More than meets the I: the diverse antiviral and cellular functions of interferon-induced transmembrane proteins

The palmitoyltransferase ZDHHC20 enhances interferon-induced transmembrane protein 3 (IFITM3) palmitoylation and antiviral activity

(2017) Temet M. McMichael et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

The antiviral restriction factor IFN-induced transmembrane protein 3 prevents cytokine-driven CMV pathogenesis

(2017) Maria A. Stacey et al.   JOURNAL OF CLINICAL INVESTIGATION

ZMPSTE24 defends against influenza and other pathogenic viruses

(2017) Bishi Fu et al.   JOURNAL OF EXPERIMENTAL MEDICINE

pH Optimum of Hemagglutinin-Mediated Membrane Fusion Determines Sensitivity of Influenza A Viruses to the Interferon-Induced Antiviral State and IFITMs

(2017) Thomas Gerlach et al.   JOURNAL OF VIROLOGY

The V3 Loop of HIV-1 Env Determines Viral Susceptibility to IFITM3 Impairment of Viral Infectivity

(2017) Yimeng Wang et al.   JOURNAL OF VIROLOGY

Δ20 IFITM2 differentially restricts X4 and R5 HIV-1

(2017) Wan-Lin Wu et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Resistance to type 1 interferons is a major determinant of HIV-1 transmission fitness

(2017) Shilpa S. Iyer et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

On the Whereabouts of HIV-1 Cellular Entry and Its Fusion Ports

(2017) G. Maria Jakobsdottir et al.   TRENDS IN MOLECULAR MEDICINE

Noroviruses Co-opt the Function of Host Proteins VAPA and VAPB for Replication via a Phenylalanine–Phenylalanine-Acidic-Tract-Motif Mimic in Nonstructural Viral Protein NS1/2

(2017) Broc T. McCune et al.   mBio

Delineating CD4 dependency of HIV-1: Adaptation to infect low level CD4 expressing target cells widens cellular tropism but severely impacts on envelope functionality

(2017) David Beauparlant et al.   PLoS Pathogens

Interference with the production of infectious viral particles and bimodal inhibition of replication are broadly conserved antiviral properties of IFITMs

(2017) Kevin Tartour et al.   PLoS Pathogens

Ambra1 spatially regulates Src activity and Src/FAK-mediated cancer cell invasion via trafficking networks

(2017) Christina Schoenherr et al.   eLife

Resistance of Transmitted Founder HIV-1 to IFITM-Mediated Restriction

(2016) Toshana L. Foster et al.   Cell Host & Microbe

Natural mutations in IFITM3 modulate post‐translational regulation and toggle antiviral specificity

(2016) Alex A Compton et al.   EMBO REPORTS

The Interferon-Stimulated Gene IFITM3 Restricts Infection and Pathogenesis of Arthritogenic and Encephalitic Alphaviruses

(2016) Subhajit Poddar et al.   JOURNAL OF VIROLOGY

The Interferon-Stimulated GeneIfitm3Restricts West Nile Virus Infection and Pathogenesis

(2016) Matthew J. Gorman et al.   JOURNAL OF VIROLOGY

Virion Background and Efficiency of Virion Incorporation Determine Susceptibility of Simian Immunodeficiency Virus Env-Driven Viral Entry to Inhibition by IFITM Proteins

(2016) Florian Wrensch et al.   JOURNAL OF VIROLOGY

Nonhuman Primate IFITM Proteins Are Potent Inhibitors of HIV and SIV

(2016) Jordan Wilkins et al.   PLoS One

Combined approaches of EPR and NMR illustrate only one transmembrane helix in the human IFITM3

(2016) Shenglong Ling et al.   Scientific Reports

The IFITMs Inhibit Zika Virus Replication

(2016) George Savidis et al.   Cell Reports

IFITM1 promotes the metastasis of human colorectal cancer via CAV-1

(2015) Fang Yu et al.   CANCER LETTERS

The Interferon-induced Transmembrane Proteins, IFITM1, IFITM2, and IFITM3 Inhibit Hepatitis C Virus Entry

(2015) Sumudu K. Narayana et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Primate lentiviruses are differentially inhibited by interferon-induced transmembrane proteins

(2015) Jin Qian et al.   VIROLOGY

BAG3 promotes pancreatic ductal adenocarcinoma growth by activating stromal macrophages

(2015) Alessandra Rosati et al.   Nature Communications

Amino Acids Stimulate TORC1 through Lst4-Lst7, a GTPase-Activating Protein Complex for the Rag Family GTPase Gtr2

(2015) Marie-Pierre Péli-Gulli et al.   Cell Reports

E3 Ubiquitin Ligase NEDD4 Promotes Influenza Virus Infection by Decreasing Levels of the Antiviral Protein IFITM3

(2015) Nicholas M. Chesarino et al.   PLoS Pathogens

Human Cytomegalovirus Exploits Interferon-Induced Transmembrane Proteins To Facilitate Morphogenesis of the Virion Assembly Compartment

(2015) Maorong Xie et al.   JOURNAL OF VIROLOGY

Respiratory DC Use IFITM3 to Avoid Direct Viral Infection and Safeguard Virus-Specific CD8+ T Cell Priming

(2015) Giuseppe Infusini et al.   PLoS One

IFITM Proteins Incorporated into HIV-1 Virions Impair Viral Fusion and Spread

(2014) Alex A. Compton et al.   Cell Host & Microbe

Rhinovirus Uses a Phosphatidylinositol 4-Phosphate/Cholesterol Counter-Current for the Formation of Replication Compartments at the ER-Golgi Interface

(2014) Pascal S. Roulin et al.   Cell Host & Microbe

Identification of an endocytic signal essential for the antiviral action of IFITM3

(2014) Rui Jia et al.   CELLULAR MICROBIOLOGY

Regulation of the trafficking and antiviral activity of IFITM3 by post-translational modifications

(2014) Nicholas M Chesarino et al.   Future Microbiology

Phosphorylation of the Antiviral Protein Interferon-inducible Transmembrane Protein 3 (IFITM3) Dually Regulates Its Endocytosis and Ubiquitination

(2014) Nicholas M. Chesarino et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Mechanism and biological significance of the overexpression of IFITM3 in gastric cancer

(2014) JUN HU et al.   ONCOLOGY REPORTS

Interferon induction of IFITM proteins promotes infection by human coronavirus OC43

(2014) X. Zhao et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

IFITM proteins are incorporated onto HIV-1 virion particles and negatively imprint their infectivity

(2014) Kevin Tartour et al.   Retrovirology

IFITM Proteins Inhibit Entry Driven by the MERS-Coronavirus Spike Protein: Evidence for Cholesterol-Independent Mechanisms

(2014) Florian Wrensch et al.   Viruses-Basel

Evidence Showing that Tetraspanins Inhibit HIV-1-Induced Cell-Cell Fusion at a Post-Hemifusion Stage

(2014) Menelaos Symeonides et al.   Viruses-Basel

Coupling of replication and assembly in flaviviruses

(2014) Swapna Apte-Sengupta et al.   Current Opinion in Virology

IFITM proteins—cellular inhibitors of viral entry

(2014) SE Smith et al.   Current Opinion in Virology

Unique Features of HIV-1 Spread through T Cell Virological Synapses

(2014) Raymond A. Alvarez et al.   PLoS Pathogens

IFITM3 Restricts Influenza A Virus Entry by Blocking the Formation of Fusion Pores following Virus-Endosome Hemifusion

(2014) Tanay M. Desai et al.   PLoS Pathogens

The Antiviral Effector IFITM3 Disrupts Intracellular Cholesterol Homeostasis to Block Viral Entry

(2013) Samad Amini-Bavil-Olyaee et al.   Cell Host & Microbe

Astroglial IFITM3 mediates neuronal impairments following neonatal immune challenge in mice

(2013) Daisuke Ibi et al.   GLIA

Interferon-induced Transmembrane Protein 3 Is a Type II Transmembrane Protein

(2013) Charles C. Bailey et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

IFITMs Restrict the Replication of Multiple Pathogenic Viruses

(2013) Jill M. Perreira et al.   JOURNAL OF MOLECULAR BIOLOGY

Palmitoylation on Conserved and Nonconserved Cysteines of Murine IFITM1 Regulates Its Stability and Anti-Influenza A Virus Activity

(2013) J. C. Hach et al.   JOURNAL OF VIROLOGY

Amphotericin B Increases Influenza A Virus Infection by Preventing IFITM3-Mediated Restriction

(2013) Tsai-Yu Lin et al.   Cell Reports

IFITM Proteins Restrict Viral Membrane Hemifusion

(2013) Kun Li et al.   PLoS Pathogens

Evolution of vertebrate interferon inducible transmembrane proteins

(2012) Danielle Hickford et al.   BMC GENOMICS

IFITM1 is a tight junction protein that inhibits hepatitis C virus entry

(2012) Courtney Wilkins et al.   HEPATOLOGY

Interferon-inducible transmembrane proteins of the innate immune response act as membrane organizers by influencing clathrin and v-ATPase localization and function

(2012) Yin Shen Wee et al.   Innate Immunity

IFITM3 restricts the morbidity and mortality associated with influenza

(2012) Aaron R. Everitt et al.   NATURE

The Dispanins: A Novel Gene Family of Ancient Origin That Contains 14 Human Members

(2012) Markus Sällman Almén et al.   PLoS One

Evolutionary Dynamics of the Interferon-Induced Transmembrane Gene Family in Vertebrates

(2012) Zhao Zhang et al.   PLoS One

Membrane curvature and its generation by BAR proteins

(2012) Carsten Mim et al.   TRENDS IN BIOCHEMICAL SCIENCES

Acid-dependent viral entry

(2012) Ángela Vázquez-Calvo et al.   VIRUS RESEARCH

Ifitm3 Limits the Severity of Acute Influenza in Mice

(2012) Charles C. Bailey et al.   PLoS Pathogens

The role of tetraspanins in fusion

(2011) Marzieh Fanaei et al.   BIOCHEMICAL SOCIETY TRANSACTIONS

A diverse range of gene products are effectors of the type I interferon antiviral response

(2011) John W. Schoggins et al.   NATURE

IFITM3 Inhibits Influenza A Virus Infection by Preventing Cytosolic Entry

(2011) Eric M. Feeley et al.   PLoS Pathogens

Distinct Patterns of IFITM-Mediated Restriction of Filoviruses, SARS Coronavirus, and Influenza A Virus

(2011) I-Chueh Huang et al.   PLoS Pathogens

The Small Interferon-Induced Transmembrane Genes and Proteins

(2010) Fredy Siegrist et al.   JOURNAL OF INTERFERON AND CYTOKINE RESEARCH

The IFITM Proteins Inhibit HIV-1 Infection

(2010) J. Lu et al.   JOURNAL OF VIROLOGY

Palmitoylome profiling reveals S-palmitoylation–dependent antiviral activity of IFITM3

(2010) Jacob S Yount et al.   Nature Chemical Biology

Binding of IFITM1 enhances the inhibiting effect of caveolin-1 on ERK activation

(2009) Y. Xu et al.   ACTA BIOCHIMICA ET BIOPHYSICA SINICA

The IFITM Proteins Mediate Cellular Resistance to Influenza A H1N1 Virus, West Nile Virus, and Dengue Virus

(2009) Abraham L. Brass et al.   CELL

Formation of Syncytia Is Repressed by Tetraspanins in Human Immunodeficiency Virus Type 1-Producing Cells

(2009) J. Weng et al.   JOURNAL OF VIROLOGY

Interferon-induced transmembrane 3 binds osteopontin in vitro: expressed in vivo IFITM3 reduced OPN expression

(2009) M K El-Tanani et al.   ONCOGENE

Host Cell Factors and Functions Involved in Vesicular Stomatitis Virus Entry

(2008) H. K. Johannsdottir et al.   JOURNAL OF VIROLOGY

Tetherin inhibits retrovirus release and is antagonized by HIV-1 Vpu

(2008) Stuart J. D. Neil et al.   NATURE