Defining therapeutic targets for renal fibrosis: Exploiting the biology of pathogenesis
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Title
Defining therapeutic targets for renal fibrosis: Exploiting the biology of pathogenesis
Authors
Keywords
Renal fibrosis, Chronic kidney disease, Renal tubular epithelial cells, Inflammation, Therapeutic strategy
Journal
BIOMEDICINE & PHARMACOTHERAPY
Volume 143, Issue -, Pages 112115
Publisher
Elsevier BV
Online
2021-09-03
DOI
10.1016/j.biopha.2021.112115
References
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Note: Only part of the references are listed.- Regulation and function of CX3CR1 and its ligand CX3CL1 in kidney disease
- (2021) Sibylle von Vietinghoff et al. CELL AND TISSUE RESEARCH
- KIM-1 mediates fatty acid uptake by renal tubular cells to promote progressive diabetic kidney disease
- (2021) Yutaro Mori et al. Cell Metabolism
- A Novel Dipeptidyl Peptidase-4 Inhibitor DA-1229 Ameliorates Tubulointerstitial Fibrosis in Cyclosporine Nephrotoxicity in Mice
- (2021) Hye Sook Min et al. Life-Basel
- Critical roles of SMYD2 lysine methyltransferase in mediating renal fibroblast activation and kidney fibrosis
- (2021) Lirong Liu et al. FASEB JOURNAL
- Mesenchymal stem cells ameliorate renal fibrosis by galectin-3/Akt/GSK3β/Snail signaling pathway in adenine-induced nephropathy rat
- (2021) Huajun Tang et al. Stem Cell Research & Therapy
- Sulforaphane Ameliorates Diabetes-Induced Renal Fibrosis through Epigenetic Up-Regulation of BMP-7
- (2021) Lili Kong et al. Diabetes & Metabolism Journal
- Tectorigenin attenuates diabetic nephropathy by improving vascular endothelium dysfunction through activating AdipoR1/2 pathway
- (2020) Shu Yang et al. PHARMACOLOGICAL RESEARCH
- Polydatin attenuates renal fibrosis in diabetic mice through regulating the Cx32-Nox4 signaling pathway
- (2020) Zhi-quan Chen et al. ACTA PHARMACOLOGICA SINICA
- Extracellular vesicles produced by bone marrow mesenchymal stem cells attenuate renal fibrosis, in part by inhibiting the RhoA/ROCK pathway, in a UUO rat model
- (2020) Zhengzhou Shi et al. Stem Cell Research & Therapy
- Oxymatrine Inhibits Twist-Mediated Renal Tubulointerstitial Fibrosis by Upregulating Id2 Expression
- (2020) Ying Xiao et al. Frontiers in Physiology
- Macrophages: versatile players in renal inflammation and fibrosis
- (2019) Patrick Ming-Kuen Tang et al. Nature Reviews Nephrology
- Beraprost sodium mitigates renal interstitial fibrosis through repairing renal microvessels
- (2019) Shulin Li et al. JOURNAL OF MOLECULAR MEDICINE-JMM
- Activation mechanisms and multifaceted effects of mast cells in ischemia reperfusion injury
- (2019) Zhigang He et al. EXPERIMENTAL CELL RESEARCH
- Fibroblast-specific plasminogen activator inhibitor-1 depletion ameliorates renal interstitial fibrosis after unilateral ureteral obstruction
- (2019) Lan Yao et al. NEPHROLOGY DIALYSIS TRANSPLANTATION
- TGF-β inhibitor therapy decreases fibrosis and stimulates cardiac improvement in a pre-clinical study of chronic Chagas’ heart disease
- (2019) Roberto Rodrigues Ferreira et al. PLoS Neglected Tropical Diseases
- Integrin-Linked Kinase Deficiency in Collecting Duct Principal Cell Promotes Necroptosis of Principal Cell and Contributes to Kidney Inflammation and Fibrosis
- (2019) Ming Huang et al. JOURNAL OF THE AMERICAN SOCIETY OF NEPHROLOGY
- Targeting renal fibrosis: Mechanisms and drug delivery systems
- (2018) Madalina V. Nastase et al. ADVANCED DRUG DELIVERY REVIEWS
- Mechanisms of Renal Fibrosis
- (2018) Benjamin D. Humphreys Annual Review of Physiology
- The preventive and therapeutic implication for renal fibrosis by targetting TGF-β/Smad3 signaling
- (2018) Yun Zhang et al. CLINICAL SCIENCE
- CX3CL1/CX3CR1 Axis, as the Therapeutic Potential in Renal Diseases: Friend or Foe?
- (2018) Quan Zhuang et al. CURRENT GENE THERAPY
- Suppression of Endothelial-to-Mesenchymal Transition by SIRT (Sirtuin) 3 Alleviated the Development of Hypertensive Renal InjuryNovelty and Significance
- (2018) Jing-rong Lin et al. HYPERTENSION
- Renal tubule injury: a driving force toward chronic kidney disease
- (2018) Bi-Cheng Liu et al. KIDNEY INTERNATIONAL
- NLRP3 inflammasome inhibition ameliorates tubulointerstitial injury in the remnant kidney model
- (2018) Orestes Foresto-Neto et al. LABORATORY INVESTIGATION
- Cellular and molecular mechanisms of kidney fibrosis
- (2018) Sonja Djudjaj et al. MOLECULAR ASPECTS OF MEDICINE
- Sex and gender disparities in the epidemiology and outcomes of chronic kidney disease
- (2018) Juan Jesus Carrero et al. Nature Reviews Nephrology
- Dickkopf-3 in aberrant endothelial secretome triggers renal fibroblast activation and endothelial–mesenchymal transition
- (2018) Mark Lipphardt et al. NEPHROLOGY DIALYSIS TRANSPLANTATION
- Angiopoietin-1 deficiency increases renal capillary rarefaction and tubulointerstitial fibrosis in mice
- (2018) Krishnapriya Loganathan et al. PLoS One
- A model for positive feedback control of the transformation of fibroblasts to myofibroblasts
- (2018) Elliot L. Elson et al. PROGRESS IN BIOPHYSICS & MOLECULAR BIOLOGY
- Early Phase Mast Cell Activation Determines the Chronic Outcome of Renal Ischemia–Reperfusion Injury
- (2017) Luca Danelli et al. JOURNAL OF IMMUNOLOGY
- Tubule-Derived Wnts Are Required for Fibroblast Activation and Kidney Fibrosis
- (2017) Dong Zhou et al. JOURNAL OF THE AMERICAN SOCIETY OF NEPHROLOGY
- Macrophage-to-Myofibroblast Transition Contributes to Interstitial Fibrosis in Chronic Renal Allograft Injury
- (2017) Ying-Ying Wang et al. JOURNAL OF THE AMERICAN SOCIETY OF NEPHROLOGY
- Beta 2-adrenergic receptor agonists are novel regulators of macrophage activation in diabetic renal and cardiovascular complications
- (2017) Hyunjin Noh et al. KIDNEY INTERNATIONAL
- Chronic Kidney Disease
- (2017) Angela C Webster et al. LANCET
- Effects of tanshinone IIA on the regulation of renal proximal tubular fibrosis
- (2017) Luoyuan Cao et al. Molecular Medicine Reports
- Complement C5a inhibition moderates lipid metabolism and reduces tubulointerstitial fibrosis in diabetic nephropathy
- (2017) Wai Han Yiu et al. NEPHROLOGY DIALYSIS TRANSPLANTATION
- Diabetes Aggravates Post-ischaemic Renal Fibrosis through Persistent Activation of TGF-β1 and Shh Signalling
- (2017) Dong-Jin Kim et al. Scientific Reports
- Galectin-3 in Renal Pathology: More Than Just an Innocent Bystander?
- (2016) Valérie Desmedt et al. AMERICAN JOURNAL OF NEPHROLOGY
- The origin of renal fibroblasts/myofibroblasts and the signals that trigger fibrosis
- (2016) Yu Bo Yang Sun et al. DIFFERENTIATION
- Tenascin-C Is a Major Component of the Fibrogenic Niche in Kidney Fibrosis
- (2016) Haiyan Fu et al. JOURNAL OF THE AMERICAN SOCIETY OF NEPHROLOGY
- Tumor Necrosis Factor-Like Weak Inducer of Apoptosis Accelerates the Progression of Renal Fibrosis in Lupus Nephritis by Activating SMAD and p38 MAPK in TGF-β1 Signaling Pathway
- (2016) Zhiqin Liu et al. MEDIATORS OF INFLAMMATION
- TGF-β: the master regulator of fibrosis
- (2016) Xiao-ming Meng et al. Nature Reviews Nephrology
- An Overview of Pathways of Regulated Necrosis in Acute Kidney Injury
- (2016) Jesper Kers et al. SEMINARS IN NEPHROLOGY
- NLRP3 inflammasome activation is involved in Ang II-induced kidney damage via mitochondrial dysfunction
- (2016) Yi Wen et al. Oncotarget
- Matrix metalloproteinase 12 modulates high-fat-diet induced glomerular fibrogenesis and inflammation in a mouse model of obesity
- (2016) Honglin Niu et al. Scientific Reports
- The Future Burden of CKD in the United States: A Simulation Model for the CDC CKD Initiative
- (2015) Thomas J. Hoerger et al. AMERICAN JOURNAL OF KIDNEY DISEASES
- Regulation of Renal Fibrosis by Macrophage Polarization
- (2015) Bixia Pan et al. CELLULAR PHYSIOLOGY AND BIOCHEMISTRY
- CKD of Uncertain Etiology: A Systematic Review
- (2015) J. Lunyera et al. Clinical Journal of the American Society of Nephrology
- Necroinflammation in Kidney Disease
- (2015) S. R. Mulay et al. JOURNAL OF THE AMERICAN SOCIETY OF NEPHROLOGY
- Failed Tubule Recovery, AKI-CKD Transition, and Kidney Disease Progression
- (2015) M. A. Venkatachalam et al. JOURNAL OF THE AMERICAN SOCIETY OF NEPHROLOGY
- C3a and C5a receptor antagonists ameliorate endothelial-myofibroblast transition via the Wnt/β-catenin signaling pathway in diabetic kidney disease
- (2015) Ling Li et al. METABOLISM-CLINICAL AND EXPERIMENTAL
- Epithelial-to-mesenchymal transition induces cell cycle arrest and parenchymal damage in renal fibrosis
- (2015) Sara Lovisa et al. NATURE MEDICINE
- Diverse origins of the myofibroblast—implications for kidney fibrosis
- (2015) Lucas L. Falke et al. Nature Reviews Nephrology
- Tubular atrophy in the pathogenesis of chronic kidney disease progression
- (2015) Jeffrey R. Schelling PEDIATRIC NEPHROLOGY
- Macrophages in Kidney Injury, Inflammation, and Fibrosis
- (2015) Qi Cao et al. PHYSIOLOGY
- TGF-β/Smad signaling in renal fibrosis
- (2015) Xiao-Ming Meng et al. Frontiers in Physiology
- Activation of the Nlrp3 inflammasome by mitochondrial reactive oxygen species: A novel mechanism of albumin-induced tubulointerstitial inflammation
- (2014) Dan Liu et al. INTERNATIONAL JOURNAL OF BIOCHEMISTRY & CELL BIOLOGY
- Anti–microRNA-21 oligonucleotides prevent Alport nephropathy progression by stimulating metabolic pathways
- (2014) Ivan G. Gomez et al. JOURNAL OF CLINICAL INVESTIGATION
- Sonic Hedgehog Is a Novel Tubule-Derived Growth Factor for Interstitial Fibroblasts after Kidney Injury
- (2014) D. Zhou et al. JOURNAL OF THE AMERICAN SOCIETY OF NEPHROLOGY
- Specific Macrophage Subtypes Influence the Progression of Rhabdomyolysis-Induced Kidney Injury
- (2014) J. Belliere et al. JOURNAL OF THE AMERICAN SOCIETY OF NEPHROLOGY
- GQ5 Hinders Renal Fibrosis in Obstructive Nephropathy by Selectively Inhibiting TGF- -Induced Smad3 Phosphorylation
- (2014) J. Ai et al. JOURNAL OF THE AMERICAN SOCIETY OF NEPHROLOGY
- Defective fatty acid oxidation in renal tubular epithelial cells has a key role in kidney fibrosis development
- (2014) Hyun Mi Kang et al. NATURE MEDICINE
- Inflammatory processes in renal fibrosis
- (2014) Xiao-Ming Meng et al. Nature Reviews Nephrology
- Targeting CTGF, EGF and PDGF pathways to prevent progression of kidney disease
- (2014) Helena M. Kok et al. Nature Reviews Nephrology
- Pattern recognition receptors and the inflammasome in kidney disease
- (2014) Jaklien C. Leemans et al. Nature Reviews Nephrology
- Endothelial-to-mesenchymal transition and renal fibrosis in ischaemia/reperfusion injury are mediated by complement anaphylatoxins and Akt pathway
- (2014) C. Curci et al. NEPHROLOGY DIALYSIS TRANSPLANTATION
- Cell cycle arrest and the evolution of chronic kidney disease from acute kidney injury
- (2014) G. Canaud et al. NEPHROLOGY DIALYSIS TRANSPLANTATION
- EGFR signaling in renal fibrosis
- (2014) Shougang Zhuang et al. Kidney International Supplements
- Histone Deacetylase Inhibitor Enhances Recovery after AKI
- (2013) C. Cianciolo Cosentino et al. JOURNAL OF THE AMERICAN SOCIETY OF NEPHROLOGY
- Loss of Klotho Contributes to Kidney Injury by Derepression of Wnt/ -Catenin Signaling
- (2013) L. Zhou et al. JOURNAL OF THE AMERICAN SOCIETY OF NEPHROLOGY
- Mast cell chymase protects against renal fibrosis in murine unilateral ureteral obstruction
- (2013) Walid Beghdadi et al. KIDNEY INTERNATIONAL
- Unknown
- (2013) Tarcio Braga et al. MOLECULAR MEDICINE
- Origin and function of myofibroblasts in kidney fibrosis
- (2013) Valerie S LeBleu et al. NATURE MEDICINE
- Neutralization of Tumor Necrosis Factor-Alpha Reduces Renal Fibrosis and Hypertension in Rats with Renal Failure
- (2012) Frédérick J. Therrien et al. AMERICAN JOURNAL OF NEPHROLOGY
- Lysophosphatidic Acid Increases Proximal Tubule Cell Secretion of Profibrotic Cytokines PDGF-B and CTGF through LPA2- and Gαq-Mediated Rho and αvβ6 Integrin-Dependent Activation of TGF-β
- (2012) Hui Geng et al. AMERICAN JOURNAL OF PATHOLOGY
- Cellular Metabolism and Disease: What Do Metabolic Outliers Teach Us?
- (2012) Ralph J. DeBerardinis et al. CELL
- MicroRNAs, transforming growth factor beta-1, and tissue fibrosis
- (2012) Timothy Bowen et al. JOURNAL OF PATHOLOGY
- Pericyte TIMP3 and ADAMTS1 Modulate Vascular Stability after Kidney Injury
- (2012) C. Schrimpf et al. JOURNAL OF THE AMERICAN SOCIETY OF NEPHROLOGY
- Mast cell activation and degranulation promotes renal fibrosis in experimental unilateral ureteric obstruction
- (2012) Shaun A. Summers et al. KIDNEY INTERNATIONAL
- Endothelial–mesenchymal transition and its contribution to the emergence of stem cell phenotype
- (2012) Damian Medici et al. SEMINARS IN CANCER BIOLOGY
- Roles for CCN2 in normal physiological processes
- (2011) Faith Hall-Glenn et al. CELLULAR AND MOLECULAR LIFE SCIENCES
- Cellular and molecular mechanisms of renal fibrosis
- (2011) Youhua Liu Nature Reviews Nephrology
- The Inflammasomes
- (2010) Kate Schroder et al. CELL
- Epithelial Notch signaling regulates interstitial fibrosis development in the kidneys of mice and humans
- (2010) Bernhard Bielesz et al. JOURNAL OF CLINICAL INVESTIGATION
- Nod1 and Nod2 Are Expressed in Human and Murine Renal Tubular Epithelial Cells and Participate in Renal Ischemia Reperfusion Injury
- (2010) Alana A. Shigeoka et al. JOURNAL OF IMMUNOLOGY
- Epithelial cell cycle arrest in G2/M mediates kidney fibrosis after injury
- (2010) Li Yang et al. NATURE MEDICINE
- Effects of Increased Renal Tubular Vascular Endothelial Growth Factor (VEGF) on Fibrosis, Cyst Formation, and Glomerular Disease
- (2009) Samy Hakroush et al. AMERICAN JOURNAL OF PATHOLOGY
- Antibody blockade of c-fms suppresses the progression of inflammation and injury in early diabetic nephropathy in obese db/db mice
- (2009) A. K. H. Lim et al. DIABETOLOGIA
- Fuzheng Huayu recipe and vitamin E reverse renal interstitial fibrosis through counteracting TGF-β1-induced epithelial-to-mesenchymal transition
- (2009) Qing-Lan Wang et al. JOURNAL OF ETHNOPHARMACOLOGY
- Effects of Liposome Clodronate on Renal Leukocyte Populations and Renal Fibrosis in Murine Obstructive Nephropathy
- (2009) Koichiro Kitamoto et al. JOURNAL OF PHARMACOLOGICAL SCIENCES
- New Insights into Epithelial-Mesenchymal Transition in Kidney Fibrosis
- (2009) Y. Liu JOURNAL OF THE AMERICAN SOCIETY OF NEPHROLOGY
- Companies Waver in Efforts To Target Transforming Growth Factor in Cancer
- (2009) K. Garber JNCI-Journal of the National Cancer Institute
- Mast cells decrease renal fibrosis in unilateral ureteral obstruction
- (2009) Duk Hoon Kim et al. KIDNEY INTERNATIONAL
- Pericytes and Perivascular Fibroblasts Are the Primary Source of Collagen-Producing Cells in Obstructive Fibrosis of the Kidney
- (2008) Shuei-Liong Lin et al. AMERICAN JOURNAL OF PATHOLOGY
- HGF as a renotrophic and anti-fibrotic regulator in chronic renal disease
- (2008) Shinya Mizuno Frontiers in Bioscience-Landmark
- PDGF-C Is a Proinflammatory Cytokine that Mediates Renal Interstitial Fibrosis
- (2008) F. Eitner et al. JOURNAL OF THE AMERICAN SOCIETY OF NEPHROLOGY
- Fibroblasts in Kidney Fibrosis Emerge via Endothelial-to-Mesenchymal Transition
- (2008) E. M. Zeisberg et al. JOURNAL OF THE AMERICAN SOCIETY OF NEPHROLOGY
- Tissue inhibitor of metalloproteinase-1 exacerbated renal interstitial fibrosis through enhancing inflammation
- (2008) G. Cai et al. NEPHROLOGY DIALYSIS TRANSPLANTATION
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