Elongation factor ELOF1 drives transcription-coupled repair and prevents genome instability

ELOF1 is a transcription-coupled DNA repair factor that directs RNA polymerase II ubiquitylation

(2021) Yana van der Weegen et al.   NATURE CELL BIOLOGY

Using TTchem-seq for profiling nascent transcription and measuring transcript elongation

(2020) Lea H. Gregersen et al.   Nature Protocols

Ubiquitination of DNA Damage-Stalled RNAPII Promotes Transcription-Coupled Repair

(2020) Yuka Nakazawa et al.   CELL

Regulation of the RNAPII Pool Is Integral to the DNA Damage Response

(2020) Ana Tufegdžić Vidaković et al.   CELL

A Genetic Map of the Response to DNA Damage in Human Cells

(2020) Michele Olivieri et al.   CELL

Genome-wide role of Rad26 in promoting transcription-coupled nucleotide excision repair in yeast chromatin

(2020) Mingrui Duan et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Structural insight into nucleosome transcription by RNA polymerase II with elongation factors

(2019) Haruhiko Ehara et al.   SCIENCE

FACT subunit Spt16 controls UVSSA recruitment to lesion-stalled RNA Pol II and stimulates TC-NER

(2019) Franziska Wienholz et al.   NUCLEIC ACIDS RESEARCH

Fluorescently-labelled CPD and 6-4PP photolyases: new tools for live-cell DNA damage quantification and laser-assisted repair

(2019) Barbara Steurer et al.   NUCLEIC ACIDS RESEARCH

In vitro analysis of RNA polymerase II elongation complex dynamics

(2019) Yoo Jin Joo et al.   GENES & DEVELOPMENT

Transcription-mediated replication hindrance: a major driver of genome instability

(2019) Belén Gómez-González et al.   GENES & DEVELOPMENT

Generation of conditional auxin-inducible degron (AID) cells and tight control of degron-fused proteins using the degradation inhibitor auxinole

(2019) Aisha Yesbolatova et al.   METHODS

The elongation factor Elof1 is required for mammalian gastrulation

(2019) Adam P. Tellier et al.   PLoS One

The DNA damage response to transcription stress

(2019) Hannes Lans et al.   NATURE REVIEWS MOLECULAR CELL BIOLOGY

Asymmetric repair of UV damage in nucleosomes imposes a DNA strand polarity on somatic mutations in skin cancer

(2019) Peng Mao et al.   GENOME RESEARCH

Translesion and Repair DNA Polymerases: Diverse Structure and Mechanism

(2018) Wei Yang et al.   Annual Review of Biochemistry

Live-cell analysis of endogenous GFP-RPB1 uncovers rapid turnover of initiating and promoter-paused RNA Polymerase II

(2018) Barbara Steurer et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Base and nucleotide excision repair facilitate resolution of platinum drugs-induced transcription blockage

(2018) Jana Slyskova et al.   NUCLEIC ACIDS RESEARCH

NuA4 acetyltransferase is required for efficient nucleotide excision repair in yeast

(2018) Amelia J. Hodges et al.   DNA REPAIR

Genome-wide maps of alkylation damage, repair, and mutagenesis in yeast reveal mechanisms of mutational heterogeneity

(2017) Peng Mao et al.   GENOME RESEARCH

Structural basis for the initiation of eukaryotic transcription-coupled DNA repair

(2017) Jun Xu et al.   NATURE

Common TFIIH recruitment mechanism in global genome and transcription-coupled repair subpathways

(2017) Masahiko Okuda et al.   NUCLEIC ACIDS RESEARCH

Structure of the complete elongation complex of RNA polymerase II with basal factors

(2017) Haruhiko Ehara et al.   SCIENCE

Progression through mitosis promotes PARP inhibitor-induced cytotoxicity in homologous recombination-deficient cancer cells

(2017) Pepijn M. Schoonen et al.   Nature Communications

Transcription as a Threat to Genome Integrity

(2016) Hélène Gaillard et al.   Annual Review of Biochemistry

Valosin-containing Protein (VCP)/p97 Segregase Mediates Proteolytic Processing of Cockayne Syndrome Group B (CSB) in Damaged Chromatin

(2016) Jinshan He et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

CRISPR knockout screening outperforms shRNA and CRISPRi in identifying essential genes

(2016) Bastiaan Evers et al.   NATURE BIOTECHNOLOGY

deepTools2: a next generation web server for deep-sequencing data analysis

(2016) Fidel Ramírez et al.   NUCLEIC ACIDS RESEARCH

L1Base 2: more retrotransposition-active LINE-1s, more mammalian genomes

(2016) Tobias Penzkofer et al.   NUCLEIC ACIDS RESEARCH

Chromosomal landscape of UV damage formation and repair at single-nucleotide resolution

(2016) Peng Mao et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Rapid Protein Depletion in Human Cells by Auxin-Inducible Degron Tagging with Short Homology Donors

(2016) Toyoaki Natsume et al.   Cell Reports

High-resolution Digital Mapping ofN-Methylpurines in Human Cells Reveals Modulation of Their Induction and Repair by Nearest-neighbor Nucleotides

(2015) Mingyang Li et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

THZ1 Reveals Roles for Cdk7 in Co-transcriptional Capping and Pausing

(2015) Kyle A. Nilson et al.   MOLECULAR CELL

High-Resolution Chromatin Dynamics during a Yeast Stress Response

(2015) Assaf Weiner et al.   MOLECULAR CELL

Replication stress activates DNA repair synthesis in mitosis

(2015) Sheroy Minocherhomji et al.   NATURE

SUMO and ubiquitin-dependent XPC exchange drives nucleotide excision repair

(2015) Loes van Cuijk et al.   Nature Communications

Improved vectors and genome-wide libraries for CRISPR screening

(2014) Neville E Sanjana et al.   NATURE METHODS

A rapid, comprehensive system for assaying DNA repair activity and cytotoxic effects of DNA-damaging reagents

(2014) Nan Jia et al.   Nature Protocols

Simultaneous mapping of transcript ends at single-nucleotide resolution and identification of widespread promoter-associated non-coding RNA governed by TATA elements

(2014) Daechan Park et al.   NUCLEIC ACIDS RESEARCH

Easy quantitative assessment of genome editing by sequence trace decomposition

(2014) Eva K. Brinkman et al.   NUCLEIC ACIDS RESEARCH

Cockayne syndrome: The expanding clinical and mutational spectrum

(2013) Vincent Laugel   MECHANISMS OF AGEING AND DEVELOPMENT

Genome-Wide Transcriptional Effects of the Anti-Cancer Agent Camptothecin

(2013) Artur Veloso et al.   PLoS One

Genome-Scale CRISPR-Cas9 Knockout Screening in Human Cells

(2013) Ophir Shalem et al.   SCIENCE

Nucleotide Excision Repair in Eukaryotes

(2013) O. D. Scharer   Cold Spring Harbor Perspectives in Biology

RNA Polymerase Backtracking in Gene Regulation and Genome Instability

(2012) Evgeny Nudler   CELL

Mouse Rif1 is a key regulator of the replication-timing programme in mammalian cells

(2012) Daniela Cornacchia et al.   EMBO JOURNAL

KIAA1530 Protein Is Recruited by Cockayne Syndrome Complementation Group Protein A (CSA) to Participate in Transcription-coupled Repair (TCR)

(2012) Jia Fei et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

UV-sensitive syndrome protein UVSSA recruits USP7 to regulate transcription-coupled repair

(2012) Petra Schwertman et al.   NATURE GENETICS

Fast gapped-read alignment with Bowtie 2

(2012) Ben Langmead et al.   NATURE METHODS

53BP1 nuclear bodies form around DNA lesions generated by mitotic transmission of chromosomes under replication stress

(2011) Claudia Lukas et al.   NATURE CELL BIOLOGY

Uniform transitions of the general RNA polymerase II transcription complex

(2010) Andreas Mayer et al.   NATURE STRUCTURAL & MOLECULAR BIOLOGY

Involvement of Global Genome Repair, Transcription Coupled Repair, and Chromatin Remodeling in UV DNA Damage Response Changes during Development

(2010) Hannes Lans et al.   PLoS Genetics

Identification of a crenarchaeal orthologue of Elf1: implications for chromatin and transcription in Archaea

(2009) Jan-Peter Daniels et al.   Biology Direct

A Versatile Viral System for Expression and Depletion of Proteins in Mammalian Cells

(2009) Eric Campeau et al.   PLoS One