SARS‐CoV‐2 Alpha, Beta, and Delta variants display enhanced Spike‐mediated syncytia formation

Early transmissibility assessment of the N501Y mutant strains of SARS-CoV-2 in the United Kingdom, October to November 2020

(2021) Kathy Leung et al.   Eurosurveillance

Prospective mapping of viral mutations that escape antibodies used to treat COVID-19

(2021) Tyler N. Starr et al.   SCIENCE

Three-quarters attack rate of SARS-CoV-2 in the Brazilian Amazon during a largely unmitigated epidemic

(2021) Lewis F. Buss et al.   SCIENCE

Hydroxychloroquine-mediated inhibition of SARS-CoV-2 entry is attenuated by TMPRSS2

(2021) Tianling Ou et al.   PLoS Pathogens

Identification of SARS-CoV-2 spike mutations that attenuate monoclonal and serum antibody neutralization

(2021) Zhuoming Liu et al.   Cell Host & Microbe

SARS-CoV-2 and SARS-CoV spike-mediated cell-cell fusion differ in the requirements for receptor expression and proteolytic activation

(2021) Bojan F. Hörnich et al.   JOURNAL OF VIROLOGY

Resurgence of COVID-19 in Manaus, Brazil, despite high seroprevalence

(2021) Ester C Sabino et al.   LANCET

Sensitivity of SARS-CoV-2 B.1.1.7 to mRNA vaccine-elicited antibodies

(2021) Dami A. Collier et al.   NATURE

Estimated transmissibility and impact of SARS-CoV-2 lineage B.1.1.7 in England

(2021) Nicholas G. Davies et al.   SCIENCE

The effect of spike mutations on SARS-CoV-2 neutralization

(2021) Chloe Rees-Spear et al.   Cell Reports

SARS-CoV-2 variants B.1.351 and P.1 escape from neutralizing antibodies

(2021) Markus Hoffmann et al.   CELL

Structural insight into SARS-CoV-2 neutralizing antibodies and modulation of syncytia

(2021) Daniel Asarnow et al.   CELL

SARS-CoV-2 spike protein dictates syncytium-mediated lymphocyte elimination

(2021) Zhengrong Zhang et al.   CELL DEATH AND DIFFERENTIATION

Syncytia formation during SARS-CoV-2 lung infection: a disastrous unity to eliminate lymphocytes

(2021) Liangyu Lin et al.   CELL DEATH AND DIFFERENTIATION

Enhanced binding of the N501Y‐mutated SARS‐CoV‐2 spike protein to the human ACE2 receptor: insights from molecular dynamics simulations

(2021) Binquan Luan et al.   FEBS LETTERS

Preexisting autoantibodies to type I IFNs underlie critical COVID-19 pneumonia in patients with APS-1

(2021) Paul Bastard et al.   JOURNAL OF EXPERIMENTAL MEDICINE

Genomic characteristics and clinical effect of the emergent SARS-CoV-2 B.1.1.7 lineage in London, UK: a whole-genome sequencing and hospital-based cohort study

(2021) Dan Frampton et al.   LANCET INFECTIOUS DISEASES

SARS-CoV-2 B.1.1.7 and B.1.351 spike variants bind human ACE2 with increased affinity

(2021) Muthukumar Ramanathan et al.   LANCET INFECTIOUS DISEASES

Drugs that inhibit TMEM16 proteins block SARS-CoV-2 spike-induced syncytia

(2021) Luca Braga et al.   NATURE

Sensitivity of infectious SARS-CoV-2 B.1.1.7 and B.1.351 variants to neutralizing antibodies

(2021) Delphine Planas et al.   NATURE MEDICINE

Drug repurposing screens reveal cell-type-specific entry pathways and FDA-approved drugs active against SARS-Cov-2

(2021) Mark Dittmar et al.   Cell Reports

SARS-CoV-2 requires cholesterol for viral entry and pathological syncytia formation

(2021) David W Sanders et al.   eLife

TMPRSS2 expression dictates the entry route used by SARS‐CoV‐2 to infect host cells

(2021) Jana Koch et al.   EMBO JOURNAL

Effect of clinical isolate or cleavage site mutations in the SARS-CoV-2 spike protein on protein stability, cleavage, and cell–cell fusion

(2021) Chelsea T. Barrett et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Reduced sensitivity of SARS-CoV-2 variant Delta to antibody neutralization

(2021) Delphine Planas et al.   NATURE

Replicative Fitness of a SARS-CoV-2 20I/501Y.V1 Variant from Lineage B.1.1.7 in Human Reconstituted Bronchial Epithelium

(2021) Franck Touret et al.   mBio

Sequences in the cytoplasmic tail of SARS-CoV-2 Spike facilitate expression at the cell surface and syncytia formation

(2021) Jérôme Cattin-Ortolá et al.   Nature Communications

SARS-CoV-2 infection induces the dedifferentiation of multiciliated cells and impairs mucociliary clearance

(2021) Rémy Robinot et al.   Nature Communications

Recurrent emergence of SARS-CoV-2 spike deletion H69/V70 and its role in the Alpha variant B.1.1.7

(2021) Bo Meng et al.   Cell Reports

Systematic analysis of SARS-CoV-2 infection of an ACE2-negative human airway cell

(2021) Maritza Puray-Chavez et al.   Cell Reports

N501Y mutation of spike protein in SARS-CoV-2 strengthens its binding to receptor ACE2

(2021) Fang Tian et al.   eLife

SARS-CoV-2 variant prediction and antiviral drug design are enabled by RBD in vitro evolution

(2021) Jiří Zahradník et al.   Nature Microbiology

Pulmonary pathology of early phase 2019 novel coronavirus (COVID-19) pneumonia in two patients with lung cancer

(2020) Sufang Tian et al.   Journal of Thoracic Oncology

Clinical features of patients infected with 2019 novel coronavirus in Wuhan, China

(2020) Chaolin Huang et al.   LANCET

Pathological findings of COVID-19 associated with acute respiratory distress syndrome

(2020) Zhe Xu et al.   Lancet Respiratory Medicine

SARS-CoV-2 Cell Entry Depends on ACE2 and TMPRSS2 and Is Blocked by a Clinically Proven Protease Inhibitor

(2020) Markus Hoffmann et al.   CELL

Heightened Innate Immune Responses in the Respiratory Tract of COVID-19 Patients

(2020) Zhuo Zhou et al.   Cell Host & Microbe

Viral and host factors related to the clinical outcome of COVID-19

(2020) Xiaonan Zhang et al.   NATURE

Structural and functional properties of SARS-CoV-2 spike protein: potential antivirus drug development for COVID-19

(2020) Yuan Huang et al.   ACTA PHARMACOLOGICA SINICA

Tracking Changes in SARS-CoV-2 Spike: Evidence that D614G Increases Infectivity of the COVID-19 Virus

(2020) Bette Korber et al.   CELL

Presence of Genetic Variants Among Young Men With Severe COVID-19

(2020) Caspar I. van der Made et al.   JAMA-JOURNAL OF THE AMERICAN MEDICAL ASSOCIATION

A neutralizing human antibody binds to the N-terminal domain of the Spike protein of SARS-CoV-2

(2020) Xiangyang Chi et al.   SCIENCE

Impaired type I interferon activity and inflammatory responses in severe COVID-19 patients

(2020) Jérôme Hadjadj et al.   SCIENCE

Morphogenesis and cytopathic effect of SARS-CoV-2 infection in human airway epithelial cells

(2020) Na Zhu et al.   Nature Communications

Structural and Functional Analysis of the D614G SARS-CoV-2 Spike Protein Variant

(2020) Leonid Yurkovetskiy et al.   CELL

Syncytia formation by SARS‐CoV‐2 infected cells

(2020) Julian Buchrieser et al.   EMBO JOURNAL

Systems biological assessment of immunity to mild versus severe COVID-19 infection in humans

(2020) Prabhu S. Arunachalam et al.   SCIENCE

Autoantibodies against type I IFNs in patients with life-threatening COVID-19

(2020) Paul Bastard et al.   SCIENCE

The SARS-CoV-2 Spike Glycoprotein Biosynthesis, Structure, Function, and Antigenicity: Implications for the Design of Spike-Based Vaccine Immunogens

(2020) Liangwei Duan et al.   Frontiers in Immunology

Opposing activities of IFITM proteins in SARS‐CoV‐2 infection

(2020) Guoli Shi et al.   EMBO JOURNAL

SARS-CoV-2 structure and replication characterized by in situ cryo-electron tomography

(2020) Steffen Klein et al.   Nature Communications

Structural definition of a neutralization epitope on the N-terminal domain of MERS-CoV spike glycoprotein

(2019) Haixia Zhou et al.   Nature Communications

Survey of Human Chromosome 21 Gene Expression Effects on Early Development in Danio rerio

(2018) Sarah Edie et al.   G3-Genes Genomes Genetics

More than meets the I: the diverse antiviral and cellular functions of interferon-induced transmembrane proteins

(2017) Guoli Shi et al.   Retrovirology

A new cell-based assay to evaluate myogenesis in mouse myoblast C2C12 cells

(2015) Manami Kodaka et al.   EXPERIMENTAL CELL RESEARCH

IFITM Proteins Incorporated into HIV-1 Virions Impair Viral Fusion and Spread

(2014) Alex A. Compton et al.   Cell Host & Microbe

Differential Cell Line Susceptibility to the Emerging Novel Human Betacoronavirus 2c EMC/2012: Implications for Disease Pathogenesis and Clinical Manifestation

(2013) Jasper Fuk-Woo Chan, Kwok-Hung Chan, Garnet Kwan-Yue Choi, Kelvin Kai-Wang To, Herman Tse, Jian-Piao Cai et al.   JOURNAL OF INFECTIOUS DISEASES

Human Coronavirus HKU1 Infection of Primary Human Type II Alveolar Epithelial Cells: Cytopathic Effects and Innate Immune Response

(2013) Samuel R. Dominguez et al.   PLoS One

Role of the Spike Glycoprotein of Human Middle East Respiratory Syndrome Coronavirus (MERS-CoV) in Virus Entry and Syncytia Formation

(2013) Zhaohui Qian et al.   PLoS One