Synthesis of Axially Chiral Aldehydes by N‐Heterocyclic‐Carbene‐Catalyzed Desymmetrization Followed by Kinetic Resolution

Carbene-catalyzed atroposelective synthesis of axially chiral styrenes

(2022) Jia-Lei Yan et al.   Nature Communications

Catalytic atroposelective synthesis of axially chiral benzonitriles via chirality control during bond dissociation and CN group formation

(2022) Ya Lv et al.   Nature Communications

N‐Heterocyclic Carbene‐Catalyzed Atroposelective Annulation for Access to Thiazine Derivatives with C‐N Axial Chirality

(2021) Tingting Li et al.   ANGEWANDTE CHEMIE-INTERNATIONAL EDITION

Dynamic Kinetic Resolution of α-Trifluoromethyl Hemiaminals without α-Hydrogen via NHC-Catalyzed O-Acylation

(2021) Yuan-Yuan Gao et al.   ORGANIC LETTERS

Carbene-Catalyzed Alkylation of Carboxylic Esters via Direct Photoexcitation of Acyl Azolium Intermediates

(2021) Shi-Chao Ren et al.   ACS Catalysis

NHC‐Catalyzed Desymmetrization of N‐Aryl Maleimides Leading to the Atroposelective Synthesis of N‐Aryl Succinimides

(2021) Soumen Barik et al.   ANGEWANDTE CHEMIE-INTERNATIONAL EDITION

Enantioselective Synthesis of Axially Chiral Benzothiophene/Benzofuran‐Fused Biaryls by N‐Heterocyclic Carbene Catalyzed Arene Formation

(2021) Chun‐Lin Zhang et al.   ANGEWANDTE CHEMIE-INTERNATIONAL EDITION

N‐Heterocyclic Carbene/Carboxylic Acid Co‐Catalysis Enables Oxidative Esterification of Demanding Aldehydes/Enals,at Low Catalyst Loading

(2021) Albrecht Berkessel et al.   ANGEWANDTE CHEMIE-INTERNATIONAL EDITION

Recent Advances in Catalytic Asymmetric Construction of Atropisomers

(2021) Jun Kee Cheng et al.   CHEMICAL REVIEWS

Efficient Synthesis of Sulfur-Stereogenic Sulfoximines via Ru(II)-Catalyzed Enantioselective C–H Functionalization Enabled by Chiral Carboxylic Acid

(2021) Tao Zhou et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

Carbene-Catalyzed Atroposelective Annulation and Desymmetrization of Urazoles

(2021) Jiamiao Jin et al.   ORGANIC LETTERS

Carbene‐Catalyzed Asymmetric Construction of Atropisomers

(2021) Runjiang Song et al.   ANGEWANDTE CHEMIE-INTERNATIONAL EDITION

Cobalt‐Catalyzed Radical Hydroamination of Alkenes with N ‐Fluorobenzenesulfonimides

(2021) Tao Qin et al.   ANGEWANDTE CHEMIE-INTERNATIONAL EDITION

Carbene‐Catalyzed Enantioselective Hydrophosphination of α‐Bromoenals to Prepare Phosphine‐Containing Chiral Molecules

(2021) Rakesh Maiti et al.   ANGEWANDTE CHEMIE-INTERNATIONAL EDITION

Organocatalytic Higher-Order [8+2] Cycloaddition for the Assembly of Atropoenantiomeric 3-Arylindolizines

(2021) Gongming Yang et al.   ORGANIC LETTERS

Atroposelective Dynamic Kinetic Resolution via In Situ Hemiaminals Catalyzed by N-Heterocyclic Carbene

(2021) Donghui Guo et al.   ORGANIC LETTERS

Recent Progress toward the Construction of Axially Chiral Molecules Catalyzed by an N-heterocyclic Carbene

(2021) Jiaming Wang et al.   ACS Catalysis

Merging C–H and C–C Activation in Pd(II)-Catalyzed Enantioselective Synthesis of Axially Chiral Biaryls

(2021) Hao-Ming Chen et al.   CCS Chemistry

Synthesis of Axially Chiral Styrenes through Pd-Catalyzed Asymmetric C−H Olefination Enabled by an Amino Amide Transient Directing Group

(2020) Hong Song et al.   ANGEWANDTE CHEMIE-INTERNATIONAL EDITION

Combined Photoredox and Carbene Catalysis for the Synthesis of Ketones from Carboxylic Acids

(2020) Karl Scheidt et al.   ANGEWANDTE CHEMIE-INTERNATIONAL EDITION

Bifunctional N-Heterocyclic Carbenes Derived from l-Pyroglutamic Acid and Their Applications in Enantioselective Organocatalysis

(2020) Xiang-Yu Chen et al.   ACCOUNTS OF CHEMICAL RESEARCH

Asymmetric Synthesis of Silicon‐Stereogenic Silanes by Copper‐Catalyzed Desymmetrizing Protoboration of Vinylsilanes

(2020) Ge Zhang et al.   ANGEWANDTE CHEMIE-INTERNATIONAL EDITION

Enantioselective Palladaelectro‐Catalyzed C–H Activations by Transient Directing Groups: Expedient Access to Helicenes

(2020) Uttam Dhawa et al.   ANGEWANDTE CHEMIE-INTERNATIONAL EDITION

Transition Metal‐Catalyzed Enantioselective C–H Functionalization via Chiral Transient Directing Group Strategy

(2020) Gang Liao et al.   ANGEWANDTE CHEMIE-INTERNATIONAL EDITION

Cooperative NHC and Photoredox Catalysis for the Synthesis of β‐Trifluoromethylated Alkyl Aryl Ketones

(2020) Qing-Yuan Meng et al.   ANGEWANDTE CHEMIE-INTERNATIONAL EDITION

Advances in asymmetric organocatalysis over the last 10 years

(2020) Shao-Hua Xiang et al.   Nature Communications

Enantioselective Synthesis of Atropisomers Featuring Pentatomic Heteroaromatics by Pd-Catalyzed C–H Alkynylation

(2019) Shuo Zhang et al.   ACS Catalysis

Kinetic Resolution, Dynamic Kinetic Resolution and Asymmetric Desymmetrization by N-Heterocyclic Carbene Catalysis

(2019) Carmela De Risi et al.   SYNTHESIS-STUTTGART

Combining Chiral Aldehyde Catalysis and Transition-Metal Catalysis for Enantioselective α-Allylic Alkylation of Amino Acid Esters

(2019) Lei Chen et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

N-Heterocyclic Carbene-Catalyzed Decarboxylative Alkylation of Aldehydes

(2019) Takuya Ishii et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

Enantioselective Desymmetrization of 1,4‐Dihydropyridines by Oxidative NHC Catalysis

(2019) Graziano Di Carmine et al.   CHEMISTRY-A EUROPEAN JOURNAL

Asymmetric Total Synthesis of TAN-1085 Facilitated by Pd-Catalyzed Atroposelective C–H Olefination

(2019) Jun Fan et al.   ORGANIC LETTERS

Synthesis of Chiral Aldehyde Catalysts by Pd-Catalyzed Atroposelective C−H Naphthylation

(2019) Gang Liao et al.   ANGEWANDTE CHEMIE-INTERNATIONAL EDITION

Construction of N–C Axial Chirality through Atroposelective C–H Olefination of N-Arylindoles by Palladium/Amino Acid Cooperative Catalysis

(2019) Jitan Zhang et al.   ORGANIC LETTERS

NHC-Catalyzed Atroposelective Acylation of Phenols: Access to Enantiopure NOBIN Analogs by Desymmetrization

(2019) Shenci Lu et al.   ORGANIC LETTERS

NHC-catalyzed atropoenantioselective synthesis of axially chiral biaryl amino alcohols via a cooperative strategy

(2019) Gongming Yang et al.   Nature Communications

Pd-Catalyzed Atroposelective C–H Allylation and Alkenylation: Access to Enantioenriched Atropisomers Featuring Pentatomic Heteroaromatics

(2019) Hao-Ming Chen et al.   ORGANOMETALLICS

Atroposelective Arene Formation by Carbene-Catalyzed Formal [4+2] Cycloaddition

(2019) Ke Xu et al.   ANGEWANDTE CHEMIE-INTERNATIONAL EDITION

Catalytic Enantioselective Methylene C(sp3 )−H Amidation of 8-Alkylquinolines Using a Cp*RhIII /Chiral Carboxylic Acid System

(2019) Seiya Fukagawa et al.   ANGEWANDTE CHEMIE-INTERNATIONAL EDITION

Diastereo- and Atroposelective Synthesis of Bridged Biaryls Bearing an Eight-Membered Lactone through an Organocatalytic Cascade

(2019) Shenci Lu et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

Scalable, Stereocontrolled Formal Syntheses of (+)-Isoschizandrin and (+)-Steganone: Development and Applications of Palladium(II)-Catalyzed Atroposelective C−H Alkynylation

(2018) Gang Liao et al.   ANGEWANDTE CHEMIE-INTERNATIONAL EDITION

N-Heterocyclic Carbene Catalysis via Azolium Dienolates: An Efficient Strategy for Remote Enantioselective Functionalizations

(2018) Xiang-Yu Chen et al.   ANGEWANDTE CHEMIE-INTERNATIONAL EDITION

A continuing challenge: N-heterocyclic carbene-catalyzed syntheses of γ-butyrolactones

(2018) Kathleen J. R. Murauski et al.   CHEMICAL SOCIETY REVIEWS

NHC-Organocatalyzed Kinetic Resolutions, Dynamic Kinetic Resolutions and Desymmetrizations

(2018) Zhongyao Wang et al.   Chemistry-An Asian Journal

Chiral Aldehyde Catalysis for the Catalytic Asymmetric Activation of Glycine Esters

(2018) Wei Wen et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

Carbonyl catalysis enables a biomimetic asymmetric Mannich reaction

(2018) Jianfeng Chen et al.   SCIENCE

Enantioselective [3+3] atroposelective annulation catalyzed by N-heterocyclic carbenes

(2018) Changgui Zhao et al.   Nature Communications

Enantioselective Carbonyl Catalysis Enabled by Chiral Aldehydes

(2018) Shuli You et al.   ANGEWANDTE CHEMIE-INTERNATIONAL EDITION

Chiral Carboxylic Acid Enabled Achiral Rhodium(III)-Catalyzed Enantioselective C−H Functionalization

(2018) Luqing Lin et al.   ANGEWANDTE CHEMIE-INTERNATIONAL EDITION

Access to All-Carbon Spirocycles through a Carbene and Thiourea Cocatalytic Desymmetrization Cascade Reaction

(2018) Shitian Zhuo et al.   ANGEWANDTE CHEMIE-INTERNATIONAL EDITION

Pd-Catalyzed Atroposelective C−H Allylation through β-O Elimination: Diverse Synthesis of Axially Chiral Biaryls

(2018) Gang Liao et al.   ANGEWANDTE CHEMIE-INTERNATIONAL EDITION

Copper-Catalyzed Asymmetric Aminocyanation of Arylcyclopropanes for Synthesis of γ-Amino Nitriles

(2018) Shengbiao Yang et al.   ACS Catalysis

Asymmetric Nitrone Synthesis via Ligand-Enabled Copper-Catalyzed Cope-Type Hydroamination of Cyclopropene with Oxime

(2017) Zhanyu Li et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

Catalytic enantioselective synthesis of atropisomeric biaryls by a cation-directed O-alkylation

(2017) John D. Jolliffe et al.   Nature Chemistry

Organocatalytic asymmetric arylation of indoles enabled by azo groups

(2017) Liang-Wen Qi et al.   Nature Chemistry

Catalytic Enantioselective Desymmetrization Reactions to All-Carbon Quaternary Stereocenters

(2016) Xing-Ping Zeng et al.   CHEMICAL REVIEWS

Organocatalytic enantioselective desymmetrisation

(2016) A. Borissov et al.   CHEMICAL SOCIETY REVIEWS

N-Heterocyclic Carbene Catalyzed Dynamic Kinetic Resolution of Pyranones

(2015) Changgui Zhao et al.   ANGEWANDTE CHEMIE-INTERNATIONAL EDITION

Nonbiaryl and Heterobiaryl Atropisomers: Molecular Templates with Promise for Atropselective Chemical Transformations

(2015) Elango Kumarasamy et al.   CHEMICAL REVIEWS

Organocatalytic Reactions Enabled by N-Heterocyclic Carbenes

(2015) Darrin M. Flanigan et al.   CHEMICAL REVIEWS

Recent advances in employing homoenolates generated by N-heterocyclic carbene (NHC) catalysis in carbon–carbon bond-forming reactions

(2015) Rajeev S. Menon et al.   CHEMICAL SOCIETY REVIEWS

Recent advances and new concepts for the synthesis of axially stereoenriched biaryls

(2015) J. Wencel-Delord et al.   CHEMICAL SOCIETY REVIEWS

A twist of nature – the significance of atropisomers in biological systems

(2015) Jamie E. Smyth et al.   NATURAL PRODUCT REPORTS

Intermolecular Dynamic Kinetic Resolution Cooperatively Catalyzed by an N-Heterocyclic Carbene and a Lewis Acid

(2014) Zijun Wu et al.   ANGEWANDTE CHEMIE-INTERNATIONAL EDITION

Kinetic Resolution of 1,1′-Biaryl-2,2′-Diols and Amino Alcohols through NHC-Catalyzed Atroposelective Acylation

(2014) Shenci Lu et al.   ANGEWANDTE CHEMIE-INTERNATIONAL EDITION

Complete Field Guide to Asymmetric BINOL-Phosphate Derived Brønsted Acid and Metal Catalysis: History and Classification by Mode of Activation; Brønsted Acidity, Hydrogen Bonding, Ion Pairing, and Metal Phosphates

(2014) Dixit Parmar et al.   CHEMICAL REVIEWS

Enzymatic Desymmetrising Redox Reactions for the Asymmetric Synthesis of Biaryl Atropisomers

(2014) Samantha Staniland et al.   CHEMISTRY-A EUROPEAN JOURNAL

An overview of N-heterocyclic carbenes

(2014) Matthew N. Hopkinson et al.   NATURE

Spontaneous transfer of chirality in an atropisomerically enriched two-axis system

(2014) Kimberly T. Barrett et al.   NATURE

Catalytic asymmetric direct α-alkylation of amino esters by aldehydes via imine activation

(2014) Biao Xu et al.   Chemical Science

Kinetic Resolution of Tertiary Alcohols: Highly Enantioselective Access to 3-Hydroxy-3-Substituted Oxindoles

(2013) Shenci Lu et al.   ANGEWANDTE CHEMIE-INTERNATIONAL EDITION

N-Heterocyclic-Carbene-Catalyzed Asymmetric Oxidative Hetero-Diels-Alder Reactions with Simple Aliphatic Aldehydes

(2012) Xiaodan Zhao et al.   ANGEWANDTE CHEMIE-INTERNATIONAL EDITION

Organocatalytic umpolung: N-heterocyclic carbenes and beyond

(2012) Xavier Bugaut et al.   CHEMICAL SOCIETY REVIEWS

Enantioselective Fluorescent Sensors: A Tale of BINOL

(2011) Lin Pu   ACCOUNTS OF CHEMICAL RESEARCH

Generation and exploitation of acyclic azomethine imines in chiral Brønsted acid catalysis

(2011) Takuya Hashimoto et al.   Nature Chemistry

Enantioselective Formal Alkenylations of Imines Catalyzed by Axially Chiral Dicarboxylic Acid Using Vinylogous Aza-Enamines

(2010) Takuya Hashimoto et al.   ANGEWANDTE CHEMIE-INTERNATIONAL EDITION

Atroposelective Total Synthesis of Axially Chiral Biaryl Natural Products

(2010) Gerhard Bringmann et al.   CHEMICAL REVIEWS

NHC Catalyzed Oxidations of Aldehydes to Esters: Chemoselective Acylation of Alcohols in Presence of Amines

(2010) Suman De Sarkar et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

Dynamic Kinetic Resolution of Biaryl Atropisomers via Peptide-Catalyzed Asymmetric Bromination

(2010) J. L. Gustafson et al.   SCIENCE

The Challenge of Atropisomerism in Drug Discovery

(2009) Jonathan Clayden et al.   ANGEWANDTE CHEMIE-INTERNATIONAL EDITION

Total synthesis of chiral biaryl natural products by asymmetric biaryl coupling

(2009) Marisa C. Kozlowski et al.   CHEMICAL SOCIETY REVIEWS

Biomimetic Carbene-Catalyzed Oxidations of Aldehydes Using TEMPO

(2008) Joyram Guin et al.   ANGEWANDTE CHEMIE-INTERNATIONAL EDITION

The Marinopyrroles, Antibiotics of an Unprecedented Structure Class from a MarineStreptomycessp.

(2008) Chambers C. Hughes et al.   ORGANIC LETTERS

Chirality-Sensing Supramolecular Systems

(2007) Guy A. Hembury et al.   CHEMICAL REVIEWS