Dietary phytochemicals as modulators of human pregnane X receptor

Immunomodulatory and anti-inflammatory effects of sesamin: mechanisms of action and future directions

(2021) Amin F. Majdalawieh et al.   CRITICAL REVIEWS IN FOOD SCIENCE AND NUTRITION

Phenolic composition, antioxidant and cytoprotective effects of aqueous‐methanol extract from Anneslea fragrans leaves as affected by drying methods

(2021) Qimin Cui et al.   INTERNATIONAL JOURNAL OF FOOD SCIENCE AND TECHNOLOGY

Inhibitory activities of 20(R, S)-protopanaxatriol against epidermal growth factor receptor tyrosine kinase

(2021) Jingqi Zhao et al.   FOOD AND CHEMICAL TOXICOLOGY

In vitro and in silico investigations of endocrine disruption induced by metabolites of plasticizers through glucocorticoid receptor

(2021) Yue Leng et al.   FOOD AND CHEMICAL TOXICOLOGY

GR-mediated anti-inflammation of α-boswellic acid: Insights from in vitro and in silico studies

(2021) Jie Zhang et al.   FOOD AND CHEMICAL TOXICOLOGY

Anti-inflammatory action of betulin and its potential as a dissociated glucocorticoid receptor modulator

(2021) Li Ren et al.   FOOD AND CHEMICAL TOXICOLOGY

Anneslea fragrans Wall. ameliorates ulcerative colitis via inhibiting NF-κB and MAPK activation and mediating intestinal barrier integrity

(2021) Xiaocui Deng et al.   JOURNAL OF ETHNOPHARMACOLOGY

A review on pharmacological activities and synergistic effect of quercetin with small molecule agents

(2021) Haoyang Zou et al.   PHYTOMEDICINE

Differential activation of human pregnane X receptor PXR by isomeric mono-methylated indoles in intestinal and hepatic in vitro models

(2020) Barbora Vyhlídalová et al.   TOXICOLOGY LETTERS

Hop bioactive compounds in prevention of nutrition-related noncommunicable diseases

(2020) Alejandro Bravo Iniguez et al.   CRITICAL REVIEWS IN FOOD SCIENCE AND NUTRITION

Garcinoic Acid Is a Natural and Selective Agonist of Pregnane X Receptor

(2020) Desirée Bartolini et al.   JOURNAL OF MEDICINAL CHEMISTRY

Mechanistic insights into the synergistic activation of the RXR–PXR heterodimer by endocrine disruptor mixtures

(2020) Vanessa Delfosse et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Immunomodulatory activities of polysaccharides from Ganoderma on immune effector cells

(2020) Li Ren et al.   FOOD CHEMISTRY

Functional Fungal Endophytes in Coleus forskohlii Regulate Labdane Diterpene Biosynthesis for Elevated Forskolin Accumulation in Roots

(2019) Anthati Mastan et al.   MICROBIAL ECOLOGY

Clinical applications of small molecule inhibitors of Pregnane X receptor

(2019) Jeff L. Staudinger   MOLECULAR AND CELLULAR ENDOCRINOLOGY

Phenolic constituents, antioxidant and cytoprotective activities of crude extract and fractions from cultivated artichoke inflorescence

(2019) Meilian Yang et al.   INDUSTRIAL CROPS AND PRODUCTS

Grape Seed Proanthocyanidin Affects Lipid Metabolism via Changing Gut Microflora and Enhancing Propionate Production in Weaned Pigs

(2019) Yi Wu et al.   JOURNAL OF NUTRITION

Alyssin and Iberin in Cruciferous Vegetables Exert Anticancer Activity in HepG2 by Increasing Intracellular Reactive Oxygen Species and Tubulin Depolymerization

(2019) Piman Pocasap et al.   Biomolecules & Therapeutics

Systemic exposure to Ginkgo biloba extract in male F344/NCrl rats: Relevance to humans

(2019) Suramya Waidyanatha et al.   FOOD AND CHEMICAL TOXICOLOGY

Marine Ligands of the Pregnane X Receptor (PXR): An Overview

(2019) Alejandro Carazo et al.   Marine Drugs

Oleanolic acid attenuates cisplatin-induced nephrotoxicity in mice and chemosensitizes human cervical cancer cells to cisplatin cytotoxicity

(2019) Iva Potočnjak et al.   FOOD AND CHEMICAL TOXICOLOGY

Toxicity of glyphosate in feed for weanling piglets and the mechanism of glyphosate detoxification by the liver nuclear receptor CAR/PXR pathway

(2019) Huiyang Fu et al.   JOURNAL OF HAZARDOUS MATERIALS

Identification of CNS-Penetrant Aryl Sulfonamides as Isoform-Selective NaV1.6 Inhibitors with Efficacy in Mouse Models of Epilepsy

(2019) Thilo Focken et al.   JOURNAL OF MEDICINAL CHEMISTRY

Mono-methylindoles induce CYP1A genes and inhibit CYP1A1 enzyme activity in human hepatocytes and HepaRG cells

(2019) Barbora Vyhlídalová et al.   TOXICOLOGY LETTERS

Pregnane X receptor activation by its natural ligand Ginkgolide-A improves tight junction proteins expression and attenuates bacterial translocation in cirrhosis

(2019) Sundhar Mohandas et al.   CHEMICO-BIOLOGICAL INTERACTIONS

20(S)-Protopanaxadiol blocks cell cycle progression by targeting epidermal growth factor receptor

(2019) Tiehua Zhang et al.   FOOD AND CHEMICAL TOXICOLOGY

Discovery and Characterization of the Potent and Selective P2X4 Inhibitor N-[4-(3-Chlorophenoxy)-3-sulfamoylphenyl]-2-phenylacetamide (BAY-1797) and Structure-Guided Amelioration of Its CYP3A4 Induction Profile

(2019) Stefan Werner et al.   JOURNAL OF MEDICINAL CHEMISTRY

The higher osteoprotective activity of psoralidin in vivo than coumestrol is attributed by its presence of an isopentenyl group and through activated PI3K/Akt axis

(2018) Yuankun Zhai et al.   BIOMEDICINE & PHARMACOTHERAPY

Antidotal or protective effects of Curcuma longa (turmeric) and its active ingredient, curcumin, against natural and chemical toxicities: A review

(2018) Azar Hosseini et al.   BIOMEDICINE & PHARMACOTHERAPY

How similar is similar enough? A sufficient similarity case study with Ginkgo biloba extract

(2018) Natasha R. Catlin et al.   FOOD AND CHEMICAL TOXICOLOGY

Metabolomics assisted fingerprint of Hypericum perforatum chemotypes and assessment of their cytotoxic activity

(2018) Eirini Sarrou et al.   FOOD AND CHEMICAL TOXICOLOGY

Metabolic engineering of Escherichia coli for the production of indirubin from glucose

(2018) Jikun Du et al.   JOURNAL OF BIOTECHNOLOGY

Establishing Transcriptional Signatures to Differentiate PXR-, CAR-, and AhR-Mediated Regulation of Drug Metabolism and Transport Genes in Cryopreserved Human Hepatocytes

(2018) Jamie E. Moscovitz et al.   JOURNAL OF PHARMACOLOGY AND EXPERIMENTAL THERAPEUTICS

Methylindoles and Methoxyindoles are Agonists and Antagonists of Human Aryl Hydrocarbon Receptor

(2018) Martina Stepankova et al.   MOLECULAR PHARMACOLOGY

A review of dietary stilbenes: sources and bioavailability

(2018) Toni El Khawand et al.   PHYTOCHEMISTRY REVIEWS

Computational and experimental characterization of estrogenic activities of 20( S , R )-protopanaxadiol and 20( S , R )-protopanaxatriol

(2018) Tiehua Zhang et al.   Journal of Ginseng Research

Amelioration of PXR-mediated CYP3A4 induction by mGluR2 modulators

(2018) Roy J. Vaz et al.   BIOORGANIC & MEDICINAL CHEMISTRY LETTERS

Oleanolic acid reprograms the liver to protect against hepatotoxicants, but is hepatotoxic at high doses

(2018) Jie Liu et al.   LIVER INTERNATIONAL

Stilbenes: biomarkers of grapevine resistance to fungal diseases

(2018) Viret Olivier et al.   OENO One

Saponins as modulators of nuclear receptors

(2018) Tiehua Zhang et al.   CRITICAL REVIEWS IN FOOD SCIENCE AND NUTRITION

In vitro and in silico perspectives on estrogenicity of tanshinones from Salvia miltiorrhiza

(2018) Tiehua Zhang et al.   FOOD CHEMISTRY

Trans-resveratrol, but not other natural stilbenes occurring in food, carries the risk of drug-food interaction via inhibition of cytochrome P450 enzymes or interaction with xenosensor receptors

(2018) Lucie Hyrsova et al.   TOXICOLOGY LETTERS

Cytotoxicity, genotoxicity and gene expression changes elicited by exposure of human hepatic cells to Ginkgo biloba leaf extract

(2017) Maria Giuseppa Grollino et al.   FOOD AND CHEMICAL TOXICOLOGY

Oleanolic Acid-Mediated Inhibition of Pregnane X Receptor and Constitutive Androstane Receptor Attenuates Rifampin-Isoniazid Cytotoxicity

(2017) Yen-Ning Lin et al.   JOURNAL OF AGRICULTURAL AND FOOD CHEMISTRY

Biological actions and molecular effects of resveratrol, pterostilbene, and 3′-hydroxypterostilbene

(2017) Hui-Yun Tsai et al.   JOURNAL OF FOOD AND DRUG ANALYSIS

Anticancer effects of seaweed compounds fucoxanthin and phloroglucinol, alone and in combination with 5-fluorouracil in colon cells

(2017) Eduarda Lopes-Costa et al.   JOURNAL OF TOXICOLOGY AND ENVIRONMENTAL HEALTH-PART A-CURRENT ISSUES

PXR: More Than Just a Master Xenobiotic Receptor

(2017) Peter O. Oladimeji et al.   MOLECULAR PHARMACOLOGY

Alismanin A, a Triterpenoid with a C34 Skeleton from Alisma orientale as a Natural Agonist of Human Pregnane X Receptor

(2017) Chao Wang et al.   ORGANIC LETTERS

Alisol B 23-acetate from the rhizomes of Alisma orientale is a natural agonist of the human pregnane X receptor

(2017) Yuichiro Kanno et al.   PHYTOMEDICINE

Resveratrol modifies biliary secretion of cholephilic compounds in sham-operated and cholestatic rats

(2017) Eva Dolezelova et al.   WORLD JOURNAL OF GASTROENTEROLOGY

SPA70 is a potent antagonist of human pregnane X receptor

(2017) Wenwei Lin et al.   Nature Communications

De novo genome assembly of Camptotheca acuminata, a natural source of the anti-cancer compound camptothecin

(2017) Dongyan Zhao et al.   GigaScience

Phase I metabolism of 3-methylindole, an environmental pollutant, by hepatic microsomes from carp (C yprinus carpio ) and rainbow trout ( Oncorhynchus mykiss )

(2016) Vladimir Zlabek et al.   CHEMOSPHERE

Indirubin, a component of Ban-Lan-Gen, activates CYP3A4 gene transcription through the human pregnane X receptor

(2016) Takeshi Kumagai et al.   Drug Metabolism and Pharmacokinetics

Pregnane X Receptor (PXR)-Mediated Gene Repression and Cross-Talk of PXR with Other Nuclear Receptors via Coactivator Interactions

(2016) Petr Pavek   Frontiers in Pharmacology

Nuclear receptor PXR: discovery of a pharmaceutical anti-target

(2015) Steven A. Kliewer   JOURNAL OF CLINICAL INVESTIGATION

Identification and Optimization of Benzimidazole Sulfonamides as Orally Bioavailable Sphingosine 1-Phosphate Receptor 1 Antagonists with in Vivo Activity

(2015) Edward J. Hennessy et al.   JOURNAL OF MEDICINAL CHEMISTRY

Developing Adnectins That Target SRC Co-Activator Binding to PXR: A Structural Approach toward Understanding Promiscuity of PXR

(2015) Javed A. Khan et al.   JOURNAL OF MOLECULAR BIOLOGY

The discovery of Qinghaosu (artemisinin) as an effective anti-malaria drug: A unique China story

(2015) Zengyi Chang   Science China-Life Sciences

Synergistic activation of human pregnane X receptor by binary cocktails of pharmaceutical and environmental compounds

(2015) Vanessa Delfosse et al.   Nature Communications

Optical Isomers of Atorvastatin, Rosuvastatin and Fluvastatin Enantiospecifically Activate Pregnane X Receptor PXR and Induce CYP2A6, CYP2B6 and CYP3A4 in Human Hepatocytes

(2015) Martina Korhonova et al.   PLoS One

Adaptation of the human aryl hydrocarbon receptor to sense microbiota-derived indoles

(2015) Troy D. Hubbard et al.   Scientific Reports

Allyl isothiocyanate (AITC) inhibits pregnane X receptor (PXR) and constitutive androstane receptor (CAR) activation and protects against acetaminophen- and amiodarone-induced cytotoxicity

(2014) Yun-Ping Lim et al.   ARCHIVES OF TOXICOLOGY

Pregnane X Receptor as the “Sensor and Effector” in Regulating Epigenome

(2014) Xi Ma et al.   JOURNAL OF CELLULAR PHYSIOLOGY

Traditional uses, phytochemistry, pharmacology, toxicology and quality control of Alisma orientale (Sam.) Juzep: A review

(2014) Ting Tian et al.   JOURNAL OF ETHNOPHARMACOLOGY

Discovery of the CCR1 Antagonist, BMS-817399, for the Treatment of Rheumatoid Arthritis

(2014) Joseph B. Santella et al.   JOURNAL OF MEDICINAL CHEMISTRY

Tangeretin, a citrus pentamethoxyflavone, exerts cytostatic effect via p53/p21 up-regulation and suppresses metastasis in 7,12-dimethylbenz(α)anthracene-induced rat mammary carcinoma

(2014) Lakshmi Arivazhagan et al.   JOURNAL OF NUTRITIONAL BIOCHEMISTRY

Resveratrol as an Inhibitor of Pregnane X Receptor (PXR): Another Lesson in PXR Antagonism

(2014) Tomas Smutny et al.   JOURNAL OF PHARMACOLOGICAL SCIENCES

Resveratrol Suppresses the Inducible Expression of CYP3A4 Through the Pregnane X Receptor

(2014) Rongrong Deng et al.   JOURNAL OF PHARMACOLOGICAL SCIENCES

Mechanisms of Drug Resistance in Cancer Chemotherapy: Coordinated Role and Regulation of Efflux Transporters and Metabolizing Enzymes

(2013) Ramya Vadlapatla et al.   CURRENT PHARMACEUTICAL DESIGN

Evaluation of pregnane X receptor (PXR)-mediated CYP3A4 drug-drug interactions in drug development

(2013) Michael W. Sinz   DRUG METABOLISM REVIEWS

PXR antagonists and implication in drug metabolism

(2013) Sridhar Mani et al.   DRUG METABOLISM REVIEWS

Up-regulatation of CYP3A expression through pregnent X receptor by praeruptorin D isolated from Peucedanum praeruptorum Dunn

(2013) Ling Huang et al.   JOURNAL OF ETHNOPHARMACOLOGY

Regulation of Human Pregnane X Receptor and its Target Gene Cytochrome P450 3A by Praeruptorin A Isolated from the Herbal Medicine Peucedanum praeruptorum

(2013) Ling Huang et al.   PLANTA MEDICA

A global clinical view on vitamin A and carotenoids

(2012) Alfred Sommer et al.   AMERICAN JOURNAL OF CLINICAL NUTRITION

Nuclear receptors in the multidrug resistance through the regulation of drug-metabolizing enzymes and drug transporters

(2012) Yakun Chen et al.   BIOCHEMICAL PHARMACOLOGY

Xenobiotic-sensing nuclear receptors involved in drug metabolism: a structural perspective

(2012) Bret D. Wallace et al.   DRUG METABOLISM REVIEWS

Sesamin: A Naturally Occurring Lignan Inhibits CYP3A4 by Antagonizing the Pregnane X Receptor Activation

(2012) Yun-Ping Lim et al.   Evidence-based Complementary and Alternative Medicine

Fucoxanthin Attenuates Rifampin-Induced Cytochrome P450 3A4 (CYP3A4) and Multiple Drug Resistance 1 (MDR1) Gene Expression Through Pregnane X Receptor (PXR)-Mediated Pathways in Human Hepatoma HepG2 and Colon Adenocarcinoma LS174T Cells

(2012) Cheng-Ling Liu et al.   Marine Drugs

Marine sponge steroids as nuclear receptor ligands

(2012) Stefano Fiorucci et al.   TRENDS IN PHARMACOLOGICAL SCIENCES

Nuclear receptor PXR, transcriptional circuits and metabolic relevance

(2011) Chibueze A. Ihunnah et al.   BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR BASIS OF DISEASE

Identification of novel pregnane X receptor activators from traditional Chinese medicines

(2011) Chunna Yu et al.   JOURNAL OF ETHNOPHARMACOLOGY

Effective separation and analysis of E- and Z-guggulsterones in Commiphora mukul resin, guggulipid and their pharmaceutical product by high performance thin-layer chromatography-densitometric method

(2011) Syed Ghulam Musharraf et al.   JOURNAL OF PHARMACEUTICAL AND BIOMEDICAL ANALYSIS

Towards new ligands of nuclear receptors. Discovery of malaitasterol A, an unique bis-secosterol from marine sponge Theonella swinhoei

(2011) Simona De Marino et al.   ORGANIC & BIOMOLECULAR CHEMISTRY

Relaxant effects of Schisandra chinensis and its major lignans on agonists-induced contraction in guinea pig ileum

(2011) Jia-Ming Yang et al.   PHYTOMEDICINE

Activation of the human nuclear xenobiotic receptor PXR by the reverse transcriptase-targeted anti-HIV drug PNU-142721

(2011) Yuan Cheng et al.   PROTEIN SCIENCE

Flavonoids activate pregnane × receptor-mediated CYP3A4 gene expression by inhibiting cyclin-dependent kinases in HepG2 liver carcinoma cells

(2010) Hanqing Dong et al.   BMC BIOCHEMISTRY

Rational quantitative structure–activity relationship (RQSAR) screen for PXR and CAR isoform-specific nuclear receptor ligands

(2010) Ann M. Dring et al.   CHEMICO-BIOLOGICAL INTERACTIONS

Solomonsterols A and B fromTheonella swinhoei. The First Example of C-24 and C-23 Sulfated Sterols from a Marine Source Endowed with a PXR Agonistic Activity

(2010) Carmen Festa et al.   JOURNAL OF MEDICINAL CHEMISTRY

Camptothecin Attenuates Cytochrome P450 3A4 Induction by Blocking the Activation of Human Pregnane X Receptor

(2010) Y. Chen et al.   JOURNAL OF PHARMACOLOGY AND EXPERIMENTAL THERAPEUTICS

Human Pregnane X Receptor Agonism by Ginkgo biloba Extract: Assessment of the Role of Individual Ginkgolides

(2010) A. J. Lau et al.   JOURNAL OF PHARMACOLOGY AND EXPERIMENTAL THERAPEUTICS

Pharmacokinetics, tissue distribution and excretion study of dl-praeruptorin A of Peucedanum praeruptorum in rats by liquid chromatography tandem mass spectrometry

(2010) Z. Zhang et al.   PHYTOMEDICINE

Regulation of human pregnane X receptor and its target gene cytochrome P450 3A4 by Chinese herbal compounds and a molecular docking study

(2010) Ya-He Liu et al.   XENOBIOTICA

Activation of Pregnane X Receptor (PXR) and Constitutive Androstane Receptor (CAR) by Herbal Medicines

(2009) Thomas K. H. Chang   AAPS Journal

The Structural Basis of Pregnane X Receptor Binding Promiscuity

(2009) Chi-Ho Ngan et al.   BIOCHEMISTRY

Dietary Sulforaphane, a Histone Deacetylase Inhibitor for Cancer Prevention

(2009) Emily Ho et al.   JOURNAL OF NUTRITION

Human CYP3A4 and Murine Cyp3A11 Are Regulated by Equol and Genistein via the Pregnane X Receptor in a Species-Specific Manner

(2009) Yilan Li et al.   JOURNAL OF NUTRITION

Nuclear receptors CAR and PXR: Molecular, functional, and biomedical aspects

(2009) Alessandra di Masi et al.   MOLECULAR ASPECTS OF MEDICINE

Allyl isothiocyanate as a cancer chemopreventive phytochemical

(2009) Yuesheng Zhang   MOLECULAR NUTRITION & FOOD RESEARCH

Xenobiotic-Induced Transcriptional Regulation of Xenobiotic Metabolizing Enzymes of the Cytochrome P450 Superfamily in Human Extrahepatic Tissues

(2008) Petr Pavek et al.   CURRENT DRUG METABOLISM

Activation of Pregnane X Receptor and Induction of MDR1 by Dietary Phytochemicals

(2008) Hideo Satsu et al.   JOURNAL OF AGRICULTURAL AND FOOD CHEMISTRY

Structural Basis of Human Pregnane X Receptor Activation by the Hops Constituent Colupulone

(2008) D. G. Teotico et al.   MOLECULAR PHARMACOLOGY

Construction and characterization of a fully active PXR/SRC-1 tethered protein with increased stability

(2008) W. Wang et al.   PROTEIN ENGINEERING DESIGN & SELECTION

The Phytoestrogen Coumestrol Is a Naturally Occurring Antagonist of the Human Pregnane X Receptor

(2007) Hongwei Wang et al.   MOLECULAR ENDOCRINOLOGY