Envisioning how the prototypic molecular machine TFIIH functions in transcription initiation and DNA repair

RNA at DNA Double‐Strand Breaks: The Challenge of Dealing with DNA:RNA Hybrids

(2020) Judit Domingo‐Prim et al.   BIOESSAYS

Ubiquitination of DNA Damage-Stalled RNAPII Promotes Transcription-Coupled Repair

(2020) Yuka Nakazawa et al.   CELL

Regulation of the RNAPII Pool Is Integral to the DNA Damage Response

(2020) Ana Tufegdžić Vidaković et al.   CELL

Structure and mechanism of the RNA polymerase II transcription machinery

(2020) Allison C. Schier et al.   GENES & DEVELOPMENT

Biomarker-Guided Development of DNA Repair Inhibitors

(2020) James M. Cleary et al.   MOLECULAR CELL

The cooperative action of CSB, CSA, and UVSSA target TFIIH to DNA damage-stalled RNA polymerase II

(2020) Yana van der Weegen et al.   Nature Communications

Mutational signatures are jointly shaped by DNA damage and repair

(2020) Nadezda V. Volkova et al.   Nature Communications

In TFIIH the Arch domain of XPD is mechanistically essential for transcription and DNA repair

(2020) Stefan Peissert et al.   Nature Communications

Human XPG nuclease structure, assembly, and activities with insights for neurodegeneration and cancer from pathogenic mutations

(2020) Susan E. Tsutakawa et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Effective Distance for DNA-Mediated Charge Transport between Repair Proteins

(2019) Edmund C. M. Tse et al.   ACS Central Science

Transcription preinitiation complex structure and dynamics provide insight into genetic diseases

(2019) Chunli Yan et al.   NATURE STRUCTURAL & MOLECULAR BIOLOGY

The complete structure of the human TFIIH core complex

(2019) Basil J Greber et al.   eLife

Evolving SAXS versatility: solution X-ray scattering for macromolecular architecture, functional landscapes, and integrative structural biology

(2019) Chris A Brosey et al.   CURRENT OPINION IN STRUCTURAL BIOLOGY

Deficiency of nucleotide excision repair is associated with mutational signature observed in cancer

(2019) Myrthe Jager et al.   GENOME RESEARCH

Structural basis of TFIIH activation for nucleotide excision repair

(2019) Goran Kokic et al.   Nature Communications

Single-molecule visualization reveals the damage search mechanism for the human NER protein XPC-RAD23B

(2019) Na Young Cheon et al.   NUCLEIC ACIDS RESEARCH

Processing of a single ribonucleotide embedded into DNA by human nucleotide excision repair and DNA polymerase η

(2019) Akira Sassa et al.   Scientific Reports

High-resolution cryo-EM structures of TFIIH and their functional implications

(2019) Eva Nogales et al.   CURRENT OPINION IN STRUCTURAL BIOLOGY

A key interaction with RPA orients XPA in NER complexes

(2019) Agnieszka M Topolska-Woś et al.   NUCLEIC ACIDS RESEARCH

Selective small molecule PARG inhibitor causes replication fork stalling and cancer cell death

(2019) Jerry H. Houl et al.   Nature Communications

ERCC2 Helicase Domain Mutations Confer Nucleotide Excision Repair Deficiency and Drive Cisplatin Sensitivity in Muscle-Invasive Bladder Cancer

(2018) Qiang Li et al.   CLINICAL CANCER RESEARCH

Single-nucleotide resolution dynamic repair maps of UV damage inSaccharomyces cerevisiaegenome

(2018) Wentao Li et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

The essential and multifunctional TFIIH complex

(2018) Jenna K. Rimel et al.   PROTEIN SCIENCE

Molecular basis for damage recognition and verification by XPC-RAD23B and TFIIH in nucleotide excision repair

(2018) Hong Mu et al.   DNA REPAIR

Promoter Distortion and Opening in the RNA Polymerase II Cleft

(2018) Christian Dienemann et al.   MOLECULAR CELL

Structure of transcribing RNA polymerase II-nucleosome complex

(2018) Lucas Farnung et al.   Nature Communications

DNA translocation mechanism of an XPD family helicase

(2018) Kaiying Cheng et al.   eLife

Structures of transcription pre-initiation complex with TFIIH and Mediator

(2017) S. Schilbach et al.   NATURE

Core Mediator structure at 3.4 Å extends model of transcription initiation complex

(2017) Kayo Nozawa et al.   NATURE

The cryo-electron microscopy structure of human transcription factor IIH

(2017) Basil J. Greber et al.   NATURE

TFIIH generates a six-base-pair open complex during RNAP II transcription initiation and start-site scanning

(2017) Eric J Tomko et al.   NATURE STRUCTURAL & MOLECULAR BIOLOGY

Common TFIIH recruitment mechanism in global genome and transcription-coupled repair subpathways

(2017) Masahiko Okuda et al.   NUCLEIC ACIDS RESEARCH

Poly(ADP-ribose) polymerase 1 escorts XPC to UV-induced DNA lesions during nucleotide excision repair

(2017) Mihaela Robu et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Phosphate steering by Flap Endonuclease 1 promotes 5′-flap specificity and incision to prevent genome instability

(2017) Susan E. Tsutakawa et al.   Nature Communications

TFIIH generates a six-base-pair open complex during RNAP II transcription initiation and start-site scanning

(2017) Eric J Tomko et al.   NATURE STRUCTURAL & MOLECULAR BIOLOGY

Transcription leads to pervasive replisome instability in bacteria

(2017) Sarah M Mangiameli et al.   eLife

Single-Molecule Imaging Reveals that Rad4 Employs a Dynamic DNA Damage Recognition Process

(2016) Muwen Kong et al.   MOLECULAR CELL

Near-atomic resolution visualization of human transcription promoter opening

(2016) Yuan He et al.   NATURE

Somatic ERCC2 mutations are associated with a distinct genomic signature in urothelial tumors

(2016) Jaegil Kim et al.   NATURE GENETICS

Mechanism of DNA loading by the DNA repair helicase XPD

(2016) Diana Constantinescu-Aruxandei et al.   NUCLEIC ACIDS RESEARCH

Defining NADH-Driven Allostery Regulating Apoptosis-Inducing Factor

(2016) Chris A. Brosey et al.   STRUCTURE

Emerging critical roles of Fe–S clusters in DNA replication and repair

(2015) Jill O. Fuss et al.   BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR CELL RESEARCH

Nucleotide excision repair in humans

(2015) Graciela Spivak   DNA REPAIR

Genome-wide analysis of human global and transcription-coupled excision repair of UV damage at single-nucleotide resolution

(2015) Jinchuan Hu et al.   GENES & DEVELOPMENT

Constructive rescue of TFIIH instability by an alternative isoform of XPD derived from a mutated XPD allele in mild but not severe XP-D/CS

(2015) Katsuyoshi Horibata et al.   JOURNAL OF HUMAN GENETICS

Tripartite DNA Lesion Recognition and Verification by XPC, TFIIH, and XPA in Nucleotide Excision Repair

(2015) Chia-Lung Li et al.   MOLECULAR CELL

Structural insights into the recognition of cisplatin and AAF-dG lesion by Rad14 (XPA)

(2015) Sandra C. Koch et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Double-stranded DNA translocase activity of transcription factor TFIIH and the mechanism of RNA polymerase II open complex formation

(2015) James Fishburn et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Structural Insight into the Mechanism of TFIIH Recognition by the Acidic String of the Nucleotide Excision Repair Factor XPC

(2015) Masahiko Okuda et al.   STRUCTURE

Crystal Structure of a Eukaryotic GEN1 Resolving Enzyme Bound to DNA

(2015) Yijin Liu et al.   Cell Reports

A High-Fat Diet and NAD + Activate Sirt1 to Rescue Premature Aging in Cockayne Syndrome

(2014) Morten Scheibye-Knudsen et al.   Cell Metabolism

Poly(ADP-ribose)-mediated interplay of XPA and PARP1 leads to reciprocal regulation of protein function

(2014) Jan M. F. Fischer et al.   FEBS Journal

Structure of the C-terminal half of human XPB helicase and the impact of the disease-causing mutation XP11BE

(2013) Eduardo Hilario et al.   ACTA CRYSTALLOGRAPHICA SECTION D-BIOLOGICAL CRYSTALLOGRAPHY

DNA Quality Control by a Lesion Sensor Pocket of the Xeroderma Pigmentosum Group D Helicase Subunit of TFIIH

(2013) Nadine Mathieu et al.   CURRENT BIOLOGY

Functional and molecular genetic analyses of nine newly identifiedXPD-deficient patients reveal a novel mutation resulting in TTD as well as in XP/CS complex phenotypes

(2013) Annika Schäfer et al.   EXPERIMENTAL DERMATOLOGY

Strand-specific Recognition of DNA Damages by XPD Provides Insights into Nucleotide Excision Repair Substrate Versatility

(2013) Claudia N. Buechner et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

DNA Double-Strand Break Repair Pathway Choice Is Directed by Distinct MRE11 Nuclease Activities

(2013) Atsushi Shibata et al.   MOLECULAR CELL

Nucleotide Excision Repair in Eukaryotes

(2013) O. D. Scharer   Cold Spring Harbor Perspectives in Biology

PARP1 promotes nucleotide excision repair through DDB2 stabilization and recruitment of ALC1

(2012) Alex Pines et al.   JOURNAL OF CELL BIOLOGY

Atl1 Regulates Choice between Global Genome and Transcription-Coupled Repair of O6-Alkylguanines

(2012) Vitaly F. Latypov et al.   MOLECULAR CELL

TFIIH: when transcription met DNA repair

(2012) Emmanuel Compe et al.   NATURE REVIEWS MOLECULAR CELL BIOLOGY

DNA charge transport as a first step in coordinating the detection of lesions by repair proteins

(2012) P. A. Sontz et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Alkyltransferase-like protein (Atl1) distinguishes alkylated guanines for DNA repair using cation-  interactions

(2012) O. J. Wilkinson et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Human Flap Endonuclease Structures, DNA Double-Base Flipping, and a Unified Understanding of the FEN1 Superfamily

(2011) Susan E. Tsutakawa et al.   CELL

Structures of Human Exonuclease 1 DNA Complexes Suggest a Unified Mechanism for Nuclease Family

(2011) Jillian Orans et al.   CELL

XPB and XPD helicases in TFIIH orchestrate DNA duplex opening and damage verification to coordinate repair with transcription and cell cycle via CAK kinase

(2011) Jill O. Fuss et al.   DNA REPAIR

Functional and structural studies of the nucleotide excision repair helicase XPD suggest a polarity for DNA translocation

(2011) Jochen Kuper et al.   EMBO JOURNAL

UV-induced photolesions elicit ATR-kinase-dependent signaling in non-cycling cells through nucleotide excision repair-dependent and -independent pathways

(2011) M. G. Vrouwe et al.   JOURNAL OF CELL SCIENCE

ATP-Stimulated, DNA-Mediated Redox Signaling by XPD, a DNA Repair and Transcription Helicase

(2011) Timothy P. Mui et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

DNA charge transport over 34 nm

(2011) Jason D. Slinker et al.   Nature Chemistry

Unpairing and gating: sequence-independent substrate recognition by FEN superfamily nucleases

(2011) Jane A. Grasby et al.   TRENDS IN BIOCHEMICAL SCIENCES

Regulation of nucleotide excision repair activity by transcriptional and post-transcriptional control of the XPA protein

(2010) T.-H. Kang et al.   NUCLEIC ACIDS RESEARCH

Strand- and site-specific DNA lesion demarcation by the xeroderma pigmentosum group D helicase

(2010) Nadine Mathieu et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Coordination of dual incision and repair synthesis in human nucleotide excision repair

(2009) Lidija Staresincic et al.   EMBO JOURNAL

Two-Step Recognition of DNA Damage for Mammalian Nucleotide Excision Repair: Directional Binding of the XPC Complex and DNA Strand Scanning

(2009) Kaoru Sugasawa et al.   MOLECULAR CELL

The DNA-damage response in human biology and disease

(2009) Stephen P. Jackson et al.   NATURE

Structure of the human RECQ1 helicase reveals a putative strand-separation pin

(2009) A. C. W. Pike et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Redox signaling between DNA repair proteins for efficient lesion detection

(2009) A. K. Boal et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Structure of the DNA Repair Helicase XPD

(2008) Huanting Liu et al.   CELL

XPD Helicase Structures and Activities: Insights into the Cancer and Aging Phenotypes from XPD Mutations

(2008) Li Fan et al.   CELL

Persistence of repair proteins at unrepaired DNA damage distinguishes diseases withERCC2(XPD) mutations: cancer-prone xeroderma pigmentosum vs. non-cancer-prone trichothiodystrophy

(2008) Jennifer Boyle et al.   HUMAN MUTATION

Nucleotide Excision Repair Driven by the Dissociation of CAK from TFIIH

(2008) Frédéric Coin et al.   MOLECULAR CELL

Transcription-coupled DNA repair: two decades of progress and surprises

(2008) Philip C. Hanawalt et al.   NATURE REVIEWS MOLECULAR CELL BIOLOGY

Crystal Structure of the FeS Cluster–Containing Nucleotide Excision Repair Helicase XPD

(2008) Stefanie C Wolski et al.   PLOS BIOLOGY