Recombination and restart at blocked replication forks

PIF1 helicase promotes break‐induced replication in mammalian cells

(2021) Shibo Li et al.   EMBO JOURNAL

Single-strand DNA breaks cause replisome disassembly

(2021) Kyle B. Vrtis et al.   MOLECULAR CELL

Structure of the FA core ubiquitin ligase closing the ID clamp on DNA

(2021) Shengliu Wang et al.   NATURE STRUCTURAL & MOLECULAR BIOLOGY

Mechanisms of Vertebrate DNA Interstrand Cross-Link Repair

(2021) Daniel R. Semlow et al.   Annual Review of Biochemistry

Repair of DNA Breaks by Break-Induced Replication

(2021) Z.W. Kockler et al.   Annual Review of Biochemistry

FANCM regulates repair pathway choice at stalled replication forks

(2021) Arvind Panday et al.   MOLECULAR CELL

Alcohol-derived DNA crosslinks are repaired by two distinct mechanisms

(2020) Michael R. Hodskinson et al.   NATURE

Patterns of somatic structural variation in human cancer genomes

(2020) Yilong Li et al.   NATURE

FANCD2–FANCI is a clamp stabilized on DNA by monoubiquitination of FANCD2 during DNA repair

(2020) Pablo Alcón et al.   NATURE STRUCTURAL & MOLECULAR BIOLOGY

DNA clamp function of the monoubiquitinated Fanconi anaemia ID complex

(2020) Renjing Wang et al.   NATURE

RTEL1 suppresses G-quadruplex-associated R-loops at difficult-to-replicate loci in the human genome

(2020) Wei Wu et al.   NATURE STRUCTURAL & MOLECULAR BIOLOGY

Mechanisms generating cancer genome complexity from a single cell division error

(2020) Neil T. Umbreit et al.   SCIENCE

Monoubiquitination by the human Fanconi anemia core complex clamps FANCI:FANCD2 on DNA in filamentous arrays

(2020) Winnie Tan et al.   eLife

Genome-wide high-resolution mapping of mitotic DNA synthesis sites and common fragile sites by direct sequencing

(2020) Fang Ji et al.   CELL RESEARCH

High-resolution mapping of mitotic DNA synthesis regions and common fragile sites in the human genome through direct sequencing

(2020) Morgane Macheret et al.   CELL RESEARCH

The plasticity of DNA replication forks in response to clinically relevant genotoxic stress

(2020) Matteo Berti et al.   NATURE REVIEWS MOLECULAR CELL BIOLOGY

Repeat expansions confer WRN dependence in microsatellite-unstable cancers

(2020) Niek van Wietmarschen et al.   NATURE

Super-resolution visualization of distinct stalled and broken replication fork structures

(2020) Donna R. Whelan et al.   PLoS Genetics

TRAIP is a master regulator of DNA interstrand crosslink repair

(2019) R. Alex Wu et al.   NATURE

Mitotic CDK Promotes Replisome Disassembly, Fork Breakage, and Complex DNA Rearrangements

(2019) Lin Deng et al.   MOLECULAR CELL

R-Loops as Cellular Regulators and Genomic Threats

(2019) Madzia P. Crossley et al.   MOLECULAR CELL

Remodeling of Interstrand Crosslink Proximal Replisomes Is Dependent on ATR, FANCM, and FANCD2

(2019) Jing Huang et al.   Cell Reports

Replication-Coupled DNA Repair

(2019) David Cortez   MOLECULAR CELL

DNA double-strand break repair-pathway choice in somatic mammalian cells

(2019) Ralph Scully et al.   NATURE REVIEWS MOLECULAR CELL BIOLOGY

DNA Polymerase Delta Synthesizes Both Strands during Break-Induced Replication

(2019) Roberto A. Donnianni et al.   MOLECULAR CELL

Chromosome instability syndromes

(2019) A. Malcolm R. Taylor et al.   Nature Reviews Disease Primers

R Loops: From Physiological to Pathological Roles

(2019) Tatiana García-Muse et al.   CELL

Structure of the Fanconi anaemia monoubiquitin ligase complex

(2019) Shabih Shakeel et al.   NATURE

The Tandem Duplicator Phenotype Is a Prevalent Genome-Wide Cancer Configuration Driven by Distinct Gene Mutations

(2018) Francesca Menghi et al.   CANCER CELL

Replication Fork Reversal during DNA Interstrand Crosslink Repair Requires CMG Unloading

(2018) Ravindra Amunugama et al.   Cell Reports

Dual Roles of Poly(dA:dT) Tracts in Replication Initiation and Fork Collapse

(2018) Anthony Tubbs et al.   CELL

Alcohol and endogenous aldehydes damage chromosomes and mutate stem cells

(2018) Juan I. Garaycoechea et al.   NATURE

The CMG Helicase Bypasses DNA-Protein Cross-Links to Facilitate Their Repair

(2018) Justin L. Sparks et al.   CELL

The role of SLX4 and its associated nucleases in DNA interstrand crosslink repair

(2018) Wouter S Hoogenboom et al.   NUCLEIC ACIDS RESEARCH

Replication Fork Reversal: Players and Guardians

(2017) Annabel Quinet et al.   MOLECULAR CELL

Mechanism of tandem duplication formation in BRCA1-mutant cells

(2017) Nicholas A. Willis et al.   NATURE

Replication-Dependent Unhooking of DNA Interstrand Cross-Links by the NEIL3 Glycosylase

(2016) Daniel R. Semlow et al.   CELL

Fan1deficiency results in DNA interstrand cross-link repair defects, enhanced tissue karyomegaly, and organ dysfunction

(2016) Supawat Thongthip et al.   GENES & DEVELOPMENT

RAD52 Facilitates Mitotic DNA Synthesis Following Replication Stress

(2016) Rahul Bhowmick et al.   MOLECULAR CELL

Landscape of somatic mutations in 560 breast cancer whole-genome sequences

(2016) Serena Nik-Zainal et al.   NATURE

The tandem duplicator phenotype as a distinct genomic configuration in cancer

(2016) Francesca Menghi et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Polymerase δ replicates both strands after homologous recombination–dependent fork restart

(2015) Izumi Miyabe et al.   NATURE STRUCTURAL & MOLECULAR BIOLOGY

Human RECQ1 helicase-driven DNA unwinding, annealing, and branch migration: Insights from DNA complex structures

(2015) Ashley C. W. Pike et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Mus81 and converging forks limit the mutagenicity of replication fork breakage

(2015) R. Mayle et al.   SCIENCE

Polymerase δ replicates both strands after homologous recombination–dependent fork restart

(2015) Izumi Miyabe et al.   NATURE STRUCTURAL & MOLECULAR BIOLOGY

Recombination occurs within minutes of replication blockage by RTS1 producing restarted forks that are prone to collapse

(2015) Michael O Nguyen et al.   eLife

XPF-ERCC1 Acts in Unhooking DNA Interstrand Crosslinks in Cooperation with FANCD2 and FANCP/SLX4

(2014) Daisy Klein Douwel et al.   MOLECULAR CELL

BRCA1 controls homologous recombination at Tus/Ter-stalled mammalian replication forks

(2014) Nicholas A. Willis et al.   NATURE

The DNA Translocase FANCM/MHF Promotes Replication Traverse of DNA Interstrand Crosslinks

(2013) Jing Huang et al.   MOLECULAR CELL

Migrating bubble during break-induced replication drives conservative DNA synthesis

(2013) Natalie Saini et al.   NATURE

Break-induced replication occurs by conservative DNA synthesis

(2013) R. A. Donnianni et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Break-Induced Replication Repair of Damaged Forks Induces Genomic Duplications in Human Cells

(2013) Lorenzo Costantino et al.   SCIENCE

Human SNM1A and XPF-ERCC1 collaborate to initiate DNA interstrand cross-link repair

(2011) A. T. Wang et al.   GENES & DEVELOPMENT

Break-Induced Replication Is Highly Inaccurate

(2011) Angela Deem et al.   PLOS BIOLOGY

The Human RecQ Helicases, BLM and RECQ1, Display Distinct DNA Substrate Specificities

(2008) Venkateswarlu Popuri et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Remodeling of DNA replication structures by the branch point translocase FANCM

(2008) K. Gari et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA