Allyl isothiocyanate (AITC) inhibits pregnane X receptor (PXR) and constitutive androstane receptor (CAR) activation and protects against acetaminophen- and amiodarone-induced cytotoxicity

A dual function of the furanocoumarin chalepensin in inhibiting Cyp2a and inducing Cyp2b in mice: the protein stabilization and receptor-mediated activation

(2012) Wei-Sheng Lo et al.   ARCHIVES OF TOXICOLOGY

Nuclear receptors in the multidrug resistance through the regulation of drug-metabolizing enzymes and drug transporters

(2012) Yakun Chen et al.   BIOCHEMICAL PHARMACOLOGY

The effect of aprepitant and race on the pharmacokinetics of cyclophosphamide in breast cancer patients

(2012) Christine M. Walko et al.   CANCER CHEMOTHERAPY AND PHARMACOLOGY

Lower Expression of HNF4α and PGC1α Might Impair Rifampicin-mediated CYP3A4 Induction under Conditions Where PXR Is Overexpressed in Human Fetal Liver Cells

(2012) Takashi Takezawa et al.   Drug Metabolism and Pharmacokinetics

Fucoxanthin Attenuates Rifampin-Induced Cytochrome P450 3A4 (CYP3A4) and Multiple Drug Resistance 1 (MDR1) Gene Expression Through Pregnane X Receptor (PXR)-Mediated Pathways in Human Hepatoma HepG2 and Colon Adenocarcinoma LS174T Cells

(2012) Cheng-Ling Liu et al.   Marine Drugs

Targeting xenobiotic receptors PXR and CAR for metabolic diseases

(2012) Jie Gao et al.   TRENDS IN PHARMACOLOGICAL SCIENCES

Pregnane X receptor as a target for treatment of inflammatory bowel disorders

(2012) Jie Cheng et al.   TRENDS IN PHARMACOLOGICAL SCIENCES

Metformin suppresses pregnane X receptor (PXR)-regulated transactivation of CYP3A4 gene

(2011) Lucie Krausova et al.   BIOCHEMICAL PHARMACOLOGY

Anti-inflammatory potential of allyl-isothiocyanate - role of Nrf2, NF-κB and microRNA-155

(2011) Anika Eva Wagner et al.   JOURNAL OF CELLULAR AND MOLECULAR MEDICINE

Pregnane X receptor activation induces FGF19-dependent tumor aggressiveness in humans and mice

(2011) Hongwei Wang et al.   JOURNAL OF CLINICAL INVESTIGATION

Pregnane X receptor mediates the induction of P-glycoprotein by spironolactone in HepG2 cells

(2011) Juan Pablo Rigalli et al.   TOXICOLOGY

Nuclear receptors as drug targets for metabolic disease

(2010) Ira G. Schulman   ADVANCED DRUG DELIVERY REVIEWS

Overcoming drug resistance by regulating nuclear receptors

(2010) Taosheng Chen   ADVANCED DRUG DELIVERY REVIEWS

Enhanced steatosis by nuclear receptor ligands: A study in cultured human hepatocytes and hepatoma cells with a characterized nuclear receptor expression profile

(2010) Marta Moya et al.   CHEMICO-BIOLOGICAL INTERACTIONS

Camptothecin Attenuates Cytochrome P450 3A4 Induction by Blocking the Activation of Human Pregnane X Receptor

(2010) Y. Chen et al.   JOURNAL OF PHARMACOLOGY AND EXPERIMENTAL THERAPEUTICS

Endogenous Gene and Protein Expression of Drug-Transporting Proteins in Cell Lines Routinely Used in Drug Discovery Programs

(2009) G. Ahlin et al.   DRUG METABOLISM AND DISPOSITION

Rifampicin-Activated Human Pregnane X Receptor and CYP3A4 Induction Enhance Acetaminophen-Induced Toxicity

(2009) J. Cheng et al.   DRUG METABOLISM AND DISPOSITION

A Single Amino Acid Controls the Functional Switch of Human Constitutive Androstane Receptor (CAR) 1 to the Xenobiotic-Sensitive Splicing Variant CAR3

(2009) T. Chen et al.   JOURNAL OF PHARMACOLOGY AND EXPERIMENTAL THERAPEUTICS

Allyl isothiocyanate as a cancer chemopreventive phytochemical

(2009) Yuesheng Zhang   MOLECULAR NUTRITION & FOOD RESEARCH

An in vitro drug-induced hepatotoxicity screening system using CYP3A4-expressing and γ-glutamylcysteine synthetase knockdown cells

(2009) Hiroko Hosomi et al.   TOXICOLOGY IN VITRO

CYP2B6: New Insights into a Historically Overlooked Cytochrome P450 Isozyme

(2008) Hongbing Wang et al.   CURRENT DRUG METABOLISM

Cytochrome P450 and Chemical Toxicology

(2007) F. Peter Guengerich   CHEMICAL RESEARCH IN TOXICOLOGY

The Phytoestrogen Coumestrol Is a Naturally Occurring Antagonist of the Human Pregnane X Receptor

(2007) Hongwei Wang et al.   MOLECULAR ENDOCRINOLOGY