5-Lipoxygenase-activating protein rescues activity of 5-lipoxygenase mutations that delay nuclear membrane association and disrupt product formation

Time-resolved in situ assembly of the leukotriene-synthetic 5-lipoxygenase/5-lipoxygenase-activating protein complex in blood leukocytes

(2016) Jana Gerstmeier et al.   FASEB JOURNAL

Identification of the Substrate Access Portal of 5-Lipoxygenase

(2015) Sunayana Mitra et al.   BIOCHEMISTRY

5-Lipoxygenase, a key enzyme for leukotriene biosynthesis in health and disease

(2015) Olof Rådmark et al.   BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR AND CELL BIOLOGY OF LIPIDS

The structural basis for specificity in lipoxygenase catalysis

(2015) Marcia E. Newcomer et al.   PROTEIN SCIENCE

An experimental cell-based model for studying the cell biology and molecular pharmacology of 5-lipoxygenase-activating protein in leukotriene biosynthesis

(2014) Jana Gerstmeier et al.   BIOCHIMICA ET BIOPHYSICA ACTA-GENERAL SUBJECTS

The novel benzimidazole derivative BRP-7 inhibits leukotriene biosynthesisin vitroandin vivoby targeting 5-lipoxygenase-activating protein (FLAP)

(2014) C Pergola et al.   BRITISH JOURNAL OF PHARMACOLOGY

Roles of coactosin-like protein (CLP) and 5-lipoxygenase-activating protein (FLAP) in cellular leukotriene biosynthesis

(2014) D. Basavarajappa et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Cation−π Interactions As Lipid-Specific Anchors for Phosphatidylinositol-Specific Phospholipase C

(2013) Cédric Grauffel et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

Activation of 11R-Lipoxygenase Is Fully Ca2+-Dependent and Controlled by the Phospholipid Composition of the Target Membrane

(2012) Reet Järving et al.   BIOCHEMISTRY

Structure of a Calcium-dependent 11R-Lipoxygenase Suggests a Mechanism for Ca2+Regulation

(2012) Priit Eek et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

The nuclear membrane leukotriene synthetic complex is a signal integrator and transducer

(2012) Angela M. Bair et al.   MOLECULAR BIOLOGY OF THE CELL

The N-terminal β-barrel domain of mammalian lipoxygenases including mouse 5-lipoxygenase is not essential for catalytic activity and membrane binding but exhibits regulatory functions

(2011) Matthias Walther et al.   ARCHIVES OF BIOCHEMISTRY AND BIOPHYSICS

Dimerization of human 5-lipoxygenase

(2011) Ann-Kathrin Häfner et al.   BIOLOGICAL CHEMISTRY

The Structure of Human 5-Lipoxygenase

(2011) N. C. Gilbert et al.   SCIENCE

The 5-lipoxygenase/leukotriene pathway in preclinical models of cardiovascular disease

(2010) D. Poeckel et al.   CARDIOVASCULAR RESEARCH

The nuclear membrane organization of leukotriene synthesis

(2008) A. K. Mandal et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

What's all the FLAP about?: 5-lipoxygenase-activating protein inhibitors for inflammatory diseases

(2008) J EVANS et al.   TRENDS IN PHARMACOLOGICAL SCIENCES