Genome-wide mRNA profiling identifies X-box-binding protein 1 (XBP1) as an IRE1 and PUMA repressor

Triazoloacridone C-1305 impairs XBP1 splicing by acting as a potential IRE1α endoribonuclease inhibitor

(2021) Sylwia Bartoszewska et al.   CELLULAR & MOLECULAR BIOLOGY LETTERS

mTORC1 coordinates an immediate unfolded protein response-related transcriptome in activated B cells preceding antibody secretion

(2020) Brian T. Gaudette et al.   Nature Communications

IRE1 Endoribonuclease Activity Modulates Hypoxic HIF-1α Signaling in Human Endothelial Cells

(2020) Adrianna Moszyńska et al.   Biomolecules

Systematic interrogation of human promoters

(2019) Shira Weingarten-Gabbay et al.   GENOME RESEARCH

Pan-Cancer Analyses Reveal Genomic Features of FOXM1 Overexpression in Cancer

(2019) Carter Barger et al.   Cancers

miR-34c-5p modulates X-box–binding protein 1 (XBP1) expression during the adaptive phase of the unfolded protein response

(2019) Sylwia Bartoszewska et al.   FASEB JOURNAL

Key genes associated with diabetes mellitus and hepatocellular carcinoma

(2019) Gao-Min Liu et al.   PATHOLOGY RESEARCH AND PRACTICE

Caspase-mediated cleavage of IRE1 controls apoptotic cell commitment during endoplasmic reticulum stress

(2019) Anna Shemorry et al.   eLife

Genome‐wide mRNA profiling identifies RCAN1 and GADD45A as regulators of the transitional switch from survival to apoptosis during ER stress

(2019) Rafal Bartoszewski et al.   FEBS Journal

Phosphorylation of IRE1 at S729 regulates RIDD in B cells and antibody production after immunization

(2018) Chih-Hang Anthony Tang et al.   JOURNAL OF CELL BIOLOGY

Coordination between Two Branches of the Unfolded Protein Response Determines Apoptotic Cell Fate

(2018) Tsun-Kai Chang et al.   MOLECULAR CELL

ER stress signaling has an activating transcription factor 6α (ATF6)-dependent “off-switch”

(2018) Franziska Walter et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

PIWI proteins contribute to apoptosis during the UPR in human airway epithelial cells

(2018) Magdalena Gebert et al.   Scientific Reports

The unfolded protein response and endoplasmic reticulum protein targeting machineries converge on the stress sensor IRE1

(2018) Diego Acosta-Alvear et al.   eLife

Induction of early growth response gene 1 (EGR1) by endoplasmic reticulum stress is mediated by the extracellular regulated kinase (ERK) arm of the MAPK pathways

(2018) Jixiu Shan et al.   BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR CELL RESEARCH

miR-200b downregulates Kruppel Like Factor 2 (KLF2) during acute hypoxia in human endothelial cells

(2017) Rafal Bartoszewski et al.   EUROPEAN JOURNAL OF CELL BIOLOGY

The effects of care bundles on patient outcomes: a systematic review and meta-analysis

(2017) Jacqueline F. Lavallée et al.   Implementation Science

Ensembl 2018

(2017) Daniel R Zerbino et al.   NUCLEIC ACIDS RESEARCH

Enrichr: a comprehensive gene set enrichment analysis web server 2016 update

(2016) Maxim V. Kuleshov et al.   NUCLEIC ACIDS RESEARCH

Divergence and Conservation of the Major UPR Branch IRE1-bZIP Signaling Pathway across Eukaryotes

(2016) Lingrui Zhang et al.   Scientific Reports

Novel mechanism of enhancing IRE1α-XBP1 signalling via the PERK-ATF4 pathway

(2016) Akio Tsuru et al.   Scientific Reports

InteractiVenn: a web-based tool for the analysis of sets through Venn diagrams

(2015) Henry Heberle et al.   BMC BIOINFORMATICS

The unfolded protein response is shaped by the NMD pathway

(2015) R. Karam et al.   EMBO REPORTS

Cell death induced by endoplasmic reticulum stress

(2015) Raffaella Iurlaro et al.   FEBS Journal

Proteostasis control by the unfolded protein response

(2015) Claudio Hetz et al.   NATURE CELL BIOLOGY

Opposing unfolded-protein-response signals converge on death receptor 5 to control apoptosis

(2014) M. Lu et al.   SCIENCE

The proapoptotic BH3-only proteins Bim and Puma are downstream of endoplasmic reticulum and mitochondrial oxidative stress in pancreatic islets in response to glucotoxicity

(2014) J A Wali et al.   Cell Death & Disease

When ER stress reaches a dead end

(2013) Hery Urra et al.   BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR CELL RESEARCH

ER stress-induced cell death mechanisms

(2013) Renata Sano et al.   BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR CELL RESEARCH

Identification of a Novel Endoplasmic Reticulum Stress Response Element Regulated by XBP1

(2013) Michael Misiewicz et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

IRE1: ER stress sensor and cell fate executor

(2013) Yani Chen et al.   TRENDS IN CELL BIOLOGY

Nencki Genomics Database—Ensembl funcgen enhanced with intersections, user data and genome-wide TFBS motifs

(2013) Izabella Krystkowiak et al.   Database-The Journal of Biological Databases and Curation

Generation of Stable Human Cell Lines with Tetracycline-inducible (Tet-on) shRNA or cDNA Expression

(2013) Marta Gomez-Martinez et al.   Jove-Journal of Visualized Experiments

STAR: ultrafast universal RNA-seq aligner

(2012) Alexander Dobin et al.   BIOINFORMATICS

PERK is required at the ER-mitochondrial contact sites to convey apoptosis after ROS-based ER stress

(2012) T Verfaillie et al.   CELL DEATH AND DIFFERENTIATION

NOXA contributes to the sensitivity of PERK-deficient cells to ER stress

(2012) Sanjeev Gupta et al.   FEBS LETTERS

DUSP6 is a novel transcriptional target of p53 and regulates p53-mediated apoptosis by modulating expression levels of Bcl-2 family proteins

(2012) Sujan Piya et al.   FEBS LETTERS

The impact of the unfolded protein response on human disease

(2012) Shiyu Wang et al.   JOURNAL OF CELL BIOLOGY

A Novel Feedback Loop Regulates the Response to Endoplasmic Reticulum Stress via the Cooperation of Cytoplasmic Splicing and mRNA Translation

(2012) M. Majumder et al.   MOLECULAR AND CELLULAR BIOLOGY

An integrated encyclopedia of DNA elements in the human genome

(2012)   NATURE

The unfolded protein response: controlling cell fate decisions under ER stress and beyond

(2012) Claudio Hetz   NATURE REVIEWS MOLECULAR CELL BIOLOGY

The molecular basis for selective inhibition of unconventional mRNA splicing by an IRE1-binding small molecule

(2012) B. C. S. Cross et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Intricately Regulated: A Cellular Toolbox for Fine-Tuning XBP1 Expression and Activity

(2012) Andrew Byrd et al.   Cells

Genetically defining the mechanism of Puma- and Bim-induced apoptosis

(2011) S P Garrison et al.   CELL DEATH AND DIFFERENTIATION

p38 MAPK–mediated regulation of Xbp1s is crucial for glucose homeostasis

(2011) Jaemin Lee et al.   NATURE MEDICINE

Translational Pausing Ensures Membrane Targeting and Cytoplasmic Splicing of XBP1u mRNA

(2011) K. Yanagitani et al.   SCIENCE

SUMO modification regulates the transcriptional activity of XBP1

(2010) Hui Chen et al.   BIOCHEMICAL JOURNAL

Regulation of unfolded protein response modulator XBP1s by acetylation and deacetylation

(2010) Feng-Ming Wang et al.   BIOCHEMICAL JOURNAL

Signaling cell death from the endoplasmic reticulum stress response

(2010) Gordon C Shore et al.   CURRENT OPINION IN CELL BIOLOGY

Emerging Roles for XBP1, a sUPeR Transcription Factor

(2010) YIN HE et al.   GENE EXPRESSION

p53 Up-regulated Modulator of Apoptosis (PUMA) Activation Contributes to Pancreatic β-Cell Apoptosis Induced by Proinflammatory Cytokines and Endoplasmic Reticulum Stress

(2010) Esteban N. Gurzov et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Transcript assembly and quantification by RNA-Seq reveals unannotated transcripts and isoform switching during cell differentiation

(2010) Cole Trapnell et al.   NATURE BIOTECHNOLOGY

Identification of a consensus element recognized and cleaved by IRE1α

(2010) Daisuke Oikawa et al.   NUCLEIC ACIDS RESEARCH

Caspase-7: A protease involved in apoptosis and inflammation

(2009) Mohamed Lamkanfi et al.   INTERNATIONAL JOURNAL OF BIOCHEMISTRY & CELL BIOLOGY

Unconventional splicing of XBP1 mRNA occurs in the cytoplasm during the mammalian unfolded protein response

(2009) A. Uemura et al.   JOURNAL OF CELL SCIENCE

BH3-only proteins and their roles in programmed cell death

(2009) M Giam et al.   ONCOGENE

Puma indirectly activates Bax to cause apoptosis in the absence of Bid or Bim

(2008) A M Jabbour et al.   CELL DEATH AND DIFFERENTIATION

The unfolded protein response regulator GRP78/BiP is required for endoplasmic reticulum integrity and stress-induced autophagy in mammalian cells

(2008) J Li et al.   CELL DEATH AND DIFFERENTIATION

The Mechanism of Cystic Fibrosis Transmembrane Conductance Regulator Transcriptional Repression during the Unfolded Protein Response

(2008) Rafal Bartoszewski et al.   JOURNAL OF BIOLOGICAL CHEMISTRY