The mechanisms of human lymphoid chromosomal translocations and their medical relevance

Structure of an activated DNA-PK and its implications for NHEJ

(2021) Xuemin Chen et al.   MOLECULAR CELL

Cryo-EM of NHEJ supercomplexes provides insights into DNA repair

(2021) Amanda K. Chaplin et al.   MOLECULAR CELL

Mechanisms driving chromosomal translocations: lost in time and space

(2021) Dale A. Ramsden et al.   ONCOGENE

Mechanistic basis for chromosomal translocations at the E2A gene and its broader relevance to human B cell malignancies

(2021) Di Liu et al.   Cell Reports

Polymerase μ in non-homologous DNA end joining: importance of the order of arrival at a double-strand break in a purified system

(2020) Bailin Zhao et al.   NUCLEIC ACIDS RESEARCH

The molecular basis and disease relevance of non-homologous DNA end joining

(2020) Bailin Zhao et al.   NATURE REVIEWS MOLECULAR CELL BIOLOGY

Dimers of DNA-PK create a stage for DNA double-strand break repair

(2020) Amanda K. Chaplin et al.   NATURE STRUCTURAL & MOLECULAR BIOLOGY

Frequency of DNA end joining in trans is not determined by the predamage spatial proximity of double-strand breaks in yeast

(2019) Sham Sunder et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Double-strand breaks in motion: implications for chromosomal rearrangement

(2019) Thomas E. Wilson et al.   CURRENT GENETICS

Current insights into the mechanism of mammalian immunoglobulin class switch recombination

(2019) Kefei Yu et al.   CRITICAL REVIEWS IN BIOCHEMISTRY AND MOLECULAR BIOLOGY

AID–RNA polymerase II transcription-dependent deamination of IgV DNA

(2019) Phuong Pham et al.   NUCLEIC ACIDS RESEARCH

cis Elements that Mediate RNA Polymerase II Pausing Regulate Human Gene Expression

(2019) Jason A. Watts et al.   AMERICAN JOURNAL OF HUMAN GENETICS

The essential elements for the noncovalent association of two DNA ends during NHEJ synapsis

(2019) Bailin Zhao et al.   Nature Communications

A Mechanism to Minimize Errors during Non-homologous End Joining

(2019) Benjamin M. Stinson et al.   MOLECULAR CELL

Dissection of DNA double-strand-break repair using novel single-molecule forceps

(2018) Jing L. Wang et al.   NATURE STRUCTURAL & MOLECULAR BIOLOGY

Dissection of DNA double-strand-break repair using novel single-molecule forceps

(2018) Jing L. Wang et al.   NATURE STRUCTURAL & MOLECULAR BIOLOGY

A single XLF dimer bridges DNA ends during nonhomologous end joining

(2018) Thomas G. W. Graham et al.   NATURE STRUCTURAL & MOLECULAR BIOLOGY

XLF and APLF bind Ku80 at two remote sites to ensure DNA repair by non-homologous end joining

(2018) Clement Nemoz et al.   NATURE STRUCTURAL & MOLECULAR BIOLOGY

Nonhomologous DNA end-joining for repair of DNA double-strand breaks

(2017) Nicholas R. Pannunzio et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

AID and Reactive Oxygen Species Can Induce DNA Breaks within Human Chromosomal Translocation Fragile Zones

(2017) Nicholas R. Pannunzio et al.   MOLECULAR CELL

Non-homologous DNA end joining and alternative pathways to double-strand break repair

(2017) Howard H. Y. Chang et al.   NATURE REVIEWS MOLECULAR CELL BIOLOGY

DNA Ligase IV Guides End-Processing Choice during Nonhomologous End Joining

(2017) Michael P. Conlin et al.   Cell Reports

2016 US lymphoid malignancy statistics by World Health Organization subtypes

(2016) Lauren R. Teras et al.   CA-A CANCER JOURNAL FOR CLINICIANS

Two-Stage Synapsis of DNA Ends during Non-homologous End Joining

(2016) Thomas G.W. Graham et al.   MOLECULAR CELL

Sliding sleeves of XRCC4–XLF bridge DNA and connect fragments of broken DNA

(2016) Ineke Brouwer et al.   NATURE

Bridging of double-stranded breaks by the nonhomologous end-joining ligation complex is modulated by DNA end chemistry

(2016) Dylan A. Reid et al.   NUCLEIC ACIDS RESEARCH

Specific Roles of XRCC4 Paralogs PAXX and XLF during V(D)J Recombination

(2016) Chloé Lescale et al.   Cell Reports

Convergent BCL6 and lncRNA promoters demarcate the major breakpoint region for BCL6 translocations

(2015) Z. Lu et al.   BLOOD

Activation-Induced Cytidine Deaminase Expression in Human B Cell Precursors Is Essential for Central B Cell Tolerance

(2015) Tineke Cantaert et al.   IMMUNITY

Overlapping hotspots in CDRs are critical sites for V region diversification

(2015) Lirong Wei et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Organization and dynamics of the nonhomologous end-joining machinery during DNA double-strand break repair

(2015) Dylan A. Reid et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Production of IgG autoantibody requires expression of activation-induced deaminase in early-developing B cells in a mouse model of SLE

(2014) Benjamin R. Umiker et al.   EUROPEAN JOURNAL OF IMMUNOLOGY

Curiouser and curiouser: The role(s) of AID expression in self-tolerance

(2014) Garnett Kelsoe   EUROPEAN JOURNAL OF IMMUNOLOGY

Chromosomal Translocations in Human Cells Are Generated by Canonical Nonhomologous End-Joining

(2014) Hind Ghezraoui et al.   MOLECULAR CELL

BCL6 breaks occur at different AID sequence motifs in Ig-BCL6 and non-Ig-BCL6 rearrangements

(2013) Z. Lu et al.   BLOOD

Flexible ordering of antibody class switch and V(D)J joining during B-cell ontogeny

(2013) S. Kumar et al.   GENES & DEVELOPMENT

The evolving contribution of hematopoietic progenitor cells to lymphomagenesis

(2012) O. Weigert et al.   BLOOD

IgH partner breakpoint sequences provide evidence that AID initiates t(11;14) and t(8;14) chromosomal breaks in mantle cell and Burkitt lymphomas

(2012) H. A. Greisman et al.   BLOOD

Both CpG Methylation and Activation-Induced Deaminase Are Required for the Fragility of the Human bcl-2 Major Breakpoint Region: Implications for the Timing of the Breaks in the t(14;18) Translocation

(2012) X. Cui et al.   MOLECULAR AND CELLULAR BIOLOGY

Mechanisms that Promote and Suppress Chromosomal Translocations in Lymphocytes

(2011) Monica Gostissa et al.   Annual Review of Immunology

G4 motifs correlate with promoter-proximal transcriptional pausing in human genes

(2011) J. Eddy et al.   NUCLEIC ACIDS RESEARCH

Activation-induced cytidine deaminase mediates central tolerance in B cells

(2011) M. Kuraoka et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Structural characterization of filaments formed by human Xrcc4-Cernunnos/XLF complex involved in nonhomologous DNA end-joining

(2011) V. Ropars et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Overlapping activation-induced cytidine deaminase hotspot motifs in Ig class-switch recombination

(2011) L. Han et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

The Mechanism of Double-Strand DNA Break Repair by the Nonhomologous DNA End-Joining Pathway

(2010) Michael R. Lieber   Annual Review of Biochemistry

The t(14;18)(q32;q21)/IGH-MALT1 translocation in MALT lymphomas is a CpG-type translocation, but the t(11;18)(q21;q21)/API2-MALT1 translocation in MALT lymphomas is not

(2010) A. G. Tsai et al.   BLOOD

t(X;14)(p22;q32)/t(Y;14)(p11;q32) CRLF2-IGH translocations from human B-lineage ALLs involve CpG-type breaks at CRLF2, but CRLF2/P2RY8 intrachromosomal deletions do not

(2010) A. G. Tsai et al.   BLOOD

Origin of Chromosomal Translocations in Lymphoid Cancer

(2010) André Nussenzweig et al.   CELL

Activation-Induced Cytidine Deaminase Targets DNA at Sites of RNA Polymerase II Stalling by Interaction with Spt5

(2010) Rushad Pavri et al.   CELL

XLF Regulates Filament Architecture of the XRCC4·Ligase IV Complex

(2010) Michal Hammel et al.   STRUCTURE

Evidence for direct involvement of epirubicin in the formation of chromosomal translocations in t(15;17) therapy-related acute promyelocytic leukemia

(2009) A. N. Mays et al.   BLOOD

ATM and Artemis promote homologous recombination of radiation-induced DNA double-strand breaks in G2

(2009) Andrea Beucher et al.   EMBO JOURNAL

Activation-Induced Cytidine Deaminase Expression and Activity in the Absence of Germinal Centers: Insights into Hyper-IgM Syndrome

(2009) M. Kuraoka et al.   JOURNAL OF IMMUNOLOGY

Collateral Damage from Antigen Receptor Gene Diversification

(2008) Grace K. Mahowald et al.   CELL

Human Chromosomal Translocations at CpG Sites and a Theoretical Basis for Their Lineage and Stage Specificity

(2008) Albert G. Tsai et al.   CELL

Conformational Variants of Duplex DNA Correlated with Cytosine-rich Chromosomal Fragile Sites

(2008) Albert G. Tsai et al.   JOURNAL OF BIOLOGICAL CHEMISTRY