Metabolism‐induced oxidative stress and DNA damage selectively trigger genome instability in polyploid fungal cells

A role for Candida albicans superoxide dismutase enzymes in glucose signaling

(2018) Chynna N. Broxton et al.   BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS

Tuning Hsf1 levels drives distinct fungal morphogenetic programs with depletion impairing Hsp90 function and overexpression expanding the target space

(2018) Amanda O. Veri et al.   PLoS Genetics

Evolutionary Emergence of Drug Resistance in Candida Opportunistic Pathogens

(2018) Ewa Ksiezopolska et al.   Genes

Parasex Generates Phenotypic Diversityde Novoand Impacts Drug Resistance and Virulence inCandida albicans

(2017) Matthew P. Hirakawa et al.   GENETICS

Candida albicans FRE8 encodes a member of the NADPH oxidase family that produces a burst of ROS during fungal morphogenesis

(2017) Diego C. P. Rossi et al.   PLoS Pathogens

Parasex Generates Phenotypic Diversityde Novoand Impacts Drug Resistance and Virulence inCandida albicans

(2017) Matthew P. Hirakawa et al.   GENETICS

Sex accelerates adaptation

(2016) Matthew R. Goddard   NATURE

Sex speeds adaptation by altering the dynamics of molecular evolution

(2016) Michael J. McDonald et al.   NATURE

PANTHER version 11: expanded annotation data from Gene Ontology and Reactome pathways, and data analysis tool enhancements

(2016) Huaiyu Mi et al.   NUCLEIC ACIDS RESEARCH

The Interplay of Reactive Oxygen Species, Hypoxia, Inflammation, and Sirtuins in Cancer Initiation and Progression

(2016) Marco Tafani et al.   Oxidative Medicine and Cellular Longevity

Whole Genome Analysis of 132 Clinical Saccharomyces cerevisiae Strains Reveals Extensive Ploidy Variation

(2016) Yuan O. Zhu et al.   G3-Genes Genomes Genetics

The parasexual lifestyle of Candida albicans

(2015) Richard J Bennett   CURRENT OPINION IN MICROBIOLOGY

Parasexual Ploidy Reduction Drives Population Heterogeneity Through Random and Transient Aneuploidy in Candida albicans

(2015) Meleah A. Hickman et al.   GENETICS

The expanding implications of polyploidy

(2015) Kevin P. Schoenfelder et al.   JOURNAL OF CELL BIOLOGY

Polyploidy can drive rapid adaptation in yeast

(2015) Anna M. Selmecki et al.   NATURE

Bactericidal Antibiotics Induce Toxic Metabolic Perturbations that Lead to Cellular Damage

(2015) Peter Belenky et al.   Cell Reports

Adaptation to High Ethanol Reveals Complex Evolutionary Pathways

(2015) Karin Voordeckers et al.   PLoS Genetics

Parasexual Ploidy Reduction Drives Population Heterogeneity Through Random and Transient Aneuploidy in Candida albicans

(2015) Meleah A. Hickman et al.   GENETICS

Polyploidy in the Arabidopsis genus

(2014) Kirsten Bomblies et al.   CHROMOSOME RESEARCH

Identification of Transcriptional and Metabolic Programs Related to Mammalian Cell Size

(2014) Teemu P. Miettinen et al.   CURRENT BIOLOGY

Hyperdiploid tumor cells increase phenotypic heterogeneity within Glioblastoma tumors

(2014) Prudence Donovan et al.   Molecular BioSystems

Ploidy changes and genome stability in yeast

(2014) Zuzana Storchova   YEAST

Mechanism and Regulation of Meiotic Recombination Initiation

(2014) Isabel Lam et al.   Cold Spring Harbor Perspectives in Biology

Sources of DNA Double-Strand Breaks and Models of Recombinational DNA Repair

(2014) A. Mehta et al.   Cold Spring Harbor Perspectives in Biology

Rapid Mechanisms for Generating Genome Diversity: Whole Ploidy Shifts, Aneuploidy, and Loss of Heterozygosity

(2014) R. J. Bennett et al.   Cold Spring Harbor Perspectives in Medicine

A Tetraploid Intermediate Precedes Aneuploid Formation in Yeasts Exposed to Fluconazole

(2014) Benjamin D. Harrison et al.   PLOS BIOLOGY

Size Does Matter: Why Polyploid Tumor Cells are Critical Drug Targets in the War on Cancer

(2014) Jermaine Coward et al.   Frontiers in Oncology

Polyploidization in Liver Tissue

(2013) Géraldine Gentric et al.   AMERICAN JOURNAL OF PATHOLOGY

Ybp1 and Gpx3 Signaling in Candida albicans Govern Hydrogen Peroxide-Induced Oxidation of the Cap1 Transcription Factor and Macrophage Escape

(2013) Miranda J. Patterson et al.   ANTIOXIDANTS & REDOX SIGNALING

The ‘obligate diploid’ Candida albicans forms mating-competent haploids

(2013) Meleah A. Hickman et al.   NATURE

Pan-cancer patterns of somatic copy number alteration

(2013) Travis I Zack et al.   NATURE GENETICS

Polyploids Exhibit Higher Potassium Uptake and Salinity Tolerance in Arabidopsis

(2013) D.-Y. Chao et al.   SCIENCE

Control of Candida albicans Metabolism and Biofilm Formation by Pseudomonas aeruginosa Phenazines

(2013) D. K. Morales et al.   mBio

Engineered proteins detect spontaneous DNA breakage in human and bacterial cells

(2013) Chandan Shee et al.   eLife

Redox Environment, Free Radical, and Oxidative DNA Damage

(2012) Sarah J. Storr et al.   ANTIOXIDANTS & REDOX SIGNALING

STAR: ultrafast universal RNA-seq aligner

(2012) Alexander Dobin et al.   BIOINFORMATICS

DNA damage by reactive species: Mechanisms, mutation and repair

(2012) N R Jena   JOURNAL OF BIOSCIENCES

Tumorigenic polyploid cells contain elevated ROS and ARE selectively targeted by antioxidant treatment

(2011) Meejeon Roh et al.   JOURNAL OF CELLULAR PHYSIOLOGY

Death effector domain–containing protein (DEDD) is required for uterine decidualization during early pregnancy in mice

(2010) Mayumi Mori et al.   JOURNAL OF CLINICAL INVESTIGATION

Thioredoxin Regulates Multiple Hydrogen Peroxide-Induced Signaling Pathways in Candida albicans

(2010) A. da Silva Dantas et al.   MOLECULAR AND CELLULAR BIOLOGY

Control of Transcription by Cell Size

(2010) Chia-Yung Wu et al.   PLOS BIOLOGY

The DNA-damage response in human biology and disease

(2009) Stephen P. Jackson et al.   NATURE

Evolution of pathogenicity and sexual reproduction in eight Candida genomes

(2009) Geraldine Butler et al.   NATURE

Efficacy of antioxidants in the yeast Saccharomyces cerevisiae correlates with their effects on protein thiols

(2008) Sabina Bednarska et al.   BIOCHIMIE

Nonapoptotic Death ofSaccharomyces cerevisiaeCells That Is Stimulated by Hsp90 and Inhibited by Calcineurin and Cmk2 in Response to Endoplasmic Reticulum Stresses

(2008) Drew D. Dudgeon et al.   EUKARYOTIC CELL

Manganese superoxide dismutase gene dosage affects chromosomal instability and tumor onset in a mouse model of T cell lymphoma

(2008) Christopher I. van de Wetering et al.   FREE RADICAL BIOLOGY AND MEDICINE

The consequences of tetraploidy and aneuploidy

(2008) Z. Storchova et al.   JOURNAL OF CELL SCIENCE

Chronic Oxidative DNA Damage Due to DNA Repair Defects Causes Chromosomal Instability in Saccharomyces cerevisiae

(2008) N. P. Degtyareva et al.   MOLECULAR AND CELLULAR BIOLOGY

The Parasexual Cycle in Candida albicans Provides an Alternative Pathway to Meiosis for the Formation of Recombinant Strains

(2008) Anja Forche et al.   PLOS BIOLOGY