Current insights into the mechanism of mammalian immunoglobulin class switch recombination

Shieldin – the protector of DNA ends

(2019) Dheva Setiaputra et al.   EMBO REPORTS

The extruded non-template strand determines the architecture of R-loops

(2019) Yeraldinne Carrasco-Salas et al.   NUCLEIC ACIDS RESEARCH

Senataxin Mutation Reveals How R-Loops Promote Transcription by Blocking DNA Methylation at Gene Promoters

(2018) Christopher Grunseich et al.   MOLECULAR CELL

RNA Helicase DDX1 Converts RNA G-Quadruplex Structures into R-Loops to Promote IgH Class Switch Recombination

(2018) Claudia Ribeiro de Almeida et al.   MOLECULAR CELL

A licensing step links AID to transcription elongation for mutagenesis in B cells

(2018) Stephen P. Methot et al.   Nature Communications

Depletion of recombination-specific cofactors by the C-terminal mutant of the activation-induced cytidine deaminase causes the dominant negative effect on class switch recombination

(2017) Azza Al Ismail et al.   INTERNATIONAL IMMUNOLOGY

Nonhomologous DNA end-joining for repair of DNA double-strand breaks

(2017) Nicholas R. Pannunzio et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

R-Loop Depletion by Over-expressed RNase H1 in Mouse B Cells Increases Activation-Induced Deaminase Access to the Transcribed Strand without Altering Frequency of Isotype Switching

(2017) Robert W. Maul et al.   JOURNAL OF MOLECULAR BIOLOGY

AID Recognizes Structured DNA for Class Switch Recombination

(2017) Qi Qiao et al.   MOLECULAR CELL

The monoclonal S9.6 antibody exhibits highly variable binding affinities towards different R-loop sequences

(2017) Fabian König et al.   PLoS One

Antibody diversification caused by disrupted mismatch repair and promiscuous DNA polymerases

(2016) Kimberly J. Zanotti et al.   DNA REPAIR

Class-Switch Recombination in the Absence of the IgH 3′ Regulatory Region

(2016) Ahrom Kim et al.   JOURNAL OF IMMUNOLOGY

Redundant function of DNA ligase 1 and 3 in alternative end-joining during immunoglobulin class switch recombination

(2016) Shahnaz Masani et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Non-coding RNA Generated following Lariat Debranching Mediates Targeting of AID to DNA

(2015) Simin Zheng et al.   CELL

Sequence-Intrinsic Mechanisms that Target AID Mutational Outcomes on Antibody Genes

(2015) Leng-Siew Yeap et al.   CELL

RNA Exosome-Regulated Long Non-Coding RNA Transcription Controls Super-Enhancer Activity

(2015) Evangelos Pefanis et al.   CELL

DNA-PKcs Is Involved in Ig Class Switch Recombination in Human B Cells

(2015) Andrea Björkman et al.   JOURNAL OF IMMUNOLOGY

Catalytic Pocket Inaccessibility of Activation-Induced Cytidine Deaminase Is a Safeguard against Excessive Mutagenic Activity

(2015) Justin J. King et al.   STRUCTURE

Individual Substitution Mutations in the AID C Terminus That Ablate IgH Class Switch Recombination

(2015) Tatenda Kadungure et al.   PLoS One

Transcription-Associated Mutagenesis

(2014) Sue Jinks-Robertson et al.   Annual Review of Genetics

The clinical impact of deficiency in DNA non-homologous end-joining

(2014) Lisa Woodbine et al.   DNA REPAIR

Mismatch Repair Proteins and AID Activity Are Required for the Dominant Negative Function of C-Terminally Deleted AID in Class Switching

(2014) A. J. Ucher et al.   JOURNAL OF IMMUNOLOGY

Arginine Methylation Facilitates the Recruitment of TOP3B to Chromatin to Prevent R Loop Accumulation

(2014) Yanzhong Yang et al.   MOLECULAR CELL

R-loops induce repressive chromatin marks over mammalian gene terminators

(2014) Konstantina Skourti-Stathaki et al.   NATURE

Noncoding RNA transcription targets AID to divergently transcribed loci in B cells

(2014) Evangelos Pefanis et al.   NATURE

The role of G-density in switch region repeats for immunoglobulin class switch recombination

(2014) Zheng Z. Zhang et al.   NUCLEIC ACIDS RESEARCH

IgH class switching exploits a general property of two DNA breaks to be joined in cis over long chromosomal distances

(2014) M. Gostissa et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Activation induced deaminase C-terminal domain links DNA breaks to end protection and repair during class switch recombination

(2014) A. Zahn et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

The Strength of an Ig Switch Region Is Determined by Its Ability to Drive R Loop Formation and Its Number of WGCW Sites

(2014) Zheng Z. Zhang et al.   Cell Reports

AIDing Chromatin and Transcription-Coupled Orchestration of Immunoglobulin Class-Switch Recombination

(2014) Bharat Vaidyanathan et al.   Frontiers in Immunology

BCL6 breaks occur at different AID sequence motifs in Ig-BCL6 and non-Ig-BCL6 rearrangements

(2013) Z. Lu et al.   BLOOD

The THO complex component Thp2 counteracts telomeric R-loops and telomere shortening

(2013) Verena Pfeiffer et al.   EMBO JOURNAL

GC skew at the 5' and 3' ends of human genes links R-loop formation to epigenetic regulation and transcription termination

(2013) P. A. Ginno et al.   GENOME RESEARCH

The sub-nanomolar binding of DNA-RNA hybrids by the single-chain Fv fragment of antibody S9.6

(2013) Damilola D. Phillips et al.   JOURNAL OF MOLECULAR RECOGNITION

Apurinic/Apyrimidinic Endonuclease 1 Is the Essential Nuclease during Immunoglobulin Class Switch Recombination

(2013) S. Masani et al.   MOLECULAR AND CELLULAR BIOLOGY

Visualization and selective chemical targeting of RNA G-quadruplex structures in the cytoplasm of human cells

(2013) Giulia Biffi et al.   Nature Chemistry

Quantitative visualization of DNA G-quadruplex structures in human cells

(2013) Giulia Biffi et al.   Nature Chemistry

Telomeric RNA-DNA hybrids affect telomere-length dynamics and senescence

(2013) Bettina Balk et al.   NATURE STRUCTURAL & MOLECULAR BIOLOGY

R-Loop Stabilization Represses Antisense Transcription at the Arabidopsis FLC Locus

(2013) Q. Sun et al.   SCIENCE

Origin of Immunoglobulin Isotype Switching

(2012) Catherine Zhu et al.   CURRENT BIOLOGY

R-loop-mediated genome instability in mRNA cleavage and polyadenylation mutants

(2012) P. C. Stirling et al.   GENES & DEVELOPMENT

DNA-RNA hybrid formation mediates RNAi-directed heterochromatin formation

(2012) Mina Nakama et al.   GENES TO CELLS

R-Loop Formation Is a Distinctive Characteristic of Unmethylated Human CpG Island Promoters

(2012) Paul A. Ginno et al.   MOLECULAR CELL

Mice lacking Sμ tandem repeats maintain RNA polymerase patterns but exhibit histone modification pattern shifts linked to class switch site locations

(2012) Barbara B. Balter et al.   MOLECULAR IMMUNOLOGY

The RNA Exosome Targets the AID Cytidine Deaminase to Both Strands of Transcribed Duplex DNA Substrates

(2011) Uttiya Basu et al.   CELL

RNase H and Multiple RNA Biogenesis Factors Cooperate to Prevent RNA:DNA Hybrids from Generating Genome Instability

(2011) Lamia Wahba et al.   MOLECULAR CELL

Yeast Sen1 Helicase Protects the Genome from Transcription-Associated Instability

(2011) Hannah E. Mischo et al.   MOLECULAR CELL

Human Senataxin Resolves RNA/DNA Hybrids Formed at Transcriptional Pause Sites to Promote Xrn2-Dependent Termination

(2011) Konstantina Skourti-Stathaki et al.   MOLECULAR CELL

Overlapping activation-induced cytidine deaminase hotspot motifs in Ig class-switch recombination

(2011) L. Han et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Genomic deletion of the whole IgH 3' regulatory region (hs3a, hs1,2, hs3b, and hs4) dramatically affects class switch recombination and Ig secretion to all isotypes

(2010) C. Vincent-Fabert et al.   BLOOD

Loss of Topoisomerase I leads to R-loop-mediated transcriptional blocks during ribosomal RNA synthesis

(2010) A. El Hage et al.   GENES & DEVELOPMENT

Ribonuclease H: the enzymes in eukaryotes

(2009) Susana M. Cerritelli et al.   FEBS Journal

Immunoglobulin switch μ sequence causes RNA polymerase II accumulation and reduces dA hypermutation

(2009) Deepa Rajagopal et al.   JOURNAL OF EXPERIMENTAL MEDICINE

S region sequence, RNA polymerase II, and histone modifications create chromatin accessibility during class switch recombination

(2009) Lili Wang et al.   JOURNAL OF EXPERIMENTAL MEDICINE

Switch recombination and somatic hypermutation are controlled by the heavy chain 3′ enhancer region

(2009) Wesley A. Dunnick et al.   JOURNAL OF EXPERIMENTAL MEDICINE

G Clustering Is Important for the Initiation of Transcription-Induced R-Loops In Vitro, whereas High G Density without Clustering Is Sufficient Thereafter

(2009) D. Roy et al.   MOLECULAR AND CELLULAR BIOLOGY

Competition between the RNA Transcript and the Nontemplate DNA Strand during R-Loop Formation In Vitro: a Nick Can Serve as a Strong R-Loop Initiation Site

(2009) D. Roy et al.   MOLECULAR AND CELLULAR BIOLOGY

The stability of AID and its function in class-switching are critically sensitive to the identity of its nuclear-export sequence

(2009) R. Geisberger et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Mechanism and Regulation of Class Switch Recombination

(2008) Janet Stavnezer et al.   Annual Review of Immunology

AID Is Required for the Chromosomal Breaks in c-myc that Lead to c-myc/IgH Translocations

(2008) Davide F. Robbiani et al.   CELL

Transcriptional pausing and stalling causes multiple clustered mutations by human activation-induced deaminase

(2008) Chandrika Canugovi et al.   FASEB JOURNAL

Conformational Variants of Duplex DNA Correlated with Cytosine-rich Chromosomal Fragile Sites

(2008) Albert G. Tsai et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Altered kinetics of nonhomologous end joining and class switch recombination in ligase IV–deficient B cells

(2008) Li Han et al.   JOURNAL OF EXPERIMENTAL MEDICINE

Two levels of protection for the B cell genome during somatic hypermutation

(2008) Man Liu et al.   NATURE