Rapamycin persistently improves cardiac function in aged, male and female mice, even following cessation of treatment

Differential Regulation of Cardiac Function and Intracardiac Cytokines by Rapamycin in Healthy and Diabetic Rats

(2017) Christian Luck et al.   Oxidative Medicine and Cellular Longevity

mTOR Inhibition Rejuvenates the Aging Gingival Fibroblasts through Alleviating Oxidative Stress

(2017) Yiru Xia et al.   Oxidative Medicine and Cellular Longevity

A randomized controlled trial to establish effects of short-term rapamycin treatment in 24 middle-aged companion dogs

(2017) Silvan R. Urfer et al.   GeroScience

Dietary rapamycin supplementation reverses age-related vascular dysfunction and oxidative stress, while modulating nutrient-sensing, cell cycle, and senescence pathways

(2016) Lisa A. Lesniewski et al.   AGING CELL

Rapamycin transiently induces mitochondrial remodeling to reprogram energy metabolism in old hearts

(2016) Ying Ann Chiao et al.   Aging-US

Rapamycin reverses age-related increases in mitochondrial ROS production at complex I, oxidative stress, accumulation of mtDNA fragments inside nuclear DNA, and lipofuscin level, and increases autophagy, in the liver of middle-aged mice

(2016) V. Martínez-Cisuelo et al.   EXPERIMENTAL GERONTOLOGY

Recent Advances in Mammalian Target of Rapamycin Inhibitor Use in Heart and Lung Transplantation

(2016) Nowell M. Fine et al.   TRANSPLANTATION

Transient rapamycin treatment can increase lifespan and healthspan in middle-aged mice

(2016) Alessandro Bitto et al.   eLife

Extension of chronological life span by reduced TOR signaling requires down-regulation of Sch9p and involves increased mitochondrial OXPHOS complex density

(2016) Yong Pan et al.   Aging-US

Rapamycin-induced metabolic defects are reversible in both lean and obese mice

(2016) Yuhong Liu et al.   Aging-US

Cell- and molecular-level mechanisms contributing to diastolic dysfunction in HFpEF

(2015) Kenneth S. Campbell et al.   JOURNAL OF APPLIED PHYSIOLOGY

2-Deoxy adenosine triphosphate improves contraction in human end-stage heart failure

(2015) Farid Moussavi-Harami et al.   JOURNAL OF MOLECULAR AND CELLULAR CARDIOLOGY

Biochemical Genetic Pathways that Modulate Aging in Multiple Species: Figure 1.

(2015) Alessandro Bitto et al.   Cold Spring Harbor Perspectives in Medicine

The Aging Heart: Figure 1.

(2015) Ying Ann Chiao et al.   Cold Spring Harbor Perspectives in Medicine

Altered proteome turnover and remodeling by short-term caloric restriction or rapamycin rejuvenate the aging heart

(2014) Dao-Fu Dai et al.   AGING CELL

Deficiency of cardiac Acyl-CoA synthetase-1 induces diastolic dysfunction, but pathologic hypertrophy is reversed by rapamycin

(2014) David S. Paul et al.   BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR AND CELL BIOLOGY OF LIPIDS

The Global Burden of Ischemic Heart Disease in 1990 and 2010

(2014) Andrew E. Moran et al.   CIRCULATION

Cardiac Mitochondria and Reactive Oxygen Species Generation

(2014) Yeong-Renn Chen et al.   CIRCULATION RESEARCH

The incidence, management, and evolution of rapamycin-related side effects in kidney transplant recipients

(2014) Jacobien Verhave et al.   CLINICAL TRANSPLANTATION

Pathomechanisms in heart failure: the contractile connection

(2014) G. J. M. Stienen   JOURNAL OF MUSCLE RESEARCH AND CELL MOTILITY

The pathophysiology of heart failure with preserved ejection fraction

(2014) Barry A. Borlaug   Nature Reviews Cardiology

Is Treatment with Trimetazidine Beneficial in Patients with Chronic Heart Failure?

(2014) Xiang Zhou et al.   PLoS One

Strategies for the management of adverse events associated with mTOR inhibitors

(2014) Bruce Kaplan et al.   Transplantation Reviews

Late-life rapamycin treatment reverses age-related heart dysfunction

(2013) James M. Flynn et al.   AGING CELL

Rapamycin-mediated lifespan increase in mice is dose and sex dependent and metabolically distinct from dietary restriction

(2013) Richard A. Miller et al.   AGING CELL

Incidence and Survival of Hospitalized Acute Decompensated Heart Failure in Four US Communities (from the Atherosclerosis Risk in Communities Study)

(2013) Patricia P. Chang et al.   AMERICAN JOURNAL OF CARDIOLOGY

Forecasting the Impact of Heart Failure in the United States

(2013) Paul A. Heidenreich et al.   Circulation-Heart Failure

Mammalian target of rapamycin inhibitor-associated stomatitis

(2013) Christine B Boers-Doets et al.   Future Oncology

Mammalian Target of Rapamycin (mTOR) Inhibition with Rapamycin Improves Cardiac Function in Type 2 Diabetic Mice

(2013) Anindita Das et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Rapamycin Extends Life and Health in C57BL/6 Mice

(2013) Yiqiang Zhang et al.   JOURNALS OF GERONTOLOGY SERIES A-BIOLOGICAL SCIENCES AND MEDICAL SCIENCES

Safety and efficacy of everolimus- versus sirolimus-eluting stents: A systematic review and meta-analysis of 11 randomized trials

(2012) Kyung Woo Park et al.   AMERICAN HEART JOURNAL

Adverse events associated with mTOR inhibitors

(2012) Nicolas Pallet et al.   Expert Opinion On Drug Safety

Mitochondrial Complex III ROS Regulate Adipocyte Differentiation

(2011) Kathryn V. Tormos et al.   Cell Metabolism

Reactive Oxygen Species Production by Forward and Reverse Electron Fluxes in the Mitochondrial Respiratory Chain

(2011) Vitaly A. Selivanov et al.   PLoS Computational Biology

Rapamycin, But Not Resveratrol or Simvastatin, Extends Life Span of Genetically Heterogeneous Mice

(2010) Richard A. Miller et al.   JOURNALS OF GERONTOLOGY SERIES A-BIOLOGICAL SCIENCES AND MEDICAL SCIENCES

Cardiac Aging in Mice and Humans: The Role of Mitochondrial Oxidative Stress

(2010) Dao-Fu Dai et al.   TRENDS IN CARDIOVASCULAR MEDICINE

Rapamycin fed late in life extends lifespan in genetically heterogeneous mice

(2009) David E. Harrison et al.   NATURE