Transcriptional modification of host cells harboring Toxoplasma gondii bradyzoites prevents IFN gamma-mediated cell death

Seizing control: how dense granule effector proteins enable Toxoplasma to take charge

(2021) Michael W. Panas et al.   MOLECULAR MICROBIOLOGY

A Protective and Pathogenic Role for Complement During Acute Toxoplasma gondii Infection

(2021) Patricia M. Sikorski et al.   Frontiers in Cellular and Infection Microbiology

Toxoplasma gondii secreted effectors co-opt host repressor complexes to inhibit necroptosis

(2021) Alex Rosenberg et al.   Cell Host & Microbe

In Vitro Characterization of Protein Effector Export in the Bradyzoite Stage of Toxoplasma gondii

(2020) Joshua Mayoral et al.   mBio

Flexible Usage and Interconnectivity of Diverse Cell Death Pathways Protect against Intracellular Infection

(2020) Marcel Doerflinger et al.   IMMUNITY

Differential Impacts on Host Transcription by ROP and GRA Effectors from the Intracellular Parasite Toxoplasma gondii

(2020) Suchita Rastogi et al.   mBio

Toxoplasma Uses GRA16 To Upregulate Host c-Myc

(2020) Michael W. Panas et al.   mSphere

Emerging connectivity of programmed cell death pathways and its physiological implications

(2020) Sammy Bedoui et al.   NATURE REVIEWS MOLECULAR CELL BIOLOGY

PKR: A Kinase to Remember

(2019) Shunit Gal-Ben-Ari et al.   Frontiers in Molecular Neuroscience

The Toxoplasma effector TEEGR promotes parasite persistence by modulating NF-κB signalling via EZH2

(2019) Laurence Braun et al.   Nature Microbiology

Translocation of Dense Granule Effectors across the Parasitophorous Vacuole Membrane in Toxoplasma-Infected Cells Requires the Activity of ROP17, a Rhoptry Protein Kinase

(2019) Michael W. Panas et al.   mSphere

Toxoplasma gondii effector TgIST blocks type I interferon signaling to promote infection

(2019) Sumit K. Matta et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

In Vivo CRISPR Screen Identifies TgWIP as a Toxoplasma Modulator of Dendritic Cell Migration

(2019) Lamba Omar Sangaré et al.   Cell Host & Microbe

Fiery Cell Death: Pyroptosis in the Central Nervous System

(2019) Brienne A. McKenzie et al.   TRENDS IN NEUROSCIENCES

Identification of a novel protein complex essential for effector translocation across the parasitophorous vacuole membrane of Toxoplasma gondii

(2018) Nicole D. Marino et al.   PLoS Pathogens

Toxoplasmosis: A pathway to neuropsychiatric disorders

(2018) Shiraz Tyebji et al.   NEUROSCIENCE AND BIOBEHAVIORAL REVIEWS

Aspartyl Protease 5 Matures Dense Granule Proteins That Reside at the Host-Parasite Interface in Toxoplasma gondii

(2018) Michael J. Coffey et al.   mBio

Characterization of a Toxoplasma effector uncovers an alternative GSK3/β-catenin-regulatory pathway of inflammation

(2018) Huan He et al.   eLife

Toxoplasma Does Not Secrete the GRA16 and GRA24 Effectors Beyond the Parasitophorous Vacuole Membrane of Tissue Cysts

(2018) Shruthi Krishnamurthy et al.   Frontiers in Cellular and Infection Microbiology

A forward genetic screen identifies a negative regulator of rapid Ca2+-dependent cell egress (MS1) in the intracellular parasiteToxoplasma gondii

(2017) James M. McCoy et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Robust hyperparameter estimation protects against hypervariable genes and improves power to detect differential expression

(2016) Belinda Phipson et al.   Annals of Applied Statistics

Cerebral complement C1q activation in chronic Toxoplasma infection

(2016) Jianchun Xiao et al.   BRAIN BEHAVIOR AND IMMUNITY

Toxoplasma Effector Recruits the Mi-2/NuRD Complex to Repress STAT1 Transcription and Block IFN-γ-Dependent Gene Expression

(2016) Philipp Olias et al.   Cell Host & Microbe

Role of the ER and Golgi in protein export by Apicomplexa

(2016) Michael J Coffey et al.   CURRENT OPINION IN CELL BIOLOGY

Analysis of Noncanonical Calcium-Dependent Protein Kinases in Toxoplasma gondii by Targeted Gene Deletion Using CRISPR/Cas9

(2016) Shaojun Long et al.   INFECTION AND IMMUNITY

Toxoplasma gondiiTgIST co-opts host chromatin repressors dampening STAT1-dependent gene regulation and IFN-γ–mediated host defenses

(2016) Gabrielle Gay et al.   JOURNAL OF EXPERIMENTAL MEDICINE

A Novel Secreted Protein, MYR1, Is Central to Toxoplasma ’s Manipulation of Host Cells

(2016) Magdalena Franco et al.   mBio

In Vivo Biotinylation of the Toxoplasma Parasitophorous Vacuole Reveals Novel Dense Granule Proteins Important for Parasite Growth and Pathogenesis

(2016) Santhosh M. Nadipuram et al.   mBio

Identification of Potent Phosphodiesterase Inhibitors that Demonstrate Cyclic Nucleotide-Dependent Functions in Apicomplexan Parasites

(2015) Brittany L. Howard et al.   ACS Chemical Biology

The aspartyl protease TgASP5 mediates the export of theToxoplasmaGRA16 and GRA24 effectors into host cells

(2015) Aurélie Curt-Varesano et al.   CELLULAR MICROBIOLOGY

limma powers differential expression analyses for RNA-sequencing and microarray studies

(2015) Matthew E. Ritchie et al.   NUCLEIC ACIDS RESEARCH

Fundamental Roles of the Golgi-Associated Toxoplasma Aspartyl Protease, ASP5, at the Host-Parasite Interface

(2015) Pierre-Mehdi Hammoudi et al.   PLoS Pathogens

An aspartyl protease defines a novel pathway for export of Toxoplasma proteins into the host cell

(2015) Michael J Coffey et al.   eLife

The Molecular Signatures Database Hallmark Gene Set Collection

(2015) Arthur Liberzon et al.   Cell Systems

The Toxoplasma Pseudokinase ROP5 Forms Complexes with ROP18 and ROP17 Kinases that Synergize to Control Acute Virulence in Mice

(2014) Ronald D. Etheridge et al.   Cell Host & Microbe

Internalization and TLR-dependent type I interferon production by monocytes in response to Toxoplasma gondii

(2014) Seong-Ji Han et al.   IMMUNOLOGY AND CELL BIOLOGY

Selective and strain-specific NFAT4 activation by theToxoplasma gondiipolymorphic dense granule protein GRA6

(2014) Ji Su Ma et al.   JOURNAL OF EXPERIMENTAL MEDICINE

Efficient Genome Engineering of Toxoplasma gondii Using CRISPR/Cas9

(2014) Saima M. Sidik et al.   PLoS One

Efficient Gene Disruption in Diverse Strains of Toxoplasma gondii Using CRISPR/CAS9

(2014) B. Shen et al.   mBio

Toxoplasma Effector MAF1 Mediates Recruitment of Host Mitochondria and Impacts the Host Response

(2014) Lena Pernas et al.   PLOS BIOLOGY

featureCounts: an efficient general purpose program for assigning sequence reads to genomic features

(2013) Y. Liao et al.   BIOINFORMATICS

Host Cell Subversion by Toxoplasma GRA16, an Exported Dense Granule Protein that Targets the Host Cell Nucleus and Alters Gene Expression

(2013) Alexandre Bougdour et al.   Cell Host & Microbe

Toxoplasma gondii Inhibits Gamma Interferon (IFN-γ)- and IFN-β-Induced Host Cell STAT1 Transcriptional Activity by Increasing the Association of STAT1 with DNA

(2013) Emily E. Rosowski et al.   INFECTION AND IMMUNITY

AToxoplasmadense granule protein, GRA24, modulates the early immune response to infection by promoting a direct and sustained host p38 MAPK activation

(2013) Laurence Braun et al.   JOURNAL OF EXPERIMENTAL MEDICINE

The Subread aligner: fast, accurate and scalable read mapping by seed-and-vote

(2013) Yang Liao et al.   NUCLEIC ACIDS RESEARCH

Toxoplasma gondii Clonal Strains All Inhibit STAT1 Transcriptional Activity but Polymorphic Effectors Differentially Modulate IFNγ Induced Gene Expression and STAT1 Phosphorylation

(2012) Emily E. Rosowski et al.   PLoS One

Type II Toxoplasma gondii KU80 Knockout Strains Enable Functional Analysis of Genes Required for Cyst Development and Latent Infection

(2011) Barbara A. Fox et al.   EUKARYOTIC CELL

Strain-specific activation of the NF-κB pathway by GRA15, a novelToxoplasma gondiidense granule protein

(2011) Emily E. Rosowski et al.   JOURNAL OF EXPERIMENTAL MEDICINE

An aspartyl protease directs malaria effector proteins to the host cell

(2010) Justin A. Boddey et al.   NATURE

Plasmepsin V licenses Plasmodium proteins for export into the host erythrocyte

(2010) Ilaria Russo et al.   NATURE

Toxoplasma secreting Cre recombinase for analysis of host-parasite interactions

(2010) Anita A Koshy et al.   NATURE METHODS

A scaling normalization method for differential expression analysis of RNA-seq data

(2010) Mark D Robinson et al.   GENOME BIOLOGY

Testing significance relative to a fold-change threshold is a TREAT

(2009) D. J. McCarthy et al.   BIOINFORMATICS

edgeR: a Bioconductor package for differential expression analysis of digital gene expression data

(2009) M. D. Robinson et al.   BIOINFORMATICS

A single polymorphic amino acid onToxoplasma gondiikinase ROP16 determines the direct and strain-specific activation of Stat3

(2009) Masahiro Yamamoto et al.   JOURNAL OF EXPERIMENTAL MEDICINE