE
- Peripheral cytokine and fatty acid associations with neuroinflammation in AD and aMCI patients: an exploratory study
- (2020) Giulia Cisbani et al. BRAIN BEHAVIOR AND IMMUNITY
- A Protective Role of Translocator Protein in Alzheimer’s Disease Brain
- (2020) Marianna E. Jung Current Alzheimer Research
- In search of an anti-inflammatory drug for Alzheimer disease
- (2020) Erika Gyengesi et al. Nature Reviews Neurology
- Low plasma neurofilament light levels associated with raised cortical microglial activation suggest inflammation acts to protect prodromal Alzheimer’s disease
- (2020) Peter Parbo et al. Alzheimers Research & Therapy
- The Translocator Protein (TSPO) in Mitochondrial Bioenergetics and Immune Processes
- (2020) Calina Betlazar et al. Cells
- Microglial activation and tau burden predict cognitive decline in Alzheimer’s disease
- (2020) Maura Malpetti et al. BRAIN
- The relationships between neuroinflammation, beta-amyloid and tau deposition in Alzheimer’s disease: a longitudinal PET study
- (2020) Rola Ismail et al. Journal of Neuroinflammation
- A Path Toward Precision Medicine for Neuroinflammatory Mechanisms in Alzheimer's Disease
- (2020) Harald Hampel et al. Frontiers in Immunology
- Synergy between amyloid-β and tau in Alzheimer’s disease
- (2020) Marc Aurel Busche et al. NATURE NEUROSCIENCE
- Microglia Implicated in Tauopathy in the Striatum of Neurodegenerative Disease Patients from Genotype to Phenotype
- (2020) Huifangjie Li et al. INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
- Astrocytic TSPO Upregulation Appears Before Microglial TSPO in Alzheimer’s Disease
- (2020) Benjamin B. Tournier et al. JOURNAL OF ALZHEIMERS DISEASE
- Patterns of Mitochondrial TSPO Binding in Cerebral Small Vessel Disease: An in vivo PET Study With Neuropathological Comparison
- (2020) Paul Wright et al. Frontiers in Neurology
- In Vivo Assessment of Neuroinflammation in 4‐Repeat Tauopathies
- (2020) Carla Palleis et al. MOVEMENT DISORDERS
- Neuroinflammation and microglial activation in Alzheimer disease: where do we go from here?
- (2020) Fangda Leng et al. Nature Reviews Neurology
- Automatic extraction of a reference region for the noninvasive quantification of translocator protein in brain using 11C-PBR28
- (2019) Paolo Zanotti Fregonara et al. JOURNAL OF NUCLEAR MEDICINE
- Beyond the neuron–cellular interactions early in Alzheimer disease pathogenesis
- (2019) Christopher M. Henstridge et al. NATURE REVIEWS NEUROSCIENCE
- Microglial activation in early Alzheimer trajectory is associated with higher gray matter volume
- (2019) Grazia Daniela Femminella et al. NEUROLOGY
- Genetic meta-analysis of diagnosed Alzheimer’s disease identifies new risk loci and implicates Aβ, tau, immunity and lipid processing
- (2019) Brian W. Kunkle et al. NATURE GENETICS
- Spatial and temporal heterogeneity of mouse and human microglia at single-cell resolution
- (2019) Takahiro Masuda et al. NATURE
- Radiosynthesis of (R, S)‐[18F]GE387: A Potential PET Radiotracer for Imaging Translocator Protein 18 kDa (TSPO) with low binding sensitivity to the human gene polymorphism rs6971
- (2019) Luxi Qiao et al. ChemMedChem
- Neuroinflammation in mild cognitive impairment and Alzheimer’s disease: A meta-analysis
- (2019) Steven Bradburn et al. AGEING RESEARCH REVIEWS
- In vivo direct relation of tau pathology with neuroinflammation in early Alzheimer’s disease
- (2019) Tatsuhiro Terada et al. JOURNAL OF NEUROLOGY
- The role of astroglia in Alzheimer's disease: pathophysiology and clinical implications
- (2019) Amaia M Arranz et al. LANCET NEUROLOGY
- Characterization of the 18 kDa translocator protein (TSPO) expression in post‐mortem normal and Alzheimer's disease brains
- (2019) Yaxing Gui et al. BRAIN PATHOLOGY
- Fluorescence-activated cell sorting to reveal the cell origin of radioligand binding
- (2019) Benjamin B Tournier et al. JOURNAL OF CEREBRAL BLOOD FLOW AND METABOLISM
- Translocator protein in late stage Alzheimer’s disease and Dementia with Lewy bodies brains
- (2019) Jinbin Xu et al. Annals of Clinical and Translational Neurology
- Prospects and challenges of imaging neuroinflammation beyond TSPO in Alzheimer’s disease
- (2019) Delphine Boche et al. EUROPEAN JOURNAL OF NUCLEAR MEDICINE AND MOLECULAR IMAGING
- Imaging of translocator protein upregulation is selective for pro‐inflammatory polarized astrocytes and microglia
- (2019) Maria Pannell et al. GLIA
- Applications of amyloid, tau, and neuroinflammation PET imaging to Alzheimer's disease and mild cognitive impairment
- (2019) Avinash Chandra et al. HUMAN BRAIN MAPPING
- Microglial Pro-Inflammatory and Anti-Inflammatory Phenotypes Are Modulated by Translocator Protein Activation
- (2019) Pozzo et al. INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
- Microglial activation, but not tau pathology, is independently associated with amyloid positivity and memory impairment
- (2019) James Zou et al. NEUROBIOLOGY OF AGING
- A quantitative neuropathological assessment of translocator protein expression in multiple sclerosis
- (2019) Erik Nutma et al. BRAIN
- Microglial regional heterogeneity and its role in the brain
- (2019) Yun-Long Tan et al. MOLECULAR PSYCHIATRY
- Increased Inflammation and Unchanged Density of Synaptic Vesicle Glycoprotein 2A (SV2A) in the Postmortem Frontal Cortex of Alzheimer’s Disease Patients
- (2019) Athanasios Metaxas et al. Frontiers in Cellular Neuroscience
- Distinct dynamic profiles of microglial activation are associated with progression of Alzheimer's disease
- (2018) Lorraine Hamelin et al. BRAIN
- Role of Neuroinflammation in the Trajectory of Alzheimer’s Disease and in vivo Quantification Using PET
- (2018) Paul Edison et al. JOURNAL OF ALZHEIMERS DISEASE
- Does inflammation precede tau aggregation in early Alzheimer's disease? A PET study
- (2018) Peter Parbo et al. NEUROBIOLOGY OF DISEASE
- [11C]PK11195 binding in Alzheimer disease and progressive supranuclear palsy
- (2018) Luca Passamonti et al. NEUROLOGY
- TSPO ligand PK11195 improves Alzheimer-related outcomes in aged female 3xTg-AD mice
- (2018) Amy Christensen et al. NEUROSCIENCE LETTERS
- Molecular imaging of neuroinflammation in Alzheimer's disease and mild cognitive impairment
- (2018) Dunja Knezevic et al. PROGRESS IN NEURO-PSYCHOPHARMACOLOGY & BIOLOGICAL PSYCHIATRY
- Cellular Sources and Regional Variations in the Expression of the Neuroinflammatory Marker Translocator Protein (TSPO) in the Normal Brain
- (2018) Calina Betlazar et al. INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
- Imaging the evolution and pathophysiology of Alzheimer disease
- (2018) William Jagust NATURE REVIEWS NEUROSCIENCE
- In vivo molecular imaging of neuroinflammation in Alzheimer's disease
- (2018) Aisling Chaney et al. JOURNAL OF NEUROCHEMISTRY
- Generalization of endothelial modelling of TSPO PET imaging: Considerations on tracer affinities
- (2017) Gaia Rizzo et al. JOURNAL OF CEREBRAL BLOOD FLOW AND METABOLISM
- Validation of an automatic reference region extraction for the quantification of [18F]DPA-714 in dynamic brain PET studies
- (2017) Daniel García-Lorenzo et al. JOURNAL OF CEREBRAL BLOOD FLOW AND METABOLISM
- Imaging microglial activation and amyloid burden in amnestic mild cognitive impairment
- (2017) Dunja Knezevic et al. JOURNAL OF CEREBRAL BLOOD FLOW AND METABOLISM
- Kinetic modelling of [11C]PBR28 for 18 kDa translocator protein PET data: A validation study of vascular modelling in the brain using XBD173 and tissue analysis
- (2017) Mattia Veronese et al. JOURNAL OF CEREBRAL BLOOD FLOW AND METABOLISM
- Sifting through the surfeit of neuroinflammation tracers
- (2017) Paul Cumming et al. JOURNAL OF CEREBRAL BLOOD FLOW AND METABOLISM
- Pro-inflammatory activation of primary microglia and macrophages increases 18 kDa translocator protein expression in rodents but not humans
- (2017) David R Owen et al. JOURNAL OF CEREBRAL BLOOD FLOW AND METABOLISM
- In vivo PET imaging of neuroinflammation in Alzheimer’s disease
- (2017) Julien Lagarde et al. JOURNAL OF NEURAL TRANSMISSION
- Impact of Endothelial 18-kDa Translocator Protein on the Quantification of18F-DPA-714
- (2017) Catriona Wimberley et al. JOURNAL OF NUCLEAR MEDICINE
- Increased Expression of Translocator Protein (TSPO) Marks Pro-inflammatory Microglia but Does Not Predict Neurodegeneration
- (2017) Lien Beckers et al. MOLECULAR IMAGING AND BIOLOGY
- Cerebral blood flow regulation and neurovascular dysfunction in Alzheimer disease
- (2017) Kassandra Kisler et al. NATURE REVIEWS NEUROSCIENCE
- Distinct patterns of increased translocator protein in posterior cortical atrophy and amnestic Alzheimer's disease
- (2017) William C. Kreisl et al. NEUROBIOLOGY OF AGING
- The macrophage marker translocator protein (TSPO) is down-regulated on pro-inflammatory ‘M1’ human macrophages
- (2017) Nehal Narayan et al. PLoS One
- Soluble phospho-tau from Alzheimer’s disease hippocampus drives microglial degeneration
- (2016) Elisabeth Sanchez-Mejias et al. ACTA NEUROPATHOLOGICA
- A translocator protein 18 kDa ligand, Ro5-4864, inhibits ATP-induced NLRP3 inflammasome activation
- (2016) Ji-Won Lee et al. BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS
- TSPO: kaleidoscopic 18-kDa amid biochemical pharmacology, control and targeting of mitochondria
- (2016) J. Gatliff et al. BIOCHEMICAL JOURNAL
- Early and protective microglial activation in Alzheimer’s disease: a prospective study using18F-DPA-714 PET imaging
- (2016) Lorraine Hamelin et al. BRAIN
- Translocator Protein (TSPO) Affects Mitochondrial Fatty Acid Oxidation in Steroidogenic Cells
- (2016) Lan N. Tu et al. ENDOCRINOLOGY
- Parametric Binding Images of the TSPO Ligand 18F-DPA-714
- (2016) S. S. V. Golla et al. JOURNAL OF NUCLEAR MEDICINE
- A polarizing question: do M1 and M2 microglia exist?
- (2016) Richard M Ransohoff NATURE NEUROSCIENCE
- 11 C-PBR28 binding to translocator protein increases with progression of Alzheimer's disease
- (2016) William C. Kreisl et al. NEUROBIOLOGY OF AGING
- The hGFAP-driven conditional TSPO knockout is protective in a mouse model of multiple sclerosis
- (2016) Daniel J. Daugherty et al. Scientific Reports
- Influence of microglial activation on neuronal function in Alzheimer's and Parkinson's disease dementia
- (2015) Zhen Fan et al. Alzheimers & Dementia
- Validating novel tau positron emission tomography tracer [F-18]-AV-1451 (T807) on postmortem brain tissue
- (2015) Marta Marquié et al. ANNALS OF NEUROLOGY
- TSPO is a REDOX regulator of cell mitophagy
- (2015) Jemma Gatliff et al. BIOCHEMICAL SOCIETY TRANSACTIONS
- The methodology of TSPO imaging with positron emission tomography
- (2015) Federico E. Turkheimer et al. BIOCHEMICAL SOCIETY TRANSACTIONS
- Longitudinal influence of microglial activation and amyloid on neuronal function in Alzheimer’s disease
- (2015) Zhen Fan et al. BRAIN
- Quantification of [18F]DPA-714 Binding in the Human Brain: Initial Studies in Healthy Controls and Alzheimer'S Disease Patients
- (2015) Sandeep SV Golla et al. JOURNAL OF CEREBRAL BLOOD FLOW AND METABOLISM
- Optimized Quantification of Translocator Protein Radioligand 18F-DPA-714 Uptake in the Brain of Genotyped Healthy Volunteers
- (2015) S. Lavisse et al. JOURNAL OF NUCLEAR MEDICINE
- Cerebellum Can Serve As a Pseudo-Reference Region in Alzheimer Disease to Detect Neuroinflammation Measured with PET Radioligand Binding to Translocator Protein
- (2015) C. H. Lyoo et al. JOURNAL OF NUCLEAR MEDICINE
- Can Studies of Neuroinflammation in a TSPO Genetic Subgroup (HAB or MAB) Be Applied to the Entire AD Cohort?
- (2015) Z. Fan et al. JOURNAL OF NUCLEAR MEDICINE
- Innate immunity in Alzheimer's disease
- (2015) Michael T Heneka et al. NATURE IMMUNOLOGY
- Amyloid load and translocator protein 18 kDa in APPswePS1-dE9 mice: a longitudinal study
- (2015) Sophie Sérrière et al. NEUROBIOLOGY OF AGING
- The changing landscape in translocator protein (TSPO) function
- (2015) Vimal Selvaraj et al. TRENDS IN ENDOCRINOLOGY AND METABOLISM
- Macrophage Activation and Polarization: Nomenclature and Experimental Guidelines
- (2014) Peter J. Murray et al. IMMUNITY
- Determination of [11C]PBR28 Binding Potential in vivo: A First Human TSPO Blocking Study
- (2014) David R Owen et al. JOURNAL OF CEREBRAL BLOOD FLOW AND METABOLISM
- Kinetic Modeling without Accounting for the Vascular Component Impairs the Quantification of [11C]PBR28 Brain PET Data
- (2014) Gaia Rizzo et al. JOURNAL OF CEREBRAL BLOOD FLOW AND METABOLISM
- The human side of microglia
- (2014) Amy M. Smith et al. TRENDS IN NEUROSCIENCES
- Positron emission tomography and functional characterization of a complete PBR/TSPO knockout
- (2014) Richard B. Banati et al. Nature Communications
- Microglia actions in Alzheimer’s disease
- (2013) Stefan Prokop et al. ACTA NEUROPATHOLOGICA
- A Phenotypic Change But Not Proliferation Underlies Glial Responses in Alzheimer Disease
- (2013) Alberto Serrano-Pozo et al. AMERICAN JOURNAL OF PATHOLOGY
- In vivo radioligand binding to translocator protein correlates with severity of Alzheimer’s disease
- (2013) William C. Kreisl et al. BRAIN
- Ligand for Translocator Protein Reverses Pathology in a Mouse Model of Alzheimer's Disease
- (2013) A. M. Barron et al. JOURNAL OF NEUROSCIENCE
- [18F]DPA-714: Direct Comparison with [11C]PK11195 in a Model of Cerebral Ischemia in Rats
- (2013) Hervé Boutin et al. PLoS One
- The Role of 18 kDa Mitochondrial Translocator Protein (TSPO) in Programmed Cell Death, and Effects of Steroids on TSPO Expression
- (2012) L. Veenman et al. CURRENT MOLECULAR MEDICINE
- Microglial activation in Alzheimer's disease: an (R)-[11C]PK11195 positron emission tomography study
- (2012) Alie Schuitemaker et al. NEUROBIOLOGY OF AGING
- Reactive Glia not only Associates with Plaques but also Parallels Tangles in Alzheimer's Disease
- (2011) Alberto Serrano-Pozo et al. AMERICAN JOURNAL OF PATHOLOGY
- Functional characterization of the human translocator protein (18kDa) gene promoter in human breast cancer cell lines
- (2011) Amani Batarseh et al. Biochimica et Biophysica Acta-Gene Regulatory Mechanisms
- An 18-kDa Translocator Protein (TSPO) Polymorphism Explains Differences in Binding Affinity of the PET Radioligand PBR28
- (2011) David R Owen et al. JOURNAL OF CEREBRAL BLOOD FLOW AND METABOLISM
- Age and disease related changes in the translocator protein (TSPO) system in the human brain: Positron emission tomography measurements with [11C]vinpocetine
- (2011) Balázs Gulyás et al. NEUROIMAGE
- Protein Kinase Cε Regulation of Translocator Protein (18 kDa)TspoGene Expression Is Mediated through a MAPK Pathway Targeting STAT3 and c-Jun Transcription Factors
- (2010) Amani Batarseh et al. BIOCHEMISTRY
- In vivo changes in microglial activation and amyloid deposits in brain regions with hypometabolism in Alzheimer’s disease
- (2010) Masamichi Yokokura et al. EUROPEAN JOURNAL OF NUCLEAR MEDICINE AND MOLECULAR IMAGING
- Translocator protein (18 kDa)/peripheral benzodiazepine receptor specific ligands induce microglia functions consistent with an activated state
- (2010) Judy Choi et al. GLIA
- The role of microglia in amyloid clearance from the AD brain
- (2010) C. Y. Daniel Lee et al. JOURNAL OF NEURAL TRANSMISSION
- Neural mechanisms of ageing and cognitive decline
- (2010) Nicholas A. Bishop et al. NATURE
- Carbon 11–Labeled Pittsburgh Compound B and Carbon 11–Labeled (R)-PK11195 Positron Emission Tomographic Imaging in Alzheimer Disease
- (2009) Clayton A. Wiley et al. ARCHIVES OF NEUROLOGY
- Translocator protein (18 kDa) is involved in primitive erythropoiesis in zebrafish
- (2009) Christine Rampon et al. FASEB JOURNAL
- Comparative Evaluation of the Translocator Protein Radioligands 11C-DPA-713, 18F-DPA-714, and 11C-PK11195 in a Rat Model of Acute Neuroinflammation
- (2009) F. Chauveau et al. JOURNAL OF NUCLEAR MEDICINE
- Microglial activation and amyloid deposition in mild cognitive impairment: A PET study
- (2009) A. Okello et al. NEUROLOGY
- Phorbol-12-myristate 13-Acetate Acting through Protein Kinase Cε Induces Translocator Protein (18-kDa)TspoGene Expression†
- (2008) Amani Batarseh et al. BIOCHEMISTRY
- Nuclear imaging of neuroinflammation: a comprehensive review of [11C]PK11195 challengers
- (2008) Fabien Chauveau et al. EUROPEAN JOURNAL OF NUCLEAR MEDICINE AND MOLECULAR IMAGING
- Hypoosmotic swelling affects zinc homeostasis in cultured rat astrocytes
- (2008) Caroline Kruczek et al. GLIA
- The Positron Emission Tomography Ligand DAA1106 Binds With High Affinity to Activated Microglia in Human Neurological Disorders
- (2008) Sriram Venneti et al. JOURNAL OF NEUROPATHOLOGY AND EXPERIMENTAL NEUROLOGY
- Imaging of Peripheral Benzodiazepine Receptor Expression as Biomarkers of Detrimental versus Beneficial Glial Responses in Mouse Models of Alzheimer's and Other CNS Pathologies
- (2008) B. Ji et al. JOURNAL OF NEUROSCIENCE
- Novel Reference Region Model Reveals Increased Microglial and Reduced Vascular Binding of 11C-(R)-PK11195 in Patients with Alzheimer's Disease
- (2008) G. Tomasi et al. JOURNAL OF NUCLEAR MEDICINE
- PK11195 labels activated microglia in Alzheimer's disease and in vivo in a mouse model using PET
- (2008) Sriram Venneti et al. NEUROBIOLOGY OF AGING
- Expression of the translocator protein of 18 kDa by microglia, macrophages and astrocytes based on immunohistochemical localization in abnormal human brain
- (2008) M. Cosenza-Nashat et al. NEUROPATHOLOGY AND APPLIED NEUROBIOLOGY
Publish scientific posters with Peeref
Peeref publishes scientific posters from all research disciplines. Our Diamond Open Access policy means free access to content and no publication fees for authors.
Learn MoreBecome a Peeref-certified reviewer
The Peeref Institute provides free reviewer training that teaches the core competencies of the academic peer review process.
Get Started