Reversing mitochondrial defects in aged hearts: role of mitochondrial calpain activation

Sleep/wake calcium dynamics, respiratory function, and ROS production in cardiac mitochondria

(2021) Engy A. Abdel-Rahman et al.   Journal of Advanced Research

Alterations of housekeeping proteins in human aged and diseased hearts

(2021) Mei Yang et al.   PFLUGERS ARCHIV-EUROPEAN JOURNAL OF PHYSIOLOGY

Chronic metformin treatment decreases cardiac injury during ischemia-reperfusion by attenuating endoplasmic reticulum stress with improved mitochondrial function

(2021) Qun Chen et al.   Aging-US

Alterations in mitochondrial dynamics with age‐related Sirtuin1/Sirtuin3 deficiency impair cardiomyocyte contractility

(2021) Jingwen Zhang et al.   AGING CELL

Cardiac abnormalities after induction of endoplasmic reticulum stress are associated with mitochondrial dysfunction and connexin43 expression

(2021) Jinli He et al.   CLINICAL AND EXPERIMENTAL PHARMACOLOGY AND PHYSIOLOGY

Ageing Causes Ultrastructural Modification to Calcium Release Units and Mitochondria in Cardiomyocytes

(2021) Alessia Di Fonso et al.   INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

Effects of Aging on Cardiac Oxidative Stress and Transcriptional Changes in Pathways of Reactive Oxygen Species Generation and Clearance

(2021) Farhan Rizvi et al.   Journal of the American Heart Association

Endoplasmic reticulum stress-induced complex I defect: Central role of calcium overload

(2020) Ahmed A. Mohsin et al.   ARCHIVES OF BIOCHEMISTRY AND BIOPHYSICS

Aging is associated with a decline in Atg9b‐mediated autophagosome formation and appearance of enlarged mitochondria in the heart

(2020) Wenjing Liang et al.   AGING CELL

Late-life restoration of mitochondrial function reverses cardiac dysfunction in old mice

(2020) Ying Ann Chiao et al.   eLife

Aging aggravated liver ischemia and reperfusion injury by promoting hepatocyte necroptosis in an endoplasmic reticulum stress-dependent manner

(2020) Weizhe Zhong et al.   Annals of Translational Medicine

Targeting ER stress and calpain activation to reverse age-dependent mitochondrial damage in the heart

(2020) Jeremy Thompson et al.   MECHANISMS OF AGEING AND DEVELOPMENT

Increased calpain-1 in mitochondria induces dilated heart failure in mice: role of mitochondrial superoxide anion

(2019) Ting Cao et al.   BASIC RESEARCH IN CARDIOLOGY

Elderly Patients with ST-Segment Elevation Myocardial Infarction: A Patient-Centered Approach

(2019) Benoit Lattuca et al.   DRUGS & AGING

Chemical chaperones improve the functional recovery of stunned myocardium by attenuating the endoplasmic reticulum stress

(2019) Juan Ignacio Elio Mariángelo et al.   Acta Physiologica

Inhibition of the ubiquitous calpains protects complex I activity and enables improved mitophagy in hearts following ischemia-reperfusion

(2019) Qun Chen et al.   AMERICAN JOURNAL OF PHYSIOLOGY-CELL PHYSIOLOGY

SQSTM1/p62 and PPARGC1A/PGC-1alpha at the interface of autophagy and vascular senescence

(2019) Gloria Salazar et al.   Autophagy

MCU Up‐regulation contributes to myocardial ischemia‐reperfusion Injury through calpain/OPA‐1–mediated mitochondrial fusion/mitophagy Inhibition

(2019) Lichun Guan et al.   JOURNAL OF CELLULAR AND MOLECULAR MEDICINE

Angina Severity, Mortality, and Healthcare Utilization Among Veterans With Stable Angina

(2019) Mina Owlia et al.   Journal of the American Heart Association

Differential effects of various genetic mouse models of the mechanistic target of rapamycin complex I inhibition on heart failure

(2019) Dao-Fu Dai et al.   GeroScience

Rapamycin persistently improves cardiac function in aged, male and female mice, even following cessation of treatment

(2019) Ellen Quarles et al.   AGING CELL

Role of the circadian system in cardiovascular disease

(2018) Saurabh S. Thosar et al.   JOURNAL OF CLINICAL INVESTIGATION

The circadian clock in cardiovascular regulation and disease: Lessons from the Nobel Prize in Physiology or Medicine 2017

(2017) Linda W Van Laake et al.   EUROPEAN HEART JOURNAL

Inhibition of Starvation-Triggered Endoplasmic Reticulum Stress, Autophagy, and Apoptosis in ARPE-19 Cells by Taurine through Modulating the Expression of Calpain-1 and Calpain-2

(2017) Yuanyuan Zhang et al.   INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

Early Effects of Prolonged Cardiac Arrest and Ischemic Postconditioning during Cardiopulmonary Resuscitation on Cardiac and Brain Mitochondrial Function in Pigs

(2017) Timothy R. Matsuura et al.   RESUSCITATION

Activation of mitochondrial calpain and increased cardiac injury: beyond AIF release

(2016) Jeremy Thompson et al.   AMERICAN JOURNAL OF PHYSIOLOGY-HEART AND CIRCULATORY PHYSIOLOGY

Mitochondrial Metabolism in Aging Heart

(2016) Edward J. Lesnefsky et al.   CIRCULATION RESEARCH

Deficiency in Apoptosis-Inducing Factor Recapitulates Chronic Kidney Disease via Aberrant Mitochondrial Homeostasis

(2016) Melinda T. Coughlan et al.   DIABETES

Mitochondrial Ca2+ and regulation of the permeability transition pore

(2016) Stephen Hurst et al.   JOURNAL OF BIOENERGETICS AND BIOMEMBRANES

Chemical Chaperone 4-Phenylbutyric Acid Reduces Cardiac Ischemia/Reperfusion Injury by Alleviating Endoplasmic Reticulum Stress and Oxidative Stress

(2016) Lian Jian et al.   MEDICAL SCIENCE MONITOR

Heart mitochondria and calpain 1: Location, function, and targets

(2015) Qun Chen et al.   BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR BASIS OF DISEASE

Calpain-1 induces endoplasmic reticulum stress in promoting cardiomyocyte apoptosis following hypoxia/reoxygenation

(2015) Dong Zheng et al.   BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR BASIS OF DISEASE

Deletion ofcapn4Protects the Heart Against Endotoxemic Injury by Preventing ATP Synthase Disruption and Inhibiting Mitochondrial Superoxide GenerationCLINICAL PERSPECTIVE

(2015) Rui Ni et al.   Circulation-Heart Failure

Mitochondrial m-calpain opens the mitochondrial permeability transition pore in ischemia–reperfusion

(2015) Kaori Shintani-Ishida et al.   INTERNATIONAL JOURNAL OF CARDIOLOGY

Molecular Determinants of Calpain-dependent Cleavage of Junctophilin-2 Protein in Cardiomyocytes

(2015) Ang Guo et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Transient complex I inhibition at the onset of reperfusion by extracellular acidification decreases cardiac injury

(2014) Aijun Xu et al.   AMERICAN JOURNAL OF PHYSIOLOGY-CELL PHYSIOLOGY

Elevated Endoplasmic Reticulum Stress Response Contributes to Adipose Tissue Inflammation in Aging

(2014) Amiya Kumar Ghosh et al.   JOURNALS OF GERONTOLOGY SERIES A-BIOLOGICAL SCIENCES AND MEDICAL SCIENCES

Defective sarcoplasmic reticulum–mitochondria calcium exchange in aged mouse myocardium

(2014) C Fernandez-Sanz et al.   Cell Death & Disease

Mitochondrial Complex I Deficiency Increases Protein Acetylation and Accelerates Heart Failure

(2013) Georgios Karamanlidis et al.   Cell Metabolism

Activation of NADPH Oxidase 4 in the Endoplasmic Reticulum Promotes Cardiomyocyte Autophagy and Survival During Energy Stress Through the Protein Kinase RNA-Activated-Like Endoplasmic Reticulum Kinase/Eukaryotic Initiation Factor 2α/Activating Transcription Factor 4 Pathway

(2013) Sebastiano Sciarretta et al.   CIRCULATION RESEARCH

Dysfunctional survival-signaling and stress-intolerance in aged murine and human myocardium

(2013) Jason N. Peart et al.   EXPERIMENTAL GERONTOLOGY

Cytosolic p53 inhibits Parkin-mediated mitophagy and promotes mitochondrial dysfunction in the mouse heart

(2013) Atsushi Hoshino et al.   Nature Communications

Blockade of electron transport before ischemia protects mitochondria and decreases myocardial injury during reperfusion in aged rat hearts

(2012) Christine Tanaka-Esposito et al.   Translational Research

Activation of mitochondrial μ-calpain increases AIF cleavage in cardiac mitochondria during ischemia–reperfusion

(2011) Qun Chen et al.   BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS

Sarcalumenin plays a critical role in age-related cardiac dysfunction due to decreases in SERCA2a expression and activity

(2011) Qibin Jiao et al.   CELL CALCIUM

Thapsigargin triggers cardiac contractile dysfunction via NADPH oxidase-mediated mitochondrial dysfunction: Role of Akt dephosphorylation

(2011) Yingmei Zhang et al.   FREE RADICAL BIOLOGY AND MEDICINE

Postconditioning Modulates Ischemia-damaged Mitochondria During Reperfusion

(2011) Qun Chen et al.   JOURNAL OF CARDIOVASCULAR PHARMACOLOGY

Apoptosis-Inducing Factor: Structure, Function, and Redox Regulation

(2010) Irina F. Sevrioukova   ANTIOXIDANTS & REDOX SIGNALING

Calpain translocation and activation as pharmacological targets during myocardial ischemia/reperfusion

(2010) Víctor Hernando et al.   JOURNAL OF MOLECULAR AND CELLULAR CARDIOLOGY

Why Do We Still Not Have Cardioprotective Drugs?

(2009) James M. Downey et al.   CIRCULATION JOURNAL

The chemical chaperone 4-phenylbutyrate inhibits adipogenesis by modulating the unfolded protein response

(2009) Sana Basseri et al.   JOURNAL OF LIPID RESEARCH

Postconditioning inhibits mPTP opening independent of oxidative phosphorylation and membrane potential

(2009) Melanie Paillard et al.   JOURNAL OF MOLECULAR AND CELLULAR CARDIOLOGY

Bioenergetics and permeability transition pore opening in heart subsarcolemmal and interfibrillar mitochondria: Effects of aging and lifelong calorie restriction

(2009) Tim Hofer et al.   MECHANISMS OF AGEING AND DEVELOPMENT

Mechanisms Underlying Acute Protection From Cardiac Ischemia-Reperfusion Injury

(2008) Elizabeth Murphy et al.   PHYSIOLOGICAL REVIEWS