Sifting through the surfeit of neuroinflammation tracers

Pro-inflammatory activation of primary microglia and macrophages increases 18 kDa translocator protein expression in rodents but not humans

(2017) David R Owen et al.   JOURNAL OF CEREBRAL BLOOD FLOW AND METABOLISM

Brain translocator protein occupancy by ONO-2952 in healthy adults: A Phase 1 PET study using [11 C]PBR28

(2017) W. Gordon Frankle et al.   SYNAPSE

Increase of TREM2 during Aging of an Alzheimer’s Disease Mouse Model Is Paralleled by Microglial Activation and Amyloidosis

(2017) Matthias Brendel et al.   Frontiers in Aging Neuroscience

Imaging of Glial Cell Activation and White Matter Integrity in Brains of Active and Recently Retired National Football League Players

(2017) Jennifer M. Coughlin et al.   JAMA Neurology

Assessment of simplified ratio-based approaches for quantification of PET [11C]PBR28 data

(2017) Granville J. Matheson et al.   EJNMMI Research

Response to Narendran and Frankle: The Interpretation of PET Microglial Imaging in Schizophrenia

(2016) Peter S. Bloomfield et al.   AMERICAN JOURNAL OF PSYCHIATRY

Comment on Analyses and Conclusions of “Microglial Activity in People at Ultra High Risk of Psychosis and in Schizophrenia: An [11C]PBR28 PET Brain Imaging Study”

(2016) Raj Narendran et al.   AMERICAN JOURNAL OF PSYCHIATRY

Imaging of neuroinflammation in Alzheimer's disease, multiple sclerosis and stroke: Recent developments in positron emission tomography

(2016) Bieneke Janssen et al.   BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR BASIS OF DISEASE

In vivo evidence of a functional association between immune cells in blood and brain in healthy human subjects

(2016) Naoki Kanegawa et al.   BRAIN BEHAVIOR AND IMMUNITY

Translocator Protein (TSPO) Affects Mitochondrial Fatty Acid Oxidation in Steroidogenic Cells

(2016) Lan N. Tu et al.   ENDOCRINOLOGY

Kinetic analysis of the translocator protein positron emission tomography ligand [18F]GE-180 in the human brain

(2016) Claire Feeney et al.   EUROPEAN JOURNAL OF NUCLEAR MEDICINE AND MOLECULAR IMAGING

Preclinical in vivo and in vitro comparison of the translocator protein PET ligands [18F]PBR102 and [18F]PBR111

(2016) S. Eberl et al.   EUROPEAN JOURNAL OF NUCLEAR MEDICINE AND MOLECULAR IMAGING

Depiction of microglial activation in aging and dementia: Positron emission tomography with [11C]DPA713 versus [11C](R)PK11195

(2016) Masamichi Yokokura et al.   JOURNAL OF CEREBRAL BLOOD FLOW AND METABOLISM

The Variability of Translocator Protein Signal in Brain and Blood of Genotyped Healthy Humans Using In Vivo 123 I-CLINDE SPECT Imaging: A Test–Retest Study

(2016) Ling Feng et al.   JOURNAL OF NUCLEAR MEDICINE

11 C-ER176, a Radioligand for 18-kDa Translocator Protein, Has Adequate Sensitivity to Robustly Image All Three Affinity Genotypes in Human Brain

(2016) Masamichi Ikawa et al.   JOURNAL OF NUCLEAR MEDICINE

Flutriciclamide (18F-GE180) PET: First-in-Human PET Study of Novel Third-Generation In Vivo Marker of Human Translocator Protein

(2016) Z. Fan et al.   JOURNAL OF NUCLEAR MEDICINE

Quantification of ONO-2952 Occupancy of 18-kDaTranslocator Protein in Conscious Monkey Brains using Positron Emission Tomography

(2016) Katsukuni Mitsui et al.   JOURNAL OF PHARMACOLOGY AND EXPERIMENTAL THERAPEUTICS

In vivo imaging of brain microglial activity in antipsychotic-free and medicated schizophrenia: a [11C](R)-PK11195 positron emission tomography study

(2016) S E Holmes et al.   MOLECULAR PSYCHIATRY

In vivo markers of inflammatory response in recent-onset schizophrenia: a combined study using [11C]DPA-713 PET and analysis of CSF and plasma

(2016) J M Coughlin et al.   Translational Psychiatry

The impact of high and low dose ionising radiation on the central nervous system

(2016) Calina Betlazar et al.   Redox Biology

Global Deletion of TSPO Does Not Affect the Viability and Gene Expression Profile

(2016) Huaishan Wang et al.   PLoS One

Differential influence of propofol and isoflurane anesthesia in a non-human primate on the brain kinetics and binding of [18F]DPA-714, a positron emission tomography imaging marker of glial activation

(2015) Wadad Saba et al.   EUROPEAN JOURNAL OF NEUROSCIENCE

Test–retest reproducibility of [11C]PBR28 binding to TSPO in healthy control subjects

(2015) K. Collste et al.   EUROPEAN JOURNAL OF NUCLEAR MEDICINE AND MOLECULAR IMAGING

Mitochondrial Translocator Protein (TSPO) Function Is Not Essential for Heme Biosynthesis

(2015) Amy H. Zhao et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Quantification of [18F]DPA-714 Binding in the Human Brain: Initial Studies in Healthy Controls and Alzheimer'S Disease Patients

(2015) Sandeep SV Golla et al.   JOURNAL OF CEREBRAL BLOOD FLOW AND METABOLISM

Novel Pyrazolo[1,5-a]pyrimidines as Translocator Protein 18 kDa (TSPO) Ligands: Synthesis, in Vitro Biological Evaluation, [18F]-Labeling, and in Vivo Neuroinflammation PET Images

(2015) Annelaure Damont et al.   JOURNAL OF MEDICINAL CHEMISTRY

Specific binding of [18F]fluoroethyl-harmol to monoamine oxidase A in rat brain cryostat sections, and compartmental analysis of binding in living brain

(2015) Simone Maschauer et al.   JOURNAL OF NEUROCHEMISTRY

Optimized Quantification of Translocator Protein Radioligand 18F-DPA-714 Uptake in the Brain of Genotyped Healthy Volunteers

(2015) S. Lavisse et al.   JOURNAL OF NUCLEAR MEDICINE

Can Studies of Neuroinflammation in a TSPO Genetic Subgroup (HAB or MAB) Be Applied to the Entire AD Cohort?

(2015) Z. Fan et al.   JOURNAL OF NUCLEAR MEDICINE

Neuroinflammation in Alzheimer's disease

(2015) Michael T Heneka et al.   LANCET NEUROLOGY

Comparison of standardized uptake values with volume of distribution for quantitation of [11C]PBR28 brain uptake

(2015) Karmen K. Yoder et al.   NUCLEAR MEDICINE AND BIOLOGY

Imaging robust microglial activation after lipopolysaccharide administration in humans with PET

(2015) Christine M. Sandiego et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Structure and activity of tryptophan-rich TSPO proteins

(2015) Y. Guo et al.   SCIENCE

Crystal structures of translocator protein (TSPO) and mutant mimic of a human polymorphism

(2015) F. Li et al.   SCIENCE

Neuroinflammation in Temporal Lobe Epilepsy Measured Using Positron Emission Tomographic Imaging of Translocator Protein

(2015) Leah D. Gershen et al.   JAMA Neurology

Role of Translocator Protein Density, a Marker of Neuroinflammation, in the Brain During Major Depressive Episodes

(2015) Elaine Setiawan et al.   JAMA Psychiatry

Synthesis and Evaluation of Translocator 18 kDa Protein (TSPO) Positron Emission Tomography (PET) Radioligands with Low Binding Sensitivity to Human Single Nucleotide Polymorphism rs6971

(2014) Paolo Zanotti-Fregonara et al.   ACS Chemical Neuroscience

Neuroinflammation: No Rose by Any Other Name

(2014) Manuel B. Graeber   BRAIN PATHOLOGY

Alterations in Immune Cells and Mediators in the Brain: It's Not Always Neuroinflammation!

(2014) Myka L. Estes et al.   BRAIN PATHOLOGY

Emergent Properties of Microglia

(2014) Adam J. Svahn et al.   BRAIN PATHOLOGY

The 18 kDa Translocator Protein, Microglia and Neuroinflammation

(2014) Guo-Jun Liu et al.   BRAIN PATHOLOGY

Positron emission tomography imaging of the 18-kDa translocator protein (TSPO) with [18F]FEMPA in Alzheimer’s disease patients and control subjects

(2014) Andrea Varrone et al.   EUROPEAN JOURNAL OF NUCLEAR MEDICINE AND MOLECULAR IMAGING

Regulation of the Mitochondrial Permeability Transition Pore by the Outer Membrane Does Not Involve the Peripheral Benzodiazepine Receptor (Translocator Protein of 18 kDa (TSPO))

(2014) Justina Šileikytė et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Peripheral Benzodiazepine Receptor/Translocator Protein Global Knock-out Mice Are Viable with No Effects on Steroid Hormone Biosynthesis

(2014) Lan N. Tu et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Determination of [11C]PBR28 Binding Potential in vivo: A First Human TSPO Blocking Study

(2014) David R Owen et al.   JOURNAL OF CEREBRAL BLOOD FLOW AND METABOLISM

Radiosynthesis and Validation of 18F-FP-CMT, a Phenyltropane with Superior Properties for Imaging the Dopamine Transporter in Living Brain

(2014) Paul Cumming et al.   JOURNAL OF CEREBRAL BLOOD FLOW AND METABOLISM

The Simplified Reference Tissue Model: Model Assumption Violations and Their Impact on Binding Potential

(2014) Cristian A Salinas et al.   JOURNAL OF CEREBRAL BLOOD FLOW AND METABOLISM

Kinetic Modeling without Accounting for the Vascular Component Impairs the Quantification of [11C]PBR28 Brain PET Data

(2014) Gaia Rizzo et al.   JOURNAL OF CEREBRAL BLOOD FLOW AND METABOLISM

In Vivo Quantification of Cerebral Translocator Protein Binding in Humans Using 6-Chloro-2-(4'-123I-Iodophenyl)-3-(N,N-Diethyl)-Imidazo[1,2-a]Pyridine-3-Acetamide SPECT

(2014) L. Feng et al.   JOURNAL OF NUCLEAR MEDICINE

‘Neuroinflammation’ differs categorically from inflammation: transcriptomes of Alzheimer's disease, Parkinson's disease, schizophrenia and inflammatory diseases compared

(2014) Michaela D. Filiou et al.   NEUROGENETICS

Structure of the Mitochondrial Translocator Protein in Complex with a Diagnostic Ligand

(2014)  ukasz Jaremko et al.   SCIENCE

Positron emission tomography and functional characterization of a complete PBR/TSPO knockout

(2014) Richard B. Banati et al.   Nature Communications

The neuroinflammation marker translocator protein is not elevated in individuals with mild-to-moderate depression: A [11C]PBR28 PET study

(2013) Jonas Hannestad et al.   BRAIN BEHAVIOR AND IMMUNITY

Translocator Protein/Peripheral Benzodiazepine Receptor Is Not Required for Steroid Hormone Biosynthesis

(2013) Kanako Morohaku et al.   ENDOCRINOLOGY

In vivo imaging of the 18-kDa translocator protein (TSPO) with [18F]FEDAA1106 and PET does not show increased binding in Alzheimer’s disease patients

(2013) Andrea Varrone et al.   EUROPEAN JOURNAL OF NUCLEAR MEDICINE AND MOLECULAR IMAGING

Quantification of the Specific Translocator Protein Signal of 18F-PBR111 in Healthy Humans: A Genetic Polymorphism Effect on In Vivo Binding

(2013) Q. Guo et al.   JOURNAL OF NUCLEAR MEDICINE

Preclinical evaluation and quantification of [18F]MK-9470 as a radioligand for PET imaging of the type 1 cannabinoid receptor in rat brain

(2012) Cindy Casteels et al.   EUROPEAN JOURNAL OF NUCLEAR MEDICINE AND MOLECULAR IMAGING

A Genetic Polymorphism for Translocator Protein 18 Kda Affects both in Vitro and in Vivo Radioligand Binding in Human Brain to this Putative Biomarker of Neuroinflammation

(2012) William C Kreisl et al.   JOURNAL OF CEREBRAL BLOOD FLOW AND METABOLISM

Optimization of Supervised Cluster Analysis for Extracting Reference Tissue Input Curves in (R)-[11C]PK11195 Brain PET Studies

(2012) Maqsood Yaqub et al.   JOURNAL OF CEREBRAL BLOOD FLOW AND METABOLISM

Translocator Protein (18 kDa) Polymorphism (rs6971) Explains in-vivo Brain Binding Affinity of the PET Radioligand [18F]-FEPPA

(2012) Romina Mizrahi et al.   JOURNAL OF CEREBRAL BLOOD FLOW AND METABOLISM

Reactive Astrocytes Overexpress TSPO and Are Detected by TSPO Positron Emission Tomography Imaging

(2012) S. Lavisse et al.   JOURNAL OF NEUROSCIENCE

Kinetic analysis and test-retest variability of the radioligand [11C](R)-PK11195 binding to TSPO in the human brain - a PET study in control subjects

(2012) Aurelija Jučaite et al.   EJNMMI Research

[18F]GE-180: A novel fluorine-18 labelled PET tracer for imaging Translocator protein 18kDa (TSPO)

(2011) Harry Wadsworth et al.   BIOORGANIC & MEDICINAL CHEMISTRY LETTERS

Modeling the Light- and Redox-Dependent Interaction of PpsR/AppA in Rhodobacter sphaeroides

(2011) Rakesh Pandey et al.   BIOPHYSICAL JOURNAL

Evaluation of [123I]-CLINDE as a potent SPECT radiotracer to assess the degree of astroglia activation in cuprizone-induced neuroinflammation

(2011) Filomena Mattner et al.   EUROPEAN JOURNAL OF NUCLEAR MEDICINE AND MOLECULAR IMAGING

Quantitation of Translocator Protein Binding in Human Brain with the Novel Radioligand [18F]-FEPPA and Positron Emission Tomography

(2011) Pablo M Rusjan et al.   JOURNAL OF CEREBRAL BLOOD FLOW AND METABOLISM

An 18-kDa Translocator Protein (TSPO) Polymorphism Explains Differences in Binding Affinity of the PET Radioligand PBR28

(2011) David R Owen et al.   JOURNAL OF CEREBRAL BLOOD FLOW AND METABOLISM

Potential involvement of F0F1-ATP(synth)ase and reactive oxygen species in apoptosis induction by the antineoplastic agent erucylphosphohomocholine in glioblastoma cell lines

(2010) Leo Veenman et al.   APOPTOSIS

Two Binding Sites for [3H]PBR28 in Human Brain: Implications for TSPO PET Imaging of Neuroinflammation

(2010) David R Owen et al.   JOURNAL OF CEREBRAL BLOOD FLOW AND METABOLISM

Mixed-Affinity Binding in Humans with 18-kDa Translocator Protein Ligands

(2010) D. R. J. Owen et al.   JOURNAL OF NUCLEAR MEDICINE

Preclinical Evaluation of 18F-JNJ41510417 as a Radioligand for PET Imaging of Phosphodiesterase-10A in the Brain

(2010) S. Celen et al.   JOURNAL OF NUCLEAR MEDICINE

Pathways underlying neuroprogression in bipolar disorder: Focus on inflammation, oxidative stress and neurotrophic factors

(2010) M. Berk et al.   NEUROSCIENCE AND BIOBEHAVIORAL REVIEWS

A rapid solid-phase extraction method for measurement of non-metabolised peripheral benzodiazepine receptor ligands, [18F]PBR102 and [18F]PBR111, in rat and primate plasma

(2010) Andrew Katsifis et al.   NUCLEAR MEDICINE AND BIOLOGY

Quantification of Translocator Protein (18 kDa) in the Human Brain with PET and a Novel Radioligand, 18F-PBR06

(2009) Y. Fujimura et al.   JOURNAL OF NUCLEAR MEDICINE

Initial Evaluation of 11C-DPA-713, a Novel TSPO PET Ligand, in Humans

(2009) C. J. Endres et al.   JOURNAL OF NUCLEAR MEDICINE

Comparison of [11C]-(R)-PK 11195 and [11C]PBR28, two radioligands for translocator protein (18 kDa) in human and monkey: Implications for positron emission tomographic imaging of this inflammation biomarker

(2009) William C. Kreisl et al.   NEUROIMAGE

The Positron Emission Tomography Ligand DAA1106 Binds With High Affinity to Activated Microglia in Human Neurological Disorders

(2008) Sriram Venneti et al.   JOURNAL OF NEUROPATHOLOGY AND EXPERIMENTAL NEUROLOGY

Radiosynthesis and initial evaluation of [18F]-FEPPA for PET imaging of peripheral benzodiazepine receptors

(2008) Alan A. Wilson et al.   NUCLEAR MEDICINE AND BIOLOGY

Translocator protein 18 kDa (TSPO): Molecular sensor of brain injury and repair

(2008) Ming-Kai Chen et al.   PHARMACOLOGY & THERAPEUTICS

Kinetic analysis in healthy humans of a novel positron emission tomography radioligand to image the peripheral benzodiazepine receptor, a potential biomarker for inflammation

(2007) Masahiro Fujita et al.   NEUROIMAGE