Oxymatrine Inhibits Twist-Mediated Renal Tubulointerstitial Fibrosis by Upregulating Id2 Expression

Comprehensive analysis of inhibitor of differentiation/DNA-binding gene family in lung cancer using bioinformatics methods

(2020) Suming Xu et al.   BIOSCIENCE REPORTS

Periostin induces epithelial‑to‑mesenchymal transition via the integrin α5β1/TWIST‑2 axis in cholangiocarcinoma

(2020) Jumaporn Sonongbua et al.   ONCOLOGY REPORTS

Inhibitor of Differentiation 1 (ID1) Facilitates the Efficacy of Sorafenib in Non-Small Cell Lung Cancer Cells through Suppressing Epithelial to Mesenchymal Transition

(2020) Yu-xiao Zhao et al.   MEDICAL SCIENCE MONITOR

The Transcription Factor OVOL2 Represses ID2 and Drives Differentiation of Trophoblast Stem Cells and Placental Development in Mice

(2020) Mariyan J. Jeyarajah et al.   Cells

EMT Factors and Metabolic Pathways in Cancer

(2020) Ilias Georgakopoulos-Soares et al.   Frontiers in Oncology

MicroRNA‑16 inhibits migration and invasion via regulation of the Wnt/β‑catenin signaling pathway in ovarian cancer

(2019) Nan Li et al.   Oncology Letters

Oxymatrine Attenuates Tumor Growth and Deactivates STAT5 Signaling in a Lung Cancer Xenograft Model

(2019) Young Jung et al.   Cancers

Oxymatrine Inhibits Bocavirus MVC Replication, Reduces Viral Gene Expression and Decreases Apoptosis Induced by Viral Infection

(2019) Yanqin Ding et al.   VIROLOGICA SINICA

Ski-related novel protein suppresses the development of diabetic nephropathy by modulating transforming growth factor-β signaling and microRNA-21 expression

(2019) Yuanyuan Wang et al.   JOURNAL OF CELLULAR PHYSIOLOGY

Proliferation and Migration of Lung Cancer Could be Inhibited by Oxymatrine through the Regulation for miR-520/VEGF

(2019) Wen Zhou et al.   AMERICAN JOURNAL OF CHINESE MEDICINE

Advanced oxidation protein products promote lipotoxicity and tubulointerstitial fibrosis via CD36/β-catenin pathway in diabetic nephropathy

(2019) Xiao Li et al.   ANTIOXIDANTS & REDOX SIGNALING

Protective effects of oxymatrine against DSS-induced acute intestinal inflammation in mice via blocking the RhoA/ROCK signaling pathway

(2019) Yifan Wang et al.   BIOSCIENCE REPORTS

In type 2 diabetes, intensive glucose control for 5.6 years did not differ from usual care for major CV events at 14 years

(2019) Gaetano Santulli   ANNALS OF INTERNAL MEDICINE

Resveratrol suppresses the myofibroblastic phenotype and fibrosis formation in kidneys via proliferation‐related signalling pathways

(2019) Xing Zhang et al.   BRITISH JOURNAL OF PHARMACOLOGY

Anti-cancer effects of oxymatrine are mediated through multiple molecular mechanism(s) in tumor models

(2019) Clarissa Esmeralda Halim et al.   PHARMACOLOGICAL RESEARCH

BMP-7/Smads-induced inhibitor of differentiation 2 (Id2) upregulation and Id2/Twist interaction was involved in attenuating diabetic renal tubulointerstitial fibrosis

(2019) Ying Xiao et al.   INTERNATIONAL JOURNAL OF BIOCHEMISTRY & CELL BIOLOGY

Olmesartan Medoxomil, An Angiotensin II-Receptor Blocker, Ameliorates Renal Injury In db/db Mice

(2019) Ye Zhu et al.   Drug Design Development and Therapy

Urinary miRNA-27b-3p and miRNA-1228-3p correlate with the progression of Kidney Fibrosis in Diabetic Nephropathy

(2019) Francesca Conserva et al.   Scientific Reports

Expression and significance of c-kit and epithelial-mesenchymal transition (EMT) molecules in thymic epithelial tumors (TETs)

(2019) Zhigang Wu et al.   Journal of Thoracic Disease

Oxymatrine exerts organ- and tissue-protective effects by regulating inflammation, oxidative stress, apoptosis, and fibrosis: From bench to bedside

(2019) Xu Lan et al.   PHARMACOLOGICAL RESEARCH

Reduction of cancer cell viability by synergistic combination of photodynamic treatment with the inhibition of the Id protein family

(2018) Cornelia Roschger et al.   JOURNAL OF PHOTOCHEMISTRY AND PHOTOBIOLOGY B-BIOLOGY

Prognostic values of the inhibitor of DNA‑binding family members in breast cancer

(2018) Xiao‑Ling Zhou et al.   ONCOLOGY REPORTS

Oxymatrine Inhibits Transforming Growth Factor β1 (TGF-β1)-Induced Cardiac Fibroblast-to-Myofibroblast Transformation (FMT) by Mediating the Notch Signaling Pathway In Vitro

(2018) Linglu Zhao et al.   MEDICAL SCIENCE MONITOR

Canonical BMP signaling in tubular cells mediates recovery after acute kidney injury

(2018) Emilia Vigolo et al.   KIDNEY INTERNATIONAL

Localized TWIST1 and TWIST2 basic domain substitutions cause four distinct human diseases that can be modeled in Caenorhabditis elegans

(2017) Sharon Kim et al.   HUMAN MOLECULAR GENETICS

Inhibitory effects of oxymatrine on TGF-β1-induced proliferation and abnormal differentiation in rat cardiac fibroblasts via the p38MAPK and ERK1/2 signaling pathways

(2017) Yini Xu et al.   Molecular Medicine Reports

TGFΒ-induced transcription in cancer

(2017) Gaia Cantelli et al.   SEMINARS IN CANCER BIOLOGY

Multiple biological functions of Twist1 in various cancers

(2017) Zhixiang Zhao et al.   Oncotarget

Oxymatrine inhibits aldosterone-induced rat cardiac fibroblast proliferation and differentiation by attenuating smad-2,-3 and-4 expression: an in vitro study

(2016) Lingyun Fu et al.   BMC Complementary and Alternative Medicine

BMP-7 Attenuates TGF-β1-Induced Fibronectin Secretion and Apoptosis of NRK-52E Cells by the Suppression of miRNA-21

(2016) Zhong Yu et al.   ONCOLOGY RESEARCH

Oxymatrine Inhibits Renal Tubular EMT Induced by High Glucose via Upregulation of SnoN and Inhibition of TGF-β1/Smad Signaling Pathway

(2016) Lirong Liu et al.   PLoS One

Oxymatrine inhibits renal fibrosis of obstructive nephropathy by downregulating the TGF-β1-Smad3 pathway

(2016) Hong-Wei Wang et al.   RENAL FAILURE

Overexpression of Inhibitor of DNA-Binding 2 Attenuates Pulmonary Fibrosis through Regulation of c-Abl and Twist

(2015) Jibing Yang et al.   AMERICAN JOURNAL OF PATHOLOGY

The role of TWIST1 in epithelial-mesenchymal transition and cancers

(2015) Qing-Qing Zhu et al.   TUMOR BIOLOGY

Oral administration of Nitraria retusa ethanolic extract enhances hepatic lipid metabolism in db/db mice model ‘BKS.Cg-Dock7+/+ Leprdb/J’ through the modulation of lipogenesis–lipolysis balance

(2014) Feten Zar Kalai et al.   FOOD AND CHEMICAL TOXICOLOGY

Oxymatrine attenuates bleomycin-induced pulmonary fibrosis in mice via the inhibition of inducible nitric oxide synthase expression and the TGF-β/Smad signaling pathway

(2012) Zhenhua Li   INTERNATIONAL JOURNAL OF MOLECULAR MEDICINE

JunB contributes to Id2 repression and the epithelial–mesenchymal transition in response to transforming growth factor–β

(2012) Megan Gervasi et al.   JOURNAL OF CELL BIOLOGY

Normal and disease-related biological functions of Twist1 and underlying molecular mechanisms

(2011) Qian Qin et al.   CELL RESEARCH

Protective effect of oxymatrine on myocardial fibrosis induced by acute myocardial infarction in rats involved in TGF-β1-Smads signal pathway

(2011) Xiang-Chun Shen et al.   JOURNAL OF ASIAN NATURAL PRODUCTS RESEARCH

Significance of Twist expression and its association with E-cadherin in esophageal squamous cell carcinoma

(2009) Ken Sasaki et al.   JOURNAL OF EXPERIMENTAL & CLINICAL CANCER RESEARCH

Attenuation of Bleomycin-Induced Lung Fibrosis by Oxymatrine Is Associated with Regulation of Fibroblast Proliferation and Collagen Production in Primary Culture

(2008) Xiaohong Chen et al.   BASIC & CLINICAL PHARMACOLOGY & TOXICOLOGY

Induction of EMT by Twist Proteins as a Collateral Effect of Tumor-Promoting Inactivation of Premature Senescence

(2008) Stéphane Ansieau et al.   CANCER CELL