Apoptosis-Inducing Factor: Structure, Function, and Redox Regulation

NAD depletion by FK866 induces autophagy

(2014) Richard A. Billington et al.   Autophagy

IAPS : More than just inhibitors of apoptosis proteins

(2011) Laurence Dubrez-Daloz et al.   CELL CYCLE

Severe X-Linked Mitochondrial Encephalomyopathy Associated with a Mutation in Apoptosis-Inducing Factor

(2010) Daniele Ghezzi et al.   AMERICAN JOURNAL OF HUMAN GENETICS

Mitochondrial regulation of cell death: Processing of apoptosis-inducing factor (AIF)

(2010) Erik Norberg et al.   BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS

Apoptosis is regulated by the VDAC1 N-terminal region and by VDAC oligomerization: release of cytochrome c, AIF and Smac/Diablo

(2010) Varda Shoshan-Barmatz et al.   BIOCHIMICA ET BIOPHYSICA ACTA-BIOENERGETICS

Role of apoptosis-inducing factor (AIF) in programmed nuclear death during conjugation in Tetrahymena thermophila

(2010) Takahiko Akematsu et al.   BMC CELL BIOLOGY

Heat shock protein 70 silencing enhances apoptosis inducing factor-mediated cell death in hepatocellular carcinoma HepG2 cells

(2010) Qing Zhu et al.   CANCER BIOLOGY & THERAPY

A brain-specific isoform of mitochondrial apoptosis-inducing factor: AIF2

(2010) E Hangen et al.   CELL DEATH AND DIFFERENTIATION

AIF promotes chromatinolysis and caspase-independent programmed necrosis by interacting with histone H2AX

(2010) Cédric Artus et al.   EMBO JOURNAL

Activation of mitochondrial calpain and release of apoptosis-inducing factor from mitochondria in RCS rat retinal degeneration

(2010) Sayuri Mizukoshi et al.   EXPERIMENTAL EYE RESEARCH

Oxidative modification sensitizes mitochondrial apoptosis-inducing factor to calpain-mediated processing

(2010) Erik Norberg et al.   FREE RADICAL BIOLOGY AND MEDICINE

Poly(ADP-ribose) Polymerase (PARP)-1-independent Apoptosis-inducing Factor (AIF) Release and Cell Death Are Induced by Eleostearic Acid and Blocked by α-Tocopherol and MEK Inhibition

(2010) Kazunari Kondo et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Contributions of poly(ADP-ribose) polymerase-1 and -2 to nuclear translocation of apoptosis-inducing factor and injury from focal cerebral ischemia

(2010) Xiaoling Li et al.   JOURNAL OF NEUROCHEMISTRY

NAD+ Depletion Is Necessary and Sufficient forPoly(ADP-Ribose) Polymerase-1-Mediated Neuronal Death

(2010) C. C. Alano et al.   JOURNAL OF NEUROSCIENCE

Life with or without AIF

(2010) Emilie Hangen et al.   TRENDS IN BIOCHEMICAL SCIENCES

Changes of Mitochondria and Relocation of the Apoptosis-Inducing Factor during Apoptosis

(2009) A. Ivana Scovassi et al.   Annals of the New York Academy of Sciences

AIF: Not Just an Apoptosis-Inducing Factor

(2009) Nicholas Joza et al.   Annals of the New York Academy of Sciences

Outer Mitochondrial Membrane Localization of Apoptosis-Inducing Factor: Mechanistic Implications for Release

(2009) Seong-Woon Yu et al.   ASN Neuro

The proapoptotic activity of C-terminal domain of apoptosis-inducing factor (AIF) is separated from its N-terminal

(2009) YONG ZHANG et al.   BIOLOGICAL RESEARCH

Protein Kinase CK2 in Health and Disease

(2009) N. A. St-Denis et al.   CELLULAR AND MOLECULAR LIFE SCIENCES

Mitochondrial μ-calpain is not involved in the processing of apoptosis-inducing factor

(2009) Aashish Joshi et al.   EXPERIMENTAL NEUROLOGY

Calcium dysregulation induces apoptosis-inducing factor release: Cross-talk between PARP-1- and calpain- signaling pathways

(2009) Peter S. Vosler et al.   EXPERIMENTAL NEUROLOGY

Poly(ADP-ribose) signals to mitochondrial AIF: A key event in parthanatos

(2009) Yingfei Wang et al.   EXPERIMENTAL NEUROLOGY

Reactive oxygen species regulation by AIF- and complex I-depleted brain mitochondria

(2009) Shankar J. Chinta et al.   FREE RADICAL BIOLOGY AND MEDICINE

Parthanatos, a messenger of death

(2009) Karen Kate David   Frontiers in Bioscience-Landmark

Poly(ADP-ribose) Catabolism Triggers AMP-dependent Mitochondrial Energy Failure

(2009) Laura Formentini et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Mitochondrial Localization of PARP-1 Requires Interaction with Mitofilin and Is Involved in the Maintenance of Mitochondrial DNA Integrity

(2009) Marianna N. Rossi et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Redox-Linked Conformational Dynamics in Apoptosis-Inducing Factor

(2009) Irina F. Sevrioukova   JOURNAL OF MOLECULAR BIOLOGY

Calpain activation is not required for AIF translocation in PARP-1-dependent cell death (parthanatos)

(2009) Yingfei Wang et al.   JOURNAL OF NEUROCHEMISTRY

BNIP3 (Bcl-2 19 kDa Interacting Protein) Acts as Transcriptional Repressor of Apoptosis-Inducing Factor Expression Preventing Cell Death in Human Malignant Gliomas

(2009) T. R. Burton et al.   JOURNAL OF NEUROSCIENCE

Evaluation of Affinity-Tagged Protein Expression Strategies Using Local and Global Isotope Ratio Measurements

(2009) W. Judson Hervey et al.   JOURNAL OF PROTEOME RESEARCH

Tyrosine dephosphorylation of H2AX modulates apoptosis and survival decisions

(2009) Peter J. Cook et al.   NATURE

Effects of overexpression of antioxidants on the release of cytochrome c and apoptosis-inducing factor in the model of ischemia

(2009) Ilona Zemlyak et al.   NEUROSCIENCE LETTERS

Evidence for caspase effects on release of cytochrome c and AIF in a model of ischemia in cortical neurons

(2009) Maneesh H. Singh et al.   NEUROSCIENCE LETTERS

Deletion of the Mitochondrial Flavoprotein Apoptosis Inducing Factor (AIF) Induces β-Cell Apoptosis and Impairs β-Cell Mass

(2009) Fabienne T. Schulthess et al.   PLoS One

Involvement of VDAC, Bax and Ceramides in the Efflux of AIF from Mitochondria during Curcumin-Induced Apoptosis

(2009) Alwin Scharstuhl et al.   PLoS One

Targeting post-mitochondrial effectors of apoptosis for neuroprotection

(2008) Lorenzo Galluzzi et al.   BIOCHIMICA ET BIOPHYSICA ACTA-BIOENERGETICS

How lipid flippases can modulate membrane structure

(2008) Philippe F. Devaux et al.   BIOCHIMICA ET BIOPHYSICA ACTA-BIOMEMBRANES

ERp57-associated mitochondrial μ-calpain truncates apoptosis-inducing factor

(2008) Taku Ozaki et al.   BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR CELL RESEARCH

Multiple apoptogenic proteins are involved in the nuclear translocation of Apoptosis Inducing Factor during transient focal cerebral ischemia in rat

(2008) Ganta Vijay Chaitanya et al.   BRAIN RESEARCH

An increase in intracellular Ca2+ is required for the activation of mitochondrial calpain to release AIF during cell death

(2008) E Norberg et al.   CELL DEATH AND DIFFERENTIATION

The molecular archaeology of a mitochondrial death effector: AIF in Drosophila

(2008) N Joza et al.   CELL DEATH AND DIFFERENTIATION

Bid-induced release of AIF from mitochondria causes immediate neuronal cell death

(2008) S Landshamer et al.   CELL DEATH AND DIFFERENTIATION

Coupling Caspase Cleavage and Proteasomal Degradation of Proteins Carrying PEST Motif

(2008) Jose Belizario et al.   CURRENT PROTEIN & PEPTIDE SCIENCE

The SH3 domain- a family of versatile peptide- and protein-recognition module

(2008) Tomonori Kaneko   Frontiers in Bioscience-Landmark

Induction of autophagy in malignant rhabdoid tumor cells by the histone deacetylase inhibitor FK228 through AIF translocation

(2008) Motonobu Watanabe et al.   INTERNATIONAL JOURNAL OF CANCER

Brevinin-2R1 semi-selectively kills cancer cells by a distinct mechanism, which involves the lysosomal-mitochondrial death pathway

(2008) Saeid Ghavami et al.   JOURNAL OF CELLULAR AND MOLECULAR MEDICINE

Developing Postmitotic Mammalian Neurons In Vivo Lacking Apaf-1 Undergo Programmed Cell Death by a Caspase-Independent, Nonapoptotic Pathway Involving Autophagy

(2008) R. W. Oppenheim et al.   JOURNAL OF NEUROSCIENCE

Loss of Apoptosis-Inducing Factor Results in Cell-Type-Specific Neurogenesis Defects

(2008) R. Ishimura et al.   JOURNAL OF NEUROSCIENCE

Poly(ADP-ribose)-binding zinc finger motifs in DNA repair/checkpoint proteins

(2008) Ivan Ahel et al.   NATURE

Phylogeny.fr: robust phylogenetic analysis for the non-specialist

(2008) A. Dereeper et al.   NUCLEIC ACIDS RESEARCH

Proteome-wide identification of poly(ADP-ribose) binding proteins and poly(ADP-ribose)-associated protein complexes

(2008) Jean-Philippe Gagné et al.   NUCLEIC ACIDS RESEARCH

Cyclin D1 mediates resistance to apoptosis through upregulation of molecular chaperones and consequent redistribution of cell death regulators

(2008) G Roué et al.   ONCOGENE

Ciglitazone induces apoptosis via activation of p38 MAPK and AIF nuclear translocation mediated by reactive oxygen species and Ca2+ in opossum kidney cells

(2008) Chae Hwa Kwon et al.   TOXICOLOGY

Stress granules: the Tao of RNA triage

(2008) Paul Anderson et al.   TRENDS IN BIOCHEMICAL SCIENCES

HGF Increases Cisplatin Resistance via Down-Regulation of AIF in Lung Cancer Cells

(2007) Jin-Tang Chen et al.   AMERICAN JOURNAL OF RESPIRATORY CELL AND MOLECULAR BIOLOGY

Submitochondrial localization of associated μ-calpain and calpastatin

(2007) Pulak Kar et al.   ARCHIVES OF BIOCHEMISTRY AND BIOPHYSICS