Journal
ORGANIC & BIOMOLECULAR CHEMISTRY
Volume 11, Issue 46, Pages 8145-8150Publisher
ROYAL SOC CHEMISTRY
DOI: 10.1039/c3Ob41787e
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Funding
- KAKENHI from MEXT
- Daicel Chemical Industry Award in Synthetic Organic Chemistry (Japan)
- Japan Society for the Promotion of Science
- Grants-in-Aid for Scientific Research [25460018] Funding Source: KAKEN
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Nucleophilic addition of amines to 3-[(dan)boryl]benzynes (dan = 1,8-diaminonaphthalene) generated by a fluoride ion proceeded with high ortho-selectivity to give 2-borylaniline derivatives, under conditions that are tolerant to various functional groups. The (dan)boryl group of the adduct was hydrolyzed into a boronic acid under acidic conditions, which could further serve for various C-C, C-O, C-N, and C-H bond-formation reactions. The overall process provides a promising entry for preparing multisubstituted aniline derivatives.
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