DExD/H-box helicases: multifunctional regulators in antiviral innate immunity

Human DDX3X Unwinds Japanese Encephalitis and Zika Viral 5′ Terminal Regions

(2021) Corey Nelson et al.   INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

DHX15 is required to control RNA virus-induced intestinal inflammation

(2021) Junji Xing et al.   Cell Reports

Advances in the molecular mechanisms of NLRP3 inflammasome activators and inactivators

(2020) Dongling Liu et al.   BIOCHEMICAL PHARMACOLOGY

DDX39B interacts with the pattern recognition receptor pathway to inhibit NF-κB and sensitize to alkylating chemotherapy

(2020) Szymon J. Szymura et al.   BMC BIOLOGY

Toll-like Receptors and the Control of Immunity

(2020) Katherine A. Fitzgerald et al.   CELL

SUMOylation of DDX39A Alters Binding and Export of Antiviral Transcripts to Control Innate Immunity

(2020) Peidian Shi et al.   JOURNAL OF IMMUNOLOGY

Distinct and Orchestrated Functions of RNA Sensors in Innate Immunity

(2020) GuanQun Liu et al.   IMMUNITY

General and Target-Specific DExD/H RNA Helicases in Eukaryotic Translation Initiation

(2020) Leo Shen et al.   INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

Editorial Comment

(2020) Adam J. Gadzinski et al.   JOURNAL OF UROLOGY

DEAH-Box RNA Helicases in Pre-mRNA Splicing

(2020) Francesca De Bortoli et al.   TRENDS IN BIOCHEMICAL SCIENCES

DDX19 Inhibits Type I Interferon Production by Disrupting TBK1-IKKε-IRF3 Interactions and Promoting TBK1 and IKKε Degradation

(2019) Kunli Zhang et al.   Cell Reports

Double-Stranded RNA Sensors and Modulators in Innate Immunity

(2019) Sun Hur   Annual Review of Immunology

TANK-binding kinase 1 as a novel therapeutic target for viral diseases

(2019) Chunyuan Zhao et al.   EXPERT OPINION ON THERAPEUTIC TARGETS

DHX15 Is a Coreceptor for RLR Signaling That Promotes Antiviral Defense Against RNA Virus Infection

(2019) Sowmya Pattabhi et al.   JOURNAL OF INTERFERON AND CYTOKINE RESEARCH

DDX56 inhibits type I interferon by disrupting assembly of IRF3–IPO5 to inhibit IRF3 nucleus import

(2019) Dan Li et al.   JOURNAL OF CELL SCIENCE

DDX3X acts as a live-or-die checkpoint in stressed cells by regulating NLRP3 inflammasome

(2019) Parimal Samir et al.   NATURE

DDX23, an Evolutionary Conserved dsRNA Sensor, Participates in Innate Antiviral Responses by Pairing With TRIF or MAVS

(2019) Jie Ruan et al.   Frontiers in Immunology

A double-stranded RNA platform is required for the interaction between a host restriction factor and the NS1 protein of influenza A virus

(2019) Guifang Chen et al.   NUCLEIC ACIDS RESEARCH

Knockdown of DEAD-box RNA helicase DDX5 selectively attenuates serine 311 phosphorylation of NF-κB p65 subunit and expression level of anti-apoptotic factor Bcl-2

(2019) Ken Tanaka et al.   CELLULAR SIGNALLING

Regulation of cGAS- and RLR-mediated immunity to nucleic acids

(2019) Andrea Ablasser et al.   NATURE IMMUNOLOGY

The RNA Helicase DDX6 Associates with RIG-I to Augment Induction of Antiviral Signaling

(2018) Rocío Núñez et al.   INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

DDX41 Recognizes RNA/DNA Retroviral Reverse Transcripts and Is Critical for In Vivo Control of Murine Leukemia Virus Infection

(2018) Spyridon Stavrou et al.   mBio

DHX29 functions as an RNA co-sensor for MDA5-mediated EMCV-specific antiviral immunity

(2018) Qingyuan Zhu et al.   PLoS Pathogens

Poxviral protein E3–altered cytokine production reveals that DExD/H-box helicase 9 controls Toll-like receptor–stimulated immune responses

(2018) Alan Dempsey et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

A DNA-sensing–independent role of a nuclear RNA helicase, DHX9, in stimulation of NF-κB–mediated innate immunity against DNA virus infection

(2018) Yee Ching Ng et al.   NUCLEIC ACIDS RESEARCH

DDX3 directly facilitates IKKα activation and regulates downstream signalling pathways

(2018) Anthony Fullam et al.   BIOCHEMICAL JOURNAL

The DEAD-box protein DDX43 (HAGE) is a dual RNA-DNA helicase and has a K-homology domain required for full nucleic acid unwinding activity

(2017) Tanu Talwar et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Inflammasome activation and assembly at a glance

(2017) Ankit Malik et al.   JOURNAL OF CELL SCIENCE

Nlrp9b inflammasome restricts rotavirus infection in intestinal epithelial cells

(2017) Shu Zhu et al.   NATURE

DDX6 Represses Aberrant Activation of Interferon-Stimulated Genes

(2017) Jennifer H. Lumb et al.   Cell Reports

DEAD-Box Helicase DDX25 Is a Negative Regulator of Type I Interferon Pathway and Facilitates RNA Virus Infection

(2017) Tingting Feng et al.   Frontiers in Cellular and Infection Microbiology

DDX3 directly regulates TRAF3 ubiquitination and acts as a scaffold to co-ordinate assembly of signalling complexes downstream from MAVS

(2016) Lili Gu et al.   BIOCHEMICAL JOURNAL

RNase L and the NLRP3-inflammasome: An old merchant in a new trade

(2016) Shuvojit Banerjee   CYTOKINE & GROWTH FACTOR REVIEWS

Post-Translational Modification Control of Innate Immunity

(2016) Juan Liu et al.   IMMUNITY

DHX9/RHA Binding to the PBS-Segment of the Genomic RNA during HIV-1 Assembly Bolsters Virion Infectivity

(2016) Ioana Boeras et al.   JOURNAL OF MOLECULAR BIOLOGY

Spliceosome SNRNP200 Promotes Viral RNA Sensing and IRF3 Activation of Antiviral Response

(2016) Nicolas Tremblay et al.   PLoS Pathogens

The DEAD-Box RNA Helicase DDX3 Interacts with NF-κB Subunit p65 and Suppresses p65-Mediated Transcription

(2016) Nian Xiang et al.   PLoS One

Aberrant expression and dysfunction of TLR2 and its soluble form in chronic HBV infection and its regulation by antiviral therapy

(2015) Zuxiong Huang et al.   ANTIVIRAL RESEARCH

Downregulation of diacylglycerol kinase ζ enhances activation of cytokine-induced NF-κB signaling pathway

(2015) Rieko Tsuchiya et al.   BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR CELL RESEARCH

LGP2 synergy with MDA5 in RLR-mediated RNA recognition and antiviral signaling

(2015) Annie M. Bruns et al.   CYTOKINE

DDX19A Senses Viral RNA and Mediates NLRP3-Dependent Inflammasome Activation

(2015) Jiangnan Li et al.   JOURNAL OF IMMUNOLOGY

DDX60L Is an Interferon-Stimulated Gene Product Restricting Hepatitis C Virus Replication in Cell Culture

(2015) Oliver Grünvogel et al.   JOURNAL OF VIROLOGY

Nlrp6 regulates intestinal antiviral innate immunity

(2015) Penghua Wang et al.   SCIENCE

Toll-Like Receptor 3 Signaling via TRIF Contributes to a Protective Innate Immune Response to Severe Acute Respiratory Syndrome Coronavirus Infection

(2015) Allison L. Totura et al.   mBio

An autoinhibitory mechanism modulates MAVS activity in antiviral innate immune response

(2015) Yuheng Shi et al.   Nature Communications

DDX60 Is Involved in RIG-I-Dependent and Independent Antiviral Responses, and Its Function Is Attenuated by Virus-Induced EGFR Activation

(2015) Hiroyuki Oshiumi et al.   Cell Reports

Bruton’s Tyrosine Kinase Phosphorylates DDX41 and Activates Its Binding of dsDNA and STING to Initiate Type 1 Interferon Response

(2015) Koon-Guan Lee et al.   Cell Reports

A Bicistronic MAVS Transcript Highlights a Class of Truncated Variants in Antiviral Immunity

(2014) Sky W. Brubaker et al.   CELL

SnapShot: Nucleic Acid Immune Sensors, Part 2

(2014) Veit Hornung   IMMUNITY

DHX15 Senses Double-Stranded RNA in Myeloid Dendritic Cells

(2014) H. Lu et al.   JOURNAL OF IMMUNOLOGY

Gene Expression Profiling of the Response to Interferon Beta in Epstein-Barr-Transformed and Primary B Cells of Patients with Multiple Sclerosis

(2014) Rana Khsheibun et al.   PLoS One

Helicase proteins DHX29 and RIG-I cosense cytosolic nucleic acids in the human airway system

(2014) N. Sugimoto et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

The DEAH-Box RNA Helicase DHX15 Activates NF- B and MAPK Signaling Downstream of MAVS During Antiviral Responses

(2014) K. Mosallanejad et al.   Science Signaling

DAMP Molecule S100A9 Acts as a Molecular Pattern to Enhance Inflammation during Influenza A Virus Infection: Role of DDX21-TRIF-TLR4-MyD88 Pathway

(2014) Su-Yu Tsai et al.   PLoS Pathogens

DHX36 Enhances RIG-I Signaling by Facilitating PKR-Mediated Antiviral Stress Granule Formation

(2014) Ji-Seung Yoo et al.   PLoS Pathogens

The interaction between the helicase DHX33 and IPS-1 as a novel pathway to sense double-stranded RNA and RNA viruses in myeloid dendritic cells

(2013) Ying Liu et al.   Cellular & Molecular Immunology

The DHX33 RNA Helicase Senses Cytosolic RNA and Activates the NLRP3 Inflammasome

(2013) Hiroki Mitoma et al.   IMMUNITY

Human DEAD Box Helicase 3 Couples I B Kinase   to Interferon Regulatory Factor 3 Activation

(2013) L. Gu et al.   MOLECULAR AND CELLULAR BIOLOGY

DDX5 Facilitates HIV-1 Replication as a Cellular Co-Factor of Rev

(2013) Xiuxia Zhou et al.   PLoS One

DDX24 Negatively Regulates Cytosolic RNA-Mediated Innate Immune Signaling

(2013) Zhe Ma et al.   PLoS Pathogens

Regulation of NF-κB by deubiquitinases

(2012) Edward W. Harhaj et al.   IMMUNOLOGICAL REVIEWS

The helicase DDX41 recognizes the bacterial secondary messengers cyclic di-GMP and cyclic di-AMP to activate a type I interferon immune response

(2012) Kislay Parvatiyar et al.   NATURE IMMUNOLOGY

Structural insights into regulation and action of SWI2/SNF2 ATPases

(2011) Glenn Hauk et al.   CURRENT OPINION IN STRUCTURAL BIOLOGY

DDX1, DDX21, and DHX36 Helicases Form a Complex with the Adaptor Molecule TRIF to Sense dsRNA in Dendritic Cells

(2011) Zhiqiang Zhang et al.   IMMUNITY

Toll-like Receptors and Their Crosstalk with Other Innate Receptors in Infection and Immunity

(2011) Taro Kawai et al.   IMMUNITY

Herpes simplex encephalitis in children with autosomal recessive and dominant TRIF deficiency

(2011) Vanessa Sancho-Shimizu et al.   JOURNAL OF CLINICAL INVESTIGATION

DHX9 Pairs with IPS-1 To Sense Double-Stranded RNA in Myeloid Dendritic Cells

(2011) Z. Zhang et al.   JOURNAL OF IMMUNOLOGY

DDX60, a DEXD/H Box Helicase, Is a Novel Antiviral Factor Promoting RIG-I-Like Receptor-Mediated Signaling

(2011) M. Miyashita et al.   MOLECULAR AND CELLULAR BIOLOGY

The helicase DDX41 senses intracellular DNA mediated by the adaptor STING in dendritic cells

(2011) Zhiqiang Zhang et al.   NATURE IMMUNOLOGY

From unwinding to clamping — the DEAD box RNA helicase family

(2011) Patrick Linder et al.   NATURE REVIEWS MOLECULAR CELL BIOLOGY

DEAD/H BOX 3 (DDX3) helicase binds the RIG-I adaptor IPS-1 to up-regulate IFN-β-inducing potential

(2010) Hiroyuki Oshiumi et al.   EUROPEAN JOURNAL OF IMMUNOLOGY

Aspartate-glutamate-alanine-histidine box motif (DEAH)/RNA helicase A helicases sense microbial DNA in human plasmacytoid dendritic cells

(2010) T. Kim et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

LGP2 is a positive regulator of RIG-I- and MDA5-mediated antiviral responses

(2010) T. Satoh et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

DEXH-Box protein DHX30 is required for optimal function of the zinc-finger antiviral protein

(2010) Peiying Ye et al.   Protein & Cell

Atg9a controls dsDNA-driven dynamic translocation of STING and the innate immune response

(2009) T. Saitoh et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

An Antiviral Response Directed by PKR Phosphorylation of the RNA Helicase A

(2009) Anthony J. Sadler et al.   PLoS Pathogens

The DEAD-box helicase DDX3X is a critical component of the TANK-binding kinase 1-dependent innate immune response

(2008) Didier Soulat et al.   EMBO JOURNAL

Viral targeting of DEAD box protein 3 reveals its role in TBK1/IKKɛ-mediated IRF activation

(2008) Martina Schröder et al.   EMBO JOURNAL

Structure and Function of LGP2, a DEX(D/H) Helicase That Regulates the Innate Immunity Response

(2008) Ayaluru Murali et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

The DEAD-box RNA helicase DDX1 interacts with RelA and enhances nuclear factor kappaB-mediated transcription

(2008) Musarat Ishaq et al.   JOURNAL OF CELLULAR BIOCHEMISTRY

p72 DEAD box RNA helicase is required for optimal function of the zinc-finger antiviral protein

(2008) G. Chen et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA