Tetramethylpyrazine prevents liver fibrotic injury in mice by targeting hepatocyte-derived and mitochondrial DNA-enriched extracellular vesicles

Hepatocyte-specific IL11 cis-signaling drives lipotoxicity and underlies the transition from NAFLD to NASH

(2021) Jinrui Dong et al.   Nature Communications

Ligustrazine alleviates cyclophosphamide-induced hepatotoxicity via the inhibition of Txnip/Trx/NF-κB pathway

(2021) Xinfei Ma et al.   LIFE SCIENCES

Si-Ni-San ameliorates chronic colitis by modulating type I interferons-mediated inflammation

(2021) Yajie Cai et al.   PHYTOMEDICINE

Extracellular vesicles activate ATM‐Chk2 signaling pathway through the intercellular transfer of mitochondrial DNA in HBV‐infected human hepatocytes

(2021) Hiromichi Dansako et al.   FASEB JOURNAL

P2X7 receptor‐targeted regulation by tetrahydroxystilbene glucoside in alcoholic hepatosteatosis: A new strategy towards macrophage–hepatocyte crosstalk

(2020) Yu Zhang et al.   BRITISH JOURNAL OF PHARMACOLOGY

VDAC oligomers form mitochondrial pores to release mtDNA fragments and promote lupus-like disease

(2020) Jeonghan Kim et al.   SCIENCE

Cholangiocyte-Derived Exosomal lncRNA H19 Promotes Macrophage Activation and Hepatic Inflammation under Cholestatic Conditions

(2020) Xiaojiaoyang Li et al.   Cells

Extracellular Vesicles From Hepatocytes Are Therapeutic for Toxin-Mediated Fibrosis and Gene Expression in the Liver

(2020) Xinlei Li et al.   Frontiers in Cell and Developmental Biology

Hepatocyte mitochondria-derived danger signals directly activate hepatic stellate cells and drive progression of liver fibrosis

(2020) Ping An et al.   Nature Communications

Liver Fibrosis: Mechanistic Concepts and Therapeutic Perspectives

(2020) Natascha Roehlen et al.   Cells

IRE1A Stimulates Hepatocyte-derived Extracellular Vesicles That Promote Inflammation in Mice With Steatohepatitis

(2020) Debanjali Dasgupta et al.   GASTROENTEROLOGY

Genetic diversity and phylogeny analysis of Antheraea assamensis Helfer (Lepidoptera: Saturniidae) based on mitochondrial DNA sequences

(2019) Mousumi Saikia et al.   JOURNAL OF GENETICS

Cholangiocyte‐Derived Exosomal Long Noncoding RNA H19 Promotes Hepatic Stellate Cell Activation and Cholestatic Liver Fibrosis

(2019) Runping Liu et al.   HEPATOLOGY

ALDH2 deficiency promotes alcohol-associated liver cancer by activating oncogenic pathways via oxidized DNA enriched extracellular vesicles

(2019) Wonhyo Seo et al.   JOURNAL OF HEPATOLOGY

Hepatocyte Stress Increases Expression of YAP and TAZ in Hepatocytes to Promote Parenchymal Inflammation and Fibrosis

(2019) Meghan Mooring et al.   HEPATOLOGY

Hepatocyte-Derived Extracellular Vesicles Promote Endothelial Inflammation and Atherogenesis via microRNA-1

(2019) Fangjie Jiang et al.   JOURNAL OF HEPATOLOGY

Astaxanthin attenuates the increase in mitochondrial respiration during the activation of hepatic stellate cells

(2019) Minkyung Bae et al.   JOURNAL OF NUTRITIONAL BIOCHEMISTRY

Mitochondria as multifaceted regulators of cell death

(2019) Florian J. Bock et al.   NATURE REVIEWS MOLECULAR CELL BIOLOGY

Local delivery of tetramethylpyrazine eliminates the senescent phenotype of bone marrow mesenchymal stromal cells and creates an anti-inflammatory and angiogenic environment in aging mice

(2018) Bo Gao et al.   AGING CELL

High mobility group box-1 drives fibrosis progression signaling via the receptor for advanced glycation end-products in mice

(2018) Xiaodong Ge et al.   HEPATOLOGY

Pharmacotherapy for NASH: Current and emerging

(2018) Monica A. Konerman et al.   JOURNAL OF HEPATOLOGY

Ligand Activation of PPARγ by Ligustrazine Suppresses Pericyte Functions of Hepatic Stellate Cells via SMRT-Mediated Transrepression of HIF-1α

(2018) Feng Zhang et al.   Theranostics

Scavenging Circulating Mitochondrial DNA as a Potential Therapeutic Option for Multiple Organ Dysfunction in Trauma Hemorrhage

(2018) Andrew Aswani et al.   Frontiers in Immunology

Mitochondrial inner membrane permeabilisation enables mtDNA release during apoptosis

(2018) Joel S Riley et al.   EMBO JOURNAL

Impaired endothelial autophagy promotes liver fibrosis by aggravating the oxidative stress response during acute liver injury

(2018) Maria Ruart et al.   JOURNAL OF HEPATOLOGY

The role of long noncoding RNA H19 in gender disparity of cholestatic liver injury in multidrug resistance 2 gene knockout mice

(2017) Xiaojiaoyang Li et al.   HEPATOLOGY

Tetramethylpyrazine attenuates sinusoidal angiogenesis via inhibition of hedgehog signaling in liver fibrosis

(2017) Shifeng Zhao et al.   IUBMB LIFE

Pathways of production and delivery of hepatocyte exosomes

(2017) Li Chen et al.   Journal of Cell Communication and Signaling

Ligustrazine disrupts lipopolysaccharide-activated NLRP3 inflammasome pathway associated with inhibition of Toll-like receptor 4 in hepatocytes

(2016) Feng Zhang et al.   BIOMEDICINE & PHARMACOTHERAPY

Extracellular vesicles in liver pathobiology: Small particles with big impact

(2016) Petra Hirsova et al.   HEPATOLOGY

Hepatocyte mitochondrial DNA drives nonalcoholic steatohepatitis by activation of TLR9

(2016) Irma Garcia-Martinez et al.   JOURNAL OF CLINICAL INVESTIGATION

Protein S-glutathionlyation links energy metabolism to redox signaling in mitochondria

(2016) Ryan J. Mailloux et al.   Redox Biology

Tetramethylpyrazine (TMP) protects against sodium arsenite-induced nephrotoxicity by suppressing ROS production, mitochondrial dysfunction, pro-inflammatory signaling pathways and programed cell death

(2014) Xuezhong Gong et al.   ARCHIVES OF TOXICOLOGY

Circulating mitochondrial DAMPs cause inflammatory responses to injury

(2010) Qin Zhang et al.   NATURE