Article
Biochemistry & Molecular Biology
Sigal Fleisher-Berkovich, Yvonne Ventura, Maya Amoyal, Arik Dahan, Valeria Feinshtein, Leenor Alfahel, Adrian Israelson, Nirit Bernstein, Jonathan Gorelick, Shimon Ben-Shabat
Summary: Cannabigerol has the potential to be a therapeutic agent for the treatment of Multiple Sclerosis, as it can reduce neuroinflammation and neuronal loss. It acts by inhibiting the production of nitric oxide and tumor necrosis factor-alpha.
Article
Immunology
He-Tao Bian, Ling Xiao, Liang Liang, Yin-Ping Xie, Hui-Ling Wang, Gao-Hua Wang
Summary: Depression is a common mental disorder with limited effective treatments available. Studies have shown that inhibition of HDAC3, such as with RGFP966, can improve depressive-like behaviors by inhibiting neuroinflammation and microglial activation. This suggests that targeting the HDAC3 pathway could be a potential treatment strategy for depression.
INTERNATIONAL IMMUNOPHARMACOLOGY
(2021)
Article
Pharmacology & Pharmacy
S. Alboni, C. Benatti, C. Colliva, G. Radighieri, J. M. C. Blom, N. Brunello, F. Tascedda
Summary: The study demonstrates that pretreatment with Vortioxetine prevents LPS-induced cognitive memory impairment without affecting acute sickness behavior and anhedonia. Vortioxetine may impact the immune response by affecting the microglia in the hippocampus.
FRONTIERS IN PHARMACOLOGY
(2021)
Article
Medicine, Research & Experimental
Mei-Hua Jin, Dong-Qin Chen, Ying-Hua Jin, Ying-Hao Han, Hu-Nan Sun, Taeho Kwon
Summary: Neuroinflammation is linked to various neurodegenerative diseases, with abnormal activation of microglial cells and overproduction of NO playing a crucial role. Hispidin, a polyphenol from Phellinus linteus, has been shown to significantly inhibit NO production in macrophages. This study demonstrated that Hispidin can effectively reduce NO production and iNOS expression in microglial cells, suggesting its potential as a therapeutic agent for NO-induced neuroinflammation and as a novel iNOS inhibitor.
EXPERIMENTAL AND THERAPEUTIC MEDICINE
(2021)
Article
Clinical Neurology
Bruna Stefania Ferreira Mello, Adriano Jose Maia Chaves Filho, Charllyany Sabino Custodio, Patricia de Araujo Rodrigues, Jaqueline Carletti, Silvania Maria Mendes Vasconcelos, Francisca Clea Florenco de Sousa, Lia Lira Olivier Sanders, Danielle S. Macedo
Summary: The combination of doxycycline (DOXY) and the antidepressant escitalopram (ESC) appears to be an effective strategy in reversing inflammatory changes and providing protection against depression in mice.
JOURNAL OF AFFECTIVE DISORDERS
(2021)
Article
Behavioral Sciences
Anhui Fu, Fei Qiao, Hao Feng, Qing Luo
Summary: Neuroinflammation is a crucial pathophysiological process in depression. This study investigated the role of TREM-1 and its inhibition in depression using a mouse model induced by LPS. The results showed that TREM-1 inhibition by LP17 could alleviate depressive-like behaviors induced by LPS by mitigating neuroinflammation in the prefrontal cortex via the PI3K/Akt signaling pathway. These findings suggest that TREM-1 may be a promising therapeutic target for the treatment of depression.
BEHAVIOURAL BRAIN RESEARCH
(2023)
Article
Biochemistry & Molecular Biology
Meng Liy Pan, Nur Nabilah Ahmad Puzi, Yin Yin Ooi, Rajesh Ramasamy, Sharmili Vidyadaran
Summary: The latest research shows that microglia phenotype is not limited to the binary states of "resting" and "activated", but exhibits wide diversity. Testing different stimulation protocols for BV2 microglia, we found differences in the response of the cells in terms of intracellular ROS, nitric oxide, CD40 expression, and migratory capacity.
Article
Nutrition & Dietetics
Gabriele Serreli, Micaela Rita Naitza, Sonia Zodio, Vera Piera Leoni, Martina Spada, Maria Paola Melis, Anna Boronat, Monica Deiana
Summary: Ferulic acid and its metabolites show efficacy in combating inflammation by limiting the expression and activity of proinflammatory enzymes, reducing NF-κB translocation, and promoting Nrf2 expression.
Article
Immunology
Danxi Li, Di Hu, Yuta Ochi, Wakiko Arakaki, Aya Mawatari, Mika Shigeta, Yuping Wu, Emi Hayashinaka, Hiroyuki Neyama, Tsuyoshi Tahara, Yasuhiro Wada, Feng Li, Hisashi Doi, Yasuyoshi Watanabe, Yilong Cui
Summary: To investigate the mechanism of fatigue induced by peripheral infection, this study conducted a brain-wide investigation of neuroinflammation using PET imaging analysis in a peripheral pseudoinfection rat model.
FRONTIERS IN IMMUNOLOGY
(2023)
Article
Medicine, Research & Experimental
Ahmed M. Kabel, Hany H. Arab, Aliaa Atef, Remon S. Estfanous
Summary: The combination of omarigliptin and galangin may be a promising therapeutic approach for mitigating LPS-induced neuroinflammation.
Article
Behavioral Sciences
Fernando Vitor-Vieira, Fabiana C. Vilela, Alexandre Giusti-Paiva
Summary: Maternal infection during pregnancy can lead to neurodevelopmental disorders in children, such as autism spectrum disorder (ASD). This study found that maternal immune activation (MIA) can induce ASD-like symptoms in prepubertal offspring, with sex-specific effects on behavior and neuronal activation patterns in the brain.
BEHAVIOURAL BRAIN RESEARCH
(2021)
Article
Chemistry, Medicinal
Liang Liang, Hui Wang, Ying Hu, Hetao Bian, Ling Xiao, Gaohua Wang
Summary: This study investigated the effect of Oridonin on depression, neuroinflammation, and autophagy impairment induced by chronic unpredictable mild stress (CUMS). The results showed that Oridonin has a potent anti-depressive action and a stronger and longer-lasting antidepressant effect than fluoxetine. It also normalized autophagy-related protein levels and reduced levels of cytokines by blocking the interaction between NLRP3 and NEK7. These findings suggest that Oridonin may be a promising therapeutic agent for major depressive disorder.
PHYTOTHERAPY RESEARCH
(2022)
Article
Immunology
Komal Naeem, Lina Tariq Al Kury, Faiza Nasar, Abdullah Alattar, Reem Alshaman, Fawad Ali Shah, Arif-ullah Khan, Shupeng Li
Summary: The study demonstrated that carvacrol has neuroprotective effects on LPS-induced neuroinflammation and depression by modulating the antioxidant gene Nrf2, alleviating oxidative stress and inflammatory responses.
JOURNAL OF INFLAMMATION RESEARCH
(2021)
Article
Fisheries
Silas F. Eto, Dayanne C. Fernandes, Michelli I. G. Funnicelli, Joao V. C. Alecrim, Pedro G. Souza, Fabiola C. A. Carvalho, Marco A. A. Belo, Joao M. Pizauro
Summary: This study provides the first description of the ability of Nile tilapia microglia to form extracellular traps (ETs) in response to Weissella cibaria infection. The findings show that ETs formation occurred 6 hours after stimulation with lipopolysaccharide, shedding light on the mechanism of ETs formation in teleost fish microglia and W. cibaria's ability to infect these cells.
FISH & SHELLFISH IMMUNOLOGY
(2021)
Article
Immunology
Matthew G. Frank, Kathy H. Nguyen, Jayson B. Ball, Shelby Hopkins, Tel Kelley, Michael V. Baratta, Monika Fleshner, Steven F. Maier
Summary: SARS-CoV-2 infection can lead to neuroinflammation and neurological symptoms, with the structural protein S1 potentially inducing these processes independently of viral infection. Experimental findings show that S1 causes various physiological and behavioral changes in rats and microglial cells in vitro, as well as alterations in neuroimmune gene and protein expression, suggesting a role in neuroinflammatory processes via receptor engagement.
BRAIN BEHAVIOR AND IMMUNITY
(2022)
Article
Endocrinology & Metabolism
Larissa Maria Frota Cristino, Adriano Jose Maia Chaves Filho, Charllyany Sabino Custodio, Silvania Maria Mendes Vasconcelos, Francisca Clea F. de Sousa, Lia Lira O. Sanders, David Freitas de Lucena, Danielle S. Macedo
Summary: The prenatal/perinatal exposure to infections may lead to neurodevelopmental alterations and neuropsychiatric disorders. Sex influences the prevalence and symptoms of ASD, but the underlying mechanisms are poorly understood. This study aims to investigate the sex differences in behavioral and neurotrophic/inflammatory alterations triggered by LPS neonatal exposure in juvenile mice.
NEUROIMMUNOMODULATION
(2022)
Article
Dentistry, Oral Surgery & Medicine
Joana Maria dos Santos Alves, Khalil Fernandes Viana, Anamaria Falcao Pereira, Roberto Cesar Pereira Lima Junior, Mariana Lima Vale, Karuza Maria Alves Pereira, Delane Viana Gondim
Summary: The objective of this study was to identify changes in the trigeminal pathway in oral cancer and establish an effective approach to pain control. The results showed that 4-NQO induced macroscopic lesions consistent with neoplastic tumors, and histopathological analysis confirmed the presence of oral squamous cell carcinoma. Changes in nociceptive behavior, as indicated by nociceptive expression scores and increased grooming and exploratory activity, were observed. Alterations in c-Fos expression further supported the findings.
Article
Biotechnology & Applied Microbiology
Adson Avila de Souza, Adrianne Maia Lima, Daniele Dede Oliveira BezerraSousa, Francisca Cristiane Nogueira, Jose Carlos do Sacramento Neto, Lucas Pinheiro Dias, Nadine Monteiro Salgueiro Araujo, Celso Shiniti Nagano, Helio Vitoriano Nobre Junior, Cecilia Rocha da Silva, Livia Gurgel do Amaral Valente Sa, Joao Batista de Andrade Neto, Fatima Daiana Dias Barroso, Maria Elisabete Amaral de Moraes, Hermogenes David de Oliveira
Summary: This study isolated and characterized a thermostable trypsin inhibitor from chia seeds, which showed antibacterial activity against Staphylococcus aureus sensitive and resistant to methicillin. The trypsin inhibitor, named ShTI, displayed competitive inhibition and 1:1 stoichiometry ratio for the ShTI:trypsin complex. ShTI exhibited antibacterial activity alone and in combination with oxacillin, and its antibacterial action involved overproduction of reactive oxygen species and plasma membrane pore formation.
PROBIOTICS AND ANTIMICROBIAL PROTEINS
(2023)
Article
Psychiatry
Krista M. Wartchow, Rafaela C. Cordeiro, Giselli Scaini
Summary: Recent studies have found associations between bipolar disorder and inflammation, oxidative stress, abnormalities in signaling pathways, hypothalamic-pituitary-adrenal axis, and circadian rhythm linked to mitochondrial dysfunction. However, more research is needed to validate these findings and increase their predictive ability.
CURRENT OPINION IN PSYCHIATRY
(2023)
Article
Pharmacology & Pharmacy
David Nunes De Lima, Carlos Winston Luz Costa Filho, Ilgner Justa Frota, Alissandra Lima Barbosa de Oliveira, Carlos Eduardo de Souza Menezes, Adriano Jose Maia Chaves Filho, Glautemberg de Almeida Viana, Eugenio de Moura Campos, Monica Collares, Maria Goretti Rodrigues de Queiroz, Said Goncalvez da Cruz Fonseca, Silvania Maria Mendes Vasconcelos, Danielle S. Macedo, Lia Lira Olivier Sanders
Summary: This study aimed to verify the therapeutic effect of alpha-lipoic acid (ALA) supplementation in patients with schizophrenia. The results showed no significant improvement in body parameters, cognitive function, psychopathology, antipsychotic adverse effects, or oxidative stress and inflammation in the experimental group compared with placebo. A significant decrease in red blood cells, white blood cells, and platelet counts in the ALA treatment group was observed, which requires further investigation.
JOURNAL OF CLINICAL PSYCHOPHARMACOLOGY
(2023)
Article
Microbiology
Amanda D. Barbosa, Livia G. A. Sa, Joao B. A. Neto, Daniel S. Rodrigues, Vitoria P. F. Cabral, Lara E. A. Moreira, Igor G. Aguiar, Helcio S. Santos, Bruno C. Cavalcanti, Emmanuel S. Marinho, Jacilene Silva, Hemerson I. F. Magalhaes, Manoel O. Moraes, Helio V. N. Junior, Cecilia R. Silva
Summary: The aim of this study was to evaluate the in vitro antimicrobial activity of amlodipine against Staphylococcus aureus strains. The antimicrobial activity of amlodipine was evaluated using the broth microdilution method, and its interaction with oxacillin was evaluated using a checkerboard assay. The possible mechanism of action was evaluated using flow cytometry and molecular docking techniques. Results showed that amlodipine exhibited antibacterial activity against S. aureus and had synergistic effects with approximately 58% of the strains used. Amlodipine also showed good activity against forming and mature biofilms. The possible mechanism of action may be attributed to its ability to induce cell death.
FUTURE MICROBIOLOGY
(2023)
Article
Microbiology
Vitoria P. F. Cabral, Daniel S. Rodrigues, Amanda D. Barbosa, Lara E. A. Moreira, Livia G. A. Sa, Cecilia R. Silva, Joao B. A. Neto, Jacilene Silva, Emmanuel S. Marinho, Helcio S. Santos, Bruno C. Cavalcanti, Manoel O. Moraes, V. N. Helio Junior
Summary: This study evaluated the antibacterial activity of paroxetine alone and in combination with oxacillin against methicillin-sensitive and -resistant Staphylococcus aureus isolates. The results showed that paroxetine had bactericidal activity at a minimum inhibitory concentration (MIC) of 64 μg/ml, and exhibited mostly additive interactions when combined with oxacillin. Mechanism studies revealed the action of paroxetine on genetic material and membrane, as well as morphological changes in microbial cells and influence on virulence factors.
FUTURE MICROBIOLOGY
(2023)
Article
Microbiology
Daniel Sampaio Rodrigues, Vitoria Pessoa de Farias Cabral, Amanda Dias Barbosa, Livia Gurgel do Amaral Valente Sa, Lara Elloyse Almeida Moreira, Joao Batista de Andrade Neto, Cecilia Rocha da Silva, Manoel Odorico de Moraes, Jacilene Silva, Emmanuel Silva Marinho, Helcio Silva dos Santos, erica Rayanne Mota da Costa, Maria Janielly Castelo Branco Silveira, Larissa Holanda Silva, Helio Vitoriano Nobre Junior
Summary: Candida spp. infections are a serious health problem, and drug repurposing, such as using sertraline, has shown potential in treating Candida spp. biofilm infections. The present study evaluated the in vitro antibiofilm activity of sertraline and found that it effectively reduced the viability of forming and matured biofilms of all Candida species tested. Sertraline acted at low and safe concentrations, and its preventive mechanism seemed to be related to binding with ALS3. These findings suggest that sertraline could be a promising drug for treating Candida biofilm infections, but further research is needed.
JOURNAL OF MEDICAL MICROBIOLOGY
(2023)
Article
Neurosciences
Francisco Eliclecio Rodrigues da Silva, Rafaela Carneiro Cordeiro, Camila N. de Carvalho Lima, Pablo Leal Cardozo, Germana Silva Vasconcelos, Aline Santos Monte, Lia Lira Olivier Sanders, Silvania Maria Mendes Vasconcelos, David Freitas de Lucena, Breno Fiuza Cruz, Rodrigo Nicolato, Mary V. Seeman, Fabiola Mara Ribeiro, Danielle S. Macedo
Summary: This study found that females with schizophrenia experience more severe symptoms during the pre-ovulation phase of the menstrual cycle, and the administration of estrogen can alleviate these symptoms. The researchers also discovered that alterations in GPER may play a role in the gender differences observed in schizophrenia.
MOLECULAR NEUROBIOLOGY
(2023)
Review
Clinical Neurology
Paulo Levi Bezerra Martins, Ian Araujo Moura, Gabrielle Mendes, Vittoria Cristina Almeida Flexa Ribeiro, Andre Arnaud, Clarissa S. Gama, Michael Maes, Danielle S. Macedo, Joel Porfirio Pinto
Summary: This systematic review evaluated the immune alterations induced by clozapine and its relationship with clinical response. The results showed that clozapine treatment activates the compensatory immune-regulatory system and increases plasma levels of interleukin-6. Clozapine-induced immune alterations may contribute to the drug's mechanism of action and adverse effects.
EUROPEAN NEUROPSYCHOPHARMACOLOGY
(2023)
Article
Biochemistry & Molecular Biology
Rafaela C. Cordeiro, Camila N. C. Lima, Gabriel R. Fries, Giovana Zunta-Soares, Jair C. Soares, Joao Quevedo, Giselli Scaini
Summary: This study investigates the impact of mitochondrial dysfunction on bipolar disorder (BD). The study finds that BD patients have a lower mitochondrial health index (MHI) compared to non-psychiatry controls, with a negative correlation between MHI and cell-free mtDNA levels. The study further reveals that MHI is related to the expression of mitochondria quality control (MQC) proteins, and a longer illness duration, worse functional status, and higher depressive symptoms are associated with lower MHI and higher cell-free mtDNA levels.
MOLECULAR PSYCHIATRY
(2023)
Meeting Abstract
Clinical Neurology
Giselli Scaini, Krista M. Wartchow, Rafaela C. Cordeiro, Bashar Asir, Giovana Zunta-Soares, Albert J. Fenoy, Jair C. Soares, Joao Luciano de Quevedo
Meeting Abstract
Neurosciences
Rafaela Carneiro Cordeiro, Krista M. Wartchow, Tina Li, Bashar Asi, Giovana Zunta-Soares, Albert J. Fenoy, Jair C. Soares, Joao Quevedo, Giselli Scaini
BIOLOGICAL PSYCHIATRY
(2023)
Article
Parasitology
Adriano Jose Maia Chaves Filho, Paloma Marinho Juca, Michelle Verde Ramo Soares, Caio Andrade de Oliveira, Raul Cavalcante de Sousa, Deniele Bezerra Los, Remo Castro Russo, Juliana Navarro Ueda Yaochite, Danielle S. Macedo
Summary: This study investigates the effects of recombinant SARS-CoV-2 S1 receptor-binding domain (RBD) peptide on immune activation in murine macrophage and microglial cells. The results show that the effects of the peptide vary depending on the cell line, exposure time, and concentration.
MEMORIAS DO INSTITUTO OSWALDO CRUZ
(2023)