Intricately Regulated: A Cellular Toolbox for Fine-Tuning XBP1 Expression and Activity

MicroRNA-30c-2* limits expression of proadaptive factor XBP1 in the unfolded protein response

(2012) Andrew E. Byrd et al.   JOURNAL OF CELL BIOLOGY

A Novel Feedback Loop Regulates the Response to Endoplasmic Reticulum Stress via the Cooperation of Cytoplasmic Splicing and mRNA Translation

(2012) M. Majumder et al.   MOLECULAR AND CELLULAR BIOLOGY

ER Stress Negatively Modulates the Expression of the miR-199a/214 Cluster to Regulates Tumor Survival and Progression in Human Hepatocellular Cancer

(2012) Quanlu Duan et al.   PLoS One

The Unfolded Protein Response (UPR)-activated Transcription Factor X-box-binding Protein 1 (XBP1) Induces MicroRNA-346 Expression That Targets the Human Antigen Peptide Transporter 1 (TAP1) mRNA and Governs Immune Regulatory Genes

(2011) Rafal Bartoszewski et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

A CHOP-regulated microRNA controls rhodopsin expression

(2011) Shannon Behrman et al.   JOURNAL OF CELL BIOLOGY

Integrating the mechanisms of apoptosis induced by endoplasmic reticulum stress

(2011) Ira Tabas et al.   NATURE CELL BIOLOGY

p38 MAPK–mediated regulation of Xbp1s is crucial for glucose homeostasis

(2011) Jaemin Lee et al.   NATURE MEDICINE

Regulation of glucose homeostasis through a XBP-1–FoxO1 interaction

(2011) Yingjiang Zhou et al.   NATURE MEDICINE

Dual and opposing roles of the unfolded protein response regulated by IRE1  and XBP1 in proinsulin processing and insulin secretion

(2011) A.-H. Lee et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Translational Pausing Ensures Membrane Targeting and Cytoplasmic Splicing of XBP1u mRNA

(2011) K. Yanagitani et al.   SCIENCE

The Unfolded Protein Response: From Stress Pathway to Homeostatic Regulation

(2011) P. Walter et al.   SCIENCE

SUMO modification regulates the transcriptional activity of XBP1

(2010) Hui Chen et al.   BIOCHEMICAL JOURNAL

Regulation of unfolded protein response modulator XBP1s by acetylation and deacetylation

(2010) Feng-Ming Wang et al.   BIOCHEMICAL JOURNAL

Endoplasmic Reticulum Stress and the Inflammatory Basis of Metabolic Disease

(2010) Gökhan S. Hotamisligil   CELL

TLR activation of the transcription factor XBP1 regulates innate immune responses in macrophages

(2010) Fabio Martinon et al.   NATURE IMMUNOLOGY

A regulatory subunit of phosphoinositide 3-kinase increases the nuclear accumulation of X-box–binding protein-1 to modulate the unfolded protein response

(2010) Jonathon N Winnay et al.   NATURE MEDICINE

The regulatory subunits of PI3K, p85α and p85β, interact with XBP-1 and increase its nuclear translocation

(2010) Sang Won Park et al.   NATURE MEDICINE

XBP1: the last two decades

(2009) L H Glimcher   ANNALS OF THE RHEUMATIC DISEASES

MicroRNAs: Target Recognition and Regulatory Functions

(2009) David P. Bartel   CELL

pXBP1(U), a Negative Regulator of the Unfolded Protein Response Activator pXBP1(S), Targets ATF6 but not ATF4 in Proteasome-mediated Degradation

(2009) Hiderou Yoshida et al.   CELL STRUCTURE AND FUNCTION

Direct proteasome binding and subsequent degradation of unspliced XBP-1 prevent its intracellular aggregation

(2009) Ami Navon et al.   FEBS LETTERS

Unconventional splicing of XBP1 mRNA occurs in the cytoplasm during the mammalian unfolded protein response

(2009) A. Uemura et al.   JOURNAL OF CELL SCIENCE

Cotranslational Targeting of XBP1 Protein to the Membrane Promotes Cytoplasmic Splicing of Its Own mRNA

(2009) Kota Yanagitani et al.   MOLECULAR CELL

XBP1 Links ER Stress to Intestinal Inflammation and Confers Genetic Risk for Human Inflammatory Bowel Disease

(2008) Arthur Kaser et al.   CELL

ATF6 Is a Transcription Factor Specializing in the Regulation of Quality Control Proteins in the Endoplasmic Reticulum

(2008) Yusuke Adachi et al.   CELL STRUCTURE AND FUNCTION

The role of FoxO in the regulation of metabolism

(2008) D N Gross et al.   ONCOGENE

Regulation of Hepatic Lipogenesis by the Transcription Factor XBP1

(2008) A.-H. Lee et al.   SCIENCE