Editing of the gut microbiota reduces carcinogenesis in mouse models of colitis-associated colorectal cancer

The human gut bacterial genotoxin colibactin alkylates DNA

(2019) Matthew R. Wilson et al.   SCIENCE

Bacteroides fragilis Toxin Coordinates a Pro-carcinogenic Inflammatory Cascade via Targeting of Colonic Epithelial Cells

(2018) Liam Chung et al.   Cell Host & Microbe

Healthy hosts rule within: ecological forces shaping the gut microbiota

(2018) Mariana X. Byndloss et al.   Mucosal Immunology

Patients with familial adenomatous polyposis harbor colonic biofilms containing tumorigenic bacteria

(2018) Christine M. Dejea et al.   SCIENCE

The Colibactin Genotoxin Generates DNA Interstrand Cross-Links in Infected Cells

(2018) Nadège Bossuet-Greif et al.   mBio

DNA damage response genes mark the early transition from colitis to neoplasia in colitis-associated colon cancer

(2018) Stephen P. Sharp et al.   GENE

Precision editing of the gut microbiota ameliorates colitis

(2018) Wenhan Zhu et al.   NATURE

Roles for Intestinal Bacteria, Viruses, and Fungi in Pathogenesis of Inflammatory Bowel Diseases and Therapeutic Approaches

(2017) R. Balfour Sartor et al.   GASTROENTEROLOGY

Gut microbiota: Role in pathogen colonization, immune responses, and inflammatory disease

(2017) Joseph M. Pickard et al.   IMMUNOLOGICAL REVIEWS

Microbiota-activated PPAR-γ signaling inhibits dysbiotic Enterobacteriaceae expansion

(2017) Mariana X. Byndloss et al.   SCIENCE

Microbiome and colorectal cancer: Unraveling host-microbiota interactions in colitis-associated colorectal cancer development

(2017) Mingsong Kang et al.   SEMINARS IN IMMUNOLOGY

Intergenerational transfer of antibiotic-perturbed microbiota enhances colitis in susceptible mice

(2017) Anjelique F. Schulfer et al.   Nature Microbiology

Gut Microbiota, Inflammation, and Colorectal Cancer

(2016) Caitlin A. Brennan et al.   Annual Review of Microbiology

Effects of Different Levels of Molybdenum on Rumen Microbiota and Trace Elements Changes in Tissues from Goats

(2016) Sihui Zhou et al.   BIOLOGICAL TRACE ELEMENT RESEARCH

Global patterns and trends in colorectal cancer incidence and mortality

(2016) Melina Arnold et al.   GUT

Iron Homeostasis Regulates the Genotoxicity of Escherichia coli That Produces Colibactin

(2016) Sophie Tronnet et al.   INFECTION AND IMMUNITY

Establishing the colitis-associated cancer progression mouse models

(2016) Haiming Zheng et al.   INTERNATIONAL JOURNAL OF IMMUNOPATHOLOGY AND PHARMACOLOGY

Host-mediated sugar oxidation promotes post-antibiotic pathogen expansion

(2016) Franziska Faber et al.   NATURE

Microcins mediate competition among Enterobacteriaceae in the inflamed gut

(2016) Martina Sassone-Corsi et al.   NATURE

Inflammatory networks underlying colorectal cancer

(2016) Audrey Lasry et al.   NATURE IMMUNOLOGY

QseC inhibition as an antivirulence approach for colitis-associated bacteria

(2016) Michelle G. Rooks et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Quantitative Imaging of Gut Microbiota Spatial Organization

(2015) Kristen A. Earle et al.   Cell Host & Microbe

Small-molecule inhibitors prevent the genotoxic and protumoural effects induced by colibactin-producing bacteria

(2015) Antony Cougnoux et al.   GUT

The colibactin warhead crosslinks DNA

(2015) Maria I. Vizcaino et al.   Nature Chemistry

Gut microbiome development along the colorectal adenoma–carcinoma sequence

(2015) Qiang Feng et al.   Nature Communications

Quantitative Profiling of Colorectal Cancer-Associated Bacteria Reveals Associations between Fusobacterium spp., Enterotoxigenic Bacteroides fragilis (ETBF) and Clinicopathological Features of Colorectal Cancer

(2015) Katie S. Viljoen et al.   PLoS One

Microbes, Microbiota, and Colon Cancer

(2014) Cynthia L. Sears et al.   Cell Host & Microbe

Bacterial genotoxin colibactin promotes colon tumour growth by inducing a senescence-associated secretory phenotype

(2014) Antony Cougnoux et al.   GUT

Escherichia coli Isolate for Studying Colonization of the Mouse Intestine and Its Application to Two-Component Signaling Knockouts

(2014) M. Lasaro et al.   JOURNAL OF BACTERIOLOGY

Intracellular colon cancer-associated Escherichia coli promote protumoral activities of human macrophages by inducing sustained COX-2 expression

(2014) Jennifer Raisch et al.   LABORATORY INVESTIGATION

Colon cancer-associated B2Escherichia colicolonize gut mucosa and promote cell proliferation

(2014) Jennifer Raisch   WORLD JOURNAL OF GASTROENTEROLOGY

Screening metatranscriptomes for toxin genes as functional drivers of human colorectal cancer

(2013) Bas E. Dutilh et al.   BEST PRACTICE & RESEARCH IN CLINICAL GASTROENTEROLOGY

Fusobacterium nucleatum Potentiates Intestinal Tumorigenesis and Modulates the Tumor-Immune Microenvironment

(2013) Aleksandar D. Kostic et al.   Cell Host & Microbe

Probiotic Bacteria Reduce Salmonella Typhimurium Intestinal Colonization by Competing for Iron

(2013) Elisa Deriu et al.   Cell Host & Microbe

Fusobacterium nucleatum Promotes Colorectal Carcinogenesis by Modulating E-Cadherin/β-Catenin Signaling via its FadA Adhesin

(2013) Mara Roxana Rubinstein et al.   Cell Host & Microbe

Endotoxicity of Lipopolysaccharide as a Determinant of T-Cell−Mediated Colitis Induction in Mice

(2013) Kerstin Gronbach et al.   GASTROENTEROLOGY

Colonic mucosa-associated diffusely adherentafaC+ Escherichia coliexpressinglpfAandpksare increased in inflammatory bowel disease and colon cancer

(2013) Maelle Prorok-Hamon et al.   GUT

Dysbiosis Signature of Fecal Microbiota in Colorectal Cancer Patients

(2013) Na Wu et al.   MICROBIAL ECOLOGY

High Prevalence of Mucosa-Associated E. coli Producing Cyclomodulin and Genotoxin in Colon Cancer

(2013) Emmanuel Buc et al.   PLoS One

Host-Derived Nitrate Boosts Growth of E. coli in the Inflamed Gut

(2013) S. E. Winter et al.   SCIENCE

An Escherichia coli Effector Protein Promotes Host Mutation via Depletion of DNA Mismatch Repair Proteins

(2013) O. D. K. Maddocks et al.   mBio

Streptomycin-Induced Inflammation Enhances Escherichia coli Gut Colonization Through Nitrate Respiration

(2013) A. M. Spees et al.   mBio

Persistent infection with Crohn’s disease-associated adherent-invasive Escherichia coli leads to chronic inflammation and intestinal fibrosis

(2013) Cherrie-Lee N. Small et al.   Nature Communications

Interplay between Siderophores and Colibactin Genotoxin Biosynthetic Pathways in Escherichia coli

(2013) Patricia Martin et al.   PLoS Pathogens

EMPeror: a tool for visualizing high-throughput microbial community data

(2013) Yoshiki Vázquez-Baeza et al.   GigaScience

Animal models of colorectal cancer

(2012) Robert L. Johnson et al.   CANCER AND METASTASIS REVIEWS

Transient Inability to Manage Proteobacteria Promotes Chronic Gut Inflammation in TLR5-Deficient Mice

(2012) Frederic A. Carvalho et al.   Cell Host & Microbe

Why is the molybdenum-substituted tungsten-dependent formaldehyde ferredoxin oxidoreductase not active? A quantum chemical study

(2012) Rong-Zhen Liao   JOURNAL OF BIOLOGICAL INORGANIC CHEMISTRY

Diversity, stability and resilience of the human gut microbiota

(2012) Catherine A. Lozupone et al.   NATURE

IBD—what role do Proteobacteria play?

(2012) Indrani Mukhopadhya et al.   Nature Reviews Gastroenterology & Hepatology

A bacterial driver–passenger model for colorectal cancer: beyond the usual suspects

(2012) Harold Tjalsma et al.   NATURE REVIEWS MICROBIOLOGY

The SILVA ribosomal RNA gene database project: improved data processing and web-based tools

(2012) Christian Quast et al.   NUCLEIC ACIDS RESEARCH

Human Intestinal Lumen and Mucosa-Associated Microbiota in Patients with Colorectal Cancer

(2012) Weiguang Chen et al.   PLoS One

Regulated Virulence Controls the Ability of a Pathogen to Compete with the Gut Microbiota

(2012) N. Kamada et al.   SCIENCE

Intestinal Inflammation Targets Cancer-Inducing Activity of the Microbiota

(2012) J. C. Arthur et al.   SCIENCE

Inflammation and colorectal cancer: colitis-associated neoplasia

(2012) Sergei I. Grivennikov   Seminars in Immunopathology

Chronic Intestinal Inflammation Induces Stress-Response Genes in Commensal Escherichia coli

(2011) Laura G. Patwa et al.   GASTROENTEROLOGY

Fusobacterium nucleatum infection is prevalent in human colorectal carcinoma

(2011) M. Castellarin et al.   GENOME RESEARCH

Genomic analysis identifies association of Fusobacterium with colorectal carcinoma

(2011) A. D. Kostic et al.   GENOME RESEARCH

Structural segregation of gut microbiota between colorectal cancer patients and healthy volunteers

(2011) Tingting Wang et al.   ISME Journal

PrimerBank: a PCR primer database for quantitative gene expression analysis, 2012 update

(2011) X. Wang et al.   NUCLEIC ACIDS RESEARCH

Enterobacteriaceae Act in Concert with the Gut Microbiota to Induce Spontaneous and Maternally Transmitted Colitis

(2010) Wendy S. Garrett et al.   Cell Host & Microbe

Proof-of-concept trial on the efficacy of sodium tungstate in human obesity

(2010) F. Hanzu et al.   DIABETES OBESITY & METABOLISM

The Role of Pathogenic Microbes and Commensal Bacteria in Irritable Bowel Syndrome

(2010) Stephen Collins et al.   DIGESTIVE DISEASES

QIIME allows analysis of high-throughput community sequencing data

(2010) J Gregory Caporaso et al.   NATURE METHODS

Abnormal CEACAM6 expression in Crohn disease patients favors gut colonization and inflammation by Adherent-InvasiveE. coli

(2010) Nicolas Barnich et al.   Virulence

Contribution of Flagellin Pattern Recognition to Intestinal Inflammation during Salmonella enterica Serotype Typhimurium Infection

(2009) S. E. Winter et al.   INFECTION AND IMMUNITY

Genetic Structure and Distribution of the Colibactin Genomic Island among Members of the Family Enterobacteriaceae

(2009) J. Putze et al.   INFECTION AND IMMUNITY

General Trends in Trace Element Utilization Revealed by Comparative Genomic Analyses of Co, Cu, Mo, Ni, and Se

(2009) Yan Zhang et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Crohn's disease adherent-invasiveEscherichia colicolonize and induce strong gut inflammation in transgenic mice expressing human CEACAM

(2009) Frédéric A. Carvalho et al.   JOURNAL OF EXPERIMENTAL MEDICINE

A human colonic commensal promotes colon tumorigenesis via activation of T helper type 17 T cell responses

(2009) Shaoguang Wu et al.   NATURE MEDICINE

Complete genome sequence of the extremely acidophilic methanotroph isolate V4, Methylacidiphilum infernorum, a representative of the bacterial phylum Verrucomicrobia

(2008) Shaobin Hou et al.   Biology Direct

T Cells Help To Amplify Inflammatory Responses Induced by Salmonella enterica Serotype Typhimurium in the Intestinal Mucosa

(2008) I. Godinez et al.   INFECTION AND IMMUNITY

The Vi-capsule prevents Toll-like receptor 4 recognition of Salmonella

(2007) R. Paul Wilson et al.   CELLULAR MICROBIOLOGY