The impact of DAMP-mediated inflammation in severe COVID-19 and related disorders

COVID-19 and Toll-Like Receptor 4 (TLR4): SARS-CoV-2 May Bind and Activate TLR4 to Increase ACE2 Expression, Facilitating Entry and Causing Hyperinflammation

(2021) Mohamed M. Aboudounya et al.   MEDIATORS OF INFLAMMATION

Anti-IL6 treatment of serious COVID-19 disease

(2021) Laura Castelnovo et al.   MEDICINE

Looking beyond COVID-19 vaccine phase 3 trials

(2021) Jerome H. Kim et al.   NATURE MEDICINE

Disease severity-specific neutrophil signatures in blood transcriptomes stratify COVID-19 patients

(2021) Anna C. Aschenbrenner et al.   Genome Medicine

Circulating mitochondrial DNA is an early indicator of severe illness and mortality from COVID-19

(2021) Davide Scozzi et al.   JCI Insight

Attributes and predictors of long COVID

(2021) Carole H. Sudre et al.   NATURE MEDICINE

CD52 Is Elevated on B cells of SLE Patients and Regulates B Cell Function

(2021) Kartik Bhamidipati et al.   Frontiers in Immunology

The spatial landscape of lung pathology during COVID-19 progression

(2021) André F. Rendeiro et al.   NATURE

Synthetic Siglec-9 Agonists Inhibit Neutrophil Activation Associated with COVID-19

(2021) Corleone S. Delaveris et al.   ACS Central Science

Role of DAMPs in respiratory virus-induced acute respiratory distress syndrome—with a preliminary reference to SARS-CoV-2 pneumonia

(2021) Walter Gottlieb Land   GENES AND IMMUNITY

Integrated analysis of plasma and single immune cells uncovers metabolic changes in individuals with COVID-19

(2021) Jihoon W. Lee et al.   NATURE BIOTECHNOLOGY

Evolution of NETosis markers and DAMPs have prognostic value in critically ill COVID-19 patients

(2021) Joram Huckriede et al.   Scientific Reports

Long COVID or Post-acute Sequelae of COVID-19 (PASC): An Overview of Biological Factors That May Contribute to Persistent Symptoms

(2021) Amy D. Proal et al.   Frontiers in Microbiology

Siglecs as Immune Cell Checkpoints in Disease

(2020) Shiteng Duan et al.   Annual Review of Immunology

A pneumonia outbreak associated with a new coronavirus of probable bat origin

(2020) Peng Zhou et al.   NATURE

Clinical Characteristics of Coronavirus Disease 2019 in China

(2020) Wei-jie Guan et al.   NEW ENGLAND JOURNAL OF MEDICINE

Pulmonary Arterial Thrombosis in COVID-19 With Fatal Outcome: Results From a Prospective, Single-Center, Clinicopathologic Case Series

(2020) Sigurd F. Lax et al.   ANNALS OF INTERNAL MEDICINE

Imbalanced Host Response to SARS-CoV-2 Drives Development of COVID-19

(2020) Daniel Blanco-Melo et al.   CELL

Heightened Innate Immune Responses in the Respiratory Tract of COVID-19 Patients

(2020) Zhuo Zhou et al.   Cell Host & Microbe

Immunology of COVID-19: current state of the science

(2020) Nicolas Vabret et al.   IMMUNITY

Neutrophil-to-lymphocyte ratio as an independent risk factor for mortality in hospitalized patients with COVID-19

(2020) Yuwei Liu et al.   JOURNAL OF INFECTION

Endothelial cell infection and endotheliitis in COVID-19

(2020) Zsuzsanna Varga et al.   LANCET

Alemtuzumab in multiple sclerosis during the COVID-19 pandemic: A mild uncomplicated infection despite intense immunosuppression

(2020) Tiziana Carandini et al.   Multiple Sclerosis Journal

Single-cell landscape of bronchoalveolar immune cells in patients with COVID-19

(2020) Mingfeng Liao et al.   NATURE MEDICINE

SARS-CoV-2 entry factors are highly expressed in nasal epithelial cells together with innate immune genes

(2020) Waradon Sungnak et al.   NATURE MEDICINE

Pulmonary Vascular Endothelialitis, Thrombosis, and Angiogenesis in Covid-19

(2020) Maximilian Ackermann et al.   NEW ENGLAND JOURNAL OF MEDICINE

SARS-CoV-2 productively infects human gut enterocytes

(2020) Mart M. Lamers et al.   SCIENCE

New understanding of the damage of SARS-CoV-2 infection outside the respiratory system

(2020) Yuhao Zhang et al.   BIOMEDICINE & PHARMACOTHERAPY

Neutrophil Extracellular Traps (NETs) Contribute to Immunothrombosis in COVID-19 Acute Respiratory Distress Syndrome

(2020) Elizabeth A Middleton et al.   BLOOD

Platelet Gene Expression and Function in COVID-19 Patients

(2020) Bhanu Kanth Manne et al.   BLOOD

Endothelial dysfunction in COVID-19: a position paper of the ESC Working Group for Atherosclerosis and Vascular Biology, and the ESC Council of Basic Cardiovascular Science

(2020) Paul C Evans et al.   CARDIOVASCULAR RESEARCH

Severe COVID-19 is marked by a dysregulated myeloid cell compartment

(2020) Jonas Schulte-Schrepping et al.   CELL

Elevated calprotectin and abnormal myeloid cell subsets discriminate severe from mild COVID-19

(2020) Aymeric Silvin et al.   CELL

Elevated serum levels of S100A8/A9 and HMGB1 at hospital admission are correlated with inferior clinical outcomes in COVID-19 patients

(2020) Liting Chen et al.   Cellular & Molecular Immunology

Targeting human TLRs to combat COVID‐19: A solution?

(2020) Ritwik Patra et al.   JOURNAL OF MEDICAL VIROLOGY

COVID-19 severity correlates with airway epithelium–immune cell interactions identified by single-cell analysis

(2020) Robert Lorenz Chua et al.   NATURE BIOTECHNOLOGY

Impaired type I interferon activity and inflammatory responses in severe COVID-19 patients

(2020) Jérôme Hadjadj et al.   SCIENCE

Incidence of thrombotic complications in critically ill ICU patients with COVID-19

(2020) F.A. Klok et al.   THROMBOSIS RESEARCH

COVID-19 in a multiple sclerosis (MS) patient treated with alemtuzumab: insight to the immune response after COVID

(2020) Celsi Fiorella et al.   Multiple Sclerosis and Related Disorders

Targeting the NLRP3 Inflammasome in Severe COVID-19

(2020) Tracey L. Freeman et al.   Frontiers in Immunology

Vascular occlusion by neutrophil extracellular traps in COVID-19

(2020) Moritz Leppkes et al.   EBioMedicine

Immunophenotyping of COVID-19 and influenza highlights the role of type I interferons in development of severe COVID-19

(2020) Jeong Seok Lee et al.   Science Immunology

Neutrophil extracellular traps in COVID-19

(2020) Yu Zuo et al.   JCI Insight

SARS-CoV-2 infects and induces cytotoxic effects in human cardiomyocytes

(2020) Denisa Bojkova et al.   CARDIOVASCULAR RESEARCH

Neutrophils and Contact Activation of Coagulation as Potential Drivers of Covid-19

(2020) Matthias H. Busch et al.   CIRCULATION

SARS-CoV-2–triggered neutrophil extracellular traps mediate COVID-19 pathology

(2020) Flavio Protasio Veras et al.   JOURNAL OF EXPERIMENTAL MEDICINE

COVID‐19 infection induces readily detectable morphologic and inflammation‐related phenotypic changes in peripheral blood monocytes

(2020) Dan Zhang et al.   JOURNAL OF LEUKOCYTE BIOLOGY

Mechanisms of SARS-CoV-2 transmission and pathogenesis

(2020) Andrew G. Harrison et al.   TRENDS IN IMMUNOLOGY

The specific metabolome profiling of patients infected by SARS-COV-2 supports the key role of tryptophan-nicotinamide pathway and cytosine metabolism

(2020) H. Blasco et al.   Scientific Reports

Abnormal immunity of non-survivors with COVID-19: predictors for mortality

(2020) Yang Zhao et al.   Infectious Diseases of Poverty

Potential COVID-19 infection in patients with severe multiple sclerosis treated with alemtuzumab

(2020) Jorge Matías-Guiu et al.   Multiple Sclerosis and Related Disorders

Mild COVID-19 infection in a patient with multiple sclerosis and severe depletion of T-lymphocyte subsets due to alemtuzumab

(2020) Carlos Guevara et al.   Multiple Sclerosis and Related Disorders

COVID-19 and multiple sclerosis: A description of two cases on alemtuzumab

(2020) Eva Fernández-Díaz et al.   Multiple Sclerosis and Related Disorders

Human Mesenchymal Stromal Cells Are Resistant to SARS-CoV-2 Infection under Steady-State, Inflammatory Conditions and in the Presence of SARS-CoV-2-Infected Cells

(2020) Richard Schäfer et al.   Stem Cell Reports

Excessive Neutrophils and Neutrophil Extracellular Traps in COVID-19

(2020) Jun Wang et al.   Frontiers in Immunology

Multi-Omics Resolves a Sharp Disease-State Shift between Mild and Moderate COVID-19

(2020) Yapeng Su et al.   CELL

Induction of alarmin S100A8/A9 mediates activation of aberrant neutrophils in the pathogenesis of COVID-19

(2020) Qirui Guo et al.   Cell Host & Microbe

Blood molecular markers associated with COVID‐19 immunopathology and multi‐organ damage

(2020) Yan‐Mei Chen et al.   EMBO JOURNAL

Longitudinal Multi-omics Analyses Identify Responses of Megakaryocytes, Erythroid Cells, and Plasmablasts as Hallmarks of Severe COVID-19

(2020) Joana P. Bernardes et al.   IMMUNITY

Neutrophil more than platelet activation associates with thrombotic complications in COVID-19 patients

(2020) E Petito et al.   JOURNAL OF INFECTIOUS DISEASES

Facing up to long COVID

(2020) The Lancet   LANCET

Pathophysiology of COVID-19-associated acute respiratory distress syndrome – Authors' reply

(2020) Giacomo Grasselli et al.   Lancet Respiratory Medicine

CD24 signalling through macrophage Siglec-10 is a target for cancer immunotherapy

(2019) Amira A. Barkal et al.   NATURE

Markers of neutrophil extracellular traps predict adverse outcome in community-acquired pneumonia: secondary analysis of a randomised controlled trial

(2018) Fahim Ebrahimi et al.   EUROPEAN RESPIRATORY JOURNAL

CD52 glycan binds the proinflammatory B box of HMGB1 to engage the Siglec-10 receptor and suppress human T cell function

(2018) Esther Bandala-Sanchez et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Necroptosis in anti-viral inflammation

(2018) Himani Nailwal et al.   CELL DEATH AND DIFFERENTIATION

Combined effect of anti-high-mobility group box-1 monoclonal antibody and peramivir against influenza A virus-induced pneumonia in mice

(2018) Kazuki Hatayama et al.   JOURNAL OF MEDICAL VIROLOGY

HMGB1 binds to activated platelets via the receptor for advanced glycation end products and is present in platelet rich human coronary artery thrombi

(2015) Michael Bode et al.   THROMBOSIS AND HAEMOSTASIS

Siglec-G-CD24 axis controls the severity of graft-versus-host disease in mice

(2014) T. Toubai et al.   BLOOD

Thrombosis: tangled up in NETs

(2013) K. Martinod et al.   BLOOD

NETosis: how vital is it?

(2013) B. G. Yipp et al.   BLOOD

CD52 as both a marker and an effector molecule of T cells with regulatory action: Identification of novel regulatory T cells

(2013) Buka Samten   Cellular & Molecular Immunology

Endothelial injury in sepsis

(2013) Marcel Levi et al.   INTENSIVE CARE MEDICINE

Depletion of blood neutrophils from patients with sepsis: treatment for the future?

(2013) Sion M. Lewis et al.   INTERNATIONAL IMMUNOPHARMACOLOGY

DAMPs activating innate and adaptive immune responses in COPD

(2013) S D Pouwels et al.   Mucosal Immunology

T cell regulation mediated by interaction of soluble CD52 with the inhibitory receptor Siglec-10

(2013) Esther Bandala-Sanchez et al.   NATURE IMMUNOLOGY

NETosis and NADPH oxidase: at the intersection of host defense, inflammation, and injury

(2013) Nikolaos G. Almyroudis et al.   Frontiers in Immunology

Neutrophil extracellular traps

(2013) Mélanie Demers et al.   OncoImmunology

Siglecs and Immune Regulation

(2012) Shiv Pillai et al.   Annual Review of Immunology

Neutrophil Extracellular Trap (NET) Impact on Deep Vein Thrombosis

(2012) Tobias A. Fuchs et al.   ARTERIOSCLEROSIS THROMBOSIS AND VASCULAR BIOLOGY

Intravascular Neutrophil Extracellular Traps Capture Bacteria from the Bloodstream during Sepsis

(2012) Braedon McDonald et al.   Cell Host & Microbe

Neutrophil extracellular traps: Is immunity the second function of chromatin?

(2012) Volker Brinkmann et al.   JOURNAL OF CELL BIOLOGY

Netting Neutrophils Induce Endothelial Damage, Infiltrate Tissues, and Expose Immunostimulatory Molecules in Systemic Lupus Erythematosus

(2011) E. Villanueva et al.   JOURNAL OF IMMUNOLOGY

Targeting Toll-like receptors: Emerging therapeutics for multiple sclerosis management

(2011) M. Gambuzza et al.   JOURNAL OF NEUROIMMUNOLOGY

Amelioration of sepsis by inhibiting sialidase-mediated disruption of the CD24-SiglecG interaction

(2011) Guo-Yun Chen et al.   NATURE BIOTECHNOLOGY

Activated endothelial cells induce neutrophil extracellular traps and are susceptible to NETosis-mediated cell death

(2010) Anurag Kumar Gupta et al.   FEBS LETTERS

DAMPening Inflammation by Modulating TLR Signalling

(2010) A. M. Piccinini et al.   MEDIATORS OF INFLAMMATION

HMGB1 induces human lung endothelial cell cytoskeletal rearrangement and barrier disruption

(2010) Rachel K. Wolfson et al.   MICROVASCULAR RESEARCH

Reciprocal coupling of coagulation and innate immunity via neutrophil serine proteases

(2010) Steffen Massberg et al.   NATURE MEDICINE

Extracellular DNA traps promote thrombosis

(2010) T. A. Fuchs et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Molecular mimicry of host sialylated glycans allows a bacterial pathogen to engage neutrophil Siglec-9 and dampen the innate immune response

(2009) A. F. Carlin et al.   BLOOD

Extracellular histones are major mediators of death in sepsis

(2009) Jun Xu et al.   NATURE MEDICINE

Netting neutrophils in autoimmune small-vessel vasculitis

(2009) Kai Kessenbrock et al.   NATURE MEDICINE

CD24 and Siglec-10 Selectively Repress Tissue Damage-Induced Immune Responses

(2009) G.-Y. Chen et al.   SCIENCE

Opening the flood-gates: how neutrophil-endothelial interactions regulate permeability

(2009) Matthew R. DiStasi et al.   TRENDS IN IMMUNOLOGY