JHU-083 selectively blocks glutaminase activity in brain CD11b+ cells and prevents depression-associated behaviors induced by chronic social defeat stress

Mechanistic Target of Rapamycin–Independent Antidepressant Effects of ( R )-Ketamine in a Social Defeat Stress Model

(2018) Chun Yang et al.   BIOLOGICAL PSYCHIATRY

Cell-type-specific role for nucleus accumbens neuroligin-2 in depression and stress susceptibility

(2018) Mitra Heshmati et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Reversal of Stress-Induced Social Interaction Deficits by Buprenorphine

(2017) Caroline A Browne et al.   INTERNATIONAL JOURNAL OF NEUROPSYCHOPHARMACOLOGY

N-(Pivaloyloxy)alkoxy-carbonyl Prodrugs of the Glutamine Antagonist 6-Diazo-5-oxo-l-norleucine (DON) as a Potential Treatment for HIV Associated Neurocognitive Disorders

(2017) Michael T. Nedelcovych et al.   JOURNAL OF MEDICINAL CHEMISTRY

Molecular basis of dendritic atrophy and activity in stress susceptibility

(2017) T C Francis et al.   MOLECULAR PSYCHIATRY

Microglial recruitment of IL-1β-producing monocytes to brain endothelium causes stress-induced anxiety

(2017) D B McKim et al.   MOLECULAR PSYCHIATRY

Social stress induces neurovascular pathology promoting depression

(2017) Caroline Menard et al.   NATURE NEUROSCIENCE

Targeting glutamate signalling in depression: progress and prospects

(2017) James W. Murrough et al.   NATURE REVIEWS DRUG DISCOVERY

Cell-Type-Specific Epigenetic Editing at the Fosb Gene Controls Susceptibility to Social Defeat Stress

(2017) Peter J Hamilton et al.   NEUROPSYCHOPHARMACOLOGY

Glutamine antagonist-mediated immune suppression decreases pathology but delays virus clearance in mice during nonfatal alphavirus encephalomyelitis

(2017) Victoria K. Baxter et al.   VIROLOGY

Dopamine neuron dependent behaviors mediated by glutamate cotransmission

(2017) Susana Mingote et al.   eLife

The serum protein levels of the tPA–BDNF pathway are implicated in depression and antidepressant treatment

(2017) H Jiang et al.   Translational Psychiatry

Altered KYN/TRP, Gln/Glu, and Met/methionine sulfoxide ratios in the blood plasma of medication-free patients with major depressive disorder

(2017) Hidehiro Umehara et al.   Scientific Reports

A Double-Blind, Randomized, Placebo-Controlled, Dose-Frequency Study of Intravenous Ketamine in Patients With Treatment-Resistant Depression

(2016) Jaskaran B. Singh et al.   AMERICAN JOURNAL OF PSYCHIATRY

Essential Role of Mesolimbic Brain-Derived Neurotrophic Factor in Chronic Social Stress–Induced Depressive Behaviors

(2016) Ja Wook Koo et al.   BIOLOGICAL PSYCHIATRY

Neuroanatomic Differences Associated With Stress Susceptibility and Resilience

(2016) Christoph Anacker et al.   BIOLOGICAL PSYCHIATRY

Therapeutic Modulation of Glutamate Receptors in Major Depressive Disorder

(2016) Brittany Jaso et al.   Current Neuropharmacology

The effects of low-dose ketamine on the prefrontal cortex and amygdala in treatment-resistant depression: A randomized controlled study

(2016) Cheng-Ta Li et al.   HUMAN BRAIN MAPPING

Discovery of 6-Diazo-5-oxo-l-norleucine (DON) Prodrugs with Enhanced CSF Delivery in Monkeys: A Potential Treatment for Glioblastoma

(2016) Rana Rais et al.   JOURNAL OF MEDICINAL CHEMISTRY

Protective Effects of Glutamine Antagonist 6-Diazo-5-Oxo-l-Norleucine in Mice with Alphavirus Encephalomyelitis

(2016) Sivabalan Manivannan et al.   JOURNAL OF VIROLOGY

Co-activation of VEGF and NMDA receptors promotes synaptic targeting of AMPA receptors

(2016) G A Vargish et al.   MOLECULAR PSYCHIATRY

Conceptual convergence: increased inflammation is associated with increased basal ganglia glutamate in patients with major depression

(2016) E Haroon et al.   MOLECULAR PSYCHIATRY

Dysregulation of Prefrontal Cortex-Mediated Slow-Evolving Limbic Dynamics Drives Stress-Induced Emotional Pathology

(2016) Rainbo Hultman et al.   NEURON

EphB2 in the Medial Prefrontal Cortex Regulates Vulnerability to Stress

(2016) Ruo-Xi Zhang et al.   NEUROPSYCHOPHARMACOLOGY

Inflammation, Glutamate and Glia: A Trio of Trouble in Mood Disorders

(2016) Ebrahim Haroon et al.   NEUROPSYCHOPHARMACOLOGY

Genetic Isolation of Hypothalamic Neurons that Regulate Context-Specific Male Social Behavior

(2016) Marta E. Soden et al.   Cell Reports

Efficacy and Safety of Basimglurant as Adjunctive Therapy for Major Depression

(2016) Jorge A. Quiroz et al.   JAMA Psychiatry

Abnormality in glutamine–glutamate cycle in the cerebrospinal fluid of cognitively intact elderly individuals with major depressive disorder: a 3-year follow-up study

(2016) K Hashimoto et al.   Translational Psychiatry

Neurological sequelae induced by alphavirus infection of the CNS are attenuated by treatment with the glutamine antagonist 6-diazo-5-oxo-l-norleucine

(2015) Michelle C. Potter et al.   JOURNAL OF NEUROVIROLOGY

A pilot in vivo proton magnetic resonance spectroscopy study of amino acid neurotransmitter response to ketamine treatment of major depressive disorder

(2015) M S Milak et al.   MOLECULAR PSYCHIATRY

Social deficits in IRSp53 mutant mice improved by NMDAR and mGluR5 suppression

(2015) Woosuk Chung et al.   NATURE NEUROSCIENCE

Cell type– and brain region–resolved mouse brain proteome

(2015) Kirti Sharma et al.   NATURE NEUROSCIENCE

Evaluation of TrkB and BDNF transcripts in prefrontal cortex, hippocampus, and striatum from subjects with schizophrenia, bipolar disorder, and major depressive disorder

(2015) Veronica Reinhart et al.   NEUROBIOLOGY OF DISEASE

Multiple Nicotinic Acetylcholine Receptor Subtypes in the Mouse Amygdala Regulate Affective Behaviors and Response to Social Stress

(2015) Yann S Mineur et al.   NEUROPSYCHOPHARMACOLOGY

Double Dissociation of the Roles of Metabotropic Glutamate Receptor 5 and Oxytocin Receptor in Discrete Social Behaviors

(2015) Ivana Mesic et al.   NEUROPSYCHOPHARMACOLOGY

Targeting glutamine metabolism rescues mice from late-stage cerebral malaria

(2015) Emile B. Gordon et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Role of Translocator Protein Density, a Marker of Neuroinflammation, in the Brain During Major Depressive Episodes

(2015) Elaine Setiawan et al.   JAMA Psychiatry

R-ketamine: a rapid-onset and sustained antidepressant without psychotomimetic side effects

(2015) C Yang et al.   Translational Psychiatry

Antidepressant-like Effects of Cortical Deep Brain Stimulation Coincide With Pro-neuroplastic Adaptations of Serotonin Systems

(2014) Avin Veerakumar et al.   BIOLOGICAL PSYCHIATRY

Expression of Gls and Gls2 glutaminase isoforms in astrocytes

(2014) Carolina Cardona et al.   GLIA

Knockdown of Interleukin-1 Receptor Type-1 on Endothelial Cells Attenuated Stress-Induced Neuroinflammation and Prevented Anxiety-Like Behavior

(2014) E. S. Wohleb et al.   JOURNAL OF NEUROSCIENCE

Prefrontal Cortical Circuit for Depression- and Anxiety-Related Behaviors Mediated by Cholecystokinin: Role of  FosB

(2014) V. Vialou et al.   JOURNAL OF NEUROSCIENCE

Deficient neuron-microglia signaling results in impaired functional brain connectivity and social behavior

(2014) Yang Zhan et al.   NATURE NEUROSCIENCE

Neurocognitive Effects of Ketamine and Association with Antidepressant Response in Individuals with Treatment-Resistant Depression: A Randomized Controlled Trial

(2014) James W Murrough et al.   NEUROPSYCHOPHARMACOLOGY

Individual differences in the peripheral immune system promote resilience versus susceptibility to social stress

(2014) Georgia E. Hodes et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Small molecule glutaminase inhibitors block glutamate release from stimulated microglia

(2013) Ajit G. Thomas et al.   BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS

From Pathophysiology to Novel Antidepressant Drugs: Glial Contributions to the Pathology and Treatment of Mood Disorders

(2013) Gerard Sanacora et al.   BIOLOGICAL PSYCHIATRY

Rapid-Acting Glutamatergic Antidepressants: The Path to Ketamine and Beyond

(2013) John H. Krystal et al.   BIOLOGICAL PSYCHIATRY

Targeting the Glutamatergic System for the Treatment of HIV-Associated Neurocognitive Disorders

(2013) Michelle C. Potter et al.   Journal of Neuroimmune Pharmacology

Functional connectivity between the amygdala and prefrontal cortex in medication-naive individuals with major depressive disorder

(2013) Lingtao Kong et al.   JOURNAL OF PSYCHIATRY & NEUROSCIENCE

Astrocyte-derived ATP modulates depressive-like behaviors

(2013) Xiong Cao et al.   NATURE MEDICINE

Multiple sclerosis and glutamate excitotoxicity

(2012) Milos Kostic et al.   REVIEWS IN THE NEUROSCIENCES

A Randomized Controlled Trial of the Tumor Necrosis Factor Antagonist Infliximab for Treatment-Resistant Depression

(2012) Charles L. Raison et al.   JAMA Psychiatry

Activation of a ΔFOSB dependent gene expression pattern in the dorsolateral prefrontal cortex of patients with major depressive disorder

(2011) Jean-Raymond Teyssier et al.   JOURNAL OF AFFECTIVE DISORDERS

Glutaminase Dysregulation in HIV-1-Infected Human Microglia Mediates Neurotoxicity: Relevant to HIV-1-Associated Neurocognitive Disorders

(2011) Y. Huang et al.   JOURNAL OF NEUROSCIENCE

 -Adrenergic Receptor Antagonism Prevents Anxiety-Like Behavior and Microglial Reactivity Induced by Repeated Social Defeat

(2011) E. S. Wohleb et al.   JOURNAL OF NEUROSCIENCE

A standardized protocol for repeated social defeat stress in mice

(2011) Sam A Golden et al.   Nature Protocols

The role of glutamate in neuronal ischemic injury: the role of spark in fire

(2011) Botros B. Kostandy   NEUROLOGICAL SCIENCES

Assessment of Social Interaction Behaviors

(2011) Oksana Kaidanovich-Beilin et al.   Jove-Journal of Visualized Experiments

Inhibition of Glutaminase Preferentially Slows Growth of Glioma Cells with Mutant IDH1

(2010) M. J. Seltzer et al.   CANCER RESEARCH

Rett Syndrome Microglia Damage Dendrites and Synapses by the Elevated Release of Glutamate

(2010) I. Maezawa et al.   JOURNAL OF NEUROSCIENCE

Mesolimbic Dopamine Neurons in the Brain Reward Circuit Mediate Susceptibility to Social Defeat and Antidepressant Action

(2010) J.-L. Cao et al.   JOURNAL OF NEUROSCIENCE

Altered expression of genes involved in inflammation and apoptosis in frontal cortex in major depression

(2010) R C Shelton et al.   MOLECULAR PSYCHIATRY

ΔFosB in brain reward circuits mediates resilience to stress and antidepressant responses

(2010) Vincent Vialou et al.   NATURE NEUROSCIENCE

Animal models of neuropsychiatric disorders

(2010) Eric J Nestler et al.   NATURE NEUROSCIENCE

Glutamate receptors, neurotoxicity and neurodegeneration

(2010) Anthony Lau et al.   PFLUGERS ARCHIV-EUROPEAN JOURNAL OF PHYSIOLOGY

Inflammation and Its Discontents: The Role of Cytokines in the Pathophysiology of Major Depression

(2009) Andrew H. Miller et al.   BIOLOGICAL PSYCHIATRY

Glutaminase-Deficient Mice Display Hippocampal Hypoactivity, Insensitivity to Pro-Psychotic Drugs and Potentiated Latent Inhibition: Relevance to Schizophrenia

(2009) Inna Gaisler-Salomon et al.   NEUROPSYCHOPHARMACOLOGY

Blockade of Glutamate Release from Microglia Attenuates Experimental Autoimmune Encephalomyelitis in Mice

(2009) Jin Shijie et al.   TOHOKU JOURNAL OF EXPERIMENTAL MEDICINE

Targeting the glutamatergic system to develop novel, improved therapeutics for mood disorders

(2008) Gerard Sanacora et al.   NATURE REVIEWS DRUG DISCOVERY

Novel Drugs and Therapeutic Targets for Severe Mood Disorders

(2008) Sanjay J Mathew et al.   NEUROPSYCHOPHARMACOLOGY