General and Target-Specific DExD/H RNA Helicases in Eukaryotic Translation Initiation

Identification of a selective DDX3X inhibitor with newly developed quantitative high-throughput RNA helicase assays

(2020) Shoichi Nakao et al.   BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS

Modulation of RNA Condensation by the DEAD-Box Protein eIF4A

(2020) Devin Tauber et al.   CELL

Rocaglates Induce Gain-of-Function Alterations to eIF4A and eIF4F

(2020) Jennifer Chu et al.   Cell Reports

RK-33 Is a Broad-Spectrum Antiviral Agent That Targets DEAD-Box RNA Helicase DDX3X

(2020) Sundy N. Y. Yang et al.   Cells

CRISPR-Based Screen Links an Inhibitor of Nonsense-Mediated Decay to eIF4A3 Target Engagement

(2020) Regina Cencic et al.   ACS Chemical Biology

Condensation of Ded1p Promotes a Translational Switch from Housekeeping to Stress Protein Production

(2020) Christiane Iserman et al.   CELL

hCLE/RTRAF-HSPC117-DDX1-FAM98B: A New Cap-Binding Complex That Activates mRNA Translation

(2019) Alejandra Pazo et al.   Frontiers in Physiology

The Organizing Principles of Eukaryotic Ribosome Recruitment

(2019) Jerry Pelletier et al.   Annual Review of Biochemistry

DEAD-box helicase eIF4A2 inhibits CNOT7 deadenylation activity

(2019) Hedda A Meijer et al.   NUCLEIC ACIDS RESEARCH

DEAD-box ATPases are global regulators of phase-separated organelles

(2019) Maria Hondele et al.   NATURE

mRNA Deadenylation Is Coupled to Translation Rates by the Differential Activities of Ccr4-Not Nucleases

(2018) Michael W. Webster et al.   MOLECULAR CELL

PABP Cooperates with the CCR4-NOT Complex to Promote mRNA Deadenylation and Block Precocious Decay

(2018) Hyerim Yi et al.   MOLECULAR CELL

eIF4A alleviates the translational repression mediated by classical secondary structures more than by G-quadruplexes

(2018) Joseph A Waldron et al.   NUCLEIC ACIDS RESEARCH

DHX29 functions as an RNA co-sensor for MDA5-mediated EMCV-specific antiviral immunity

(2018) Qingyuan Zhu et al.   PLoS Pathogens

α-Proteobacterial RNA Degradosomes Assemble Liquid-Liquid Phase-Separated RNP Bodies

(2018) Nadra Al-Husini et al.   MOLECULAR CELL

The helicase Ded1p controls use of near-cognate translation initiation codons in 5′ UTRs

(2018) Ulf-Peter Guenther et al.   NATURE

Structural basis of G-quadruplex unfolding by the DEAH/RHA helicase DHX36

(2018) Michael C. Chen et al.   NATURE

OUP accepted manuscript

(2018)   NUCLEIC ACIDS RESEARCH

RNAi-mediated knockdown of the Rhau helicase preferentially depletes proteins with a Guanine-quadruplex motif in the 5'-UTR of their mRNA

(2018) Karen Vester et al.   BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS

The Translation Inhibitor Rocaglamide Targets a Bimolecular Cavity between eIF4A and Polypurine RNA

(2018) Shintaro Iwasaki et al.   MOLECULAR CELL

The RNA helicase DHX33 is required for cancer cell proliferation in human glioblastoma and confers resistance to PI3K/mTOR inhibition

(2018) Hongzhong Wang et al.   CELLULAR SIGNALLING

The DEAD-box RNA helicase DDX41 is a novel repressor of p21WAF1/CIP1mRNA translation

(2017) Dominik Peters et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

DND1 maintains germline stem cells via recruitment of the CCR4–NOT complex to target mRNAs

(2017) Masashi Yamaji et al.   NATURE

A helicase-independent activity of eIF4A in promoting mRNA recruitment to the human ribosome

(2017) Masaaki Sokabe et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Cap-binding protein 4EHP effects translation silencing by microRNAs

(2017) Clément Chapat et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Yeast eIF4A enhances recruitment of mRNAs regardless of their structural complexity

(2017) Paul Yourik et al.   eLife

High-Throughput Screening to Identify Inhibitors of DEAD Box Helicase DDX41

(2017) Mariko Yoneyama-Hirozane et al.   SLAS Discovery

ATPase-Modulated Stress Granules Contain a Diverse Proteome and Substructure

(2016) Saumya Jain et al.   CELL

nanoCAGE reveals 5′ UTR features that define specific modes of translation of functionally related MTOR-sensitive mRNAs

(2016) Valentina Gandin et al.   GENOME RESEARCH

RNA Helicase Associated with AU-rich Element (RHAU/DHX36) Interacts with the 3′-Tail of the Long Non-coding RNA BC200 (BCYRN1)

(2016) Evan P. Booy et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

The RNA Helicase eIF4A Is Required for Sapovirus Translation

(2016) Myra Hosmillo et al.   JOURNAL OF VIROLOGY

DHX29 reduces leaky scanning through an upstream AUG codon regardless of its nucleotide context

(2016) Vera P. Pisareva et al.   NUCLEIC ACIDS RESEARCH

RHAU helicase stabilizes G4 in its nucleotide-free state and destabilizes G4 upon ATP hydrolysis

(2016) Huijuan You et al.   NUCLEIC ACIDS RESEARCH

eIF4B stimulates translation of long mRNAs with structured 5′ UTRs and low closed-loop potential but weak dependence on eIF4G

(2016) Neelam Dabas Sen et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

DHX29 and eIF3 cooperate in ribosomal scanning on structured mRNAs during translation initiation

(2016) Vera P. Pisareva et al.   RNA

RNA G-quadruplexes are globally unfolded in eukaryotic cells and depleted in bacteria

(2016) J. U. Guo et al.   SCIENCE

The biology of DHX9 and its potential as a therapeutic target

(2016) Teresa Lee et al.   Oncotarget

Targeting the eIF4F Translation Initiation Complex: A Critical Nexus for Cancer Development

(2015) J. Pelletier et al.   CANCER RESEARCH

Genome-wide analysis of translational efficiency reveals distinct but overlapping functions of yeast DEAD-box RNA helicases Ded1 and eIF4A

(2015) Neelam Dabas Sen et al.   GENOME RESEARCH

Deregulation of Internal Ribosome Entry Site-Mediated p53 Translation in Cancer Cells with Defective p53 Response to DNA Damage

(2015) Marie-Jo Halaby et al.   MOLECULAR AND CELLULAR BIOLOGY

The DHX33 RNA Helicase Promotes mRNA Translation Initiation

(2015) Yandong Zhang et al.   MOLECULAR AND CELLULAR BIOLOGY

The Hippo Pathway Effector YAP Regulates Motility, Invasion, and Castration-Resistant Growth of Prostate Cancer Cells

(2015) Lin Zhang et al.   MOLECULAR AND CELLULAR BIOLOGY

Structure of mammalian eIF3 in the context of the 43S preinitiation complex

(2015) Amedee des Georges et al.   NATURE

Targeting the translation machinery in cancer

(2015) Mamatha Bhat et al.   NATURE REVIEWS DRUG DISCOVERY

eIF4AII is dispensable for miRNA-mediated gene silencing

(2015) Gabriela Galicia-Vázquez et al.   RNA

Factor-dependent processivity in human eIF4A DEAD-box helicase

(2015) C. Garcia-Garcia et al.   SCIENCE

Post-transcriptional Regulation of Nkx2-5 by RHAU in Heart Development

(2015) Junwei Nie et al.   Cell Reports

Structure of a Human 4E-T/DDX6/CNOT1 Complex Reveals the Different Interplay of DDX6-Binding Proteins with the CCR4-NOT Complex

(2015) Sevim Ozgur et al.   Cell Reports

The eIF4E-Binding Protein 4E-T Is a Component of the mRNA Decay Machinery that Bridges the 5′ and 3′ Termini of Target mRNAs

(2015) Tamiko Nishimura et al.   Cell Reports

Translational Control Protein 80 Stimulates IRES-Mediated Translation of p53 mRNA in Response to DNA Damage

(2015) Marie-Jo Halaby et al.   Biomed Research International

Aven recognition of RNA G-quadruplexes regulates translation of the mixed lineage leukemia protooncogenes

(2015) Palaniraja Thandapani et al.   eLife

The Ded1/DDX3 subfamily of DEAD-box RNA helicases

(2014) Deepak Sharma et al.   CRITICAL REVIEWS IN BIOCHEMISTRY AND MOLECULAR BIOLOGY

DDX3 DEAD-Box RNA Helicase Is a Host Factor That Restricts Hepatitis B Virus Replication at the Transcriptional Level

(2014) C. Ko et al.   JOURNAL OF VIROLOGY

A DDX6-CNOT1 Complex and W-Binding Pockets in CNOT9 Reveal Direct Links between miRNA Target Recognition and Silencing

(2014) Ying Chen et al.   MOLECULAR CELL

Structural and Biochemical Insights to the Role of the CCR4-NOT Complex and DDX6 ATPase in MicroRNA Repression

(2014) Hansruedi Mathys et al.   MOLECULAR CELL

RNA G-quadruplexes cause eIF4A-dependent oncogene translation in cancer

(2014) Andrew L. Wolfe et al.   NATURE

Minimal, encapsulated proteomic-sample processing applied to copy-number estimation in eukaryotic cells

(2014) Nils A Kulak et al.   NATURE METHODS

DDX6 and its orthologs as modulators of cellular and viral RNA expression

(2014) Dirk H. Ostareck et al.   Wiley Interdisciplinary Reviews-RNA

Structure of the Mammalian Ribosomal 43S Preinitiation Complex Bound to the Scanning Factor DHX29

(2013) Yaser Hashem et al.   CELL

Identification of DEAD-box RNA Helicase 6 (DDX6) as a Cellular Modulator of Vascular Endothelial Growth Factor Expression under Hypoxia

(2013) Sebastian de Vries et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

eIF4B and eIF4G Jointly Stimulate eIF4A ATPase and Unwinding Activities by Modulation of the eIF4A Conformational Cycle

(2013) Alexandra Zoi Andreou et al.   JOURNAL OF MOLECULAR BIOLOGY

Translational Repression and eIF4A2 Activity Are Critical for MicroRNA-Mediated Gene Regulation

(2013) H. A. Meijer et al.   SCIENCE

The role of the DEAD-box RNA helicase DDX3 in mRNA metabolism

(2013) Ricardo Soto-Rifo et al.   Wiley Interdisciplinary Reviews-RNA

The DEAH-box helicase RHAU is an essential gene and critical for mouse hematopoiesis

(2012) J. C. Lai et al.   BLOOD

DEAD-box protein DDX3 associates with eIF4F to promote translation of selected mRNAs

(2012) Ricardo Soto-Rifo et al.   EMBO JOURNAL

Tumor Suppressor PDCD4 Represses Internal Ribosome Entry Site-Mediated Translation of Antiapoptotic Proteins and Is Regulated by S6 Kinase 2

(2012) U. Liwak et al.   MOLECULAR AND CELLULAR BIOLOGY

The DEAD-box helicase DDX3 supports the assembly of functional 80S ribosomes

(2012) Rene Geissler et al.   NUCLEIC ACIDS RESEARCH

Roles of individual domains in the function of DHX29, an essential factor required for translation of structured mammalian mRNAs

(2012) V. Dhote et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

A cellular response linking eIF4AI activity to eIF4AII transcription

(2012) G. Galicia-Vazquez et al.   RNA

Targeting Synthetic Lethal Interactions between Myc and the eIF4F Complex Impedes Tumorigenesis

(2012) Chen-Ju Lin et al.   Cell Reports

Human DHX9 helicase preferentially unwinds RNA-containing displacement loops (R-loops) and G-quadruplexes

(2011) Prasun Chakraborty et al.   DNA REPAIR

Host translational control of a polydnavirus, Cotesia plutellae bracovirus, by sequestering host eIF4A to prevent formation of a translation initiation complex

(2011) V. P. Surakasi et al.   INSECT MOLECULAR BIOLOGY

Duplex Unwinding and ATPase Activities of the DEAD-Box Helicase eIF4A Are Coupled by eIF4G and eIF4B

(2011) Ali R. ze et al.   JOURNAL OF MOLECULAR BIOLOGY

Identification of DHX33 as a Mediator of rRNA Synthesis and Cell Growth

(2011) Y. Zhang et al.   MOLECULAR AND CELLULAR BIOLOGY

GW182 Proteins Directly Recruit Cytoplasmic Deadenylase Complexes to miRNA Targets

(2011) Joerg E. Braun et al.   MOLECULAR CELL

The DEAD-Box Protein Ded1 Modulates Translation by the Formation and Resolution of an eIF4F-mRNA Complex

(2011) Angela Hilliker et al.   MOLECULAR CELL

mRNA helicases: the tacticians of translational control

(2011) Armen Parsyan et al.   NATURE REVIEWS MOLECULAR CELL BIOLOGY

From unwinding to clamping — the DEAD box RNA helicase family

(2011) Patrick Linder et al.   NATURE REVIEWS MOLECULAR CELL BIOLOGY

G4 Resolvase 1 tightly binds and unwinds unimolecular G4-DNA

(2011) Banabihari Giri et al.   NUCLEIC ACIDS RESEARCH

The DEAH-box RNA helicase RHAU binds an intramolecular RNA G‐quadruplex in TERC and associates with telomerase holoenzyme

(2011) Simon Lattmann et al.   NUCLEIC ACIDS RESEARCH

A Motif Unique to the Human Dead-Box Protein DDX3 Is Important for Nucleic Acid Binding, ATP Hydrolysis, RNA/DNA Unwinding and HIV-1 Replication

(2011) Anna Garbelli et al.   PLoS One

DEAD-box RNA helicase Belle/DDX3 and the RNA interference pathway promote mitotic chromosome segregation

(2011) J. W. Pek et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

A novel role of RNA helicase A in regulation of translation of type I collagen mRNAs

(2011) Z. Manojlovic et al.   RNA

Functional impairment of eIF4A and eIF4G factors correlates with inhibition of influenza virus mRNA translation

(2011) Emilio Yángüez et al.   VIROLOGY

SF1 and SF2 helicases: family matters

(2010) Margaret E Fairman-Williams et al.   CURRENT OPINION IN STRUCTURAL BIOLOGY

Bypassing of stems versus linear base-by-base inspection of mammalian mRNAs during ribosomal scanning

(2010) Irina S Abaeva et al.   EMBO JOURNAL

Features of Double-stranded RNA-binding Domains of RNA Helicase A Are Necessary for Selective Recognition and Translation of Complex mRNAs

(2010) Arnaz Ranji et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

DDX3 Regulates Cell Growth through Translational Control of Cyclin E1

(2010) M.-C. Lai et al.   MOLECULAR AND CELLULAR BIOLOGY

The 5' Guanosine Tracts of Human Telomerase RNA Are Recognized by the G-Quadruplex Binding Domain of the RNA Helicase DHX36 and Function To Increase RNA Accumulation

(2010) A. N. Sexton et al.   MOLECULAR AND CELLULAR BIOLOGY

Synergistic activation of eIF4A by eIF4B and eIF4G

(2010) Klaus H. Nielsen et al.   NUCLEIC ACIDS RESEARCH

eIF4G stimulates the activity of the DEAD box protein eIF4A by a conformational guidance mechanism

(2010) Manuel Hilbert et al.   NUCLEIC ACIDS RESEARCH

Pathway of ATP utilization and duplex rRNA unwinding by the DEAD-box helicase, DbpA

(2010) A. Henn et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

RNA helicases at work: binding and rearranging

(2010) Eckhard Jankowsky   TRENDS IN BIOCHEMICAL SCIENCES

The mechanism of ATP-dependent RNA unwinding by DEAD box proteins

(2009) Manuel Hilbert et al.   BIOLOGICAL CHEMISTRY

Topology and Regulation of the Human eIF4A/4G/4H Helicase Complex in Translation Initiation

(2009) Assen Marintchev et al.   CELL

Molecular dissection of the eukaryotic initiation factor 4E (eIF4E) export-competent RNP

(2009) Ivan Topisirovic et al.   EMBO JOURNAL

Motif III in Superfamily 2 “Helicases” Helps Convert the Binding Energy of ATP into a High-Affinity RNA Binding Site in the Yeast DEAD-Box Protein Ded1

(2009) Josette Banroques et al.   JOURNAL OF MOLECULAR BIOLOGY

Binding of LARP6 to the Conserved 5′ Stem–Loop Regulates Translation of mRNAs Encoding Type I Collagen

(2009) Le Cai et al.   JOURNAL OF MOLECULAR BIOLOGY

RNA helicase A modulates translation of HIV-1 and infectivity of progeny virions

(2009) Cheryl Bolinger et al.   NUCLEIC ACIDS RESEARCH

Crystal structure of the eIF4A-PDCD4 complex

(2009) J. H. Chang et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

The helicase protein DHX29 promotes translation initiation, cell proliferation, and tumorigenesis

(2009) Armen Parsyan et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Translation Initiation on Mammalian mRNAs with Structured 5′UTRs Requires DExH-Box Protein DHX29

(2008) Vera P. Pisareva et al.   CELL

Therapeutic suppression of translation initiation modulates chemosensitivity in a mouse lymphoma model

(2008) Marie-Eve Bordeleau et al.   JOURNAL OF CLINICAL INVESTIGATION

The ATPase Cycle Mechanism of the DEAD-box rRNA Helicase, DbpA

(2008) Arnon Henn et al.   JOURNAL OF MOLECULAR BIOLOGY

Translational Control by a Small RNA: Dendritic BC1 RNA Targets the Eukaryotic Initiation Factor 4A Helicase Mechanism

(2008) D. Lin et al.   MOLECULAR AND CELLULAR BIOLOGY

Human DDX3 functions in translation and interacts with the translation initiation factor eIF3

(2008) C.-S. Lee et al.   NUCLEIC ACIDS RESEARCH

Selective Pharmacological Targeting of a DEAD Box RNA Helicase

(2008) Lisa Lindqvist et al.   PLoS One

A Translation Initiation Element Specific to mRNAs with Very Short 5′UTR that Also Regulates Transcription

(2008) Rofa Elfakess et al.   PLoS One

Cooperative binding of ATP and RNA induces a closed conformation in a DEAD box RNA helicase

(2008) B. Theissen et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

ATP hydrolysis is required for DEAD-box protein recycling but not for duplex unwinding

(2008) F. Liu et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

The DEAD-Box RNA Helicase Ded1p Affects and Accumulates in Saccharomyces cerevisiae P-Bodies

(2007) Carla Beckham et al.   MOLECULAR BIOLOGY OF THE CELL