Journal
SEMINARS IN CANCER BIOLOGY
Volume 22, Issue 5-6, Pages 379-384Publisher
ACADEMIC PRESS LTD- ELSEVIER SCIENCE LTD
DOI: 10.1016/j.semcancer.2012.04.004
Keywords
Endothelial-mesenchymal transition; EMT; EndMT; Stem cells; TGF-beta
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Funding
- National Institutes of Health [R01HL112860, CA125550, CA155370, CA151925, DK55001, DK81576]
- John Butler Mulliken Foundation
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Vascular endothelial cells can demonstrate considerable plasticity to generate other cell types during embryonic development and disease progression. This process occurs through a cell differentiation mechanism known as endothelial-mesenchymal transition (EndMT). The generation of mesenchymal cells from endothelium is a crucial step in endothelial cell differentiation to several lineages including fibroblasts, myofibroblasts, mural cells, osteoblasts, chondrocytes, and adipocytes. Such differentiation patterns have been observed in systems of cardiac development, fibrosis, diabetic nephropathy, heterotopic ossification and cancer. Here we describe the EndMT program and discuss the current evidence of EndMT-mediated acquisition of stem cell characteristics and multipotent differentiation capabilities. (C) 2012 Elsevier Ltd. All rights reserved.
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