WASp triggers mechanosensitive actin patches to facilitate immune cell migration in dense tissues

Pinching the cortex of live cells reveals thickness instabilities caused by myosin II motors

(2021) Valentin Laplaud et al.   Science Advances

Principles of self-organization and load adaptation by the actin cytoskeleton during clathrin-mediated endocytosis

(2020) Matthew Akamatsu et al.   eLife

The stiffness of living tissues and its implications for tissue engineering

(2020) Carlos F. Guimarães et al.   Nature Reviews Materials

Cellular locomotion using environmental topography

(2020) Anne Reversat et al.   NATURE

Mouse T cell priming is enhanced by maturation-dependent stiffening of the dendritic cell cortex

(2020) Daniel Blumenthal et al.   eLife

Adaptive F-Actin Polymerization and Localized ATP Production Drive Basement Membrane Invasion in the Absence of MMPs

(2019) Laura C. Kelley et al.   DEVELOPMENTAL CELL

Efficient Front-Rear Coupling in Neutrophil Chemotaxis by Dynamic Myosin II Localization

(2019) Tony Y.-C. Tsai et al.   DEVELOPMENTAL CELL

Nuclear positioning facilitates amoeboid migration along the path of least resistance

(2019) Jörg Renkawitz et al.   NATURE

Proteolytic and Opportunistic Breaching of the Basement Membrane Zone by Immune Cells during Tumor Initiation

(2019) Maaike C.W. van den Berg et al.   Cell Reports

Mechanical Point Loading Induces Cortex Stiffening and Actin Reorganization

(2019) Jinrong Hu et al.   BIOPHYSICAL JOURNAL

ilastik: interactive machine learning for (bio)image analysis

(2019) Stuart Berg et al.   NATURE METHODS

Membrane curvature underlies actin reorganization in response to nanoscale surface topography

(2019) Hsin-Ya Lou et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Probing the mechanical landscape – new insights into podosome architecture and mechanics

(2019) Koen van den Dries et al.   JOURNAL OF CELL SCIENCE

Concise Language Promotes Clear Thinking about Cell Shape and Locomotion

(2018) Lillian K. Fritz-Laylin et al.   BIOESSAYS

A Flat BAR Protein Promotes Actin Polymerization at the Base of Clathrin-Coated Pits

(2018) Leonardo Almeida-Souza et al.   CELL

Ultrastructure of the actin cytoskeleton

(2018) Tatyana M Svitkina   CURRENT OPINION IN CELL BIOLOGY

Fast and efficient genetic engineering of hematopoietic precursor cells for the study of dendritic cell migration

(2018) Alexander Leithner et al.   EUROPEAN JOURNAL OF IMMUNOLOGY

Enucleated cells reveal differential roles of the nucleus in cell migration, polarity, and mechanotransduction

(2018) David M. Graham et al.   JOURNAL OF CELL BIOLOGY

Chemokines and integrins independently tune actin flow and substrate friction during intranodal migration of T cells

(2018) Miroslav Hons et al.   NATURE IMMUNOLOGY

Forces drive basement membrane invasion inCaenorhabditis elegans

(2018) Rodrigo Cáceres et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

WASP and SCAR are evolutionarily conserved in actin-filled pseudopod-based motility

(2017) Lillian K. Fritz-Laylin et al.   JOURNAL OF CELL BIOLOGY

TrackMate: An open and extensible platform for single-particle tracking

(2017) Jean-Yves Tinevez et al.   METHODS

Actin-based protrusions of migrating neutrophils are intrinsically lamellar and facilitate direction changes

(2017) Lillian K Fritz-Laylin et al.   eLife

Focal Adhesion–Independent Cell Migration

(2016) Ewa K. Paluch et al.   Annual Review of Cell and Developmental Biology

Functional Coordination of WAVE and WASP in C. elegans Neuroblast Migration

(2016) Zhiwen Zhu et al.   DEVELOPMENTAL CELL

Diversified actin protrusions promote environmental exploration but are dispensable for locomotion of leukocytes

(2016) Alexander Leithner et al.   NATURE CELL BIOLOGY

Perinuclear Arp2/3-driven actin polymerization enables nuclear deformation to facilitate cell migration through complex environments

(2016) Hawa-Racine Thiam et al.   Nature Communications

Biphasic response of cell invasion to matrix stiffness in three-dimensional biopolymer networks

(2015) Nadine R. Lang et al.   Acta Biomaterialia

Actin Flows Mediate a Universal Coupling between Cell Speed and Cell Persistence

(2015) Paolo Maiuri et al.   CELL

Platelet actin nodules are podosome-like structures dependent on Wiskott–Aldrich syndrome protein and ARP2/3 complex

(2015) Natalie S. Poulter et al.   Nature Communications

Mechanical interplay between invadopodia and the nucleus in cultured cancer cells

(2015) Or-Yam Revach et al.   Scientific Reports

Visualizing the functional architecture of the endocytic machinery

(2015) Andrea Picco et al.   eLife

Actin foci facilitate activation of the phospholipase C-γ in primary T lymphocytes via the WASP pathway

(2015) Sudha Kumari et al.   eLife

Detection of Rare Antigen-Presenting Cells through T Cell-Intrinsic Meandering Motility, Mediated by Myo1g

(2014) Audrey Gérard et al.   CELL

Cellular Control of Cortical Actin Nucleation

(2014) Miia Bovellan et al.   CURRENT BIOLOGY

Self-organization of protrusions and polarity during eukaryotic chemotaxis

(2014) Brian R Graziano et al.   CURRENT OPINION IN CELL BIOLOGY

Expression of Wiskott-Aldrich Syndrome Protein in Dendritic Cells Regulates Synapse Formation and Activation of Naive CD8+ T Cells

(2014) J. Pulecio et al.   JOURNAL OF IMMUNOLOGY

Steering cell migration: lamellipodium dynamics and the regulation of directional persistence

(2014) Matthias Krause et al.   NATURE REVIEWS MOLECULAR CELL BIOLOGY

Guiding cell migration by tugging

(2013) Sergey V Plotnikov et al.   CURRENT OPINION IN CELL BIOLOGY

Physical limits of cell migration: Control by ECM space and nuclear deformation and tuning by proteolysis and traction force

(2013) Katarina Wolf et al.   JOURNAL OF CELL BIOLOGY

Hematopoietic progenitor cell lines with myeloid and lymphoid potential

(2013) Vanessa Redecke et al.   NATURE METHODS

Integrin-Matrix Clusters Form Podosome-like Adhesions in the Absence of Traction Forces

(2013) Cheng-han Yu et al.   Cell Reports

SCAR knockouts inDictyostelium: WASP assumes SCAR’s position and upstream regulators in pseudopods

(2012) Douwe M. Veltman et al.   JOURNAL OF CELL BIOLOGY

Fiji: an open-source platform for biological-image analysis

(2012) Johannes Schindelin et al.   NATURE METHODS

New insights into the regulation and cellular functions of the ARP2/3 complex

(2012) Jeremy D. Rotty et al.   NATURE REVIEWS MOLECULAR CELL BIOLOGY

Synergistic BAR–NPF interactions in actin-driven membrane remodeling

(2012) Shiro Suetsugu et al.   TRENDS IN CELL BIOLOGY

Keratocyte Lamellipodial Protrusion Is Characterized by a Concave Force-Velocity Relation

(2011) Fabian Heinemann et al.   BIOPHYSICAL JOURNAL

Structural Organization of the Actin Cytoskeleton at Sites of Clathrin-Mediated Endocytosis

(2011) Agnieszka Collins et al.   CURRENT BIOLOGY

The 'ins' and 'outs' of podosomes and invadopodia: characteristics, formation and function

(2011) Danielle A. Murphy et al.   NATURE REVIEWS MOLECULAR CELL BIOLOGY

A High Precision Survey of the Molecular Dynamics of Mammalian Clathrin-Mediated Endocytosis

(2011) Marcus J. Taylor et al.   PLOS BIOLOGY

An invasive podosome-like structure promotes fusion pore formation during myoblast fusion

(2010) Kristin L. Sens et al.   JOURNAL OF CELL BIOLOGY

Lifeact mice for studying F-actin dynamics

(2010) Julia Riedl et al.   NATURE METHODS

Cdc42 interacting protein 4 (CIP4) is essential for integrin-dependent T-cell trafficking

(2010) S. Koduru et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Dictyostelium amoebae and neutrophils can swim

(2010) N. P. Barry et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Wiskott–Aldrich Syndrome: Immunodeficiency resulting from defective cell migration and impaired immunostimulatory activation

(2009) Gerben Bouma et al.   IMMUNOBIOLOGY

Plasticity of cell migration: a multiscale tuning model

(2009) Peter Friedl et al.   JOURNAL OF CELL BIOLOGY

Preformed portals facilitate dendritic cell entry into afferent lymphatic vessels

(2009) Holger Pflicke et al.   JOURNAL OF EXPERIMENTAL MEDICINE

Adaptive force transmission in amoeboid cell migration

(2009) Jörg Renkawitz et al.   NATURE CELL BIOLOGY

Arp2/3 complex interactions and actin network turnover in lamellipodia

(2008) Frank PL Lai et al.   EMBO JOURNAL

Rapid leukocyte migration by integrin-independent flowing and squeezing

(2008) Tim Lämmermann et al.   NATURE

Lifeact: a versatile marker to visualize F-actin

(2008) Julia Riedl et al.   NATURE METHODS