Mechanism of tandem duplication formation in BRCA1-mutant cells

BRCA1–BARD1 promotes RAD51-mediated homologous DNA pairing

(2017) Weixing Zhao et al.   NATURE

HRDetect is a predictor of BRCA1 and BRCA2 deficiency based on mutational signatures

(2017) Helen Davies et al.   NATURE MEDICINE

Ovarian Cancers Harboring Inactivating Mutations inCDK12Display a Distinct Genomic Instability Pattern Characterized by Large Tandem Duplications

(2016) Tatiana Popova et al.   CANCER RESEARCH

RAD52 Facilitates Mitotic DNA Synthesis Following Replication Stress

(2016) Rahul Bhowmick et al.   MOLECULAR CELL

Landscape of somatic mutations in 560 breast cancer whole-genome sequences

(2016) Serena Nik-Zainal et al.   NATURE

Detecting DNA double-stranded breaks in mammalian genomes by linear amplification–mediated high-throughput genome-wide translocation sequencing

(2016) Jiazhi Hu et al.   Nature Protocols

Transcription–replication conflicts: how they occur and how they are resolved

(2016) Tatiana García-Muse et al.   NATURE REVIEWS MOLECULAR CELL BIOLOGY

Tandem duplications contribute to not one but two distinct phenotypes

(2016) Johnathan Watkins et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Reply to Watkins et al.: Whole-genome sequencing-based identification of diverse tandem duplicator phenotypes in human cancers

(2016) Francesca Menghi et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

The tandem duplicator phenotype as a distinct genomic configuration in cancer

(2016) Francesca Menghi et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Complex Breakpoints and Template Switching Associated with Non-canonical Termination of Homologous Recombination in Mammalian Cells

(2016) Andrea J. Hartlerode et al.   PLoS Genetics

What is the DNA repair defect underlying Fanconi anemia?

(2015) Julien P Duxin et al.   CURRENT OPINION IN CELL BIOLOGY

Functions and regulation of the multitasking FANCM family of DNA motor proteins

(2015) Xiaoyu Xue et al.   GENES & DEVELOPMENT

Translesion Polymerases Drive Microhomology-Mediated Break-Induced Replication Leading to Complex Chromosomal Rearrangements

(2015) Cynthia J. Sakofsky et al.   MOLECULAR CELL

Replication fork reversal in eukaryotes: from dead end to dynamic response

(2015) Kai J. Neelsen et al.   NATURE REVIEWS MOLECULAR CELL BIOLOGY

Mus81 and converging forks limit the mutagenicity of replication fork breakage

(2015) R. Mayle et al.   SCIENCE

Recombination occurs within minutes of replication blockage by RTS1 producing restarted forks that are prone to collapse

(2015) Michael O Nguyen et al.   eLife

Chromosome rearrangements via template switching between diverged repeated sequences

(2014) Ranjith P. Anand et al.   GENES & DEVELOPMENT

CtIP-mediated resection is essential for viability and can operate independently of BRCA1

(2014) Federica Polato et al.   JOURNAL OF EXPERIMENTAL MEDICINE

BRCA1 Promotes Unloading of the CMG Helicase from a Stalled DNA Replication Fork

(2014) David T. Long et al.   MOLECULAR CELL

BRCA1 controls homologous recombination at Tus/Ter-stalled mammalian replication forks

(2014) Nicholas A. Willis et al.   NATURE

Genome-wide detection of DNA double-stranded breaks induced by engineered nucleases

(2014) Richard L Frock et al.   NATURE BIOTECHNOLOGY

The Escherichia coli Tus–Ter replication fork barrier causes site-specific DNA replication perturbation in yeast

(2014) Nicolai B. Larsen et al.   Nature Communications

Replication Stress-Induced Genome Instability: The Dark Side of Replication Maintenance by Homologous Recombination

(2013) Antony M. Carr et al.   JOURNAL OF MOLECULAR BIOLOGY

Migrating bubble during break-induced replication drives conservative DNA synthesis

(2013) Natalie Saini et al.   NATURE

Causes and consequences of replication stress

(2013) Michelle K. Zeman et al.   NATURE CELL BIOLOGY

Break-Induced DNA Replication

(2013) R. P. Anand et al.   Cold Spring Harbor Perspectives in Biology

BRCA1 and CtIP suppress long-tract gene conversion between sister chromatids

(2013) Gurushankar Chandramouly et al.   Nature Communications

A Distinct Replication Fork Protection Pathway Connects Fanconi Anemia Tumor Suppressors to RAD51-BRCA1/2

(2012) Katharina Schlacher et al.   CANCER CELL

BRCA1 Is Required for Postreplication Repair after UV-Induced DNA Damage

(2011) Shailja Pathania et al.   MOLECULAR CELL

Homology-directed Fanconi anemia pathway cross-link repair is dependent on DNA replication

(2011) Koji Nakanishi et al.   NATURE STRUCTURAL & MOLECULAR BIOLOGY

Hydroxyurea induces de novo copy number variants in human cells

(2011) M. F. Arlt et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

53BP1 Inhibits Homologous Recombination in Brca1-Deficient Cells by Blocking Resection of DNA Breaks

(2010) Samuel F. Bunting et al.   CELL

Break-induced replication: What is it and what is it for?

(2010) Bertrand Llorente et al.   CELL CYCLE

Homologous Recombination Restarts Blocked Replication Forks at the Expense of Genome Rearrangements by Template Exchange

(2010) Sarah Lambert et al.   MOLECULAR CELL

The DNA Damage Response: Making It Safe to Play with Knives

(2010) Alberto Ciccia et al.   MOLECULAR CELL

Alternative end-joining is suppressed by the canonical NHEJ component Xrcc4–ligase IV during chromosomal translocation formation

(2010) Deniz Simsek et al.   NATURE STRUCTURAL & MOLECULAR BIOLOGY

Susceptibility Pathways in Fanconi's Anemia and Breast Cancer

(2010) Alan D. D'Andrea   NEW ENGLAND JOURNAL OF MEDICINE

PALB2 is an integral component of the BRCA complex required for homologous recombination repair

(2009) S. M. H. Sy et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

A Microhomology-Mediated Break-Induced Replication Model for the Origin of Human Copy Number Variation

(2009) P. J. Hastings et al.   PLoS Genetics

Lentiviral Transduction of Mammary Stem Cells for Analysis of Gene Function during Development and Cancer

(2008) Bryan E. Welm et al.   Cell Stem Cell

Segmental Duplications Arise from Pol32-Dependent Repair of Broken Forks through Two Alternative Replication-Based Mechanisms

(2008) Celia Payen et al.   PLoS Genetics