4.7 Article

Development and Application of O-(Trimethylsilyl)aryl Fluorosulfates for the Synthesis of Arynes

Journal

JOURNAL OF ORGANIC CHEMISTRY
Volume 80, Issue 13, Pages 6890-6896

Publisher

AMER CHEMICAL SOC
DOI: 10.1021/acs.joc.5b00923

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Funding

  1. NSFC [21202072, 21102141, 21432003]
  2. Fundamental Research Funds for the Central Universities [860976, 861966]

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A class of o-(trimethylsilyl)aryl fluorosulfates was synthesized by a concise method and successfully used as aryne precursors for the first time. Different trapping agents such as azides, furans, and acyl acetoacetates could successfully react with the aryne precursors under mild conditions with good to excellent yields.

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