AID–RNA polymerase II transcription-dependent deamination of IgV DNA

Random Walk Enzymes: Information Theory, Quantum Isomorphism, and Entropy Dispersion

(2019) Chi H. Mak et al.   JOURNAL OF PHYSICAL CHEMISTRY A

A licensing step links AID to transcription elongation for mutagenesis in B cells

(2018) Stephen P. Methot et al.   Nature Communications

Structure of paused transcription complex Pol II–DSIF–NELF

(2018) Seychelle M. Vos et al.   NATURE

Structure of activated transcription complex Pol II–DSIF–PAF–SPT6

(2018) Seychelle M. Vos et al.   NATURE

AID Recognizes Structured DNA for Class Switch Recombination

(2017) Qi Qiao et al.   MOLECULAR CELL

Structural basis for the initiation of eukaryotic transcription-coupled DNA repair

(2017) Jun Xu et al.   NATURE

Structure of the complete elongation complex of RNA polymerase II with basal factors

(2017) Haruhiko Ehara et al.   SCIENCE

Structural analysis of the activation-induced deoxycytidine deaminase required in immunoglobulin diversification

(2016) Phuong Pham et al.   DNA REPAIR

Structure of transcribing mammalian RNA polymerase II

(2016) Carrie Bernecky et al.   NATURE

Rates and mechanisms of bacterial mutagenesis from maximum-depth sequencing

(2016) Justin Jee et al.   NATURE

PAF1, a Molecular Regulator of Promoter-Proximal Pausing by RNA Polymerase II

(2015) Fei Xavier Chen et al.   CELL

Overlapping hotspots in CDRs are critical sites for V region diversification

(2015) Lirong Wei et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

RNA polymerase II-associated factor 1 regulates the release and phosphorylation of paused RNA polymerase II

(2015) M. Yu et al.   SCIENCE

Activation-induced deoxycytidine deaminase (AID) co-transcriptional scanning at single-molecule resolution

(2015) Gayan Senavirathne et al.   Nature Communications

Spt5 accumulation at variable genes distinguishes somatic hypermutation in germinal center B cells from ex vivo–activated cells

(2014) Robert W. Maul et al.   JOURNAL OF EXPERIMENTAL MEDICINE

Transcription factors TFIIF and TFIIS promote transcript elongation by RNA polymerase II by synergistic and independent mechanisms

(2014) V. Schweikhard et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

A source of the single-stranded DNA substrate for activation-induced deaminase during somatic hypermutation

(2014) Xiaohua Wang et al.   Nature Communications

Single-molecule tracking of the transcription cycle by sub-second RNA detection

(2014) Zhengjian Zhang et al.   eLife

A Mathematical Model for Scanning and Catalysis on Single-stranded DNA, Illustrated with Activation-induced Deoxycytidine Deaminase

(2013) Chi H. Mak et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Lineage Structure of the Human Antibody Repertoire in Response to Influenza Vaccination

(2013) N. Jiang et al.   Science Translational Medicine

Transcription elongation factors DSIF and NELF: Promoter-proximal pausing and beyond

(2012) Yuki Yamaguchi et al.   Biochimica et Biophysica Acta-Gene Regulatory Mechanisms

A role for the RNA pol II–associated PAF complex in AID-induced immune diversification

(2012) Katharina L. Willmann et al.   JOURNAL OF EXPERIMENTAL MEDICINE

Promoter-proximal pausing of RNA polymerase II: emerging roles in metazoans

(2012) Karen Adelman et al.   NATURE REVIEWS GENETICS

B-cell receptor, clinical course and prognosis in chronic lymphocytic leukaemia: the growing saga of the IGHV3 subgroup gene usage

(2011) Michele Dal-Bo et al.   BRITISH JOURNAL OF HAEMATOLOGY

The RNA Exosome Targets the AID Cytidine Deaminase to Both Strands of Transcribed Duplex DNA Substrates

(2011) Uttiya Basu et al.   CELL

Somatic hypermutation: Processivity of the cytosine deaminase AID and error-free repair of the resulting uracils

(2011) Ursula Storb et al.   CELL CYCLE

Analysis of a Single-stranded DNA-scanning Process in Which Activation-induced Deoxycytidine Deaminase (AID) Deaminates C to U Haphazardly and Inefficiently to Ensure Mutational Diversity

(2011) Phuong Pham et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Activation-Induced Cytidine Deaminase Induces Reproducible DNA Breaks at Many Non-Ig Loci in Activated B Cells

(2011) Ori Staszewski et al.   MOLECULAR CELL

Detection and quantification of rare mutations with massively parallel sequencing

(2011) I. Kinde et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Activation-Induced Cytidine Deaminase Targets DNA at Sites of RNA Polymerase II Stalling by Interaction with Spt5

(2010) Rushad Pavri et al.   CELL

The Human PAF1 Complex Acts in Chromatin Transcription Elongation Both Independently and Cooperatively with SII/TFIIS

(2010) Jaehoon Kim et al.   CELL

Deep-sequencing identification of the genomic targets of the cytidine deaminase AID and its cofactor RPA in B lymphocytes

(2010) Arito Yamane et al.   NATURE IMMUNOLOGY

V-region mutation in vitro, in vivo, and in silico reveal the importance of the enzymatic properties of AID and the sequence environment

(2009) T. MacCarthy et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

The Biochemistry of Somatic Hypermutation

(2008) Jonathan U. Peled et al.   Annual Review of Immunology

Mechanism and Regulation of Class Switch Recombination

(2008) Janet Stavnezer et al.   Annual Review of Immunology

Transcriptional pausing and stalling causes multiple clustered mutations by human activation-induced deaminase

(2008) Chandrika Canugovi et al.   FASEB JOURNAL

Two levels of protection for the B cell genome during somatic hypermutation

(2008) Man Liu et al.   NATURE

Antisense transcripts from immunoglobulin heavy-chain locus V(D)J and switch regions

(2008) T. Perlot et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA