Monoubiquitination by the human Fanconi anemia core complex clamps FANCI:FANCD2 on DNA in filamentous arrays

FANCD2–FANCI is a clamp stabilized on DNA by monoubiquitination of FANCD2 during DNA repair

(2020) Pablo Alcón et al.   NATURE STRUCTURAL & MOLECULAR BIOLOGY

Preparation and purification of mono-ubiquitinated proteins using Avi-tagged ubiquitin

(2020) Winnie Tan et al.   PLoS One

ATR-Mediated FANCI Phosphorylation Regulates Both Ubiquitination and Deubiquitination of FANCD2

(2020) Winnie Tan et al.   Frontiers in Cell and Developmental Biology

DNA clamp function of the monoubiquitinated Fanconi anaemia ID complex

(2020) Renjing Wang et al.   NATURE

A Fanci knockout mouse model reveals common and distinct functions for FANCI and FANCD2

(2019) Emilie L Dubois et al.   NUCLEIC ACIDS RESEARCH

Phosphorylation of FANCD2 Inhibits the FANCD2/FANCI Complex and Suppresses the Fanconi Anemia Pathway in the Absence of DNA Damage

(2019) David Lopez-Martinez et al.   Cell Reports

Interdependence of bacterial cell division and genome segregation and its potential in drug development

(2018) Hari S. Misra et al.   MICROBIOLOGICAL RESEARCH

Histone Methylation by SETD1A Protects Nascent DNA through the Nucleosome Chaperone Activity of FANCD2

(2018) Martin R. Higgs et al.   MOLECULAR CELL

A structural and dynamic model for the assembly of Replication Protein A on single-stranded DNA

(2018) Luke A. Yates et al.   Nature Communications

A defined role for multiple Fanconi anemia gene products in DNA-damage-associated ubiquitination

(2017) Winnie Tan et al.   EXPERIMENTAL HEMATOLOGY

Constitutive role of the Fanconi anemia D2 gene in the replication stress response

(2017) Yanyan Tian et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Fanconi anemia FANCD2 and FANCI proteins regulate the nuclear dynamics of splicing factors

(2017) María Moriel-Carretero et al.   JOURNAL OF CELL BIOLOGY

Mechanism of Ubiquitination and Deubiquitination in the Fanconi Anemia Pathway

(2017) Sylvie van Twest et al.   MOLECULAR CELL

Functions of Replication Protein A as a Sensor of R Loops and a Regulator of RNaseH1

(2017) Hai Dang Nguyen et al.   MOLECULAR CELL

The identification of FANCD2 DNA binding domains reveals nuclear localization sequences

(2017) Joshi Niraj et al.   NUCLEIC ACIDS RESEARCH

FANCI and FANCD2 have common as well as independent functions during the cellular replication stress response

(2017) Elizabeth L. Thompson et al.   NUCLEIC ACIDS RESEARCH

The FA Core Complex Contains a Homo-dimeric Catalytic Module for the Symmetric Mono-ubiquitination of FANCI-FANCD2

(2017) Paolo Swuec et al.   Cell Reports

A dual protease approach for expression and affinity purification of recombinant proteins

(2016) Sreejith Raran-Kurussi et al.   ANALYTICAL BIOCHEMISTRY

FANCD2 Facilitates Replication through Common Fragile Sites

(2016) Advaitha Madireddy et al.   MOLECULAR CELL

Human BRCA1–BARD1 ubiquitin ligase activity counteracts chromatin barriers to DNA resection

(2016) Ruth M Densham et al.   NATURE STRUCTURAL & MOLECULAR BIOLOGY

FANCI-FANCD2 stabilizes the RAD51-DNA complex by binding RAD51 and protects the 5′-DNA end

(2016) Koichi Sato et al.   NUCLEIC ACIDS RESEARCH

The FANCD2–FANCI complex is recruited to DNA interstrand crosslinks before monoubiquitination of FANCD2

(2016) Chih-Chao Liang et al.   Nature Communications

Human BRCA1–BARD1 ubiquitin ligase activity counteracts chromatin barriers to DNA resection

(2016) Ruth M Densham et al.   NATURE STRUCTURAL & MOLECULAR BIOLOGY

SnapShot: Fanconi Anemia and Associated Proteins

(2015) Anderson T. Wang et al.   CELL

A Human Interactome in Three Quantitative Dimensions Organized by Stoichiometries and Abundances

(2015) Marco Y. Hein et al.   CELL

FANCD2, FANCJ and BRCA2 cooperate to promote replication fork recovery independently of the Fanconi Anemia core complex

(2015) Maya Raghunandan et al.   CELL CYCLE

DNA2 drives processing and restart of reversed replication forks in human cells

(2015) Saravanabhavan Thangavel et al.   JOURNAL OF CELL BIOLOGY

The Fanconi Anemia Pathway Maintains Genome Stability by Coordinating Replication and Transcription

(2015) Rebekka A. Schwab et al.   MOLECULAR CELL

Replication fork reversal in eukaryotes: from dead end to dynamic response

(2015) Kai J. Neelsen et al.   NATURE REVIEWS MOLECULAR CELL BIOLOGY

FANCI Regulates Recruitment of the FA Core Complex at Sites of DNA Damage Independently of FANCD2

(2015) Maria Castella et al.   PLoS Genetics

The Fanconi Anemia DNA Repair Pathway: Structural and Functional Insights into a Complex Disorder

(2014) Helen Walden et al.   Annual Review of Biophysics

Distinct functional roles for the two SLX4 ubiquitin-binding UBZ domains mutated in Fanconi anemia

(2014) C. Lachaud et al.   JOURNAL OF CELL SCIENCE

XPF-ERCC1 Acts in Unhooking DNA Interstrand Crosslinks in Cooperation with FANCD2 and FANCP/SLX4

(2014) Daisy Klein Douwel et al.   MOLECULAR CELL

Regulation of FANCD2 and FANCI monoubiquitination by their interaction and by DNA

(2014) Simonne Longerich et al.   NUCLEIC ACIDS RESEARCH

FANCD2 and CtIP Cooperate to Repair DNA Interstrand Crosslinks

(2014) Olga Murina et al.   Cell Reports

The BRCA1-Interacting Protein Abraxas Is Required for Genomic Stability and Tumor Suppression

(2014) Andy Castillo et al.   Cell Reports

Xmipp 3.0: An improved software suite for image processing in electron microscopy

(2013) J.M. de la Rosa-Trevín et al.   JOURNAL OF STRUCTURAL BIOLOGY

RPA Coordinates DNA End Resection and Prevents Formation of DNA Hairpins

(2013) Huan Chen et al.   MOLECULAR CELL

FANCD2 Binds MCM Proteins and Controls Replisome Function upon Activation of S Phase Checkpoint Signaling

(2013) Gérald Lossaint et al.   MOLECULAR CELL

Ubiquitin-Binding Proteins: Decoders of Ubiquitin-Mediated Cellular Functions

(2012) Koraljka Husnjak et al.   Annual Review of Biochemistry

Regulation of the Fanconi anemia pathway by a CUE ubiquitin-binding domain in the FANCD2 protein

(2012) M. A. Rego et al.   BLOOD

A Distinct Replication Fork Protection Pathway Connects Fanconi Anemia Tumor Suppressors to RAD51-BRCA1/2

(2012) Katharina Schlacher et al.   CANCER CELL

Distinct functions of human RECQ helicases WRN and BLM in replication fork recovery and progression after hydroxyurea-induced stalling

(2012) Julia M. Sidorova et al.   DNA REPAIR

Histone chaperone activity of Fanconi anemia proteins, FANCD2 and FANCI, is required for DNA crosslink repair

(2012) Koichi Sato et al.   EMBO JOURNAL

The nucleoid-associated protein Dan organizes chromosomal DNA through rigid nucleoprotein filament formation in E. coli during anoxia

(2012) Ci Ji Lim et al.   NUCLEIC ACIDS RESEARCH

Fanconi anemia proteins FANCD2 and FANCI exhibit different DNA damage responses during S-phase

(2012) Archana Sareen et al.   NUCLEIC ACIDS RESEARCH

Regulation of the Fanconi anemia pathway by a SUMO-like delivery network

(2011) K. Yang et al.   GENES & DEVELOPMENT

Structure of the FANCI-FANCD2 Complex: Insights into the Fanconi Anemia DNA Repair Pathway

(2011) Woo Joo et al.   SCIENCE

Identification of KIAA1018/FAN1, a DNA Repair Nuclease Recruited to DNA Damage by Monoubiquitinated FANCD2

(2010) Craig MacKay et al.   CELL

Deficiency of FANCD2-Associated Nuclease KIAA1018/FAN1 Sensitizes Cells to Interstrand Crosslinking Agents

(2010) Katja Kratz et al.   CELL

High-resolution profiling of γH2AX around DNA double strand breaks in the mammalian genome

(2010) Jason S Iacovoni et al.   EMBO JOURNAL

RAD18-dependent Recruitment of SNM1A to DNA Repair Complexes by a Ubiquitin-binding Zinc Finger

(2010) Kailin Yang et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

A Genetic Screen Identifies FAN1, a Fanconi Anemia-Associated Nuclease Necessary for DNA Interstrand Crosslink Repair

(2010) Agata Smogorzewska et al.   MOLECULAR CELL

ParA2, a Vibrio cholerae chromosome partitioning protein, forms left-handed helical filaments on DNA

(2010) M. P. Hui et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

FANCI Binds Branched DNA and Is Monoubiquitinated by UBE2T-FANCL

(2009) Simonne Longerich et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

DNA Polymerase POLN Participates in Cross-Link Repair and Homologous Recombination

(2009) G.-L. Moldovan et al.   MOLECULAR AND CELLULAR BIOLOGY

FANCM Connects the Genome Instability Disorders Bloom's Syndrome and Fanconi Anemia

(2009) Andrew J. Deans et al.   MOLECULAR CELL

FANCI phosphorylation functions as a molecular switch to turn on the Fanconi anemia pathway

(2008) Masamichi Ishiai et al.   NATURE STRUCTURAL & MOLECULAR BIOLOGY