Gut microbiota-derived short-chain fatty acids and colorectal cancer: Ready for clinical translation?

Cancer Statistics, 2021

(2021) Rebecca L. Siegel et al.   CA-A CANCER JOURNAL FOR CLINICIANS

In vitro evaluation of anti‐cancer effects of different probiotic strains on HCT‐116 cell line

(2021) Vengala Rao Yenuganti et al.   JOURNAL OF APPLIED MICROBIOLOGY

Role of Diet in Colorectal Cancer Incidence

(2021) Sajesh K. Veettil et al.   JAMA Network Open

Gut microbial metabolites facilitate anticancer therapy efficacy by modulating cytotoxic CD8+ T cell immunity

(2021) Yao He et al.   Cell Metabolism

Metformin Affects Gut Microbiome Composition and Function and Circulating Short-Chain Fatty Acids: A Randomized Trial

(2021) Noel T. Mueller et al.   DIABETES CARE

805 SOLUBLE FIBER BUT NOT INSOLUBLE FIBER PROMOTES COLORECTAL TUMORIGENESIS THROUGH MODULATING GUT MICROBIOTA AND METABOLITES IN MICE

(2021) Jia Yang et al.   GASTROENTEROLOGY

A Phase I Study of an IDO-1 Inhibitor (LY3381916) as Monotherapy and in Combination With an Anti-PD-L1 Antibody (LY3300054) in Patients With Advanced Cancer

(2021) Nuria Kotecki et al.   JOURNAL OF IMMUNOTHERAPY

Fecal Microbiome Transplantation from Children with Autism Spectrum Disorder Modulates Tryptophan and Serotonergic Synapse Metabolism and Induces Altered Behaviors in Germ-Free Mice

(2021) Lu Xiao et al.   mSystems

Gut Microbiota–Derived Short-Chain Fatty Acids Promote Prostate Cancer Growth via IGF1 Signaling

(2021) Makoto Matsushita et al.   CANCER RESEARCH

Acetate differentially regulates IgA reactivity to commensal bacteria

(2021) Tadashi Takeuchi et al.   NATURE

Dietary fiber‐derived short‐chain fatty acids: A potential therapeutic target to alleviate obesity‐related nonalcoholic fatty liver disease

(2021) Shumin Zhang et al.   Obesity Reviews

Gut microbiota-derived short-chain fatty acids regulate IL-17 production by mouse and human intestinal γδ T cells

(2021) Louise Dupraz et al.   Cell Reports

A. Muciniphila Suppresses Colorectal Tumorigenesis by Inducing TLR2/NLRP3-Mediated M1-Like TAMs

(2021) Lina Fan et al.   Cancer Immunology Research

Gut microbiome variation modulates the effects of dietary fiber on host metabolism

(2021) Sofia M. Murga-Garrido et al.   Microbiome

Precision Microbiome Modulation with Discrete Dietary Fiber Structures Directs Short-Chain Fatty Acid Production

(2020) Edward C. Deehan et al.   Cell Host & Microbe

Expression of Free Fatty Acid Receptor 2 by Dendritic Cells Prevents Their Expression of Interleukin 27 and Is Required for Maintenance of Mucosal Barrier and Immune Response Against Colorectal Tumors in Mice

(2020) Sydney Lavoie et al.   GASTROENTEROLOGY

Discovery of the gut microbial signature driving the efficacy of prebiotic intervention in obese patients

(2020) Julie Rodriguez et al.   GUT

Fecal Microbiota Transplantation Prevents Intestinal Injury, Upregulation of Toll-Like Receptors, and 5-Fluorouracil/Oxaliplatin-Induced Toxicity in Colorectal Cancer

(2020) Ching-Wei Chang et al.   INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

Gut metabolomics profiling of non-small cell lung cancer (NSCLC) patients under immunotherapy treatment

(2020) Andrea Botticelli et al.   Journal of Translational Medicine

The complex relationship between drugs and the microbiome

(2020) Neil Savage   NATURE

Improving Risk–Benefit in Faecal Transplantation through Microbiome Screening

(2020) Lito E. Papanicolas et al.   TRENDS IN MICROBIOLOGY

B cell-intrinsic epigenetic modulation of antibody responses by dietary fiber-derived short-chain fatty acids

(2020) Helia N. Sanchez et al.   Nature Communications

Endogenous murine microbiota member Faecalibaculum rodentium and its human homologue protect from intestinal tumour growth

(2020) Elena Zagato et al.   Nature Microbiology

Immune Responses Raised in an Experimental Colon Carcinoma Model Following Oral Administration of Lactobacillus casei

(2020) Georgios Aindelis et al.   Cancers

Sodium butyrate modulates gut microbiota and immune response in colorectal cancer liver metastatic mice

(2020) Ximei Ma et al.   CELL BIOLOGY AND TOXICOLOGY

Microbiota-Derived Metabolites Suppress Arthritis by Amplifying Aryl-Hydrocarbon Receptor Activation in Regulatory B Cells

(2020) Elizabeth C. Rosser et al.   Cell Metabolism

Diet and sedentary behaviour in relation to cancer survival. A report from the national health and nutrition examination survey linked to the U.S. mortality registry

(2020) Cristian Ricci et al.   CLINICAL NUTRITION

Estimation of Absolute Risk of Colorectal Cancer Based on Healthy Lifestyle, Genetic Risk, and Colonoscopy Status in a Population-Based Study

(2020) Prudence R. Carr et al.   GASTROENTEROLOGY

Systemic short chain fatty acids limit antitumor effect of CTLA-4 blockade in hosts with cancer

(2020) Clélia Coutzac et al.   Nature Communications

Berberine and its structural analogs have differing effects on functional profiles of individual gut microbiomes

(2020) Leyuan Li et al.   Gut Microbes

Cancer-protective effect of a synbiotic combination between Lactobacillus gasseri 505 and a Cudrania tricuspidata leaf extract on colitis-associated colorectal cancer

(2020) Nam Su Oh et al.   Gut Microbes

Gut microbial metabolites alter IgA immunity in type 1 diabetes

(2020) Juan Huang et al.   JCI Insight

Association of Short-Chain Fatty Acids in the Gut Microbiome With Clinical Response to Treatment With Nivolumab or Pembrolizumab in Patients With Solid Cancer Tumors

(2020) Motoo Nomura et al.   JAMA Network Open

Streptococcus thermophilus inhibits colorectal tumorigenesis through secreting β-galactosidase

(2020) Qing Li et al.   GASTROENTEROLOGY

The International Scientific Association for Probiotics and Prebiotics (ISAPP) consensus statement on the definition and scope of synbiotics

(2020) Kelly S. Swanson et al.   Nature Reviews Gastroenterology & Hepatology

Intestinal microbiota-derived short-chain fatty acids regulation of immune cell IL-22 production and gut immunity

(2020) Wenjing Yang et al.   Nature Communications

Importance of probiotics in the prevention and treatment of colorectal cancer

(2019) Majid Eslami et al.   JOURNAL OF CELLULAR PHYSIOLOGY

Editing of the gut microbiota reduces carcinogenesis in mouse models of colitis-associated colorectal cancer

(2019) Wenhan Zhu et al.   JOURNAL OF EXPERIMENTAL MEDICINE

Metagenomic and metabolomic analyses reveal distinct stage-specific phenotypes of the gut microbiota in colorectal cancer

(2019) Shinichi Yachida et al.   NATURE MEDICINE

A Derivative of Butyric Acid, the Fermentation Metabolite of Staphylococcus epidermidis, Inhibits the Growth of a Staphylococcus aureus Strain Isolated from Atopic Dermatitis Patients

(2019) Supitchaya Traisaeng et al.   Toxins

Gut Microbiome Fermentation Determines the Efficacy of Exercise for Diabetes Prevention

(2019) Yan Liu et al.   Cell Metabolism

Is a vegan or a vegetarian diet associated with the microbiota composition in the gut? Results of a new cross-sectional study and systematic review

(2019) Iris Trefflich et al.   CRITICAL REVIEWS IN FOOD SCIENCE AND NUTRITION

Influence of the Gut Microbiome, Diet, and Environment on Risk of Colorectal Cancer

(2019) Mingyang Song et al.   GASTROENTEROLOGY

Metabolite-Sensing Receptor Ffar2 Regulates Colonic Group 3 Innate Lymphoid Cells and Gut Immunity

(2019) Eunyoung Chun et al.   IMMUNITY

An orally administered butyrate-releasing xylan derivative reduces inflammation in dextran sulphate sodium-induced murine colitis

(2019) Zhengqi Zha et al.   INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES

Immunomodulating Activity and Therapeutic Effects of Short Chain Fatty Acids and Tryptophan Post-biotics in Inflammatory Bowel Disease

(2019) Edda Russo et al.   Frontiers in Immunology

Clostridium butyricum, a butyrate-producing probiotic, inhibits intestinal tumor development through modulating Wnt signaling and gut microbiota

(2019) Danfeng Chen et al.   CANCER LETTERS

Short-Chain Fatty Acids Improve Poststroke Recovery via Immunological Mechanisms

(2019) Rebecca Sadler et al.   JOURNAL OF NEUROSCIENCE

Lysates of Lactobacillus acidophilus combined with CTLA-4-blocking antibodies enhance antitumor immunity in a mouse colon cancer model

(2019) Qian Zhuo et al.   Scientific Reports

Exercise Alters Gut Microbiota Composition and Function in Lean and Obese Humans

(2018) JACOB M. ALLEN et al.   MEDICINE AND SCIENCE IN SPORTS AND EXERCISE

Ingestion of an Inulin-Enriched Pork Sausage Product Positively Modulates the Gut Microbiome and Metabolome of Healthy Rats

(2018) Rebekka Thøgersen et al.   MOLECULAR NUTRITION & FOOD RESEARCH

Microbiome: Gut microbiota sways response to cancer immunotherapy

(2018) Ashley York   NATURE REVIEWS MICROBIOLOGY

The Amount of Bifidobacterium Genus in Colorectal Carcinoma Tissue in Relation to Tumor Characteristics and Clinical Outcome

(2018) Keisuke Kosumi et al.   AMERICAN JOURNAL OF PATHOLOGY

Fecal Microbiota Transplantation: Current Status in Treatment of GI and Liver Disease

(2018) Byron P. Vaughn et al.   Clinical Gastroenterology and Hepatology

Microbiota-derived short-chain fatty acids promote Th1 cell IL-10 production to maintain intestinal homeostasis

(2018) Mingming Sun et al.   Nature Communications

SCFAs strongly stimulate PYY production in human enteroendocrine cells

(2018) P. Larraufie et al.   Scientific Reports

Stimuli-Responsive Nano-Architecture Drug-Delivery Systems to Solid Tumor Micromilieu: Past, Present, and Future Perspectives

(2018) Hossam S. El-Sawy et al.   ACS Nano

Dysregulated Microbial Fermentation of Soluble Fiber Induces Cholestatic Liver Cancer

(2018) Vishal Singh et al.   CELL

Inhibiting antibiotic-resistant Enterobacteriaceae by microbiota-mediated intracellular acidification

(2018) Matthew T. Sorbara et al.   JOURNAL OF EXPERIMENTAL MEDICINE

Fecal microbiota transplantation for refractory immune checkpoint inhibitor-associated colitis

(2018) Yinghong Wang et al.   NATURE MEDICINE

Butyrate Produced by Commensal Bacteria Down-Regulates Indolamine 2,3-Dioxygenase 1 (IDO-1) Expression via a Dual Mechanism in Human Intestinal Epithelial Cells

(2018) Camille Martin-Gallausiaux et al.   Frontiers in Immunology

Gavage of Fecal Samples From Patients With Colorectal Cancer Promotes Intestinal Carcinogenesis in Germ-Free and Conventional Mice

(2017) Sunny H. Wong et al.   GASTROENTEROLOGY

Butyrate reduces appetite and activates brown adipose tissue via the gut-brain neural circuit

(2017) Zhuang Li et al.   GUT

Fecal microbiota transplant from a rational stool donor improves hepatic encephalopathy: A randomized clinical trial

(2017) Jasmohan S. Bajaj et al.   HEPATOLOGY

Butyrate suppresses motility of colorectal cancer cells via deactivating Akt/ERK signaling in histone deacetylase dependent manner

(2017) Qingran Li et al.   JOURNAL OF PHARMACOLOGICAL SCIENCES

Expert consensus document: The International Scientific Association for Probiotics and Prebiotics (ISAPP) consensus statement on the definition and scope of prebiotics

(2017) Glenn R. Gibson et al.   Nature Reviews Gastroenterology & Hepatology

Gut microbiome modulates response to anti–PD-1 immunotherapy in melanoma patients

(2017) V. Gopalakrishnan et al.   SCIENCE

Cost-effectiveness analysis of fecal microbiota transplantation for inflammatory bowel disease

(2017) Ting Zhang et al.   Oncotarget

Increased colonic propionate reduces anticipatory reward responses in the human striatum to high-energy foods

(2016) Claire S Byrne et al.   AMERICAN JOURNAL OF CLINICAL NUTRITION

An orally administered butyrate-releasing derivative reduces neutrophil recruitment and inflammation in dextran sulphate sodium-induced murine colitis

(2016) Raffaele Simeoli et al.   BRITISH JOURNAL OF PHARMACOLOGY

From Dietary Fiber to Host Physiology: Short-Chain Fatty Acids as Key Bacterial Metabolites

(2016) Ara Koh et al.   CELL

High-fat diet enhances stemness and tumorigenicity of intestinal progenitors

(2016) Semir Beyaz et al.   NATURE

Tissue adaptation of regulatory and intraepithelial CD4+ T cells controls gut inflammation

(2016) T. Sujino et al.   SCIENCE

Short Chain Fatty Acids Prevent High-fat-diet-induced Obesity in Mice by Regulating G Protein-coupled Receptors and Gut Microbiota

(2016) Yuanyuan Lu et al.   Scientific Reports

Crosstalk between Microbiota-Derived Short-Chain Fatty Acids and Intestinal Epithelial HIF Augments Tissue Barrier Function

(2015) Caleb J. Kelly et al.   Cell Host & Microbe

Short-Chain Fatty Acids Protect Against High-Fat Diet–Induced Obesity via a PPARγ-Dependent Switch From Lipogenesis to Fat Oxidation

(2015) Gijs den Besten et al.   DIABETES

Host microbiota constantly control maturation and function of microglia in the CNS

(2015) Daniel Erny et al.   NATURE NEUROSCIENCE

Metabolite-sensing receptors GPR43 and GPR109A facilitate dietary fibre-induced gut homeostasis through regulation of the inflammasome

(2015) Laurence Macia et al.   Nature Communications

Modulation of gut microbiota by berberine and metformin during the treatment of high-fat diet-induced obesity in rats

(2015) Xu Zhang et al.   Scientific Reports

The International Scientific Association for Probiotics and Prebiotics consensus statement on the scope and appropriate use of the term probiotic

(2014) Colin Hill et al.   Nature Reviews Gastroenterology & Hepatology

The Role of Intestinal Microbiota in Development of Irinotecan Toxicity and in Toxicity Reduction through Dietary Fibres in Rats

(2014) Xiaoxi B. Lin et al.   PLoS One

The microbial metabolite butyrate regulates intestinal macrophage function via histone deacetylase inhibition

(2014) Pamela V. Chang et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

The short-chain fatty acid acetate reduces appetite via a central homeostatic mechanism

(2014) Gary Frost et al.   Nature Communications

A Gnotobiotic Mouse Model Demonstrates That Dietary Fiber Protects against Colorectal Tumorigenesis in a Microbiota- and Butyrate-Dependent Manner

(2014) D. R. Donohoe et al.   Cancer Discovery

Guidelines for Diagnosis, Treatment and Prevention of Clostridium difficile Infections

(2013) Christina M Surawicz et al.   AMERICAN JOURNAL OF GASTROENTEROLOGY

Molecular Pathways: Gene-Environment Interactions Regulating Dietary Fiber Induction of Proliferation and Apoptosis via Butyrate for Cancer Prevention

(2013) S. J. Bultman   CLINICAL CANCER RESEARCH

IDO1 Metabolites Activate β-catenin Signaling to Promote Cancer Cell Proliferation and Colon Tumorigenesis in Mice

(2013) Ameet I. Thaker et al.   GASTROENTEROLOGY

The gut microbiota — masters of host development and physiology

(2013) Felix Sommer et al.   NATURE REVIEWS MICROBIOLOGY

Commensal Bacteria Control Cancer Response to Therapy by Modulating the Tumor Microenvironment

(2013) N. Iida et al.   SCIENCE

The Microbial Metabolites, Short-Chain Fatty Acids, Regulate Colonic Treg Cell Homeostasis

(2013) P. M. Smith et al.   SCIENCE

Oral Supplementation of Butyrate Reduces Mucositis and Intestinal Permeability Associated with 5-Fluorouracil Administration

(2012) Talita Mayra Ferreira et al.   LIPIDS

Irinotecan (CPT-11) Chemotherapy Alters Intestinal Microbiota in Tumour Bearing Rats

(2012) Xiaoxi B. Lin et al.   PLoS One

Short-Chain Fatty Acids Stimulate Glucagon-Like Peptide-1 Secretion via the G-Protein-Coupled Receptor FFAR2

(2011) G. Tolhurst et al.   DIABETES

Structural segregation of gut microbiota between colorectal cancer patients and healthy volunteers

(2011) Tingting Wang et al.   ISME Journal

The regulation of intestinal mucin MUC2 expression by short-chain fatty acids: implications for epithelial protection

(2009) Nanda Burger-van Paassen et al.   BIOCHEMICAL JOURNAL

GPR109A Is a G-protein-Coupled Receptor for the Bacterial Fermentation Product Butyrate and Functions as a Tumor Suppressor in Colon

(2009) M. Thangaraju et al.   CANCER RESEARCH

Butyrate Enhances the Intestinal Barrier by Facilitating Tight Junction Assembly via Activation of AMP-Activated Protein Kinase in Caco-2 Cell Monolayers

(2009) Luying Peng et al.   JOURNAL OF NUTRITION

GPR109A, GPR109B and GPR81, a family of hydroxy-carboxylic acid receptors

(2009) Kashan Ahmed et al.   TRENDS IN PHARMACOLOGICAL SCIENCES

Effects of the gut microbiota on host adiposity are modulated by the short-chain fatty-acid binding G protein-coupled receptor, Gpr41

(2008) B. S. Samuel et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA