Journal
EUROSURVEILLANCE
Volume 26, Issue 1, Pages 15-21Publisher
EUR CENTRE DIS PREVENTION & CONTROL
DOI: 10.2807/1560-7917.ES.2020.26.1.2002106
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Funding
- Health and Medical Research Fund [CID-HKU2]
- General Research Fund [17110020]
- InnoHK programme from the Government of the Hong Kong Special Administrative Region
- National Natural Science Foundation of China (NSFC) Excellent Young Scientists Fund (Hong Kong and Macau) [31922087]
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Two new lineages of SARS-CoV-2 with the N501Y mutation in the receptor-binding domain of the spike protein have spread rapidly in the United Kingdom. The 501Y lineage without amino acid deletion Delta 69/Delta 70 was estimated to be 10% more transmissible than the 501N lineage, while the 501Y lineage with amino acid deletion Delta 69/Delta 70 was estimated to be 75% more transmissible than the 501N lineage.
Two new SARS-CoV-2 lineages with the N501Y mutation in the receptor-binding domain of the spike protein spread rapidly in the United Kingdom. We estimated that the earlier 501Y lineage without amino acid deletion Delta 69/Delta 70, circulating mainly between early September and mid-November, was 10% (6-13%) more transmissible than the 501N lineage, and the 501Y lineage with amino acid deletion Delta 69/Delta 70, circulating since late September, was 75% (70-80%) more transmissible than the 501N lineage.
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