Selective enhancement of endothelial BMPR-II with BMP9 reverses pulmonary arterial hypertension

Heterozygous Null Bone Morphogenetic Protein Receptor Type 2 Mutations Promote SRC Kinase-dependent Caveolar Trafficking Defects and Endothelial Dysfunction in Pulmonary Arterial Hypertension

(2014) Allison R. Prewitt et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Evidence for Right Ventricular Lipotoxicity in Heritable Pulmonary Arterial Hypertension

(2013) Anna R. Hemnes et al.   AMERICAN JOURNAL OF RESPIRATORY AND CRITICAL CARE MEDICINE

Anti-Inflammatory and Antiatherogenic Role of BMP Receptor II in Endothelial Cells

(2013) Chan Woo Kim et al.   ARTERIOSCLEROSIS THROMBOSIS AND VASCULAR BIOLOGY

Bone Morphogenetic Proteins Protect Pulmonary Microvascular Endothelial Cells From Apoptosis by Upregulating α-B-Crystallin

(2013) Mariana Ciumas et al.   ARTERIOSCLEROSIS THROMBOSIS AND VASCULAR BIOLOGY

The ALK-1/Smad1 pathway in cardiovascular physiopathology. A new target for therapy?

(2013) María González-Núñez et al.   BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR BASIS OF DISEASE

Pathview: an R/Bioconductor package for pathway-based data integration and visualization

(2013) Weijun Luo et al.   BIOINFORMATICS

SMAD1 Deficiency in Either Endothelial or Smooth Muscle Cells Can Predispose Mice to Pulmonary Hypertension

(2013) Chul Han et al.   HYPERTENSION

FK506 activates BMPR2, rescues endothelial dysfunction, and reverses pulmonary hypertension

(2013) Edda Spiekerkoetter et al.   JOURNAL OF CLINICAL INVESTIGATION

In vitro Self-Assembly of Human Pericyte-Supported Endothelial Microvessels in Three-Dimensional Coculture: A Simple Model for Interrogating Endothelial-Pericyte Interactions

(2013) J.P. Waters et al.   JOURNAL OF VASCULAR RESEARCH

Abnormal Trafficking of Endogenously Expressed BMPR2 Mutant Allelic Products in Patients with Heritable Pulmonary Arterial Hypertension

(2013) Andrea L. Frump et al.   PLoS One

A Practical and Efficient Cellular Substrate for the Generation of Induced Pluripotent Stem Cells from Adults: Blood-Derived Endothelial Progenitor Cells

(2012) Imbisaat Geti et al.   Stem Cells Translational Medicine

Altered MicroRNA Processing in Heritable Pulmonary Arterial Hypertension

(2011) Kylie M. Drake et al.   AMERICAN JOURNAL OF RESPIRATORY AND CRITICAL CARE MEDICINE

Attenuation of leukocyte recruitment via CXCR1/2 inhibition stops the progression of PAH in mice with genetic ablation of endothelial BMPR-II

(2011) V. J. Burton et al.   BLOOD

BMP9 is produced by hepatocytes and circulates mainly in an active mature form complexed to its prodomain

(2011) Marie Bidart et al.   CELLULAR AND MOLECULAR LIFE SCIENCES

Targeted gene delivery of BMPR2 attenuates pulmonary hypertension

(2011) A. M. Reynolds et al.   EUROPEAN RESPIRATORY JOURNAL

Molecular genetic characterization of SMAD signaling molecules in pulmonary arterial hypertension

(2011) Md. Talat Nasim et al.   HUMAN MUTATION

Bone morphogenetic protein receptor II regulates pulmonary artery endothelial cell barrier function

(2010) V. J. Burton et al.   BLOOD

GAGE: generally applicable gene set enrichment for pathway analysis

(2009) Weijun Luo et al.   BMC BIOINFORMATICS

Altered Bone Morphogenetic Protein and Transforming Growth Factor-β Signaling in Rat Models of Pulmonary Hypertension

(2009) Lu Long et al.   CIRCULATION

Bone Morphogenetic Protein (BMP) and Activin Type II Receptors Balance BMP9 Signals Mediated by Activin Receptor-like Kinase-1 in Human Pulmonary Artery Endothelial Cells

(2009) Paul D. Upton et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Cellular and Molecular Basis of Pulmonary Arterial Hypertension

(2009) Nicholas W. Morrell et al.   JOURNAL OF THE AMERICAN COLLEGE OF CARDIOLOGY

A novel signaling pathway impact analysis

(2008) Adi Laurentiu Tarca et al.   BIOINFORMATICS

Genetic Ablation of the Bmpr2 Gene in Pulmonary Endothelium Is Sufficient to Predispose to Pulmonary Arterial Hypertension

(2008) Kwon-Ho Hong et al.   CIRCULATION

Mutations in Bone Morphogenetic Protein Type II Receptor Cause Dysregulation of Id Gene Expression in Pulmonary Artery Smooth Muscle Cells

(2008) Jun Yang et al.   CIRCULATION RESEARCH

Bone Morphogenetic Protein-9 Is a Circulating Vascular Quiescence Factor

(2008) Laurent David et al.   CIRCULATION RESEARCH

Increased susceptibility to hypoxic pulmonary hypertension in Bmpr2 mutant mice is associated with endothelial dysfunction in the pulmonary vasculature

(2007) David B. Frank et al.   AMERICAN JOURNAL OF PHYSIOLOGY-LUNG CELLULAR AND MOLECULAR PHYSIOLOGY