A wrinkle in time: circadian biology in pulmonary vascular health and disease

Short-term exposure to intermittent hypoxia leads to changes in gene expression seen in chronic pulmonary disease

(2021) Gang Wu et al.   eLife

Circadian misalignment promotes vascular smooth muscle cell apoptosis via defective autophagy

(2021) Zhenyu Guo et al.   JOURNAL OF MOLECULAR HISTOLOGY

Integration of feeding behavior by the liver circadian clock reveals network dependency of metabolic rhythms

(2021) Carolina M. Greco et al.   Science Advances

Molecular clock REV-ERBα regulates cigarette smoke–induced pulmonary inflammation and epithelial-mesenchymal transition

(2021) Qixin Wang et al.   JCI Insight

The circadian clock component BMAL1 regulates SARS-CoV-2 entry and replication in lung epithelial cells

(2021) Xiaodong Zhuang et al.   iScience

BMAL1-Downregulation Aggravates Porphyromonas Gingivalis-Induced Atherosclerosis by Encouraging Oxidative Stress

(2020) Mengru Xie et al.   CIRCULATION RESEARCH

Programmed ‘disarming’ of the neutrophil proteome reduces the magnitude of inflammation

(2020) Jose M. Adrover et al.   NATURE IMMUNOLOGY

Resveratrol Prevents Right Ventricle Remodeling and Dysfunction in Monocrotaline-Induced Pulmonary Arterial Hypertension with a Limited Improvement in the Lung Vasculature

(2020) Eduardo Vázquez-Garza et al.   Oxidative Medicine and Cellular Longevity

Reduced caloric intake and periodic fasting independently contribute to metabolic effects of caloric restriction

(2020) Nikkhil Velingkaar et al.   AGING CELL

Knockout of the Circadian Clock Protein PER1 Results in Sex-Dependent Alterations of ET-1 Production in Mice in Response to a High Salt Diet plus Mineralocorticoid Treatment

(2020) Lauren G Douma et al.   CANADIAN JOURNAL OF PHYSIOLOGY AND PHARMACOLOGY

Activated pathogenic Th17 lymphocytes induce hypertension following high-fructose intake in Dahl salt-sensitive but not Dahl salt-resistant rats

(2020) Eunjo Lee et al.   Disease Models & Mechanisms

The role of circadian clock gene BMAL1 in vascular proliferation

(2020) Akira Takaguri et al.   EUROPEAN JOURNAL OF PHARMACOLOGY

Endothelin Receptor Antagonists: Status Quo and Future Perspectives for Targeted Therapy

(2020) Frederik C. Enevoldsen et al.   Journal of Clinical Medicine

Out of Breath, Out of Time: Interactions between HIF and Circadian Rhythms

(2020) Emma J O'Connell et al.   AMERICAN JOURNAL OF PHYSIOLOGY-CELL PHYSIOLOGY

Bmal1 Deletion in Myeloid Cells Attenuates Atherosclerotic Lesion Development and Restrains Abdominal Aortic Aneurysm Formation in Hyperlipidemic Mice

(2020) Guangrui Yang et al.   ARTERIOSCLEROSIS THROMBOSIS AND VASCULAR BIOLOGY

Synchronization of the circadian clock by time-restricted feeding with progressive increasing calorie intake. Resemblances and differences regarding a sustained hypocaloric restriction

(2020) Ana Cristina García-Gaytán et al.   Scientific Reports

Selective BMP-9 Inhibition Partially Protects Against Experimental Pulmonary Hypertension

(2019) Ly Tu et al.   CIRCULATION RESEARCH

Clock Gene Expression is Altered in Veterans with Sleep Apnea

(2019) Muna T Canales et al.   PHYSIOLOGICAL GENOMICS

Circadian rhythms and the molecular clock in cardiovascular biology and disease

(2019) Sandra Crnko et al.   Nature Reviews Cardiology

Sleep modulates haematopoiesis and protects against atherosclerosis

(2019) Cameron S. McAlpine et al.   NATURE

Neuropeptide changes in the suprachiasmatic nucleus are associated with the development of hypertension

(2019) Ajda Yilmaz et al.   CHRONOBIOLOGY INTERNATIONAL

Chemokine signaling axis between endothelial and myeloid cells regulates development of pulmonary hypertension associated with pulmonary fibrosis and hypoxia

(2019) Aline C Oliveira et al.   AMERICAN JOURNAL OF PHYSIOLOGY-LUNG CELLULAR AND MOLECULAR PHYSIOLOGY

Circadian Rhythm of Vascular Function in Midlife Adults

(2019) Saurabh S. Thosar et al.   ARTERIOSCLEROSIS THROMBOSIS AND VASCULAR BIOLOGY

Why Lungs Keep Time: Circadian Rhythms and Lung Immunity

(2019) Charles Nosal et al.   Annual Review of Physiology

Medicine in the Fourth Dimension

(2019) Christopher R. Cederroth et al.   Cell Metabolism

Rev-erbα can regulate the NF-κB/NALP3 pathway to modulate lipopolysaccharide-induced acute lung injury and inflammation

(2019) Dapeng Yu et al.   INTERNATIONAL IMMUNOPHARMACOLOGY

Targeting Glioblastoma Stem Cells through Disruption of the Circadian Clock

(2019) Zhen Dong et al.   Cancer Discovery

A Neutrophil Timer Coordinates Immune Defense and Vascular Protection

(2019) José M. Adrover et al.   IMMUNITY

Quercetin, caffeic acid and resveratrol regulate circadian clock genes and aging-related genes in young and old human lung fibroblast cells

(2019) Yoshinori Okada et al.   MOLECULAR BIOLOGY REPORTS

Nobiletin fortifies mitochondrial respiration in skeletal muscle to promote healthy aging against metabolic challenge

(2019) Kazunari Nohara et al.   Nature Communications

Alternations of Circadian Clock Genes Expression and Oscillation in Obstructive Sleep Apnea

(2019) Yang et al.   Journal of Clinical Medicine

Emergency myelopoiesis contributes to immune cell exhaustion and pulmonary vascular remodelling

(2019) Chunhua Fu et al.   BRITISH JOURNAL OF PHARMACOLOGY

Melatonin inhibits inflammasome-associated activation of endothelium and macrophages attenuating pulmonary arterial hypertension

(2019) Jingyuan Zhang et al.   CARDIOVASCULAR RESEARCH

Effects of Intermittent Fasting on Health, Aging, and Disease

(2019) Rafael de Cabo et al.   NEW ENGLAND JOURNAL OF MEDICINE

Hypoxia induces a time- and tissue-specific response that elicits intertissue circadian clock misalignment

(2019) Gal Manella et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

OUP accepted manuscript

(2018)   ACTA BIOCHIMICA ET BIOPHYSICA SINICA

Protective Role of Myelocytic Nitric Oxide Synthases against Hypoxic Pulmonary Hypertension in Mice

(2018) Takaaki Ogoshi et al.   AMERICAN JOURNAL OF RESPIRATORY AND CRITICAL CARE MEDICINE

PPARγ Regulates Mitochondrial Structure and Function and Human Pulmonary Artery Smooth Muscle Cell Proliferation

(2018) Samantha M. Yeligar et al.   AMERICAN JOURNAL OF RESPIRATORY CELL AND MOLECULAR BIOLOGY

Myeloid-derived Suppressor Cells Are Necessary for Development of Pulmonary Hypertension

(2018) Andrew J. Bryant et al.   AMERICAN JOURNAL OF RESPIRATORY CELL AND MOLECULAR BIOLOGY

Deletion of BMAL1 in Smooth Muscle Cells Protects Mice From Abdominal Aortic AneurysmsHighlights

(2018) Jenny Lutshumba et al.   ARTERIOSCLEROSIS THROMBOSIS AND VASCULAR BIOLOGY

DOCA/salt hypertension alters Period1 and orexin-related gene expression in the medulla and hypothalamus of male rats: Diurnal influences

(2018) M.E. Hernandez et al.   AUTONOMIC NEUROSCIENCE-BASIC & CLINICAL

New perspectives on the role of melatonin in human sleep, circadian rhythms and their regulation

(2018) Nava Zisapel   BRITISH JOURNAL OF PHARMACOLOGY

Acid Suspends the Circadian Clock in Hypoxia through Inhibition of mTOR

(2018) Zandra E. Walton et al.   CELL

Chrono-pharmacological Targeting of the CCL2-CCR2 Axis Ameliorates Atherosclerosis

(2018) Carla Winter et al.   Cell Metabolism

Bmal1 in Perivascular Adipose Tissue Regulates Resting-Phase Blood Pressure Through Transcriptional Regulation of Angiotensinogen

(2018) Lin Chang et al.   CIRCULATION

Identification of circadian clock modulators from existing drugs

(2018) T Katherine Tamai et al.   EMBO Molecular Medicine

A potential therapeutic role for angiotensin-converting enzyme 2 in human pulmonary arterial hypertension

(2018) Anna R. Hemnes et al.   EUROPEAN RESPIRATORY JOURNAL

Circadian clock-mediated regulation of blood pressure

(2018) Lauren G. Douma et al.   FREE RADICAL BIOLOGY AND MEDICINE

Involvement of Neuroinflammation in the Pathogenesis of Monocrotaline-Induced Pulmonary HypertensionNovelty and Significance

(2018) Ravindra K. Sharma et al.   HYPERTENSION

Dec1 and CLOCK Regulate Na+/K+-ATPase β1 Subunit Expression and Blood Pressure

(2018) Ayumu Nakashima et al.   HYPERTENSION

Circadian clock component REV-ERBα controls homeostatic regulation of pulmonary inflammation

(2018) Marie Pariollaud et al.   JOURNAL OF CLINICAL INVESTIGATION

Ectopic upregulation of membrane-bound IL6R drives vascular remodeling in pulmonary arterial hypertension

(2018) Yuichi Tamura et al.   JOURNAL OF CLINICAL INVESTIGATION

Inflammatory Macrophage Expansion in Pulmonary Hypertension Depends upon Mobilization of Blood-Borne Monocytes

(2018) Jonathan Florentin et al.   JOURNAL OF IMMUNOLOGY

MMP-2 and MMP-9 contribute to the angiogenic effect produced by hypoxia/15-HETE in pulmonary endothelial cells

(2018) Ying Liu et al.   JOURNAL OF MOLECULAR AND CELLULAR CARDIOLOGY

PPARγ agonist pioglitazone reverses pulmonary hypertension and prevents right heart failure via fatty acid oxidation

(2018) Ekaterina Legchenko et al.   Science Translational Medicine

Vasculature on the clock: Circadian rhythm and vascular dysfunction

(2018) Sandra Crnko et al.   VASCULAR PHARMACOLOGY

The choroid plexus is an important circadian clock component

(2018) Jihwan Myung et al.   Nature Communications

The Circadian Clock Controls Immune Checkpoint Pathway in Sepsis

(2018) Wenjun Deng et al.   Cell Reports

mTOR signaling regulates central and peripheral circadian clock function

(2018) Chidambaram Ramanathan et al.   PLoS Genetics

Spontaneous pulmonary hypertension in genetic mouse models of natural killer cell deficiency

(2018) Matthew T. Ratsep et al.   AMERICAN JOURNAL OF PHYSIOLOGY-LUNG CELLULAR AND MOLECULAR PHYSIOLOGY

Resveratrol inhibits monocrotaline-induced pulmonary arterial remodeling by suppression of SphK1-mediated NF-κB activation

(2018) Wenhua Shi et al.   LIFE SCIENCES

Neuroglobin correlates with cryptochrome-1 in obstructive sleep apnea with primary aldosteronism

(2018) Rimawati Tedjasukmana et al.   PLoS One

Circadian clock protein BMAL1 regulates IL-1β in macrophages via NRF2

(2018) James O. Early et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Training the Circadian Clock, Clocking the Drugs, and Drugging the Clock to Prevent, Manage, and Treat Chronic Diseases

(2018) Gabriele Sulli et al.   TRENDS IN PHARMACOLOGICAL SCIENCES

Female C57BL/6J mice lacking the circadian clock protein PER1 are protected from nondipping hypertension

(2018) Lauren G. Douma et al.   AMERICAN JOURNAL OF PHYSIOLOGY-REGULATORY INTEGRATIVE AND COMPARATIVE PHYSIOLOGY

Redox Biology of Peroxisome Proliferator-Activated Receptor-γ in Pulmonary Hypertension

(2018) Victor Tseng et al.   ANTIOXIDANTS & REDOX SIGNALING

The Circadian Protein Period2 Suppresses mTORC1 Activity via Recruiting Tsc1 to mTORC1 Complex

(2018) Rong Wu et al.   Cell Metabolism

Haemodynamic definitions and updated clinical classification of pulmonary hypertension

(2018) Gérald Simonneau et al.   EUROPEAN RESPIRATORY JOURNAL

Inflammation induces endothelial-to-mesenchymal transition and promotes vascular calcification through downregulation of BMPR2

(2018) Gonzalo Sánchez-Duffhues et al.   JOURNAL OF PATHOLOGY

The emerging link between cancer, metabolism, and circadian rhythms

(2018) Selma Masri et al.   NATURE MEDICINE

SUMOylation of ROR-γt inhibits IL-17 expression and inflammation via HDAC2

(2018) Amir Kumar Singh et al.   Nature Communications

Hypoxia-induced PD-L1/PD-1 crosstalk impairs T-cell function in sleep apnoea

(2017) Carolina Cubillos-Zapata et al.   EUROPEAN RESPIRATORY JOURNAL

Myeloid Bmal1 deletion increases monocyte recruitment and worsens atherosclerosis

(2017) Mingyu Huo et al.   FASEB JOURNAL

A circadian clock gene, PER2, activates HIF-1 as an effector molecule for recruitment of HIF-1α to promoter regions of its downstream genes

(2017) Minoru Kobayashi et al.   FEBS Journal

Expansion of CD11b+Ly6Ghigh and CD11b+CD49d+ myeloid cells with suppressive potential in mice with chronic inflammation and light-at-night-induced circadian disruption

(2017) Yuliya V. Perfilyeva et al.   INFLAMMATION RESEARCH

Melatonin Attenuates Pulmonary Hypertension in Chronically Hypoxic Rats

(2017) Ming Hung et al.   INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

Targeting Vascular Remodeling to Treat Pulmonary Arterial Hypertension

(2017) A.A. Roger Thompson et al.   TRENDS IN MOLECULAR MEDICINE

Aberrant Proteostasis of BMAL1 Underlies Circadian Abnormalities in a Paradigmatic mTOR-opathy

(2017) Jonathan O. Lipton et al.   Cell Reports

Desoxycorticosterone pivalate-salt treatment leads to non-dipping hypertension in Per1 knockout mice

(2016) K. Solocinski et al.   Acta Physiologica

Macitentan: A Review in Pulmonary Arterial Hypertension

(2016) Gillian M. Keating   American Journal of Cardiovascular Drugs

Carbazole-containing sulfonamides and sulfamides: Discovery of cryptochrome modulators as antidiabetic agents

(2016) Paul S. Humphries et al.   BIOORGANIC & MEDICINAL CHEMISTRY LETTERS

Group III Pulmonary Hypertension

(2016) James R. Klinger   CARDIOLOGY CLINICS

The Small Molecule Nobiletin Targets the Molecular Oscillator to Enhance Circadian Rhythms and Protect against Metabolic Syndrome

(2016) Baokun He et al.   Cell Metabolism

CLOCK and BMAL1 Regulate Muscle Insulin Sensitivity via SIRT1 in Male Mice

(2016) Jun Liu et al.   ENDOCRINOLOGY

Low-Salt Diet and Circadian Dysfunction Synergize to Induce Angiotensin II–Dependent Hypertension in Mice

(2016) Paramita Pati et al.   HYPERTENSION

Resveratrol alleviate hypoxic pulmonary hypertension via anti-inflammation and anti-oxidant pathways in rats

(2016) Dunquan Xu et al.   International Journal of Medical Sciences

Symptom Interference Severity and Health-Related Quality of Life in Pulmonary Arterial Hypertension

(2016) Lea Ann Matura et al.   JOURNAL OF PAIN AND SYMPTOM MANAGEMENT

SENP-1 enhances hypoxia-induced proliferation of rat pulmonary artery smooth muscle cells by regulating hypoxia-inducible factor-1α

(2016) FANG ZHOU et al.   Molecular Medicine Reports

Transcriptional architecture of the mammalian circadian clock

(2016) Joseph S. Takahashi   NATURE REVIEWS GENETICS

Endotoxin Disrupts Circadian Rhythms in Macrophages via Reactive Oxygen Species

(2016) Yusi Wang et al.   PLoS One

Mechanisms linking circadian clocks, sleep, and neurodegeneration

(2016) Erik S. Musiek et al.   SCIENCE

Calorie restriction regulates circadian clock gene expression through BMAL1 dependent and independent mechanisms

(2016) Sonal A. Patel et al.   Scientific Reports

BMAL1-dependent regulation of the mTOR signaling pathway delays aging

(2016) Rohini V. Khapre et al.   Aging-US

Per2-Mediated Vascular Dysfunction Is Caused by the Upregulation of the Connective Tissue Growth Factor (CTGF)

(2016) Vaishnavi Jadhav et al.   PLoS One

Negative reciprocal regulation between Sirt1 and Per2 modulates the circadian clock and aging

(2016) Rui-Hong Wang et al.   Scientific Reports

Circadian molecular clock in lung pathophysiology

(2015) Isaac K. Sundar et al.   AMERICAN JOURNAL OF PHYSIOLOGY-LUNG CELLULAR AND MOLECULAR PHYSIOLOGY

Regulation of Oxidative Stress in Pulmonary Artery Endothelium. Modulation of Extracellular Superoxide Dismutase and NOX4 Expression Using Histone Deacetylase Class I Inhibitors

(2015) Igor N. Zelko et al.   AMERICAN JOURNAL OF RESPIRATORY CELL AND MOLECULAR BIOLOGY

Circadian Clock–Coupled Lung Cellular and Molecular Functions in Chronic Airway Diseases

(2015) Isaac K. Sundar et al.   AMERICAN JOURNAL OF RESPIRATORY CELL AND MOLECULAR BIOLOGY

Disruption of Sirtuin 1–Mediated Control of Circadian Molecular Clock and Inflammation in Chronic Obstructive Pulmonary Disease

(2015) Hongwei Yao et al.   AMERICAN JOURNAL OF RESPIRATORY CELL AND MOLECULAR BIOLOGY

Why Sleep Is Important for Health: A Psychoneuroimmunology Perspective

(2015) Michael R. Irwin   Annual Review of Psychology

Endothelial-to-Mesenchymal Transition in Pulmonary Hypertension

(2015) B. Ranchoux et al.   CIRCULATION

Exercise training improves peak oxygen consumption and haemodynamics in patients with severe pulmonary arterial hypertension and inoperable chronic thrombo-embolic pulmonary hypertension: a prospective, randomized, controlled trial

(2015) Nicola Ehlken et al.   EUROPEAN HEART JOURNAL

Overexpression of circadian clock protein cryptochrome (CRY) 1 alleviates sleep deprivation-induced vascular inflammation in a mouse model

(2015) Bing Qin et al.   IMMUNOLOGY LETTERS

Increased SUMO-1 expression in response to hypoxia: Interaction with HIF-1α in hypoxic pulmonary hypertension

(2015) YONGLIANG JIANG et al.   INTERNATIONAL JOURNAL OF MOLECULAR MEDICINE

Calorie Restriction Attenuates Monocrotaline-induced Pulmonary Arterial Hypertension in Rats

(2015) Mingge Ding et al.   JOURNAL OF CARDIOVASCULAR PHARMACOLOGY

PDK1 orchestrates early NK cell development through induction of E4BP4 expression and maintenance of IL-15 responsiveness

(2015) Meixiang Yang et al.   JOURNAL OF EXPERIMENTAL MEDICINE

Melatonin as a preventive and curative therapy against pulmonary hypertension

(2015) Gerald Maarman et al.   JOURNAL OF PINEAL RESEARCH

How sleep and wakefulness influence circadian rhythmicity: effects of insufficient and mistimed sleep on the animal and human transcriptome

(2015) Simon N. Archer et al.   JOURNAL OF SLEEP RESEARCH

Upregulation of the gene expression of CLOCK is correlated with hypoxia-inducible factor 1α in advanced varicose lesions

(2015) XIAO TANG et al.   Molecular Medicine Reports

Selective enhancement of endothelial BMPR-II with BMP9 reverses pulmonary arterial hypertension

(2015) Lu Long et al.   NATURE MEDICINE

hCLOCK Causes Rho-Kinase-Mediated Endothelial Dysfunction and NF-κB-Mediated Inflammatory Responses

(2015) Xiao Tang et al.   Oxidative Medicine and Cellular Longevity

The role of sleep hygiene in promoting public health: A review of empirical evidence

(2015) Leah A. Irish et al.   SLEEP MEDICINE REVIEWS

Dietary proanthocyanidins modulate BMAL1 acetylation, Nampt expression and NAD levels in rat liver

(2015) Aleix Ribas-Latre et al.   Scientific Reports

Resveratrol prevents hypoxia-induced arginase II expression and proliferation of human pulmonary artery smooth muscle cells via Akt-dependent signaling

(2014) Bernadette Chen et al.   AMERICAN JOURNAL OF PHYSIOLOGY-LUNG CELLULAR AND MOLECULAR PHYSIOLOGY

Sleep disturbance, symptoms, psychological distress, and health-related quality of life in pulmonary arterial hypertension

(2014) Lea Ann Matura et al.   European Journal of Cardiovascular Nursing

SuHx rat model: partly reversible pulmonary hypertension and progressive intima obstruction

(2014) M. A. de Raaf et al.   EUROPEAN RESPIRATORY JOURNAL

CRY1, CRY2 and PRKCDBP genetic variants in metabolic syndrome

(2014) Leena Kovanen et al.   HYPERTENSION RESEARCH

α1-Adrenergic Receptor Signaling in Osteoblasts Regulates Clock Genes and Bone Morphogenetic Protein 4 Expression through Up-regulation of the Transcriptional Factor Nuclear Factor IL-3 (Nfil3)/E4 Promoter-binding Protein 4 (E4BP4)

(2014) Takao Hirai et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Tissue-specific and time-dependent regulation of the endothelin axis by the circadian clock protein Per1

(2014) Jacob Richards et al.   LIFE SCIENCES

The rhythmic expression of clock genes attenuated in human plaque-derived vascular smooth muscle cells

(2014) Changpo Lin et al.   Lipids in Health and Disease

Effect of Th17 and Treg Axis Disorder on Outcomes of Pulmonary Arterial Hypertension in Connective Tissue Diseases

(2014) Saren Gaowa et al.   MEDIATORS OF INFLAMMATION

REV-ERB and ROR nuclear receptors as drug targets

(2014) Douglas J. Kojetin et al.   NATURE REVIEWS DRUG DISCOVERY

A circadian gene expression atlas in mammals: Implications for biology and medicine

(2014) Ray Zhang et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Chronic Sleep Fragmentation Induces Endothelial Dysfunction and Structural Vascular Changes in Mice

(2014) Alba Carreras et al.   SLEEP

Direct and Indirect Suppression of Interleukin-6 Gene Expression in Murine Macrophages by Nuclear Orphan Receptor REV-ERBα

(2014) Shogo Sato et al.   TheScientificWorldJOURNAL

Circadian rhythm reprogramming during lung inflammation

(2014) Jeffrey A. Haspel et al.   Nature Communications

Circadian Variation in Vascular Function and Regenerative Capacity in Healthy Humans

(2014) Ibhar Al Mheid et al.   Journal of the American Heart Association

Circadian rhythms, Wnt/beta-catenin pathway and PPAR alpha/gamma profiles in diseases with primary or secondary cardiac dysfunction

(2014) Yves Lecarpentier et al.   Frontiers in Physiology

Everolimus in Patients with Severe Pulmonary Hypertension: A Safety and Efficacy Pilot Trial

(2014) Hans-Jürgen Seyfarth et al.   Pulmonary Circulation

Nitric Oxide Deficiency and Endothelial Dysfunction in Pulmonary Arterial Hypertension

(2013) James R. Klinger et al.   AMERICAN JOURNAL OF RESPIRATORY AND CRITICAL CARE MEDICINE

Rapamycin Reverses Pulmonary Artery Smooth Muscle Cell Proliferation in Pulmonary Hypertension

(2013) Amal Houssaini et al.   AMERICAN JOURNAL OF RESPIRATORY CELL AND MOLECULAR BIOLOGY

Sleep is not just for the brain: transcriptional responses to sleep in peripheral tissues

(2013) Ron C Anafi et al.   BMC GENOMICS

Clock controls angiogenesis

(2013) Lasse Jensen et al.   CELL CYCLE

Hemodynamic Improvement of Pulmonary Arterial Hypertension After Bariatric Surgery: Potential Role for Metabolic Regulation

(2013) M. E. Pugh et al.   DIABETES CARE

Circadian clock function is disrupted by environmental tobacco/cigarette smoke, leading to lung inflammation and injury via a SIRT1-BMAL1 pathway

(2013) Jae-Woong Hwang et al.   FASEB JOURNAL

Chronic phase advance alters circadian physiological rhythms and peripheral molecular clocks

(2013) Gretchen Wolff et al.   JOURNAL OF APPLIED PHYSIOLOGY

A Circadian Clock Gene, Rev-erb , Modulates the Inflammatory Function of Macrophages through the Negative Regulation of Ccl2 Expression

(2013) S. Sato et al.   JOURNAL OF IMMUNOLOGY

Chronotherapy improves blood pressure control and reduces vascular risk in CKD

(2013) Ramón C. Hermida et al.   Nature Reviews Nephrology

Increased Atherosclerotic Lesions in LDL Receptor Deficient Mice With Hematopoietic Nuclear Receptor Rev‐erbα Knock‐ Down

(2013) Hongling Ma et al.   Journal of the American Heart Association

Intense Physiological Light Upregulates Vascular Endothelial Growth Factor and Enhances Choroidal Neovascularization via Peroxisome Proliferator-Activated Receptor γ Coactivator-1α in Mice

(2012) Takashi Ueta et al.   ARTERIOSCLEROSIS THROMBOSIS AND VASCULAR BIOLOGY

Time-Restricted Feeding without Reducing Caloric Intake Prevents Metabolic Diseases in Mice Fed a High-Fat Diet

(2012) Megumi Hatori et al.   Cell Metabolism

Histone Deacetylation Inhibition in Pulmonary Hypertension

(2012) Lan Zhao et al.   CIRCULATION

Increased Superoxide and Endothelial NO Synthase Uncoupling in Blood Vessels of Bmal1-Knockout Mice

(2012) Ciprian B. Anea et al.   CIRCULATION RESEARCH

Per2Mutation Recapitulates the Vascular Phenotype of Diabetes in the Retina and Bone Marrow

(2012) Ashay D. Bhatwadekar et al.   DIABETES

Scheduled Exercise Phase Shifts the Circadian Clock in Skeletal Muscle

(2012) GRETCHEN WOLFF et al.   MEDICINE AND SCIENCE IN SPORTS AND EXERCISE

Regulation of circadian behaviour and metabolism by REV-ERB-α and REV-ERB-β

(2012) Han Cho et al.   NATURE

RORγ directly regulates the circadian expression of clock genes and downstream targets in vivo

(2012) Yukimasa Takeda et al.   NUCLEIC ACIDS RESEARCH

cGMP-Phosphodiesterase Inhibition Enhances Photic Responses and Synchronization of the Biological Circadian Clock in Rodents

(2012) Santiago A. Plano et al.   PLoS One

Identification of Small Molecule Activators of Cryptochrome

(2012) T. Hirota et al.   SCIENCE

Opposing Effects of Circadian Clock Genes Bmal1 and Period2 in Regulation of VEGF-Dependent Angiogenesis in Developing Zebrafish

(2012) Lasse Dahl Jensen et al.   Cell Reports

Suppression of Histone Deacetylases Worsens Right Ventricular Dysfunction after Pulmonary Artery Banding in Rats

(2011) Harm J. Bogaard et al.   AMERICAN JOURNAL OF RESPIRATORY AND CRITICAL CARE MEDICINE

Nobiletin Attenuates VLDL Overproduction, Dyslipidemia, and Atherosclerosis in Mice With Diet-Induced Insulin Resistance

(2011) E. E. Mulvihill et al.   DIABETES

Altered Expression of Circadian Clock Genes in Human Chronic Myeloid Leukemia

(2011) Ming-Yu Yang et al.   JOURNAL OF BIOLOGICAL RHYTHMS

Resveratrol Dietary Supplementation Shortens the Free-Running Circadian Period and Decreases Body Temperature in a Prosimian Primate

(2011) Fabien Pifferi et al.   JOURNAL OF BIOLOGICAL RHYTHMS

Calpain mediates pulmonary vascular remodeling in rodent models of pulmonary hypertension, and its inhibition attenuates pathologic features of disease

(2011) Wanli Ma et al.   JOURNAL OF CLINICAL INVESTIGATION

All-trans retinoic acid modifies the expression of clock and disease marker genes

(2011) Hadas Sherman et al.   JOURNAL OF NUTRITIONAL BIOCHEMISTRY

Tissue-intrinsic dysfunction of circadian clock confers transplant arteriosclerosis

(2011) B. Cheng et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Effect of Exercise and Respiratory Training on Clinical Progression and Survival in Patients with Severe Chronic Pulmonary Hypertension

(2011) Ekkehard Grünig et al.   RESPIRATION

A Molecular Mechanism for Circadian Clock Negative Feedback

(2011) H. A. Duong et al.   SCIENCE

E4BP4: an unexpected player in the immune response

(2011) Victoria Male et al.   TRENDS IN IMMUNOLOGY

Matrix Metalloproteinase 2 and 9 Dysfunction Underlie Vascular Stiffness in Circadian Clock Mutant Mice

(2010) Ciprian B. Anea et al.   ARTERIOSCLEROSIS THROMBOSIS AND VASCULAR BIOLOGY

Effect of All-Trans-Retinoic Acid on the Development of Chronic Hypoxia-Induced Pulmonary Hypertension

(2010) Erquan Zhang et al.   CIRCULATION JOURNAL

The Association Between Disease Activity and Duration in Systemic Sclerosis

(2010) J. G. WALKER et al.   JOURNAL OF RHEUMATOLOGY

Temperature as a Universal Resetting Cue for Mammalian Circadian Oscillators

(2010) E. D. Buhr et al.   SCIENCE

Association of glypican-3 expression with growth signaling molecules in hepatocellular carcinoma

(2010) Noriyuki Akutsu   WORLD JOURNAL OF GASTROENTEROLOGY

Bmp2 and Bmp4 exert opposing effects in hypoxic pulmonary hypertension

(2009) Lynda Anderson et al.   AMERICAN JOURNAL OF PHYSIOLOGY-REGULATORY INTEGRATIVE AND COMPARATIVE PHYSIOLOGY

Resveratrol Prevents Monocrotaline-Induced Pulmonary Hypertension in Rats

(2009) Anna Csiszar et al.   HYPERTENSION

Scheduled Bright Light for Treatment of Insomnia in Older Adults

(2009) Leah Friedman et al.   JOURNAL OF THE AMERICAN GERIATRICS SOCIETY

Salt-sensitive hypertension in circadian clock–deficient Cry-null mice involves dysregulated adrenal Hsd3b6

(2009) Masao Doi et al.   NATURE MEDICINE

Nocturnal hypoxic stress activates invasive ability of monocytes in patients with obstructive sleep apnoea syndrome

(2009) Shinji TAMAKI et al.   RESPIROLOGY

Vascular circadian rhythms in a mouse vascular smooth muscle cell line (Movas-1)

(2008) Jennifer A. Chalmers et al.   AMERICAN JOURNAL OF PHYSIOLOGY-REGULATORY INTEGRATIVE AND COMPARATIVE PHYSIOLOGY

SIRT1 Regulates Circadian Clock Gene Expression through PER2 Deacetylation

(2008) Gad Asher et al.   CELL

Vascular PPARγ Controls Circadian Variation in Blood Pressure and Heart Rate through Bmal1

(2008) Ningning Wang et al.   Cell Metabolism

Increased Vascular Senescence and Impaired Endothelial Progenitor Cell Function Mediated by Mutation of Circadian Gene Per2

(2008) Chao-Yung Wang et al.   CIRCULATION

Reduced Nitric Oxide Causes Age-Associated Impairment of Circadian Rhythmicity

(2008) Takeshige Kunieda et al.   CIRCULATION RESEARCH

Circadian Timing in the Lung; A Specific Role for Bronchiolar Epithelial Cells

(2008) J. E. Gibbs et al.   ENDOCRINOLOGY

Peripheral Circadian Clock Rhythmicity Is Retained in the Absence of Adrenergic Signaling

(2007) Dermot F. Reilly et al.   ARTERIOSCLEROSIS THROMBOSIS AND VASCULAR BIOLOGY