3-Azidoarynes: Generation and Regioselective Reactions

Hexadehydro-Diels–Alder Reaction: Benzyne Generation via Cycloisomerization of Tethered Triynes

(2021) Lucas L. Fluegel et al.   CHEMICAL REVIEWS

o-Silylaryl Triflates: A Journey of Kobayashi Aryne Precursors

(2021) Jiarong Shi et al.   CHEMICAL REVIEWS

Azide⋅⋅⋅Oxygen Interaction: A Crystal Engineering Tool for Conformational Locking

(2021) Mithun C. Madhusudhanan et al.   ANGEWANDTE CHEMIE-INTERNATIONAL EDITION

Construction of N-Heterocycles Fused with a Highly Substituted Benzene Ring by a Benzyne-Mediated Cyclization/Functionalization Cascade Reaction and Its Application to the Total Synthesis of Marine Natural Products

(2021) Hidetoshi Tokuyama   CHEMICAL & PHARMACEUTICAL BULLETIN

The Aryne-Abramov Reaction as a 1,2-Benzdiyne Platform for the Generation and Solvent-Dependent Trapping of 3-Phosphonyl Benzynes

(2021) Brianna M. Bembenek et al.   JOURNAL OF ORGANIC CHEMISTRY

1,3-Aza-Brook Rearrangement of Aniline Derivatives: In Situ Generation of 3-Aminoaryne via 1,3-C-(sp2)-to-N Silyl Migration

(2021) Young-Kyo Jeon et al.   ORGANIC LETTERS

Strategies toward Aryne Multifunctionalization via 1,2-Benzdiyne and Benzyne

(2020) Jia He et al.   ACCOUNTS OF CHEMICAL RESEARCH

Analysis of Benzenoid Substitution Patterns in Small Molecule Active Pharmaceutical Ingredients

(2020) Aleksandra Nilova et al.   JOURNAL OF MEDICINAL CHEMISTRY

Aryne Precursors for Selective Generation of 3-Haloarynes: Preparation and Application to Synthetic Reactions

(2020) Eito Yoshioka et al.   JOURNAL OF ORGANIC CHEMISTRY

Synthesis of NMs-DACN: Small and Hydrophilic Click Reaction Device

(2019) Yuuya Kawasaki et al.   CHEMISTRY LETTERS

3-Thioaryne Intermediates for the Synthesis of Diverse Thioarenes

(2019) Yu Nakamura et al.   ORGANIC LETTERS

Facile Synthesis of Diverse 2,6-Disubstituted Arylsilanes via Silylamination and Silylsulfanylation of Aryne Intermediates Generated from o-Iodoaryl Triflates

(2019) Yu Nakamura et al.   CHEMISTRY LETTERS

Aryne Trifunctionalization Enabled by 3-Silylaryne as a 1,2-Benzdiyne Equivalent

(2018) Chunjie Lv et al.   ORGANIC LETTERS

Transition-Metal-Free Activation of Amide Bond by Arynes

(2018) Hideto Miyabe   MOLECULES

Recent advances in reactions between arynes and organosulfur compounds

(2018) Tsubasa Matsuzawa et al.   TETRAHEDRON LETTERS

Selective Aryne Formation via Grob Fragmentation from the [2+2] Cycloadducts of 3-Triflyloxyarynes

(2017) Jiarong Shi et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

Three-Component Coupling of Triflyloxy-Substituted Benzocyclobutenones, Organolithium Reagents, and Arynophiles Promoted by Generation of Aryne via Carbon–Carbon Bond Cleavage

(2017) Keisuke Uchida et al.   ORGANIC LETTERS

Thieme Chemistry Journals Awardees: Where Are They Now? One-Pot Synthesis of Versatile Buckle Units for Click Chemistry: 4,8-Diazacyclononynes (DACNs)

(2017) Kazunobu Igawa et al.   SYNLETT

Thiazolobenzyne: a versatile intermediate for multisubstituted benzothiazoles

(2016) Suguru Yoshida et al.   CHEMICAL COMMUNICATIONS

Synthesis of biaryls using aryne intermediates

(2016) José-Antonio García-López et al.   CHEMICAL SOCIETY REVIEWS

Synthesis of Diverse Benzotriazoles from Aryne Precursors Bearing an Azido Group via Inter- and Intramolecular Cycloadditions

(2016) Suguru Yoshida et al.   CHEMISTRY LETTERS

Aryne Relay Chemistry en Route to Aminoarenes: Synthesis of 3-Aminoaryne Precursors via Regioselective Silylamination of 3-(Triflyloxy)arynes

(2016) Suguru Yoshida et al.   ORGANIC LETTERS

Controlled Generation of 3-Triflyloxyarynes

(2016) Suguru Yoshida et al.   SYNTHESIS-STUTTGART

1,3- and 1,4-Benzdiyne equivalents for regioselective synthesis of polycyclic heterocycles

(2016) Takashi Ikawa et al.   Chemical Science

Generation of Arynes Using Trimethylsilylmethyl Grignard Reagent for Activation of ortho-Iodoaryl or ortho-Sulfinylaryl Triflates

(2015) Suguru Yoshida et al.   CHEMISTRY LETTERS

The Renaissance and Bright Future of Synthetic Aryne Chemistry

(2015) Suguru Yoshida et al.   CHEMISTRY LETTERS

Facile Synthesis of Diverse Multisubstituted ortho-Silylaryl Triflates via C–H Borylation

(2015) Suguru Yoshida et al.   CHEMISTRY LETTERS

[3 + 2] Cycloadditions of Azides with Arynes via Photolysis of Phthaloyl Peroxide Derivatives

(2015) Denghu Chang et al.   JOURNAL OF ORGANIC CHEMISTRY

Development and Application of O-(Trimethylsilyl)aryl Fluorosulfates for the Synthesis of Arynes

(2015) Qiao Chen et al.   JOURNAL OF ORGANIC CHEMISTRY

Trifluoromethanesulfonyloxy-group-directed regioselective (3 + 2) cycloadditions of benzynes for the synthesis of functionalized benzo-fused heterocycles

(2015) Takashi Ikawa et al.   ORGANIC & BIOMOLECULAR CHEMISTRY

Computational predictions of substituted benzyne and indolyne regioselectivities

(2015) Elias Picazo et al.   TETRAHEDRON LETTERS

Heteroatom-embedded Medium-Sized Cycloalkynes: Concise Synthesis, Structural Analysis, and Reactions

(2014) Runyan Ni et al.   ANGEWANDTE CHEMIE-INTERNATIONAL EDITION

An efficient generation method and remarkable reactivities of 3-triflyloxybenzyne

(2014) Suguru Yoshida et al.   CHEMICAL COMMUNICATIONS

Enabling the Use of Heterocyclic Arynes in Chemical Synthesis

(2014) Adam E. Goetz et al.   JOURNAL OF ORGANIC CHEMISTRY

Photoactivated Bioconjugation Between ortho-Azidophenols and Anilines: A Facile Approach to Biomolecular Photopatterning

(2014) Kareem M. El Muslemany et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

The Role of Aryne Distortions, Steric Effects, and Charges in Regioselectivities of Aryne Reactions

(2014) Jose M. Medina et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

Modular synthesis of bis- and tris-1,2,3-triazoles by permutable sequential azide–aryne and azide–alkyne cycloadditions

(2014) Suguru Yoshida et al.   ORGANIC & BIOMOLECULAR CHEMISTRY

1,3-Dipolar Cycloaddition of Pyridynes and Azides: Concise Synthesis of Triazolopyridines

(2013) Yoshihiro Sato et al.   HETEROCYCLES

Regiocomplementary Cycloaddition Reactions of Boryl- and Silylbenzynes with 1,3-Dipoles: Selective Synthesis of Benzo-Fused Azole Derivatives

(2013) Takashi Ikawa et al.   JOURNAL OF ORGANIC CHEMISTRY

ortho-Selective nucleophilic addition of amines to 3-borylbenzynes: synthesis of multisubstituted anilines by the triple role of the boryl group

(2013) Akira Takagi et al.   ORGANIC & BIOMOLECULAR CHEMISTRY

Generation of 3-borylbenzynes, their regioselective Diels–Alder reactions, and theoretical analysis

(2013) Akira Takagi et al.   TETRAHEDRON

An Efficient Computational Model to Predict the Synthetic Utility of Heterocyclic Arynes

(2012) Adam E. Goetz et al.   ANGEWANDTE CHEMIE-INTERNATIONAL EDITION

Arynes and Cyclohexyne in Natural Product Synthesis

(2012) Christian M. Gampe et al.   ANGEWANDTE CHEMIE-INTERNATIONAL EDITION

A Comprehensive History of Arynes in Natural Product Total Synthesis

(2012) Pamela M. Tadross et al.   CHEMICAL REVIEWS

Multicomponent Coupling Reaction of Arynes for Construction of Heterocyclic Skeletons

(2012) Hiroto Yoshida et al.   HETEROCYCLES

Design and Application of New Imidazolylsulfonate-Based Benzyne Precursor: An Efficient Triflate Alternative

(2012) Szabolcs Kovács et al.   ORGANIC LETTERS

Overturning Indolyne Regioselectivities and Synthesis of Indolactam V

(2011) Sarah M. Bronner et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

Preparation and Regioselective Diels-Alder Reactions of Borylbenzynes: Synthesis of Functionalized Arylboronates

(2010) Takashi Ikawa et al.   ANGEWANDTE CHEMIE-INTERNATIONAL EDITION

Total Synthesis of Clavicipitic Acid and Aurantioclavine: Stereochemistry of Clavicipitic Acid Revisited

(2010) Zhengren Xu et al.   JOURNAL OF ORGANIC CHEMISTRY

Indolyne and Aryne Distortions and Nucleophilic Regioselectivites

(2010) Paul H.-Y. Cheong et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

Indolyne Experimental and Computational Studies: Synthetic Applications and Origins of Selectivities of Nucleophilic Additions

(2010) G-Yoon J. Im et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

Iodination of phenols in water using easy to handle amine-iodine complexes

(2010) Lívia C. R. M. da Frota et al.   JOURNAL OF THE BRAZILIAN CHEMICAL SOCIETY

Regioselective Reactions of Highly Substituted Arynes

(2010) Pamela M. Tadross et al.   ORGANIC LETTERS

Benzyne Click Chemistry with in Situ Generated Aromatic Azides

(2009) Fengzhi Zhang et al.   ORGANIC LETTERS

Synthesis of Biaryl Compounds through Three-Component Assembly: Ambidentate Effect of thetert-Butyldimethylsilyl Group for Regioselective Diels-Alder and Hiyama Coupling Reactions

(2008) Shuji Akai et al.   ANGEWANDTE CHEMIE-INTERNATIONAL EDITION

Copper-free ‘click’: 1,3-dipolar cycloaddition of azides and arynes

(2008) Lachlan Campbell-Verduyn et al.   ORGANIC & BIOMOLECULAR CHEMISTRY

Benzyne Click Chemistry: Synthesis of Benzotriazoles from Benzynes and Azides

(2008) Feng Shi et al.   ORGANIC LETTERS

A smooth access to benzotriazoles via azide-benzyne cycloaddition

(2008) S. Chandrasekhar et al.   TETRAHEDRON