Transcription-coupled repair and the transcriptional response to UV-Irradiation

Structural insights into preinitiation complex assembly on core promoters

(2021) Xizi Chen et al.   SCIENCE

Elongation factor ELOF1 drives transcription-coupled repair and prevents genome instability

(2021) Marit E. Geijer et al.   NATURE CELL BIOLOGY

LEO1 is a partner for Cockayne syndrome protein B (CSB) in response to transcription-blocking DNA damage

(2021) Vinod Tiwari et al.   NUCLEIC ACIDS RESEARCH

Ubiquitination of DNA Damage-Stalled RNAPII Promotes Transcription-Coupled Repair

(2020) Yuka Nakazawa et al.   CELL

Regulation of the RNAPII Pool Is Integral to the DNA Damage Response

(2020) Ana Tufegdžić Vidaković et al.   CELL

Genome-wide role of Rad26 in promoting transcription-coupled nucleotide excision repair in yeast chromatin

(2020) Mingrui Duan et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Structural basis of Mfd-dependent transcription termination

(2020) Jing Shi et al.   NUCLEIC ACIDS RESEARCH

Cockayne syndrome B protein acts as an ATP-dependent processivity factor that helps RNA polymerase II overcome nucleosome barriers

(2020) Jun Xu et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

UCSF ChimeraX : Structure visualization for researchers, educators, and developers

(2020) Eric F. Pettersen et al.   PROTEIN SCIENCE

Envisioning how the prototypic molecular machine TFIIH functions in transcription initiation and DNA repair

(2020) Susan E. Tsutakawa et al.   DNA REPAIR

Causes and consequences of RNA polymerase II stalling during transcript elongation

(2020) Melvin Noe Gonzalez et al.   NATURE REVIEWS MOLECULAR CELL BIOLOGY

Mfd regulates RNA polymerase association with hard-to-transcribe regions in vivo, especially those with structured RNAs

(2020) Mark N. Ragheb et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Structural basis of ubiquitin recognition by the winged-helix domain of Cockayne syndrome group B protein

(2019) Tomio S Takahashi et al.   NUCLEIC ACIDS RESEARCH

Evidence that Moderate Eviction of Spt5 and Promotion of Error-Free Transcriptional Bypass by Rad26 Facilitates Transcription Coupled Nucleotide Excision Repair

(2019) Kathiresan Selvam et al.   JOURNAL OF MOLECULAR BIOLOGY

Structural basis of TFIIH activation for nucleotide excision repair

(2019) Goran Kokic et al.   Nature Communications

Elongation Factor TFIIS Prevents Transcription Stress and R-Loop Accumulation to Maintain Genome Stability

(2019) Diana Zatreanu et al.   MOLECULAR CELL

A key interaction with RPA orients XPA in NER complexes

(2019) Agnieszka M Topolska-Woś et al.   NUCLEIC ACIDS RESEARCH

Mfd Dynamically Regulates Transcription via a Release and Catch-Up Mechanism

(2018) Tung T. Le et al.   CELL

RPA and XPA interaction with DNA structures mimicking intermediates of the late stages in nucleotide excision repair

(2018) Yuliya S. Krasikova et al.   PLoS One

The Cellular Response to Transcription-Blocking DNA Damage

(2018) Lea H. Gregersen et al.   TRENDS IN BIOCHEMICAL SCIENCES

Mfd translocase is necessary and sufficient for transcription-coupled repair inEscherichia coli

(2017) Ogun Adebali et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

RNA polymerase II is released from the DNA template during transcription-coupled repair in mammalian cells

(2017) Yi-Ying Chiou et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Structural basis for the initiation of eukaryotic transcription-coupled DNA repair

(2017) Jun Xu et al.   NATURE

Structure of a transcribing RNA polymerase II–DSIF complex reveals a multidentate DNA–RNA clamp

(2017) Carrie Bernecky et al.   NATURE STRUCTURAL & MOLECULAR BIOLOGY

Common TFIIH recruitment mechanism in global genome and transcription-coupled repair subpathways

(2017) Masahiko Okuda et al.   NUCLEIC ACIDS RESEARCH

NAP1L1 accelerates activation and decreases pausing to enhance nucleosome remodeling by CSB

(2017) Ju Yeon Lee et al.   NUCLEIC ACIDS RESEARCH

Xeroderma pigmentosum-Cockayne syndrome complex

(2017) Valerie Natale et al.   Orphanet Journal of Rare Diseases

Genome-wide transcription-coupled repair inEscherichia coliis mediated by the Mfd translocase

(2017) Ogun Adebali et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Structure of the complete elongation complex of RNA polymerase II with basal factors

(2017) Haruhiko Ehara et al.   SCIENCE

ATM and CDK2 control chromatin remodeler CSB to inhibit RIF1 in DSB repair pathway choice

(2017) Nicole L. Batenburg et al.   Nature Communications

Structure of a transcribing RNA polymerase II–DSIF complex reveals a multidentate DNA–RNA clamp

(2017) Carrie Bernecky et al.   NATURE STRUCTURAL & MOLECULAR BIOLOGY

Role of XPD in cellular functions: To TFIIH and beyond

(2016) Bennett Van Houten et al.   DNA REPAIR

The Mitochondrial Basis of Aging

(2016) Nuo Sun et al.   MOLECULAR CELL

Reconstruction of bacterial transcription-coupled repair at single-molecule resolution

(2016) Jun Fan et al.   NATURE

Near-atomic resolution visualization of human transcription promoter opening

(2016) Yuan He et al.   NATURE

Cullin–RING ubiquitin E3 ligase regulation by the COP9 signalosome

(2016) Simone Cavadini et al.   NATURE

Sen1, the yeast homolog of human senataxin, plays a more direct role than Rad26 in transcription coupled DNA repair

(2016) Wentao Li et al.   NUCLEIC ACIDS RESEARCH

A ubiquitylation site in Cockayne syndrome B required for repair of oxidative DNA damage, but not for transcription-coupled nucleotide excision repair

(2016) Michael Ranes et al.   NUCLEIC ACIDS RESEARCH

ppGpp couples transcription to DNA repair in E. coli

(2016) V. Kamarthapu et al.   SCIENCE

Pharmacological Bypass of Cockayne Syndrome B Function in Neuronal Differentiation

(2016) Yuming Wang et al.   Cell Reports

The Cockayne Syndrome Natural History (CoSyNH) study: clinical findings in 102 individuals and recommendations for care

(2015) Brian T. Wilson et al.   GENETICS IN MEDICINE

Understanding Xeroderma Pigmentosum Complementation Groups Using Gene Expression Profiling after UV-Light Exposure

(2015) Nikola Bowden et al.   INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

Tripartite DNA Lesion Recognition and Verification by XPC, TFIIH, and XPA in Nucleotide Excision Repair

(2015) Chia-Lung Li et al.   MOLECULAR CELL

Gene Length Matters in Neurons

(2015) Mark J. Zylka et al.   NEURON

Structural insights into the recognition of cisplatin and AAF-dG lesion by Rad14 (XPA)

(2015) Sandra C. Koch et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Double-stranded DNA translocase activity of transcription factor TFIIH and the mechanism of RNA polymerase II open complex formation

(2015) James Fishburn et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Kinetic gating mechanism of DNA damage recognition by Rad4/XPC

(2015) Xuejing Chen et al.   Nature Communications

UvrD facilitates DNA repair by pulling RNA polymerase backwards

(2014) Vitaly Epshtein et al.   NATURE

Insights into how Spt5 functions in transcription elongation and repressing transcription coupled DNA repair

(2014) Wentao Li et al.   NUCLEIC ACIDS RESEARCH

Regulation of the Rhp26ERCC6/CSBchromatin remodeler by a novel conserved leucine latch motif

(2014) Lanfeng Wang et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Dysregulation of gene expression as a cause of Cockayne syndrome neurological disease

(2014) Yuming Wang et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

In TFIIH, XPD Helicase Is Exclusively Devoted to DNA Repair

(2014) Jochen Kuper et al.   PLOS BIOLOGY

UVSSA and USP7, a new couple in transcription-coupled DNA repair

(2013) Petra Schwertman et al.   CHROMOSOMA

Cockayne syndrome: The expanding clinical and mutational spectrum

(2013) Vincent Laugel   MECHANISMS OF AGEING AND DEVELOPMENT

Mitochondrial deficiency in Cockayne syndrome

(2013) Morten Scheibye-Knudsen et al.   MECHANISMS OF AGEING AND DEVELOPMENT

Cockayne syndrome group B (CSB) protein: At the crossroads of transcriptional networks

(2013) Renier Vélez-Cruz et al.   MECHANISMS OF AGEING AND DEVELOPMENT

ATP-Dependent Chromatin Remodeling by Cockayne Syndrome Protein B and NAP1-Like Histone Chaperones Is Required for Efficient Transcription-Coupled DNA Repair

(2013) Iltaeg Cho et al.   PLoS Genetics

Basic mechanism of transcription by RNA polymerase II

(2012) Vladimir Svetlov et al.   Biochimica et Biophysica Acta-Gene Regulatory Mechanisms

Ubiquitylation and degradation of elongating RNA polymerase II: The last resort

(2012) Marcus D. Wilson et al.   Biochimica et Biophysica Acta-Gene Regulatory Mechanisms

Mechanism of Release and Fate of Excised Oligonucleotides during Nucleotide Excision Repair

(2012) Michael G. Kemp et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Nucleotide excision repair–initiating proteins bind to oxidative DNA lesions in vivo

(2012) Hervé Menoni et al.   JOURNAL OF CELL BIOLOGY

RNA Polymerase II Collision Interrupts Convergent Transcription

(2012) David J. Hobson et al.   MOLECULAR CELL

Initiation of transcription-coupled repair characterized at single-molecule resolution

(2012) Kévin Howan et al.   NATURE

Mutations in UVSSA cause UV-sensitive syndrome and impair RNA polymerase IIo processing in transcription-coupled nucleotide-excision repair

(2012) Yuka Nakazawa et al.   NATURE GENETICS

Mutations in UVSSA cause UV-sensitive syndrome and destabilize ERCC6 in transcription-coupled DNA repair

(2012) Xue Zhang et al.   NATURE GENETICS

UV-sensitive syndrome protein UVSSA recruits USP7 to regulate transcription-coupled repair

(2012) Petra Schwertman et al.   NATURE GENETICS

The Molecular Basis of CRL4DDB2/CSA Ubiquitin Ligase Architecture, Targeting, and Activation

(2011) Eric S. Fischer et al.   CELL

Xeroderma pigmentosum

(2011) Alan R Lehmann et al.   Orphanet Journal of Rare Diseases

A Ubiquitin-Binding Domain in Cockayne Syndrome B Required for Transcription-Coupled Nucleotide Excision Repair

(2010) Roy Anindya et al.   MOLECULAR CELL

Evidence that Transcript Cleavage Is Essential for RNA Polymerase II Transcription and Cell Viability

(2010) Stefan Sigurdsson et al.   MOLECULAR CELL

Three DNA Polymerases, Recruited by Different Mechanisms, Carry Out NER Repair Synthesis in Human Cells

(2010) Tomoo Ogi et al.   MOLECULAR CELL

Localization of xeroderma pigmentosum group A protein and replication protein A on damaged DNA in nucleotide excision repair

(2010) Yuliya S. Krasikova et al.   NUCLEIC ACIDS RESEARCH

Strand- and site-specific DNA lesion demarcation by the xeroderma pigmentosum group D helicase

(2010) Nadine Mathieu et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Two-stage dynamic DNA quality check by xeroderma pigmentosum group C protein

(2009) Ulrike Camenisch et al.   EMBO JOURNAL

Molecular insights into the recruitment of TFIIH to sites of DNA damage

(2009) Valentyn Oksenych et al.   EMBO JOURNAL

Coordination of dual incision and repair synthesis in human nucleotide excision repair

(2009) Lidija Staresincic et al.   EMBO JOURNAL

Cockayne Syndrome Group B Protein Stimulates Repair of Formamidopyrimidines by NEIL1 DNA Glycosylase

(2009) Meltem Muftuoglu et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

The C-terminal Repeat Domain of Spt5 Plays an Important Role in Suppression of Rad26-independent Transcription Coupled Repair

(2009) Baojin Ding et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Eukaryotic Translesion Polymerases and Their Roles and Regulation in DNA Damage Tolerance

(2009) L. S. Waters et al.   MICROBIOLOGY AND MOLECULAR BIOLOGY REVIEWS

Stability, Flexibility, and Dynamic Interactions of Colliding RNA Polymerase II Elongation Complexes

(2009) Hideaki Saeki et al.   MOLECULAR CELL

Two-Step Recognition of DNA Damage for Mammalian Nucleotide Excision Repair: Directional Binding of the XPC Complex and DNA Strand Scanning

(2009) Kaoru Sugasawa et al.   MOLECULAR CELL

Distinct ubiquitin ligases act sequentially for RNA polymerase II polyubiquitylation

(2009) M. Harreman et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Genome-Wide Analysis of Factors Affecting Transcription Elongation and DNA Repair: A New Role for PAF and Ccr4-Not in Transcription-Coupled Repair

(2009) Hélène Gaillard et al.   PLoS Genetics

Structural Basis of UV DNA-Damage Recognition by the DDB1–DDB2 Complex

(2008) Andrea Scrima et al.   CELL

Accumulation of (5′S)-8,5′-cyclo-2′-deoxyadenosine in organs of Cockayne syndrome complementation group B gene knockout mice

(2008) Güldal Kirkali et al.   DNA REPAIR

Mammalian Elongin A complex mediates DNA-damage-induced ubiquitylation and degradation of Rpb1

(2008) Takashi Yasukawa et al.   EMBO JOURNAL

Reversal of RNA Polymerase II Ubiquitylation by the Ubiquitin Protease Ubp3

(2008) Kristian Kvint et al.   MOLECULAR CELL

Nucleotide Excision Repair Driven by the Dissociation of CAK from TFIIH

(2008) Frédéric Coin et al.   MOLECULAR CELL

DNA polymerases and human disease

(2008) Lawrence A. Loeb et al.   NATURE REVIEWS GENETICS