Glutamine Antagonist Synergizes with Electrodynamic Therapy to Induce Tumor Regression and Systemic Antitumor Immunity

Intratumoral IL-12 delivery empowers CAR-T cell immunotherapy in a pre-clinical model of glioblastoma

(2021) Giulia Agliardi et al.   Nature Communications

Nanoscale coordination polymers induce immunogenic cell death by amplifying radiation therapy mediated oxidative stress

(2021) Zhusheng Huang et al.   Nature Communications

Direct control of CAR T cells through small molecule-regulated antibodies

(2021) Spencer Park et al.   Nature Communications

Immunogenic Cell Death Inducing Fluorinated Mitochondria‐Disrupting Helical Polypeptide Synergizes with PD‐L1 Immune Checkpoint Blockade

(2021) Seong Dong Jeong et al.   Advanced Science

Hypoxia-inducible factor activity promotes antitumor effector function and tissue residency by CD8+ T cells

(2021) Ilkka Liikanen et al.   JOURNAL OF CLINICAL INVESTIGATION

Targeting monoamine oxidase A for T cell–based cancer immunotherapy

(2021) Xi Wang et al.   Science Immunology

Tumor hypoxia-activated combinatorial nanomedicine triggers systemic antitumor immunity to effectively eradicate advanced breast cancer

(2021) Jing Liu et al.   BIOMATERIALS

Uptake of oxidized lipids by the scavenger receptor CD36 promotes lipid peroxidation and dysfunction in CD8+ T cells in tumors

(2021) Shihao Xu et al.   IMMUNITY

Icaritin Exacerbates Mitophagy and Synergizes with Doxorubicin to Induce Immunogenic Cell Death in Hepatocellular Carcinoma

(2020) Zhuo Yu et al.   ACS Nano

Application of Mitochondrially Targeted Nanoconstructs to Neoadjuvant X-ray-Induced Photodynamic Therapy for Rectal Cancer

(2020) Wei Deng et al.   ACS Central Science

MnO x Nanospikes as Nanoadjuvants and Immunogenic Cell Death Drugs with Enhanced Antitumor Immunity and Antimetastatic Effect

(2020) Binbin Ding et al.   ANGEWANDTE CHEMIE-INTERNATIONAL EDITION

Engineering antigen as photosensitiser nanocarrier to facilitate ROS triggered immune cascade for photodynamic immunotherapy

(2020) Huaiji Wang et al.   BIOMATERIALS

Preparation of TiH1.924 nanodots by liquid-phase exfoliation for enhanced sonodynamic cancer therapy

(2020) Fei Gong et al.   Nature Communications

Porous Pt Nanospheres Incorporated with GOx to Enable Synergistic Oxygen‐Inductive Starvation/Electrodynamic Tumor Therapy

(2020) Zijie Lu et al.   Advanced Science

Nanoscale Metal–Organic Frameworks for Cancer Immunotherapy

(2020) Kaiyuan Ni et al.   ACCOUNTS OF CHEMICAL RESEARCH

Suppressing the Radiation-Induced Corrosion of Bismuth Nanoparticles for Enhanced Synergistic Cancer Radiophototherapy

(2020) Ruyi Zhou et al.   ACS Nano

Self‐Degradable Supramolecular Photosensitizer with High Photodynamic Therapeutic Efficiency and Improved Safety

(2020) Bin Yuan et al.   ANGEWANDTE CHEMIE-INTERNATIONAL EDITION

Porous Pt nanoparticles loaded with doxorubicin to enable synergistic Chemo-/Electrodynamic Therapy

(2020) Tong Chen et al.   BIOMATERIALS

Chitosan/γ-PGA nanoparticles-based immunotherapy as adjuvant to radiotherapy in breast cancer

(2020) Flávia Castro et al.   BIOMATERIALS

Design of a novel mitochondria targetable turn-on fluorescence probe for hydrogen peroxide and its two-photon bioimaging applications

(2020) Kangnan Wang et al.   CHINESE CHEMICAL LETTERS

Self-Amplification of Tumor Oxidative Stress with Degradable Metallic Complexes for Synergistic Cascade Tumor Therapy

(2020) Gui Chen et al.   NANO LETTERS

Polymeric Nanoparticles with ROS‐Responsive Prodrug and Platinum Nanozyme for Enhanced Chemophotodynamic Therapy of Colon Cancer

(2020) Ying Hao et al.   Advanced Science

Carrier-free nanoassembly of doxorubicin prodrug and siRNA for combinationally inducing immunogenic cell death and reversing immunosuppression

(2020) Senbiao Chen et al.   Nano Today

Serine-70 phosphorylated Bcl-2 prevents oxidative stress-induced DNA damage by modulating the mitochondrial redox metabolism

(2020) Stephen Jun Fei Chong et al.   NUCLEIC ACIDS RESEARCH

Nanoparticle-Enhanced Radiotherapy to Trigger Robust Cancer Immunotherapy

(2019) Qian Chen et al.   ADVANCED MATERIALS

Tumor-Targeted Delivery of 6-Diazo-5-oxo-l-norleucine (DON) Using Substituted Acetylated Lysine Prodrugs

(2019) Lukáš Tenora et al.   JOURNAL OF MEDICINAL CHEMISTRY

Tumor Microenvironment-Activatable Prodrug Vesicles for Nanoenabled Cancer Chemoimmunotherapy Combining Immunogenic Cell Death Induction and CD47 Blockade

(2019) Fangyuan Zhou et al.   ADVANCED MATERIALS

Platinum Nanoparticles to Enable Electrodynamic Therapy for Effective Cancer Treatment

(2019) Tongxu Gu et al.   ADVANCED MATERIALS

Targeting photodynamic and photothermal therapy to the endoplasmic reticulum enhances immunogenic cancer cell death

(2019) Wei Li et al.   Nature Communications

Multifunctional Nanoregulator Reshapes Immune Microenvironment and Enhances Immune Memory for Tumor Immunotherapy

(2019) Meng Yu et al.   Advanced Science

Activating Antitumor Immunity and Antimetastatic Effect Through Polydopamine‐Encapsulated Core–Shell Upconversion Nanoparticles

(2019) Shuangqian Yan et al.   ADVANCED MATERIALS

A pH-Activatable nanoparticle for dual-stage precisely mitochondria-targeted photodynamic anticancer therapy

(2019) Tong Qi et al.   BIOMATERIALS

Metabolism‐induced oxidative stress and DNA damage selectively trigger genome instability in polyploid fungal cells

(2019) Gregory J Thomson et al.   EMBO JOURNAL

In Situ Polymerized Hollow Mesoporous Organosilica Biocatalysis Nanoreactor for Enhancing ROS‐Mediated Anticancer Therapy

(2019) Ling Li et al.   ADVANCED FUNCTIONAL MATERIALS

Massively Evoking Immunogenic Cell Death by Focused Mitochondrial Oxidative Stress using an AIE Luminogen with a Twisted Molecular Structure

(2019) Chao Chen et al.   ADVANCED MATERIALS

Glutamine blockade induces divergent metabolic programs to overcome tumor immune evasion

(2019) Robert D. Leone et al.   SCIENCE

Co-localized delivery of nanomedicine and nanovaccine augments the postoperative cancer immunotherapy by amplifying T-cell responses

(2019) Xiang Liu et al.   BIOMATERIALS

Targeting tumor-intrinsic hexosamine biosynthesis sensitizes pancreatic cancer to anti-PD1 therapy

(2019) Nikita S. Sharma et al.   JOURNAL OF CLINICAL INVESTIGATION

Disrupting a converging metabolic target turns up the immunologic-heat in pancreatic tumors

(2019) Won Jin Ho et al.   JOURNAL OF CLINICAL INVESTIGATION

Oxidative damage diminishes mitochondrial DNA polymerase replication fidelity

(2019) Andrew P Anderson et al.   NUCLEIC ACIDS RESEARCH

Laser Immunotherapy in Combination with Perdurable PD-1 Blocking for Treatment of Metastatic Tumor

(2018) Lihua Luo et al.   ACS Nano

Dinaciclib induces immunogenic cell death and enhances anti-PD1–mediated tumor suppression

(2018) Dewan Md Sakib Hossain et al.   JOURNAL OF CLINICAL INVESTIGATION

Binary Cooperative Prodrug Nanoparticles Improve Immunotherapy by Synergistically Modulating Immune Tumor Microenvironment

(2018) Bing Feng et al.   ADVANCED MATERIALS

Hexosamine Biosynthetic Pathway Inhibition Leads to AML Cell Differentiation and Cell Death

(2018) Abhishek Asthana et al.   MOLECULAR CANCER THERAPEUTICS

JHU-083 selectively blocks glutaminase activity in brain CD11b+ cells and prevents depression-associated behaviors induced by chronic social defeat stress

(2018) Xiaolei Zhu et al.   NEUROPSYCHOPHARMACOLOGY