Triazoloacridone C-1305 impairs XBP1 splicing by acting as a potential IRE1α endoribonuclease inhibitor

Clinicopathological significance of endoplasmic reticulum stress proteins in ovarian carcinoma

(2020) Soma Samanta et al.   Scientific Reports

Unfolded protein response (UPR) integrated signaling networks determine cell fate during hypoxia

(2020) Sylwia Bartoszewska et al.   CELLULAR & MOLECULAR BIOLOGY LETTERS

The UPR sensor IRE1α and the adenovirus E3-19K glycoprotein sustain persistent and lytic infections

(2020) Vibhu Prasad et al.   Nature Communications

EDock: blind protein–ligand docking by replica-exchange monte carlo simulation

(2020) Wenyi Zhang et al.   Journal of Cheminformatics

Utilizing Genome-Wide mRNA Profiling to Identify the Cytotoxic Chemotherapeutic Mechanism of Triazoloacridone C-1305 as Direct Microtubule Stabilization

(2020) Jarosław Króliczewski et al.   Cancers

The emerging role of XBP1 in cancer

(2020) Shanshan Chen et al.   BIOMEDICINE & PHARMACOTHERAPY

IRE1 Endoribonuclease Activity Modulates Hypoxic HIF-1α Signaling in Human Endothelial Cells

(2020) Adrianna Moszyńska et al.   Biomolecules

The Effects of Single Nucleotide Polymorphisms in Cancer RNAi Therapies

(2020) Magdalena Gebert et al.   Cancers

Activation of the IRE1 RNase through remodeling of the kinase front pocket by ATP-competitive ligands

(2020) Elena Ferri et al.   Nature Communications

The Unfolded Protein Response: Detecting and Responding to Fluctuations in the Protein-Folding Capacity of the Endoplasmic Reticulum

(2019) G. Elif Karagöz et al.   Cold Spring Harbor Perspectives in Biology

Modulation of the sigma-1 receptor–IRE1 pathway is beneficial in preclinical models of inflammation and sepsis

(2019) Dorian A. Rosen et al.   Science Translational Medicine

miR-34c-5p modulates X-box–binding protein 1 (XBP1) expression during the adaptive phase of the unfolded protein response

(2019) Sylwia Bartoszewska et al.   FASEB JOURNAL

Caspase-mediated cleavage of IRE1 controls apoptotic cell commitment during endoplasmic reticulum stress

(2019) Anna Shemorry et al.   eLife

eIF2α-CHOP-BCl-2/JNK and IRE1α-XBP1/JNK signaling promote apoptosis and inflammation and support the proliferation of Newcastle disease virus

(2019) Yanrong Li et al.   Cell Death & Disease

Genome‐wide mRNA profiling identifies RCAN1 and GADD45A as regulators of the transitional switch from survival to apoptosis during ER stress

(2019) Rafal Bartoszewski et al.   FEBS Journal

Pharmacological targeting of MYC-regulated IRE1/XBP1 pathway suppresses MYC-driven breast cancer

(2018) Na Zhao et al.   JOURNAL OF CLINICAL INVESTIGATION

Transmembrane E3 ligase RNF183 mediates ER stress-induced apoptosis by degrading Bcl-xL

(2018) Yanfang Wu et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Coordination between Two Branches of the Unfolded Protein Response Determines Apoptotic Cell Fate

(2018) Tsun-Kai Chang et al.   MOLECULAR CELL

Inhibition of IRE1 RNase activity modulates the tumor cell secretome and enhances response to chemotherapy

(2018) Susan E. Logue et al.   Nature Communications

The Unfolded Protein Response in Breast Cancer

(2018) Eoghan McGrath et al.   Cancers

The role of the unfolded protein response in cancer progression: From oncogenesis to chemoresistance

(2018) Emma Madden et al.   BIOLOGY OF THE CELL

miR-200b downregulates Kruppel Like Factor 2 (KLF2) during acute hypoxia in human endothelial cells

(2017) Rafal Bartoszewski et al.   EUROPEAN JOURNAL OF CELL BIOLOGY

Acridine Derivatives as Inhibitors of the IRE1 -XBP1 Pathway Are Cytotoxic to Human Multiple Myeloma

(2016) D. Jiang et al.   MOLECULAR CANCER THERAPEUTICS

Enrichr: a comprehensive gene set enrichment analysis web server 2016 update

(2016) Maxim V. Kuleshov et al.   NUCLEIC ACIDS RESEARCH

Endoplasmic reticulum stress and IRE-1 signaling cause apoptosis in colon cancer cells in response to andrographolide treatment

(2016) Aditi Banerjee et al.   Oncotarget

Cell death induced by endoplasmic reticulum stress

(2015) Raffaella Iurlaro et al.   FEBS Journal

Heteroclitic XBP1 peptides evoke tumor-specific memory cytotoxic T lymphocytes against breast cancer, colon cancer, and pancreatic cancer cells

(2015) Jooeun Bae et al.   OncoImmunology

HTSeq--a Python framework to work with high-throughput sequencing data

(2014) S. Anders et al.   BIOINFORMATICS

ER stress-induced cell death mechanisms

(2013) Renata Sano et al.   BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR CELL RESEARCH

p58IPK-Mediated Attenuation of the Proapoptotic PERK-CHOP Pathway Allows Malignant Progression upon Low Glucose

(2013) Anne-Laure Huber et al.   MOLECULAR CELL

IRE1: ER stress sensor and cell fate executor

(2013) Yani Chen et al.   TRENDS IN CELL BIOLOGY

MicroRNA-30c-2* limits expression of proadaptive factor XBP1 in the unfolded protein response

(2012) Andrew E. Byrd et al.   JOURNAL OF CELL BIOLOGY

The molecular basis for selective inhibition of unconventional mRNA splicing by an IRE1-binding small molecule

(2012) B. C. S. Cross et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Avogadro: an advanced semantic chemical editor, visualization, and analysis platform

(2012) Marcus D Hanwell et al.   Journal of Cheminformatics

The Unfolded Protein Response (UPR)-activated Transcription Factor X-box-binding Protein 1 (XBP1) Induces MicroRNA-346 Expression That Targets the Human Antigen Peptide Transporter 1 (TAP1) mRNA and Governs Immune Regulatory Genes

(2011) Rafal Bartoszewski et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Increased cytotoxicity of an unusual DNA topoisomerase II inhibitor compound C-1305 toward HeLa cells with downregulated PARP-1 activity results from re-activation of the p53 pathway and modulation of mitotic checkpoints

(2010) Michal Sabisz et al.   BIOCHEMICAL PHARMACOLOGY

Transcript assembly and quantification by RNA-Seq reveals unannotated transcripts and isoform switching during cell differentiation

(2010) Cole Trapnell et al.   NATURE BIOTECHNOLOGY

Unconventional splicing of XBP1 mRNA occurs in the cytoplasm during the mammalian unfolded protein response

(2009) A. Uemura et al.   JOURNAL OF CELL SCIENCE

The unfolded protein response regulator GRP78/BiP is required for endoplasmic reticulum integrity and stress-induced autophagy in mammalian cells

(2008) J Li et al.   CELL DEATH AND DIFFERENTIATION

Expression and splicing of the unfolded protein response gene XBP-1 are significantly associated with clinical outcome of endocrine-treated breast cancer

(2008) Michael P.A. Davies et al.   INTERNATIONAL JOURNAL OF CANCER