Extracellular vesicles in liver pathobiology: Small particles with big impact

Communication by Extracellular Vesicles: Where We Are and Where We Need to Go

(2016) Mercedes Tkach et al.   CELL

Lipid-Induced Signaling Causes Release of Inflammatory Extracellular Vesicles From Hepatocytes

(2016) Petra Hirsova et al.   GASTROENTEROLOGY

Hepatocyte mitochondrial DNA drives nonalcoholic steatohepatitis by activation of TLR9

(2016) Irma Garcia-Martinez et al.   JOURNAL OF CLINICAL INVESTIGATION

Hepatocyte exosomes mediate liver repair and regeneration via sphingosine-1-phosphate

(2016) Hiroyuki Nojima et al.   JOURNAL OF HEPATOLOGY

Alcohol stimulates macrophage activation through caspase-dependent hepatocyte derived release of CD40L containing extracellular vesicles

(2016) Vikas K. Verma et al.   JOURNAL OF HEPATOLOGY

Exosomes in liver pathology

(2016) Keisaku Sato et al.   JOURNAL OF HEPATOLOGY

Proteomic comparison defines novel markers to characterize heterogeneous populations of extracellular vesicle subtypes

(2016) Joanna Kowal et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Subtoxic Alterations in Hepatocyte-Derived Exosomes: An Early Step in Drug-Induced Liver Injury?

(2016) Natalie S. Holman et al.   TOXICOLOGICAL SCIENCES

Tumor-derived exosomes regulate expression of immune function-related genes in human T cell subsets

(2016) Laurent Muller et al.   Scientific Reports

Extracellular vesicle long noncoding RNA as potential biomarkers of liver cancer

(2015) Swathi Mohankumar et al.   Briefings in Functional Genomics

Phosphatidylserine Vesicles Enable Efficient En Bloc Transmission of Enteroviruses

(2015) Ying-Han Chen et al.   CELL

Embryonic Stem Cell-Derived Exosomes Promote Endogenous Repair Mechanisms and Enhance Cardiac Function Following Myocardial Infarction

(2015) M. Khan et al.   CIRCULATION RESEARCH

Hepatitis C Virus Infection Induces Autocrine Interferon Signaling by Human Liver Endothelial Cells and Release of Exosomes, Which Inhibits Viral Replication

(2015) Silvia Giugliano et al.   GASTROENTEROLOGY

Vps4A functions as a tumor suppressor by regulating the secretion and uptake of exosomal microRNAs in human hepatoma cells

(2015) Jin-xing Wei et al.   HEPATOLOGY

Mixed lineage kinase 3 mediates release of C-X-C motif ligand 10-bearing chemotactic extracellular vesicles from lipotoxic hepatocytes

(2015) Samar H. Ibrahim et al.   HEPATOLOGY

MicroRNA Cargo of Extracellular Vesicles from Alcohol-exposed Monocytes Signals Naive Monocytes to Differentiate into M2 Macrophages

(2015) Banishree Saha et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Exosome Adherence and Internalization by Hepatic Stellate Cells Triggers Sphingosine 1-Phosphate-dependent Migration

(2015) Ruisi Wang et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Increased number of circulating exosomes and their microRNA cargos are potential novel biomarkers in alcoholic hepatitis

(2015) Fatemeh Momen-Heravi et al.   Journal of Translational Medicine

Intercellular Transmission of Viral Populations with Vesicles

(2015) Nihal Altan-Bonnet et al.   JOURNAL OF VIROLOGY

Tumour exosome integrins determine organotropic metastasis

(2015) Ayuko Hoshino et al.   NATURE

Pancreatic cancer exosomes initiate pre-metastatic niche formation in the liver

(2015) Bruno Costa-Silva et al.   NATURE CELL BIOLOGY

Extracellular Vesicles in Cancer: Exosomes, Microvesicles and the Emerging Role of Large Oncosomes

(2015) Valentina R. Minciacchi et al.   SEMINARS IN CELL & DEVELOPMENTAL BIOLOGY

Large oncosomes contain distinct protein cargo and represent a separate functional class of tumor-derived extracellular vesicles

(2015) Valentina R. Minciacchi et al.   Oncotarget

Exosomes derived from alcohol-treated hepatocytes horizontally transfer liver specific miRNA-122 and sensitize monocytes to LPS

(2015) Fatemeh Momen-Heravi et al.   Scientific Reports

Microparticles Release by Adipocytes Act as “Find-Me” Signals to Promote Macrophage Migration

(2015) Akiko Eguchi et al.   PLoS One

Microvesicles and exosomes for intracardiac communication

(2014) Joost P.G. Sluijter et al.   CARDIOVASCULAR RESEARCH

Biogenesis and secretion of exosomes

(2014) Joanna Kowal et al.   CURRENT OPINION IN CELL BIOLOGY

Human bile contains MicroRNA-laden extracellular vesicles that can be used for cholangiocarcinoma diagnosis

(2014) Ling Li et al.   HEPATOLOGY

Hepatitis E virus egress depends on the exosomal pathway, with secretory exosomes derived from multivesicular bodies

(2014) S. Nagashima et al.   JOURNAL OF GENERAL VIROLOGY

Quantitative proteomic analysis of hepatocyte-secreted extracellular vesicles reveals candidate markers for liver toxicity

(2014) Eva Rodríguez-Suárez et al.   Journal of Proteomics

Involvement of Extracellular Vesicle Long Noncoding RNA (linc-VLDLR) in Tumor Cell Responses to Chemotherapy

(2014) Kenji Takahashi et al.   MOLECULAR CANCER RESEARCH

Circulating Extracellular Vesicles with Specific Proteome and Liver MicroRNAs Are Potential Biomarkers for Liver Injury in Experimental Fatty Liver Disease

(2014) Davide Povero et al.   PLoS One

Exosomes mediate intercellular transfer of pro-fibrogenic connective tissue growth factor (CCN2) between hepatic stellate cells, the principal fibrotic cells in the liver

(2014) Alyssa Charrier et al.   SURGERY

Exosomes from Hepatitis C Infected Patients Transmit HCV Infection and Contain Replication Competent Viral RNA in Complex with Ago2-miR122-HSP90

(2014) Terence N. Bukong et al.   PLoS Pathogens

Tetraspanins in Extracellular Vesicle Formation and Function

(2014) Zoraida Andreu et al.   Frontiers in Immunology

Epigenetic regulation of connective tissue growth factor by MicroRNA-214 delivery in exosomes from mouse or human hepatic stellate cells

(2013) Li Chen et al.   HEPATOLOGY

Extracellular vesicles: Exosomes, microvesicles, and friends

(2013) Graça Raposo et al.   JOURNAL OF CELL BIOLOGY

Analysis of ESCRT functions in exosome biogenesis, composition and secretion highlights the heterogeneity of extracellular vesicles

(2013) Marina Colombo et al.   JOURNAL OF CELL SCIENCE

Innate Immune Cell-Derived Microparticles Facilitate Hepatocarcinoma Metastasis by Transferring Integrin  M 2 to Tumor Cells

(2013) J. Ma et al.   JOURNAL OF IMMUNOLOGY

Mixed lineage kinase 3 deficient mice are protected against the high fat high carbohydrate diet-induced steatohepatitis

(2013) Samar H. Ibrahim et al.   LIVER INTERNATIONAL

Exosomes mediate the cell-to-cell transmission of IFN-α-induced antiviral activity

(2013) Jianhua Li et al.   NATURE IMMUNOLOGY

Exosome-mediated transmission of hepatitis C virus between human hepatoma Huh7.5 cells

(2013) V. Ramakrishnaiah et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

A comprehensive characterization of membrane vesicles released by autophagic human endothelial cells

(2013) Nicolas Pallet et al.   PROTEOMICS

Lipid-Induced Toxicity Stimulates Hepatocytes to Release Angiogenic Microparticles That Require Vanin-1 for Uptake by Endothelial Cells

(2013) D. Povero et al.   Science Signaling

Delivery of therapeutic agents by nanoparticles made of grapefruit-derived lipids

(2013) Qilong Wang et al.   Nature Communications

Rab27a Supports Exosome-Dependent and -Independent Mechanisms That Modify the Tumor Microenvironment and Can Promote Tumor Progression

(2012) A. Bobrie et al.   CANCER RESEARCH

Circulating Microparticles as Disease-Specific Biomarkers of Severity of Inflammation in Patients With Hepatitis C or Nonalcoholic Steatohepatitis

(2012) Miroslaw Kornek et al.   GASTROENTEROLOGY

Circulating microRNAs in exosomes indicate hepatocyte injury and inflammation in alcoholic, drug-induced, and inflammatory liver diseases

(2012) Shashi Bala et al.   HEPATOLOGY

Anticancer Drugs Cause Release of Exosomes with Heat Shock Proteins from Human Hepatocellular Carcinoma Cells That Elicit Effective Natural Killer Cell Antitumor Responsesin Vitro

(2012) Li-Hong Lv et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Activated T Cell Exosomes Promote Tumor Invasion via Fas Signaling Pathway

(2012) Z. Cai et al.   JOURNAL OF IMMUNOLOGY

Get on the exosome bus with ALIX

(2012) James H. Hurley et al.   NATURE CELL BIOLOGY

Comprehensive miRNA Expression Analysis in Peripheral Blood Can Diagnose Liver Disease

(2012) Yoshiki Murakami et al.   PLoS One

Formation and release of arrestin domain-containing protein 1-mediated microvesicles (ARMMs) at plasma membrane by recruitment of TSG101 protein

(2012) J. F. Nabhan et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Exosomes Derived from Human Umbilical Cord Mesenchymal Stem Cells Alleviate Liver Fibrosis

(2012) Tingfen Li et al.   STEM CELLS AND DEVELOPMENT

Microparticles in Hemostasis and Thrombosis

(2011) A. Phillip Owens et al.   CIRCULATION RESEARCH

MVB vesicle formation: ESCRT-dependent, ESCRT-independent and everything in between

(2011) Markus Babst   CURRENT OPINION IN CELL BIOLOGY

The Tetraspanin CD63 Regulates ESCRT-Independent and -Dependent Endosomal Sorting during Melanogenesis

(2011) Guillaume van Niel et al.   DEVELOPMENTAL CELL

Microparticle-associated nucleic acids mediate trait dominance in cancer

(2011) Ritu Jaiswal et al.   FASEB JOURNAL

Intercellular nanovesicle-mediated microRNA transfer: A mechanism of environmental modulation of hepatocellular cancer cell growth

(2011) Takayuki Kogure et al.   HEPATOLOGY

Biliary exosomes influence cholangiocyte regulatory mechanisms and proliferation through interaction with primary cilia

(2010) Anatoliy I. Masyuk et al.   AMERICAN JOURNAL OF PHYSIOLOGY-GASTROINTESTINAL AND LIVER PHYSIOLOGY

Human T cell microparticles circulate in blood of hepatitis patients and induce fibrolytic activation of hepatic stellate cells

(2010) Miroslaw Kornek et al.   HEPATOLOGY

Regulation of exosome secretion by Rab35 and its GTPase-activating proteins TBC1D10A–C

(2010) Chieh Hsu et al.   JOURNAL OF CELL BIOLOGY

Microvesicles: mediators of extracellular communication during cancer progression

(2010) V. Muralidharan-Chari et al.   JOURNAL OF CELL SCIENCE

Intrahepatic angiogenesis and sinusoidal remodeling in chronic liver disease: New targets for the treatment of portal hypertension?

(2010) Dominique Thabut et al.   JOURNAL OF HEPATOLOGY

ARF6-Regulated Shedding of Tumor Cell-Derived Plasma Membrane Microvesicles

(2009) Vandhana Muralidharan-Chari et al.   CURRENT BIOLOGY

Immature myeloid cells induced by a high-fat diet contribute to liver inflammation

(2009) Zhong-bin Deng et al.   HEPATOLOGY

Microenvironmental pH Is a Key Factor for Exosome Traffic in Tumor Cells

(2009) Isabella Parolini et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Tumor-Derived Microvesicles Promote Regulatory T Cell Expansion and Induce Apoptosis in Tumor-Reactive Activated CD8+ T Lymphocytes

(2009) E. U. Wieckowski et al.   JOURNAL OF IMMUNOLOGY

Rab27a and Rab27b control different steps of the exosome secretion pathway

(2009) Matias Ostrowski et al.   NATURE CELL BIOLOGY

Rab GTPases as coordinators of vesicle traffic

(2009) Harald Stenmark   NATURE REVIEWS MOLECULAR CELL BIOLOGY

Endothelial expression of autocrine VEGF upon the uptake of tumor-derived microvesicles containing oncogenic EGFR

(2009) K. Al-Nedawi et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

MHC II in Dendritic Cells is Targeted to Lysosomes or T Cell-Induced Exosomes Via Distinct Multivesicular Body Pathways

(2009) Sonja I. Buschow et al.   TRAFFIC

Liver Cell–Derived Microparticles Activate Hedgehog Signaling and Alter Gene Expression in Hepatic Endothelial Cells

(2008) Rafal P. Witek et al.   GASTROENTEROLOGY

Thrombosis and anticoagulation in liver disease

(2008) Dominique Charles Valla   HEPATOLOGY

Intercellular transfer of the oncogenic receptor EGFRvIII by microvesicles derived from tumour cells

(2008) Khalid Al-Nedawi et al.   NATURE CELL BIOLOGY

Hepatic Stellate Cells: Protean, Multifunctional, and Enigmatic Cells of the Liver

(2008) Scott L. Friedman   PHYSIOLOGICAL REVIEWS

Ceramide Triggers Budding of Exosome Vesicles into Multivesicular Endosomes

(2008) K. Trajkovic et al.   SCIENCE