Increased calpain-1 in mitochondria induces dilated heart failure in mice: role of mitochondrial superoxide anion

Practical guidelines for rigor and reproducibility in preclinical and clinical studies on cardioprotection

(2018) Hans Erik Bøtker et al.   BASIC RESEARCH IN CARDIOLOGY

ARC regulates programmed necrosis and myocardial ischemia/reperfusion injury through the inhibition of mPTP opening

(2018) Tao Xu et al.   Redox Biology

Evolving concepts in dilated cardiomyopathy

(2017) Marco Merlo et al.   EUROPEAN JOURNAL OF HEART FAILURE

Activation of mitochondrial calpain and increased cardiac injury: beyond AIF release

(2016) Jeremy Thompson et al.   AMERICAN JOURNAL OF PHYSIOLOGY-HEART AND CIRCULATORY PHYSIOLOGY

Disruption of calpain reduces lipotoxicity-induced cardiac injury by preventing endoplasmic reticulum stress

(2016) Shengcun Li et al.   BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR BASIS OF DISEASE

Therapeutic inhibition of mitochondrial reactive oxygen species with mito-TEMPO reduces diabetic cardiomyopathy

(2016) Rui Ni et al.   FREE RADICAL BIOLOGY AND MEDICINE

Calpain research for drug discovery: challenges and potential

(2016) Yasuko Ono et al.   NATURE REVIEWS DRUG DISCOVERY

Heart mitochondria and calpain 1: Location, function, and targets

(2015) Qun Chen et al.   BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR BASIS OF DISEASE

Distinct mPTP activation mechanisms in ischaemia–reperfusion: contributions of Ca2+, ROS, pH, and inorganic polyphosphate

(2015) Lea K. Seidlmayer et al.   CARDIOVASCULAR RESEARCH

Regulation of Signal Transduction by Reactive Oxygen Species in the Cardiovascular System

(2015) D. I. Brown et al.   CIRCULATION RESEARCH

Deletion ofcapn4Protects the Heart Against Endotoxemic Injury by Preventing ATP Synthase Disruption and Inhibiting Mitochondrial Superoxide GenerationCLINICAL PERSPECTIVE

(2015) Rui Ni et al.   Circulation-Heart Failure

Mitochondrial calpain-1 disrupts ATP synthase and induces superoxide generation in type-1 diabetic hearts: a novel mechanism contributing to diabetic cardiomyopathy

(2015) Rui Ni et al.   DIABETES

Mitochondrial m-calpain opens the mitochondrial permeability transition pore in ischemia–reperfusion

(2015) Kaori Shintani-Ishida et al.   INTERNATIONAL JOURNAL OF CARDIOLOGY

Altered FoF1 ATP synthase and susceptibility to mitochondrial permeability transition pore during ischaemia and reperfusion in aging cardiomyocytes

(2015) Celia Fernandez-Sanz et al.   THROMBOSIS AND HAEMOSTASIS

Sites of Superoxide and Hydrogen Peroxide Production by Muscle Mitochondria Assessedex Vivounder Conditions Mimicking Rest and Exercise

(2014) Renata L. S. Goncalves et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Cardiovascular remodelling in coronary artery disease and heart failure

(2014) Gerd Heusch et al.   LANCET

Production of Reactive Oxygen Species in the Diabetic Heart

(2013) Yasushi Teshima et al.   CIRCULATION JOURNAL

Global Proteomics and Pathway Analysis of Pressure-Overload–Induced Heart Failure and Its Attenuation by Mitochondrial-Targeted Peptides

(2013) Dao-Fu Dai et al.   Circulation-Heart Failure

Mitochondria in Vascular Health and Disease

(2012) Peter Dromparis et al.   Annual Review of Physiology

Deficiency ofCapn4Gene Inhibits Nuclear Factor-κB (NF-κB) Protein Signaling/Inflammation and Reduces Remodeling after Myocardial Infarction

(2012) Jian Ma et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Activation of mitochondrial μ-calpain increases AIF cleavage in cardiac mitochondria during ischemia–reperfusion

(2011) Qun Chen et al.   BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS

Mitochondrial Oxidative Stress Mediates Angiotensin II–Induced Cardiac Hypertrophy and Gαq Overexpression–Induced Heart Failure

(2011) Dao-Fu Dai et al.   CIRCULATION RESEARCH

Targeted Inhibition of Calpain Reduces Myocardial Hypertrophy and Fibrosis in Mouse Models of Type 1 Diabetes

(2011) Ying Li et al.   DIABETES

Mitochondrial Targeted Antioxidant Peptide Ameliorates Hypertensive Cardiomyopathy

(2011) Dao-Fu Dai et al.   JOURNAL OF THE AMERICAN COLLEGE OF CARDIOLOGY

Physiologic and Pathophysiologic Role of Calpain: Implications for the Occurrence of Atrial Fibrillation

(2010) Alicja Bukowska et al.   Cardiovascular Therapeutics

Deficiency of Rac1 Blocks NADPH Oxidase Activation, Inhibits Endoplasmic Reticulum Stress, and Reduces Myocardial Remodeling in a Mouse Model of Type 1 Diabetes

(2010) Jianmin Li et al.   DIABETES

Increased expression of calpain and elevated activity of calcineurin in the myocardium of patients with congestive heart failure

(2010) Yang   INTERNATIONAL JOURNAL OF MOLECULAR MEDICINE

Histone Deacetylase-3 Activation Promotes Tumor Necrosis Factor-α (TNF-α) Expression in Cardiomyocytes during Lipopolysaccharide Stimulation

(2010) Huaqing Zhu et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Mitochondrial calpain system: An overview

(2009) Pulak Kar et al.   ARCHIVES OF BIOCHEMISTRY AND BIOPHYSICS

Over-expression of calpastatin inhibits calpain activation and attenuates myocardial dysfunction during endotoxaemia

(2009) X. Li et al.   CARDIOVASCULAR RESEARCH

How mitochondria produce reactive oxygen species

(2008) Michael P. Murphy   BIOCHEMICAL JOURNAL